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Streamlined Workflows for Polymorph and Salt

Pre-formulation
Lead compound characterization to identify forms of an Active Pharmaceutical Ingredient (API) with optimal druggable properties (i.e. stability) and to protect intellectual property

What is a Polymorph?

Polymorphism (materials science), a solid which shares chemical composition with another material but is composed of a different crystal lattice or form, often called a polymorph. ...from Wikipedia

Problems
Early in discovery API limited; however, extensive screening required to find the most druggable forms

When performed manually, extremely labor intensive, time consuming, and analytically intensive

Solution
Miniaturize experiments to get more data points from less material

Run more experiments in parallel to shorten screening cycle times

Crystallization: Parallel Processing of 96 Samples Enables Rapid Selection of Best API Form w/ Minimal Starting Material

 
What Part of the Crystallization Workflow Does the Benchtop Instrument Automate?