
  Mrv0541 04281317412D          

 13 13  0  0  0  0            999 V2000
   -0.1620    0.1585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5526    0.5708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8858    0.5799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2672    0.1585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1620   -0.6706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5913    0.1585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9818    1.3953    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9818    0.5708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8858   -1.0829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5913   -0.6706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8858   -1.9074    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.8858    1.4045    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2672   -0.6660    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  3  1  1  0  0  0  0
  4  2  2  0  0  0  0
  5  1  2  0  0  0  0
  6  3  2  0  0  0  0
  7  8  2  0  0  0  0
  8  4  1  0  0  0  0
  9  5  1  0  0  0  0
 10  9  2  0  0  0  0
 11  9  1  0  0  0  0
 12  3  1  0  0  0  0
 13  4  1  0  0  0  0
 10  6  1  0  0  0  0
M  END
>  <CdId>
61

>  <Mol Weight>
196.63

>  <Formula>
C10H9ClO2

>  <AKOS_NUMBER>
AKOS002341062

>  <Lipinski's Rule of Five>
0

>  <XLogP (text field)>
1.37

>  <PASS_MNA_NEW_COUNT>
0

>  <PASS_RESULT_COUNT>
   21 of   464 Possible Pharmacological Effects at Pa > 0.400
  106 of  3850 Possible Mechanisms of Action at Pa > 0.400
   92 of   321 Possible Toxic and Adverse Effects at Pa > 0.400
    2 of   118 Possible Antitargets at Pa > 0.400
   24 of   195 Possible Metabolism-Related Actions at Pa > 0.400
  771 of  1610 Possible Gene Expression Regulation at Pa > 0.400
    0 of    68 Possible Transporters-Related Actions at Pa > 0.400

>  <Effects>
0,726  0,033  Antiseborrheic
0,686  0,028  Fibrinolytic
0,594  0,022  Lipid metabolism regulator
0,509  0,012  Antiseptic
0,522  0,037  Apoptosis agonist
0,497  0,018  Muscular dystrophy treatment
0,494  0,023  Antiinfective
0,495  0,025  Antiprotozoal (Leishmania)
0,533  0,064  Acute neurologic disorders treatment
0,503  0,052  Preneoplastic conditions treatment
0,517  0,068  Mucositis treatment
0,454  0,020  Skin irritation, inactive
0,494  0,065  Antidyskinetic
0,438  0,024  Antiparasitic
0,450  0,039  Antifungal
0,414  0,035  Antihypercholesterolemic
0,482  0,104  Antibacterial activity enhancer
0,412  0,045  Antimyopathies
0,446  0,094  Potassium sparing diuretic
0,418  0,104  Antinephrotoxic
0,402  0,094  Antiinflammatory

>  <Antitargets>
0,853  0,016  Ubiquinol-cytochrome-c reductase inhibitor
0,410  0,062  Superoxide dismutase inhibitor

>  <Gene_Expression>
0,962  0,002  RAD51AP1 expression enhancer
0,936  0,009  HSPD1 expression inhibitor
0,905  0,006  FGFR1 expression inhibitor
0,900  0,006  ITGB6 expression inhibitor
0,896  0,006  PPARA expression inhibitor
0,894  0,004  ZNF91 expression inhibitor
0,895  0,005  TNF expression enhancer
0,891  0,009  PHB expression inhibitor
0,887  0,006  SATB1 expression inhibitor
0,884  0,004  IL18 expression inhibitor
0,877  0,004  CDKN1C expression inhibitor
0,876  0,006  LYN expression inhibitor
0,869  0,003  GSTM2 expression inhibitor
0,870  0,005  CCL2 expression enhancer
0,857  0,004  PKM2 expression enhancer
0,861  0,009  AHR expression inhibitor
0,863  0,011  ATP1B3 expression inhibitor
0,836  0,003  EIF2B4 expression enhancer
0,835  0,003  KEAP1 expression enhancer
0,836  0,007  FUBP1 expression inhibitor
0,833  0,006  CPE expression inhibitor
0,829  0,004  CDH1 expression enhancer
0,830  0,005  WFDC2 expression enhancer
0,831  0,010  CNN1 expression enhancer
0,829  0,014  MAPT expression enhancer
0,822  0,008  ESR1 expression inhibitor
0,818  0,008  NFKBIA expression enhancer
0,826  0,021  ITGB1 expression enhancer
0,808  0,002  FASN expression inhibitor
0,817  0,011  DHRS2 expression enhancer
0,819  0,015  JUN expression enhancer
0,806  0,005  NME2 expression inhibitor
0,803  0,006  MMP2 expression enhancer
0,806  0,010  IGFBP6 expression inhibitor
0,804  0,014  APOM expression enhancer
0,803  0,013  ID1 expression inhibitor
0,792  0,003  TFAM expression inhibitor
0,796  0,010  PLIN2 expression enhancer
0,790  0,004  SCARB1 expression enhancer
0,796  0,015  BCL2L1 expression inhibitor
0,794  0,015  NBN expression inhibitor
0,801  0,023  STAR expression enhancer
0,788  0,011  TNS3 expression enhancer
0,792  0,016  ETS2 expression inhibitor
0,788  0,013  TNFRSF21 expression inhibitor
0,797  0,022  BIRC2 expression inhibitor
0,792  0,019  PLAUR expression enhancer
0,778  0,005  FTL expression enhancer
0,778  0,007  DFFA expression inhibitor
0,773  0,004  TNFSF10 expression enhancer
0,772  0,004  HMGN2 expression inhibitor
0,802  0,033  NAA15 expression inhibitor
0,773  0,006  HAPLN3 expression inhibitor
0,788  0,022  SERPINB5 expression inhibitor
0,783  0,017  PRKCA expression enhancer
0,798  0,032  CD36 expression inhibitor
0,770  0,006  PSAT1 expression inhibitor
0,784  0,020  ILF3 expression inhibitor
0,781  0,017  BIRC3 expression enhancer
0,777  0,014  PMEPA1 expression inhibitor
0,771  0,010  UBE2C expression enhancer
0,764  0,004  IMPDH2 expression enhancer
0,762  0,005  FOS expression inhibitor
0,769  0,011  ITGB7 expression enhancer
0,765  0,010  TGFA expression enhancer
0,758  0,005  PELI1 expression inhibitor
0,777  0,027  FANCC expression inhibitor
0,774  0,026  OAS2 expression enhancer
0,772  0,025  EZH2 expression inhibitor
0,757  0,013  SLC16A4 expression enhancer
0,757  0,013  IL1B expression enhancer
0,760  0,016  ETV5 expression inhibitor
0,755  0,014  IER3 expression inhibitor
0,774  0,034  CXCR1 expression enhancer
0,748  0,013  LAMC1 expression enhancer
0,757  0,022  STAT1 expression inhibitor
0,765  0,033  MYL6 expression enhancer
0,746  0,014  IGF2 expression inhibitor
0,742  0,011  ERBB4 expression inhibitor
0,768  0,036  DUSP4 expression enhancer
0,734  0,003  ALDH4A1 expression inhibitor
0,749  0,019  PRKDC expression inhibitor
0,739  0,008  G0S2 expression enhancer
0,735  0,005  IL6ST expression inhibitor
0,748  0,019  THBS1 expression enhancer
0,740  0,012  CDKN1B expression inhibitor
0,749  0,021  GTF2F1 expression inhibitor
0,738  0,012  TRIM16 expression enhancer
0,728  0,004  MANSC1 expression inhibitor
0,744  0,023  JAG1 expression inhibitor
0,727  0,006  SF3B5 expression enhancer
0,727  0,007  CRABP2 expression inhibitor
0,723  0,006  ANAPC1 expression enhancer
0,731  0,015  PIK3R2 expression inhibitor
0,746  0,030  BST2 expression enhancer
0,721  0,007  ST3GAL1 expression enhancer
0,739  0,025  TXNIP expression inhibitor
0,746  0,033  SUZ12 expression inhibitor
0,725  0,012  NOC3L expression inhibitor
0,733  0,021  IL1RN expression inhibitor
0,749  0,039  GPX1 expression inhibitor
0,716  0,007  POR expression enhancer
0,723  0,014  FOSL1 expression enhancer
0,732  0,023  TFDP2 expression inhibitor
0,720  0,012  STRBP expression inhibitor
0,731  0,024  VDR expression enhancer
0,726  0,021  MAPK8 expression inhibitor
0,717  0,012  VAT1 expression enhancer
0,764  0,062  LPL expression enhancer
0,713  0,011  PIM1 expression enhancer
0,716  0,014  HLA-B expression enhancer
0,715  0,015  GSTM3 expression inhibitor
0,726  0,027  FILIP1L expression inhibitor
0,715  0,016  SOX9 expression enhancer
0,703  0,004  CIRBP expression inhibitor
0,701  0,003  KRT17 expression inhibitor
0,703  0,007  ASAH1 expression enhancer
0,699  0,005  TRIM24 expression inhibitor
0,714  0,020  CCND1 expression inhibitor
0,697  0,005  CD47 expression inhibitor
0,706  0,015  GATA2 expression enhancer
0,690  0,005  SLC31A1 expression enhancer
0,689  0,004  MET expression enhancer
0,686  0,002  DLX4 expression enhancer
0,689  0,006  COL4A1 expression inhibitor
0,688  0,005  ASRGL1 expression enhancer
0,706  0,023  IL10 expression enhancer
0,701  0,020  NT5DC2 expression enhancer
0,701  0,020  RAI14 expression enhancer
0,701  0,020  RFTN1 expression enhancer
0,685  0,005  TGFB2 expression inhibitor
0,705  0,025  MCM6 expression enhancer
0,683  0,005  HIVEP1 expression enhancer
0,692  0,013  CYB5R2 expression enhancer
0,696  0,018  CLMN expression enhancer
0,715  0,037  SERPINB5 expression enhancer
0,696  0,019  MAFB expression inhibitor
0,696  0,024  DDX18 expression inhibitor
0,684  0,013  MYB expression inhibitor
0,675  0,004  ERCC3 expression enhancer
0,689  0,018  EFEMP1 expression inhibitor
0,679  0,008  CBLB expression inhibitor
0,702  0,032  HIF1A expression enhancer
0,683  0,015  DAB2 expression enhancer
0,687  0,020  IL6 expression inhibitor
0,671  0,005  MFN2 expression enhancer
0,671  0,005  NEIL2 expression enhancer
0,686  0,022  SLC1A1 expression enhancer
0,668  0,004  SLCO2A1 expression enhancer
0,685  0,024  CDC25C expression inhibitor
0,673  0,012  TXNRD1 expression enhancer
0,672  0,012  TGFBI expression enhancer
0,678  0,018  PLD1 expression enhancer
0,669  0,010  CSE1L expression inhibitor
0,678  0,020  BAD expression inhibitor
0,662  0,004  GPR142 expression enhancer
0,669  0,012  CDK5 expression enhancer
0,677  0,021  ELL2 expression enhancer
0,686  0,030  FGF2 expression inhibitor
0,671  0,016  EZR expression inhibitor
0,671  0,016  GAK expression inhibitor
0,671  0,016  TERF1 expression inhibitor
0,672  0,017  CTTN expression inhibitor
0,659  0,004  KCTD20 expression enhancer
0,659  0,004  LPPR2 expression enhancer
0,659  0,004  MAPK13 expression inhibitor
0,659  0,004  METTL21D expression inhibitor
0,659  0,004  PDCD7 expression enhancer
0,659  0,004  PRKAR2A expression enhancer
0,659  0,004  TSC22D1 expression inhibitor
0,659  0,004  ZKSCAN2 expression enhancer
0,659  0,004  ZMYM3 expression enhancer
0,673  0,018  TUBA4A expression enhancer
0,690  0,036  CD44 expression inhibitor
0,657  0,006  C22ORF29 expression enhancer
0,657  0,006  ETNK2 expression enhancer
0,656  0,006  PGR expression enhancer
0,674  0,024  IL1A expression inhibitor
0,667  0,017  GRPEL1 expression inhibitor
0,680  0,031  NAT1 expression enhancer
0,702  0,054  PDXK expression inhibitor
0,655  0,006  C6ORF48 expression inhibitor
0,653  0,010  CYB5A expression enhancer
0,666  0,023  SESN1 expression inhibitor
0,650  0,008  CSDA expression inhibitor
0,666  0,025  NEIL3 expression inhibitor
0,645  0,005  IL2 expression inhibitor
0,667  0,027  TIMP3 expression enhancer
0,671  0,031  ID2 expression enhancer
0,652  0,013  HMOX1 expression enhancer
0,648  0,010  OLFM1 expression enhancer
0,656  0,018  KLK6 expression enhancer
0,656  0,018  PADI3 expression enhancer
0,650  0,015  RRM2 expression enhancer
0,657  0,022  PTGS2 expression enhancer
0,639  0,005  GALNT4 expression enhancer
0,664  0,030  ALCAM expression inhibitor
0,646  0,013  SPARC expression inhibitor
0,655  0,022  GNL3 expression inhibitor
0,664  0,032  NASP expression inhibitor
0,679  0,050  TOP1 expression inhibitor
0,648  0,018  MAP2K1 expression enhancer
0,634  0,005  CCL4 expression enhancer
0,668  0,042  TMEM158 expression enhancer
0,641  0,015  NR5A2 expression enhancer
0,641  0,015  ZBTB10 expression inhibitor
0,649  0,023  WISP2 expression inhibitor
0,630  0,004  FOXD1 expression enhancer
0,637  0,013  SELE expression enhancer
0,646  0,022  RPS19 expression inhibitor
0,646  0,022  SIRT1 expression inhibitor
0,640  0,016  FEN1 expression inhibitor
0,665  0,042  GADD45A expression inhibitor
0,647  0,024  JAK2 expression inhibitor
0,647  0,024  TBC1D1 expression inhibitor
0,655  0,033  THBD expression enhancer
0,667  0,046  SRPK1 expression inhibitor
0,658  0,038  CDCA5 expression enhancer
0,660  0,040  MSMO1 expression enhancer
0,659  0,040  CASP3 expression enhancer
0,644  0,025  PRRX1 expression inhibitor
0,631  0,012  INPP4B expression inhibitor
0,648  0,029  HMBS expression inhibitor
0,626  0,009  APOA1 expression enhancer
0,628  0,014  DFFB expression inhibitor
0,641  0,026  EDN1 expression enhancer
0,656  0,042  ITGB2 expression enhancer
0,630  0,017  ISG15 expression enhancer
0,669  0,056  NFKB1 expression enhancer
0,630  0,018  AP1S2 expression enhancer
0,638  0,026  PRSS23 expression enhancer
0,619  0,007  BST2 expression inhibitor
0,644  0,033  KPNA1 expression enhancer
0,621  0,011  CEBPD expression inhibitor
0,621  0,011  HADH expression enhancer
0,621  0,011  MELK expression enhancer
0,621  0,011  TFF3 expression enhancer
0,619  0,009  LYN expression enhancer
0,627  0,017  SLC17A2 expression inhibitor
0,612  0,003  DLX2 expression enhancer
0,609  0,001  GSTM5 expression enhancer
0,627  0,018  IGFBP5 expression enhancer
0,641  0,035  EPRS expression inhibitor
0,615  0,009  E2F1 expression inhibitor
0,610  0,005  NFE2L2 expression enhancer
0,617  0,012  REL expression enhancer
0,623  0,018  PLA2G2A expression enhancer
0,609  0,005  ETS1 expression inhibitor
0,609  0,005  MLPH expression enhancer
0,626  0,023  EPHA4 expression enhancer
0,619  0,017  DEK expression inhibitor
0,615  0,012  BNIP3 expression inhibitor
0,643  0,041  IFNGR1 expression enhancer
0,659  0,058  STAT5B expression enhancer
0,642  0,041  EIF2S1 expression enhancer
0,631  0,031  NOL5A expression inhibitor
0,622  0,023  TIMP1 expression enhancer
0,634  0,036  HSPA1A expression enhancer
0,608  0,010  CEBPG expression inhibitor
0,607  0,010  F2R expression inhibitor
0,631  0,034  TNFRSF11A expression enhancer
0,612  0,016  ATR expression inhibitor
0,612  0,016  EFNA4 expression inhibitor
0,612  0,016  MARK3 expression inhibitor
0,612  0,016  SMAD1 expression inhibitor
0,615  0,021  GPX2 expression enhancer
0,633  0,039  TRAK2 expression enhancer
0,599  0,005  CABLES1 expression enhancer
0,599  0,005  CHAC2 expression enhancer
0,599  0,005  GALR2 expression inhibitor
0,599  0,005  HES2 expression enhancer
0,599  0,005  MEOX1 expression inhibitor
0,599  0,005  MFGE8 expression inhibitor
0,602  0,008  CYP11A1 expression enhancer
0,623  0,030  PCDH8 expression enhancer
0,611  0,017  NR1H2 expression inhibitor
0,662  0,069  SLC2A4 expression enhancer
0,607  0,014  ESR1 expression enhancer
0,597  0,004  CAPN9 expression enhancer
0,597  0,004  FAM107A expression inhibitor
0,597  0,004  GDPD5 expression enhancer
0,607  0,015  CSNK1D expression inhibitor
0,607  0,015  SPATA20 expression enhancer
0,598  0,007  ESR2 expression inhibitor
0,602  0,011  CBS expression inhibitor
0,611  0,020  SP2 expression inhibitor
0,623  0,033  SLC3A2 expression enhancer
0,622  0,033  CLDN4 expression enhancer
0,658  0,069  XPO1 expression inhibitor
0,610  0,021  POLE2 expression inhibitor
0,603  0,014  IFI30 expression enhancer
0,607  0,018  ADIPOR2 expression inhibitor
0,642  0,054  SFPQ expression enhancer
0,602  0,015  PDK4 expression enhancer
0,607  0,020  YWHAH expression inhibitor
0,624  0,038  PDE9A expression inhibitor
0,626  0,040  CDC25B expression enhancer
0,620  0,035  NPM3 expression inhibitor
0,620  0,035  PTEN expression inhibitor
0,618  0,032  FKBP8 expression inhibitor
0,611  0,027  EPHB4 expression inhibitor
0,611  0,027  NMT1 expression inhibitor
0,605  0,021  KLK3 expression inhibitor
0,598  0,018  BAX expression inhibitor
0,602  0,022  TRAM1 expression inhibitor
0,600  0,020  CYP11A1 expression inhibitor
0,638  0,059  EIF2S1 expression inhibitor
0,615  0,037  PDCD4 expression enhancer
0,597  0,020  ID3 expression inhibitor
0,616  0,039  CD58 expression inhibitor
0,625  0,049  ABCC5 expression enhancer
0,598  0,022  BMP1 expression inhibitor
0,619  0,044  TP53 expression enhancer
0,595  0,022  PML expression inhibitor
0,577  0,005  CXCR4 expression enhancer
0,605  0,035  ASNS expression inhibitor
0,580  0,010  DHRS3 expression enhancer
0,590  0,020  WAS expression enhancer
0,594  0,025  PTN expression enhancer
0,628  0,059  CYR61 expression enhancer
0,586  0,018  MT1X expression inhibitor
0,599  0,030  EZH1 expression enhancer
0,614  0,046  MT1A expression enhancer
0,575  0,008  COL1A1 expression enhancer
0,606  0,039  RNF4 expression inhibitor
0,597  0,030  VAV3 expression inhibitor
0,582  0,016  NCF1 expression enhancer
0,592  0,026  C1S expression enhancer
0,608  0,043  NCOA2 expression enhancer
0,608  0,043  SLC16A2 expression enhancer
0,581  0,017  PLA2G16 expression enhancer
0,581  0,017  TCEB3 expression inhibitor
0,570  0,006  ADAMTS9 expression enhancer
0,596  0,032  SERPINE2 expression enhancer
0,601  0,038  CDK2 expression inhibitor
0,568  0,007  HEY2 expression enhancer
0,578  0,016  MDK expression inhibitor
0,605  0,044  UGCG expression enhancer
0,569  0,009  IGF1R expression enhancer
0,570  0,010  RARB expression inhibitor
0,582  0,022  XRCC4 expression enhancer
0,589  0,030  SAT expression enhancer
0,565  0,006  ERCC2 expression inhibitor
0,576  0,018  EGR3 expression inhibitor
0,572  0,015  HNRNPH2 expression inhibitor
0,591  0,035  SPP1 expression enhancer
0,583  0,028  STAT3 expression inhibitor
0,588  0,033  CDC16 expression inhibitor
0,595  0,041  PCNA expression enhancer
0,604  0,049  MYB expression enhancer
0,582  0,028  TOP2A expression inhibitor
0,578  0,024  FGFR3 expression inhibitor
0,568  0,014  BFSP2 expression enhancer
0,568  0,014  EGLN3 expression enhancer
0,602  0,049  ZFP36 expression enhancer
0,600  0,047  VEGFA expression inhibitor
0,588  0,036  CLMP expression inhibitor
0,586  0,034  AKT1 expression enhancer
0,600  0,048  BAX expression enhancer
0,573  0,023  BAG5 expression inhibitor
0,575  0,025  HSP27 expression enhancer
0,559  0,010  SELENBP1 expression inhibitor
0,576  0,027  NKX3-1 expression inhibitor
0,568  0,019  AOX1 expression enhancer
0,588  0,040  IL4 expression enhancer
0,557  0,009  DOK4 expression enhancer
0,558  0,011  PPP1R3C expression inhibitor
0,563  0,016  PHGDH expression inhibitor
0,566  0,019  TRAM2 expression inhibitor
0,563  0,017  TUBB3 expression enhancer
0,563  0,017  MT1H expression inhibitor
0,564  0,023  ALPL expression enhancer
0,573  0,033  HLA-F expression enhancer
0,586  0,048  CCNE2 expression inhibitor
0,557  0,020  JUN expression inhibitor
0,547  0,010  WDR67 expression inhibitor
0,558  0,021  IGFBP2 expression inhibitor
0,571  0,035  ATP2A2 expression enhancer
0,569  0,033  DTYMK expression enhancer
0,563  0,028  PA2G4 expression inhibitor
0,566  0,033  ADSL expression inhibitor
0,559  0,026  DEPTOR expression enhancer
0,558  0,025  CXCR7 expression inhibitor
0,556  0,025  DAPK1 expression inhibitor
0,563  0,032  CREB1 expression inhibitor
0,555  0,025  ITGA6 expression inhibitor
0,560  0,031  COL3A1 expression inhibitor
0,555  0,027  IL8 expression enhancer
0,548  0,020  GALNT1 expression inhibitor
0,564  0,037  ADAM17 expression inhibitor
0,564  0,037  CTBP1 expression inhibitor
0,557  0,031  AREG expression enhancer
0,540  0,014  SH2D4A expression inhibitor
0,570  0,045  CDKN1A expression enhancer
0,538  0,014  GGH expression enhancer
0,538  0,014  STMN1 expression enhancer
0,539  0,015  BAD expression enhancer
0,563  0,039  SF1 expression inhibitor
0,577  0,054  IL6 expression enhancer
0,575  0,053  MMP15 expression inhibitor
0,535  0,013  HIST1H2BD expression enhancer
0,545  0,023  ODZ3 expression inhibitor
0,545  0,023  TBC1D9 expression inhibitor
0,591  0,070  PDIA3 expression enhancer
0,548  0,028  KLHL24 expression inhibitor
0,583  0,064  MMP7 expression enhancer
0,540  0,020  DHCR24 expression enhancer
0,534  0,014  RXRA expression enhancer
0,591  0,073  ITGA3 expression enhancer
0,524  0,008  TSKU expression enhancer
0,571  0,056  PRKAR2B expression enhancer
0,522  0,007  CXCL12 expression enhancer
0,550  0,035  CD86 expression enhancer
0,517  0,002  ASB1 expression enhancer
0,521  0,007  SLC16A1 expression inhibitor
0,550  0,038  CEACAM6 expression enhancer
0,529  0,017  NOS1 expression inhibitor
0,557  0,046  MEGF9 expression inhibitor
0,567  0,057  TMSB4X expression inhibitor
0,574  0,065  C10ORF116 expression enhancer
0,554  0,047  PDCD4 expression inhibitor
0,527  0,020  BRF1 expression inhibitor
0,523  0,016  TMSB4X expression enhancer
0,545  0,038  YWHAE expression inhibitor
0,530  0,024  HOXA10 expression enhancer
0,542  0,037  HMGA1 expression inhibitor
0,529  0,024  MYBL2 expression inhibitor
0,520  0,017  IGF2 expression enhancer
0,524  0,023  LDOC1 expression inhibitor
0,524  0,023  RPRM expression inhibitor
0,558  0,057  COL2A1 expression enhancer
0,525  0,025  CSF2 expression enhancer
0,552  0,052  MACF1 expression inhibitor
0,517  0,018  VWF expression enhancer
0,525  0,026  FOXC1 expression enhancer
0,524  0,026  PI4KA expression inhibitor
0,524  0,026  VCAN expression inhibitor
0,553  0,056  CCND2 expression enhancer
0,533  0,037  NPM1 expression inhibitor
0,542  0,046  CPNE1 expression enhancer
0,501  0,006  NQO1 expression enhancer
0,503  0,008  APOE expression enhancer
0,506  0,012  RNF144A expression inhibitor
0,506  0,012  SPRY1 expression inhibitor
0,517  0,024  AR expression inhibitor
0,505  0,012  MND1 expression inhibitor
0,563  0,071  KLK2 expression inhibitor
0,534  0,042  SIDT2 expression enhancer
0,536  0,045  ASXL1 expression inhibitor
0,536  0,045  C11ORF68 expression enhancer
0,536  0,045  CAPN7 expression inhibitor
0,536  0,045  FAM208A expression inhibitor
0,536  0,045  NKTR expression inhibitor
0,536  0,045  RABGAP1 expression inhibitor
0,536  0,045  SETD2 expression inhibitor
0,536  0,045  TIA1 expression inhibitor
0,536  0,045  TTC3 expression inhibitor
0,509  0,018  GARS expression inhibitor
0,540  0,049  DDIT4 expression enhancer
0,522  0,032  PARG expression enhancer
0,492  0,003  LHX3 expression enhancer
0,520  0,031  CDK6 expression inhibitor
0,544  0,055  TNFSF10 expression inhibitor
0,526  0,038  TRAF3 expression enhancer
0,500  0,014  NRIP1 expression enhancer
0,510  0,024  KIAA0930 expression enhancer
0,493  0,008  NBL1 expression enhancer
0,501  0,015  XPA expression enhancer
0,502  0,018  HMGB2 expression inhibitor
0,490  0,005  CTSB expression inhibitor
0,531  0,046  EIF3B expression inhibitor
0,520  0,036  FOXD1 expression inhibitor
0,524  0,040  TUBA1A expression inhibitor
0,538  0,054  TERT expression enhancer
0,507  0,024  PTEN expression enhancer
0,529  0,045  ABCC3 expression inhibitor
0,528  0,045  MLF1 expression enhancer
0,542  0,060  ITGB1 expression inhibitor
0,535  0,053  CCNA2 expression enhancer
0,535  0,053  CDK4 expression inhibitor
0,497  0,016  S100A8 expression enhancer
0,503  0,022  NEU4 expression enhancer
0,503  0,022  SH3GL2 expression inhibitor
0,519  0,038  NOLC1 expression inhibitor
0,504  0,024  GRB2 expression enhancer
0,515  0,036  EGR1 expression inhibitor
0,487  0,008  CPT1A expression enhancer
0,505  0,025  DPP4 expression enhancer
0,508  0,029  CCNE1 expression inhibitor
0,485  0,007  IL12RB1 expression inhibitor
0,528  0,050  CUTL1 expression inhibitor
0,491  0,014  PKP4 expression inhibitor
0,491  0,014  TUBGCP3 expression inhibitor
0,503  0,026  OLFML3 expression enhancer
0,508  0,030  HSBP1 expression inhibitor
0,528  0,051  BCL2 expression inhibitor
0,501  0,024  LAMC2 expression enhancer
0,517  0,040  TM4SF1 expression enhancer
0,498  0,022  MCM2 expression enhancer
0,488  0,014  EIF4E expression inhibitor
0,530  0,055  SNAI2 expression inhibitor
0,509  0,035  MT2A expression enhancer
0,501  0,027  PTPRM expression enhancer
0,526  0,052  HSPA1A expression inhibitor
0,543  0,071  MYBL1 expression enhancer
0,505  0,033  DLX4 expression inhibitor
0,527  0,055  PPARD expression inhibitor
0,501  0,030  KIF15 expression inhibitor
0,529  0,058  PRTN3 expression enhancer
0,484  0,014  SOCS2 expression enhancer
0,530  0,060  CP expression enhancer
0,563  0,094  MAPK8 expression enhancer
0,484  0,015  IFNG expression inhibitor
0,494  0,026  CYP17A1 expression enhancer
0,484  0,016  PPL expression inhibitor
0,506  0,038  RPS27L expression enhancer
0,519  0,052  JUND expression inhibitor
0,475  0,007  UGT1A10 expression enhancer
0,510  0,043  ALDH1A3 expression inhibitor
0,508  0,042  VIPR1 expression enhancer
0,475  0,010  GSN expression enhancer
0,521  0,056  ICAM1 expression enhancer
0,529  0,064  BIK expression inhibitor
0,480  0,017  MGST1 expression inhibitor
0,505  0,042  CTSD expression inhibitor
0,466  0,003  RARA expression inhibitor
0,469  0,007  RARB expression enhancer
0,501  0,038  PIM1 expression inhibitor
0,505  0,043  FUS expression inhibitor
0,532  0,071  CD38 expression enhancer
0,508  0,046  TNFRSF21 expression enhancer
0,501  0,040  THBS1 expression inhibitor
0,484  0,023  PIR expression enhancer
0,521  0,060  ORC4 expression enhancer
0,492  0,032  TP53I3 expression enhancer
0,505  0,045  MAOB expression enhancer
0,487  0,028  C5ORF32 expression enhancer
0,487  0,028  FAH expression enhancer
0,487  0,028  RRAS expression enhancer
0,487  0,028  SH3BGRL3 expression enhancer
0,582  0,124  RAD23B expression inhibitor
0,495  0,038  PGM2 expression enhancer
0,463  0,007  ITGB4 expression inhibitor
0,479  0,023  SUMO1 expression inhibitor
0,500  0,044  NPTX2 expression enhancer
0,490  0,035  RSAD2 expression enhancer
0,465  0,009  GCLC expression enhancer
0,503  0,049  CEP57 expression inhibitor
0,493  0,040  SOX9 expression inhibitor
0,558  0,106  PLAU expression inhibitor
0,492  0,040  TNNT1 expression inhibitor
0,479  0,027  CEBPD expression enhancer
0,470  0,019  ENC1 expression inhibitor
0,478  0,027  TNFSF11 expression inhibitor
0,508  0,057  RND3 expression inhibitor
0,528  0,078  FOS expression enhancer
0,508  0,058  CALR expression inhibitor
0,494  0,045  PTPRE expression enhancer
0,478  0,029  TNFRSF25 expression inhibitor
0,510  0,061  MGMT expression enhancer
0,509  0,060  CAV1 expression inhibitor
0,479  0,031  CCNK expression inhibitor
0,503  0,055  HLA-G expression enhancer
0,468  0,019  C6ORF108 expression inhibitor
0,468  0,019  CASK expression inhibitor
0,468  0,019  MAP2K5 expression inhibitor
0,468  0,019  PPP1CA expression inhibitor
0,468  0,019  TCF3 expression inhibitor
0,496  0,048  BAZ2A expression inhibitor
0,475  0,028  MT1F expression inhibitor
0,480  0,033  CDK1 expression inhibitor
0,473  0,026  LGALS3 expression enhancer
0,501  0,055  CBX1 expression inhibitor
0,471  0,025  IRF7 expression enhancer
0,465  0,019  ACSL3 expression inhibitor
0,469  0,024  PHYH expression enhancer
0,479  0,036  TGFBR2 expression enhancer
0,496  0,053  VCAM1 expression enhancer
0,462  0,019  PPAP2B expression inhibitor
0,488  0,046  KPNB1 expression enhancer
0,523  0,081  KPNA2 expression inhibitor
0,505  0,063  SEPT2 expression inhibitor
0,501  0,059  AHR expression enhancer
0,478  0,038  TNFRSF10B expression inhibitor
0,473  0,032  ID3 expression enhancer
0,483  0,044  HLA-C expression enhancer
0,478  0,040  UGT1A1 expression enhancer
0,474  0,036  TNF expression inhibitor
0,497  0,059  NAA15 expression enhancer
0,480  0,043  PTGS2 expression inhibitor
0,463  0,027  CCNB2 expression enhancer
0,499  0,063  SCARB1 expression inhibitor
0,455  0,020  HSD17B1 expression enhancer
0,509  0,073  C3 expression enhancer
0,481  0,046  ADD3 expression enhancer
0,469  0,034  EPAS1 expression enhancer
0,500  0,066  NOS2 expression enhancer
0,471  0,037  IGFBP5 expression inhibitor
0,470  0,038  SMAD3 expression enhancer
0,454  0,022  NKX3-1 expression enhancer
0,500  0,069  MMP2 expression inhibitor
0,472  0,041  CARS expression inhibitor
0,477  0,047  NR4A2 expression inhibitor
0,465  0,036  ISYNA1 expression enhancer
0,477  0,049  PPARGC1A expression enhancer
0,463  0,035  IL9 expression inhibitor
0,490  0,063  DUSP5 expression enhancer
0,464  0,038  PRDX1 expression inhibitor
0,450  0,024  IGF1R expression inhibitor
0,442  0,017  FOXN3 expression inhibitor
0,487  0,062  CCL5 expression inhibitor
0,433  0,008  LAMP3 expression inhibitor
0,487  0,063  PLA2G4A expression enhancer
0,452  0,028  PTPRK expression inhibitor
0,460  0,036  GCLM expression enhancer
0,464  0,041  TOB1 expression inhibitor
0,507  0,085  KIF23 expression enhancer
0,440  0,020  DST expression enhancer
0,469  0,051  ABLIM1 expression enhancer
0,466  0,048  TFF1 expression inhibitor
0,483  0,065  CASP9 expression inhibitor
0,456  0,039  RECQL expression inhibitor
0,447  0,030  DNMT1 expression inhibitor
0,434  0,017  PELI1 expression enhancer
0,427  0,011  COL4A2 expression inhibitor
0,445  0,029  DUSP10 expression enhancer
0,464  0,048  INCENP expression inhibitor
0,436  0,021  RGS10 expression enhancer
0,435  0,020  LPL expression inhibitor
0,449  0,035  CLDN5 expression enhancer
0,476  0,062  FN1 expression inhibitor
0,425  0,011  BRAF expression inhibitor
0,461  0,048  SERPINA3 expression enhancer
0,443  0,031  HLA-E expression enhancer
0,439  0,028  MFAP4 expression inhibitor
0,481  0,070  ACTA2 expression inhibitor
0,426  0,015  ITPK1 expression enhancer
0,454  0,043  CTNNA1 expression inhibitor
0,436  0,025  CAPN2 expression inhibitor
0,447  0,037  BID expression inhibitor
0,468  0,059  ATF3 expression inhibitor
0,463  0,055  TPM4 expression inhibitor
0,420  0,012  CCL20 expression enhancer
0,471  0,063  ABCB10 expression inhibitor
0,450  0,045  BGLAP expression inhibitor
0,467  0,062  DDX42 expression enhancer
0,446  0,042  SLC26A2 expression inhibitor
0,438  0,035  RAD51AP1 expression inhibitor
0,468  0,066  BRCA1 expression enhancer
0,419  0,018  LRP6 expression inhibitor
0,433  0,031  H1FX expression inhibitor
0,432  0,031  TK1 expression enhancer
0,465  0,064  PCAF expression enhancer
0,469  0,068  CITED2 expression inhibitor
0,430  0,030  RAN expression inhibitor
0,474  0,074  IFRD1 expression inhibitor
0,448  0,048  ASCL1 expression enhancer
0,419  0,019  SOD2 expression inhibitor
0,460  0,060  CBX3 expression inhibitor
0,442  0,043  JUNB expression inhibitor
0,441  0,042  TPO expression enhancer
0,458  0,059  CPM expression enhancer
0,430  0,032  APLP2 expression inhibitor
0,407  0,009  CTGF expression inhibitor
0,434  0,038  S100P expression enhancer
0,438  0,041  BIK expression enhancer
0,457  0,061  AKR1C1 expression enhancer
0,428  0,032  NHLRC2 expression inhibitor
0,417  0,021  MGST1 expression enhancer
0,425  0,029  LRP8 expression inhibitor
0,451  0,055  BUB1B expression enhancer
0,418  0,023  RHOC expression enhancer
0,453  0,058  SLC6A2 expression inhibitor
0,466  0,072  IL4R expression enhancer
0,470  0,075  GSTA1 expression enhancer
0,442  0,049  ARF3 expression enhancer
0,427  0,034  ZFAND5 expression inhibitor
0,432  0,039  APOD expression enhancer
0,435  0,043  SKP2 expression inhibitor
0,411  0,020  BMP6 expression inhibitor
0,446  0,055  MCM7 expression inhibitor
0,461  0,071  OS9 expression enhancer
0,420  0,029  TACC1 expression inhibitor
0,428  0,038  LAMA3 expression enhancer
0,440  0,050  CYP17A1 expression inhibitor
0,418  0,028  CYP24A1 expression enhancer
0,424  0,034  COL1A1 expression inhibitor
0,442  0,052  HSPE1 expression inhibitor
0,404  0,014  TFF1 expression enhancer
0,430  0,041  SULF2 expression enhancer
0,458  0,069  TMPRSS2 expression inhibitor
0,452  0,063  CDKN2A expression enhancer
0,453  0,064  ARL6IP5 expression enhancer
0,426  0,037  MDFI expression inhibitor
0,426  0,037  SYMPK expression inhibitor
0,475  0,087  TNFAIP2 expression enhancer
0,428  0,040  STC2 expression enhancer
0,427  0,040  PLAGL1 expression enhancer
0,475  0,087  NR4A2 expression enhancer
0,429  0,043  MMP9 expression inhibitor
0,408  0,022  FGFR1 expression enhancer
0,452  0,067  RRBP1 expression enhancer
0,431  0,046  VEGF expression enhancer
0,432  0,047  ABCG1 expression enhancer
0,419  0,035  CALU expression inhibitor
0,437  0,052  FADD expression enhancer
0,452  0,067  RAD51C expression enhancer
0,452  0,067  SMC4 expression enhancer
0,452  0,067  ZWINT expression enhancer
0,451  0,067  MVP expression enhancer
0,421  0,037  PLCB1 expression enhancer
0,430  0,047  PPARA expression enhancer
0,409  0,026  SLC7A5 expression enhancer
0,414  0,032  EPB41L2 expression inhibitor
0,408  0,027  PTGER4 expression enhancer
0,427  0,046  ERBB2 expression enhancer
0,456  0,075  FOLH1 expression inhibitor
0,438  0,059  MDK expression enhancer
0,403  0,025  SLC6A6 expression enhancer
0,425  0,050  ME1 expression enhancer
0,413  0,038  CTPS expression inhibitor
0,428  0,053  ACPP expression enhancer
0,418  0,043  APOBEC3B expression enhancer
0,441  0,067  DDIT3 expression enhancer
0,403  0,029  ZBTB1 expression enhancer
0,448  0,074  SERPINE1 expression enhancer
0,412  0,039  TNPO2 expression inhibitor
0,425  0,051  MAD1L1 expression enhancer
0,422  0,051  ZNF114 expression enhancer
0,423  0,052  ANXA1 expression inhibitor
0,441  0,071  MAP1B expression enhancer
0,459  0,088  MAF expression enhancer
0,402  0,034  CDKN2C expression enhancer
0,454  0,086  FAS expression inhibitor
0,444  0,077  NAV1 expression inhibitor
0,407  0,040  MYLIP expression enhancer
0,456  0,090  TP53TG1 expression enhancer
0,408  0,042  S100A11 expression enhancer
0,432  0,067  VIM expression inhibitor
0,426  0,061  KLF10 expression inhibitor
0,423  0,059  CALM3 expression enhancer
0,428  0,066  PRDX2 expression enhancer
0,435  0,074  DCC expression enhancer
0,411  0,051  BMP2 expression enhancer
0,414  0,054  LAMB3 expression enhancer
0,472  0,112  UNG expression inhibitor
0,419  0,060  BRD2 expression enhancer
0,419  0,060  NENF expression enhancer
0,419  0,060  SRRM2 expression inhibitor
0,419  0,060  ZCCHC2 expression inhibitor
0,421  0,061  CRH expression inhibitor
0,401  0,045  CSF3 expression enhancer
0,463  0,107  KPNA1 expression inhibitor
0,414  0,060  PSRC1 expression inhibitor
0,420  0,070  DDX24 expression inhibitor
0,410  0,061  TIMP1 expression inhibitor
0,443  0,095  VEGFA expression enhancer
0,433  0,085  AGPS expression inhibitor
0,447  0,102  CASP9 expression enhancer
0,412  0,069  CDKN1A expression inhibitor
0,402  0,060  FGFR2 expression enhancer
0,409  0,069  AHRR expression enhancer
0,432  0,092  SPATA13 expression enhancer
0,433  0,104  APOA1 expression inhibitor
0,427  0,098  TNFSF9 expression enhancer
0,420  0,091  ABCB1 expression enhancer
0,409  0,093  RASEF expression inhibitor
0,404  0,094  PSMC1 expression enhancer
0,437  0,132  MSH6 expression inhibitor
0,430  0,130  TXNRD1 expression inhibitor
0,420  0,130  INHBE expression enhancer

>  <Mechanisms>
0,853  0,016  Ubiquinol-cytochrome-c reductase inhibitor
0,809  0,018  Chlordecone reductase inhibitor
0,798  0,012  Feruloyl esterase inhibitor
0,837  0,061  Transferase stimulant
0,750  0,005  Amine dehydrogenase inhibitor
0,781  0,040  Membrane integrity agonist
0,698  0,007  3-Phytase inhibitor
0,697  0,020  Aldose reductase-like protein inhibitor
0,722  0,047  Mucomembranous protector
0,673  0,017  Guanyl-specific ribonuclease T1 inhibitor
0,635  0,008  H+-exporting ATPase inhibitor
0,632  0,021  Fatty-acyl-CoA synthase inhibitor
0,611  0,008  Pyruvate decarboxylase inhibitor
0,627  0,025  2-Hydroxyquinoline 8-monooxygenase inhibitor
0,628  0,033  Glucose oxidase inhibitor
0,627  0,033  Dehydro-L-gulonate decarboxylase inhibitor
0,622  0,033  Complement factor D inhibitor
0,594  0,022  Lipid metabolism regulator
0,576  0,011  N-hydroxyarylamine O-acetyltransferase inhibitor
0,582  0,017  Beta glucuronidase inhibitor
0,580  0,023  3-Hydroxybenzoate 6-monooxygenase inhibitor
0,564  0,010  Transketolase inhibitor
0,557  0,009  Glycerol-3-phosphate dehydrogenase inhibitor
0,570  0,023  Bisphosphoglycerate phosphatase inhibitor
0,589  0,048  NADPH peroxidase inhibitor
0,578  0,037  Glutathione thiolesterase inhibitor
0,596  0,057  Taurine dehydrogenase inhibitor
0,555  0,021  Histidine kinase inhibitor
0,589  0,068  Glycosylphosphatidylinositol phospholipase D inhibitor
0,555  0,036  Peptide agonist
0,522  0,008  2,4-Dichlorophenol 6-monooxygenase inhibitor
0,573  0,062  Phosphatase inhibitor
0,533  0,024  Spermicide
0,536  0,027  Arylsulfate sulfotransferase inhibitor
0,582  0,075  Polyporopepsin inhibitor
0,529  0,025  Malate dehydrogenase (acceptor) inhibitor
0,525  0,023  Cytochrome P450 stimulant
0,499  0,004  Phenol 2-monooxygenase inhibitor
0,500  0,010  Aminomuconate-semialdehyde dehydrogenase inhibitor
0,499  0,015  Di-trans,poly-cis-decaprenylcistransferase inhibitor
0,488  0,010  Retinoic acid metabolism inhibitor
0,567  0,090  NACHT, LRR and PYD domains-containing protein 1 inhibitor
0,544  0,070  Sugar-phosphatase inhibitor
0,494  0,023  Antiinfective
0,519  0,049  Glucan endo-1,6-beta-glucosidase inhibitor
0,498  0,038  L-glutamate oxidase inhibitor
0,464  0,004  Retinal dehydrogenase inhibitor
0,520  0,062  Acetylcholine neuromuscular blocking agent
0,502  0,044  Alkane 1-monooxygenase inhibitor
0,464  0,007  Aryl sulfotransferase inhibitor
0,510  0,057  Phospholipid-translocating ATPase inhibitor
0,466  0,014  Levansucrase inhibitor
0,485  0,042  Cl--transporting ATPase inhibitor
0,481  0,043  Cholesterol antagonist
0,468  0,034  Hydroxylamine oxidase inhibitor
0,489  0,056  27-Hydroxycholesterol 7alpha-monooxygenase inhibitor
0,445  0,013  Dolichyl-phosphatase inhibitor
0,549  0,118  Membrane permeability inhibitor
0,457  0,027  1-Acylglycerol-3-phosphate O-acyltransferase inhibitor
0,480  0,053  Galanin receptor antagonist
0,475  0,050  Nitrate reductase (cytochrome) inhibitor
0,420  0,004  4-Hydroxybenzoate 3-monooxygenase inhibitor
0,435  0,020  Succinate-semialdehyde dehydrogenase [NAD(P)+] inhibitor
0,434  0,020  Quinoprotein glucose dehydrogenase inhibitor
0,432  0,021  Uroporphyrinogen-III synthase inhibitor
0,424  0,016  CDP-4-dehydro-6-deoxyglucose reductase inhibitor
0,444  0,038  Leukotriene-B4 20-monooxygenase inhibitor
0,443  0,038  IgA-specific serine endopeptidase inhibitor
0,446  0,046  Galanin receptor 2 antagonist
0,466  0,068  UDP-N-acetylglucosamine 4-epimerase inhibitor
0,420  0,024  Glutarate-semialdehyde dehydrogenase inhibitor
0,413  0,018  Allyl-alcohol dehydrogenase inhibitor
0,423  0,028  Leukotriene-C4 synthase inhibitor
0,451  0,058  Beta-adrenergic receptor kinase inhibitor
0,451  0,058  G-protein-coupled receptor kinase inhibitor
0,418  0,029  Carbonyl reductase [NADPH] inhibitor
0,457  0,067  Calmodulin antagonist
0,460  0,073  Thioredoxin inhibitor
0,406  0,019  2-Oxoglutarate decarboxylase inhibitor
0,413  0,027  Cyclomaltodextrinase inhibitor
0,428  0,042  Gonadotropin antagonist
0,428  0,049  Fucosterol-epoxide lyase inhibitor
0,431  0,054  Aspartate-phenylpyruvate transaminase inhibitor
0,400  0,024  Botulin neurotoxin A light chain inhibitor
0,436  0,060  Aldehyde oxidase inhibitor
0,436  0,061  Sulfur reductase inhibitor
0,423  0,050  Centromere associated protein inhibitor
0,403  0,034  DNA-(apurinic or apyrimidinic site) lyase inhibitor
0,403  0,035  Sulfite oxidase inhibitor
0,420  0,056  Methylenetetrahydrofolate reductase (NADPH) inhibitor
0,428  0,064  Lipoprotein lipase inhibitor
0,439  0,082  Penicillin binding protein antagonist
0,439  0,082  Penicillin-binding protein ampH inhibitor
0,446  0,094  Potassium sparing diuretic
0,437  0,085  Glucan endo-1,3-beta-D-glucosidase inhibitor
0,457  0,105  Platelet adhesion inhibitor
0,410  0,062  Superoxide dismutase inhibitor
0,405  0,067  Linoleate diol synthase inhibitor
0,416  0,082  Histamine release inhibitor
0,408  0,089  MAP kinase stimulant
0,413  0,103  NACHT, LRR and PYD domains-containing protein 3 inhibitor
0,403  0,094  Oxygen scavenger
0,411  0,121  Omptin inhibitor
0,417  0,133  Collagen inhibitor
0,437  0,160  Transferase inhibitor
0,406  0,135  Platelet aggregation stimulant

>  <Metabolism>
0,880  0,007  CYP2J substrate
0,793  0,010  GST A substrate
0,552  0,008  GST M substrate
0,561  0,028  CYP2B6 substrate
0,527  0,003  Aldehyde dehydrogenase 2 substrate
0,530  0,026  CYP2A6 substrate
0,519  0,030  CYP2A substrate
0,502  0,018  CYP2E1 substrate
0,497  0,019  CYP2E substrate
0,490  0,015  GST P substrate
0,487  0,023  CYP4A11 substrate
0,468  0,012  Peroxidase substrate
0,465  0,013  GST P1-1 substrate
0,485  0,041  CYP2C8 substrate
0,447  0,006  Aldose reductase substrate
0,469  0,036  CYP2C19 substrate
0,494  0,065  CYP2C8 inhibitor
0,448  0,019  CYP4A substrate
0,470  0,060  CYP3A1 substrate
0,450  0,045  CYP2A8 substrate
0,449  0,068  CYP2B6 inhibitor
0,413  0,036  CYP2B substrate
0,401  0,078  CYP2A1 substrate
0,437  0,115  CYP3A2 substrate

>  <Toxicity>
0,766  0,012  Non mutagenic, Salmonella
0,759  0,011  Allergic contact dermatitis
0,765  0,036  Lichenoid eruption
0,711  0,006  Eye irritation, high
0,707  0,004  Skin irritation, moderate
0,735  0,034  Ulcer, aphthous
0,695  0,019  Immunotoxin
0,684  0,009  Irritation
0,678  0,006  Skin irritation, high
0,717  0,047  Hyperactivity
0,690  0,026  Hypercholesterolemic
0,696  0,032  Hyperglycemic
0,692  0,039  Diarrhea
0,682  0,032  Neurotoxic
0,654  0,007  Skin irritative effect
0,649  0,013  Adrenal cortex hypoplasia
0,682  0,057  Stroke
0,612  0,010  Carcinogenic, mouse
0,610  0,029  Hypomagnesemia
0,620  0,041  Hematemesis
0,618  0,045  Withdrawal
0,579  0,007  Skin irritation, weak
0,593  0,034  Hypothermic
0,565  0,019  Sensitization
0,596  0,063  Toxic, respiration
0,598  0,065  Reproductive dysfunction
0,592  0,061  Hemolysis
0,538  0,009  Eye irritation, moderate
0,560  0,034  Endocrine disruptor
0,536  0,014  Carcinogenic, mouse, male
0,578  0,065  Toxic
0,617  0,105  Shivering
0,548  0,039  Panic
0,533  0,024  Spermicide
0,543  0,041  Dyspnea
0,578  0,080  Hyponatremia
0,547  0,055  Desquamation
0,500  0,018  Carcinogenic, rat, male
0,533  0,054  Postural (orthostatic) hypotension
0,511  0,037  Photoallergy dermatitis
0,554  0,087  Fibrillation, atrial
0,510  0,044  Hirsutism
0,538  0,079  Gastrointestinal hemorrhage
0,510  0,055  Colitis
0,513  0,059  Muscle weakness
0,466  0,021  Carcinogenic, mouse, female
0,510  0,066  Hepatic necrosis
0,518  0,078  Ectropion
0,499  0,061  Hyperthermic
0,514  0,083  Weakness
0,498  0,079  Hepatotoxic
0,459  0,047  Fatty liver
0,451  0,040  Fasciculation
0,475  0,066  Delusion
0,507  0,100  Anemia, hemolytic
0,525  0,120  Cerebral hemorrhage
0,480  0,077  Weight loss
0,476  0,079  Galactorrhea
0,492  0,100  Asthma
0,449  0,059  Gastrointestinal disturbance
0,447  0,057  Embryotoxic
0,488  0,098  Excitability
0,461  0,078  Hematuria
0,450  0,071  Serum sickness
0,406  0,026  Carcinogenic, rat
0,480  0,100  Drowsiness
0,435  0,060  Teratogen
0,402  0,027  Carcinogenic
0,480  0,108  Optic neuritis
0,454  0,084  Enterocolitis
0,509  0,148  Dysesthesia
0,479  0,125  Myocardial ischemia
0,474  0,125  Alopecia (hair loss)
0,427  0,089  Fibrosis, interstitial
0,435  0,104  Extrapyramidal effect
0,428  0,098  Parotid gland enlargement
0,403  0,074  Acidosis, lactic
0,455  0,126  Optic neuropathy
0,416  0,105  Nephrotic syndrome
0,428  0,119  Inflammation
0,432  0,129  Scleroderma
0,416  0,115  Edema
0,424  0,135  Enuresis
0,405  0,139  Allergic reaction
0,413  0,148  Proteinuria
0,417  0,152  Renal insufficiency
0,406  0,142  Nightmare
0,404  0,149  Aggression
0,407  0,155  Psychosexual disorder
0,407  0,174  Akinesia
0,402  0,169  Hot flush
0,409  0,202  Ejaculation dysfunction

>  <Murcko.CdId>
61

>  <Murcko.Mol Weight>
78.1118

>  <Murcko.Formula>
C6H6

>  <Murcko.AKOS_NUMBER>
AKOS002341062

>  <Murcko.IntegerID>
60

$$$$

  Mrv0541 04281317412D          

 14 14  0  0  0  0            999 V2000
    8.0416   -3.9206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2066   -3.9206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7933   -3.1983    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4550   -3.1983    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0731   -2.4718    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9623   -3.1983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4864   -3.1858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4550   -4.6388    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3131   -3.1858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5490   -2.4843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5490   -3.9081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7265   -2.4843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7265   -3.9081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7933   -4.6388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  3  2  1  0  0  0  0
  4  1  2  0  0  0  0
  5  7  2  0  0  0  0
  6  3  1  0  0  0  0
  7  9  1  0  0  0  0
  8  1  1  0  0  0  0
  9 13  2  0  0  0  0
 10  6  1  0  0  0  0
 11  6  2  0  0  0  0
 12 10  2  0  0  0  0
 13 11  1  0  0  0  0
 14  2  1  0  0  0  0
  9 12  1  0  0  0  0
M  END
>  <CdId>
957

>  <Mol Weight>
194.184

>  <Formula>
C10H10O4

>  <AKOS_NUMBER>
AKOS016012143

>  <Lipinski's Rule of Five>
0

>  <XLogP (text field)>
0.57

>  <PASS_MNA_NEW_COUNT>
0

>  <PASS_RESULT_COUNT>
   34 of   464 Possible Pharmacological Effects at Pa > 0.400
  392 of  3850 Possible Mechanisms of Action at Pa > 0.400
  107 of   321 Possible Toxic and Adverse Effects at Pa > 0.400
    6 of   118 Possible Antitargets at Pa > 0.400
   43 of   195 Possible Metabolism-Related Actions at Pa > 0.400
  675 of  1610 Possible Gene Expression Regulation at Pa > 0.400
    0 of    68 Possible Transporters-Related Actions at Pa > 0.400

>  <Effects>
0,965  0,003  Skin irritation, inactive
0,743  0,027  Neuroprotector
0,723  0,009  Lipid metabolism regulator
0,733  0,031  Antiseborrheic
0,692  0,007  Antidiabetic
0,670  0,008  Anesthetic general
0,655  0,010  Antihypercholesterolemic
0,538  0,009  Antidiabetic (type 2)
0,594  0,076  Fibrinolytic
0,544  0,031  Leukopoiesis stimulant
0,511  0,035  Hypolipemic
0,479  0,005  Expectorant
0,508  0,035  Antihypoxic
0,468  0,004  Insecticide
0,500  0,050  Alopecia treatment
0,446  0,012  Sclerosant
0,458  0,026  Menopausal disorders treatment
0,449  0,028  Eye irritation, inactive
0,435  0,015  Antiinflammatory, intestinal
0,466  0,052  Erythropoiesis stimulant
0,456  0,049  Respiratory analeptic
0,439  0,042  Antifungal
0,464  0,067  Preneoplastic conditions treatment
0,420  0,026  Carminative
0,437  0,044  Analeptic
0,494  0,101  Kidney function stimulant
0,456  0,074  Antinephrotoxic
0,406  0,026  Inflammatory Bowel disease treatment
0,423  0,049  Immunostimulant
0,427  0,061  Apoptosis agonist
0,462  0,143  Vasodilator, cerebral
0,470  0,154  Antieczematic
0,404  0,109  Mucositis treatment
0,417  0,192  Antibacterial activity enhancer

>  <Antitargets>
0,807  0,003  GABA aminotransferase inhibitor
0,810  0,029  Ubiquinol-cytochrome-c reductase inhibitor
0,533  0,008  Catalase inhibitor
0,527  0,033  Superoxide dismutase inhibitor
0,519  0,036  Peroxidase inhibitor
0,402  0,015  Phospholipase C inhibitor

>  <Gene_Expression>
0,903  0,004  ID1 expression inhibitor
0,886  0,022  HSPD1 expression inhibitor
0,863  0,004  FGF2 expression inhibitor
0,850  0,010  SERPINB5 expression inhibitor
0,830  0,007  FUBP1 expression inhibitor
0,841  0,019  GPX1 expression inhibitor
0,834  0,012  PPARA expression inhibitor
0,849  0,037  LPL expression enhancer
0,831  0,019  TOP1 expression inhibitor
0,812  0,008  CPE expression inhibitor
0,810  0,008  CLMP expression inhibitor
0,821  0,021  DUSP4 expression enhancer
0,826  0,027  NAA15 expression inhibitor
0,815  0,016  ITGB6 expression inhibitor
0,808  0,010  TNFRSF21 expression inhibitor
0,797  0,003  PPARA expression enhancer
0,798  0,008  CDKN1C expression inhibitor
0,808  0,018  MAPT expression enhancer
0,798  0,011  NASP expression inhibitor
0,791  0,004  SCARB1 expression enhancer
0,803  0,017  ILF3 expression inhibitor
0,795  0,012  IL18 expression inhibitor
0,785  0,005  CCNA2 expression enhancer
0,787  0,009  HMGA1 expression inhibitor
0,790  0,013  MYBL1 expression enhancer
0,781  0,005  FGFR3 expression inhibitor
0,790  0,016  PRKCA expression enhancer
0,788  0,015  NBN expression inhibitor
0,791  0,027  MYL6 expression enhancer
0,772  0,009  EDN1 expression enhancer
0,770  0,009  HMBS expression inhibitor
0,769  0,014  MCM6 expression enhancer
0,774  0,018  JAG1 expression inhibitor
0,781  0,029  STAR expression enhancer
0,763  0,014  DDX18 expression inhibitor
0,760  0,012  MAFB expression inhibitor
0,780  0,032  CXCR1 expression enhancer
0,767  0,022  CD44 expression inhibitor
0,753  0,009  DFFA expression inhibitor
0,769  0,025  EZH2 expression inhibitor
0,748  0,005  CYB5A expression enhancer
0,770  0,028  SFPQ expression enhancer
0,748  0,008  CARS expression inhibitor
0,756  0,016  LYN expression inhibitor
0,739  0,005  NOS1 expression inhibitor
0,745  0,013  PRRX1 expression inhibitor
0,756  0,025  CNN1 expression enhancer
0,742  0,012  GNL3 expression inhibitor
0,744  0,013  NEIL3 expression inhibitor
0,737  0,006  BNIP3 expression inhibitor
0,746  0,016  TNS3 expression enhancer
0,749  0,020  COL2A1 expression enhancer
0,757  0,035  PDXK expression inhibitor
0,735  0,014  PCNA expression enhancer
0,728  0,010  SUV420H1 expression inhibitor
0,725  0,007  CRABP2 expression inhibitor
0,741  0,024  FILIP1L expression inhibitor
0,747  0,036  FGFR1 expression inhibitor
0,733  0,026  C10ORF116 expression enhancer
0,736  0,029  MMP7 expression enhancer
0,724  0,017  WFDC2 expression enhancer
0,740  0,034  SUZ12 expression inhibitor
0,729  0,024  NOM1 expression inhibitor
0,727  0,024  TFDP2 expression inhibitor
0,730  0,028  APOM expression enhancer
0,721  0,024  CCNE2 expression inhibitor
0,721  0,025  NAT1 expression enhancer
0,728  0,033  ATP1B3 expression inhibitor
0,711  0,016  CPNE1 expression enhancer
0,703  0,009  SP2 expression inhibitor
0,717  0,023  ETV5 expression inhibitor
0,727  0,035  SRPK1 expression inhibitor
0,716  0,025  IGFBP6 expression inhibitor
0,716  0,024  TMSB4X expression inhibitor
0,697  0,007  MMP9 expression inhibitor
0,712  0,023  MAPK8 expression inhibitor
0,707  0,020  PKM2 expression enhancer
0,698  0,014  MMP2 expression enhancer
0,748  0,064  RAD23B expression inhibitor
0,706  0,026  TRAK2 expression enhancer
0,688  0,010  CDK5 expression enhancer
0,689  0,012  PSAT1 expression inhibitor
0,695  0,018  LAMC1 expression enhancer
0,697  0,020  ZNF91 expression inhibitor
0,680  0,007  MFAP4 expression inhibitor
0,690  0,018  PTGS2 expression enhancer
0,691  0,021  IGF2 expression inhibitor
0,680  0,010  DEK expression inhibitor
0,676  0,010  IL6ST expression inhibitor
0,691  0,024  TNFRSF11A expression enhancer
0,680  0,014  PML expression inhibitor
0,700  0,035  GAS6 expression inhibitor
0,691  0,028  TP53 expression enhancer
0,672  0,010  CCNK expression inhibitor
0,681  0,020  FOSL1 expression enhancer
0,684  0,024  PTGR1 expression enhancer
0,682  0,024  ORC4 expression enhancer
0,668  0,012  CALM3 expression enhancer
0,696  0,041  PLAU expression inhibitor
0,667  0,013  CYP4A11 expression enhancer
0,670  0,016  ADSL expression inhibitor
0,668  0,017  SIDT2 expression enhancer
0,672  0,021  PRSS23 expression enhancer
0,697  0,047  CD36 expression inhibitor
0,671  0,021  PIK3R2 expression inhibitor
0,687  0,038  AHR expression inhibitor
0,659  0,011  PLAGL1 expression enhancer
0,660  0,013  PLA2G2A expression enhancer
0,669  0,022  BAD expression inhibitor
0,663  0,017  ADD3 expression enhancer
0,668  0,022  ESR1 expression inhibitor
0,680  0,035  ITGB2 expression enhancer
0,650  0,006  UGT1A1 expression enhancer
0,647  0,003  ABCG5 expression enhancer
0,647  0,003  CYP7A1 expression enhancer
0,662  0,019  MLF1 expression enhancer
0,689  0,047  OAS2 expression enhancer
0,656  0,017  CDKN1B expression inhibitor
0,668  0,031  THBS1 expression enhancer
0,661  0,024  SLC1A1 expression enhancer
0,667  0,033  ACTA2 expression inhibitor
0,684  0,052  TXNRD1 expression inhibitor
0,665  0,035  IFNGR1 expression enhancer
0,674  0,044  UNG expression inhibitor
0,676  0,046  PHB expression inhibitor
0,646  0,016  HMGA1 expression enhancer
0,647  0,018  MAP2K1 expression enhancer
0,658  0,029  SLC16A4 expression enhancer
0,640  0,013  PARG expression enhancer
0,665  0,040  PLIN2 expression enhancer
0,642  0,018  TRAM1 expression inhibitor
0,640  0,016  JUNB expression inhibitor
0,658  0,034  SATB1 expression inhibitor
0,665  0,042  GADD45A expression inhibitor
0,654  0,033  EPRS expression inhibitor
0,650  0,029  IL1A expression inhibitor
0,644  0,024  SESN1 expression inhibitor
0,634  0,014  ATR expression inhibitor
0,634  0,014  EFNA4 expression inhibitor
0,634  0,014  MARK3 expression inhibitor
0,634  0,014  SMAD1 expression inhibitor
0,631  0,013  SCML1 expression enhancer
0,631  0,013  SEPHS1 expression inhibitor
0,674  0,056  MSH6 expression inhibitor
0,633  0,015  FTL expression enhancer
0,635  0,017  ID3 expression inhibitor
0,645  0,027  ELL2 expression enhancer
0,637  0,020  EZR expression inhibitor
0,637  0,020  GAK expression inhibitor
0,637  0,020  TERF1 expression inhibitor
0,634  0,018  NR4A2 expression inhibitor
0,667  0,051  FANCC expression inhibitor
0,667  0,053  JUN expression enhancer
0,658  0,045  STAT1 expression inhibitor
0,633  0,021  CYB5R2 expression enhancer
0,629  0,018  BMP1 expression inhibitor
0,655  0,045  GTF2F1 expression inhibitor
0,634  0,023  HLA-F expression enhancer
0,649  0,039  NR4A2 expression enhancer
0,622  0,013  MDK expression inhibitor
0,631  0,023  CTTN expression inhibitor
0,637  0,028  FKBP8 expression inhibitor
0,638  0,030  NOL5A expression inhibitor
0,620  0,013  IFI30 expression enhancer
0,622  0,016  WAS expression enhancer
0,615  0,010  CSDA expression inhibitor
0,634  0,031  PMEPA1 expression inhibitor
0,638  0,038  IL1RN expression inhibitor
0,623  0,026  HLA-B expression enhancer
0,624  0,030  MEGF9 expression inhibitor
0,620  0,028  VAT1 expression enhancer
0,624  0,033  CLDN4 expression enhancer
0,609  0,019  CYP11A1 expression inhibitor
0,614  0,025  DAB2 expression enhancer
0,647  0,058  BST2 expression enhancer
0,613  0,027  ITGB7 expression enhancer
0,633  0,048  SPATA13 expression enhancer
0,594  0,009  CD47 expression inhibitor
0,611  0,028  MYC expression enhancer
0,596  0,014  REL expression enhancer
0,605  0,024  FOXD1 expression inhibitor
0,617  0,037  PRTN3 expression enhancer
0,604  0,025  MYB expression inhibitor
0,604  0,028  HLA-C expression enhancer
0,598  0,022  ACPP expression enhancer
0,584  0,008  IFNG expression inhibitor
0,591  0,017  SPARC expression inhibitor
0,588  0,015  MT1F expression inhibitor
0,582  0,009  PICALM expression inhibitor
0,588  0,015  MT1H expression inhibitor
0,588  0,015  C5ORF32 expression enhancer
0,588  0,015  FAH expression enhancer
0,588  0,015  RRAS expression enhancer
0,588  0,015  SH3BGRL3 expression enhancer
0,615  0,041  SLC16A2 expression enhancer
0,593  0,023  HSP27 expression enhancer
0,588  0,018  HOXA10 expression enhancer
0,642  0,073  MAPK8 expression enhancer
0,614  0,045  PPPDE1 expression inhibitor
0,596  0,027  NPTX2 expression enhancer
0,606  0,038  IL6 expression inhibitor
0,607  0,039  MAF expression enhancer
0,605  0,038  CALR expression inhibitor
0,627  0,060  VDR expression enhancer
0,610  0,044  KPNA2 expression inhibitor
0,608  0,043  PRKDC expression inhibitor
0,586  0,021  TGFBI expression enhancer
0,585  0,020  PRDX2 expression enhancer
0,628  0,064  STAT5B expression enhancer
0,618  0,055  PLAUR expression enhancer
0,628  0,066  NFKB1 expression enhancer
0,602  0,040  HSPA1A expression enhancer
0,578  0,018  IMPDH2 expression enhancer
0,576  0,016  TNF expression inhibitor
0,596  0,036  SOX9 expression enhancer
0,591  0,031  ATP2A2 expression enhancer
0,589  0,030  CBX1 expression inhibitor
0,583  0,024  DDX24 expression inhibitor
0,576  0,018  PLA2G16 expression enhancer
0,576  0,018  TCEB3 expression inhibitor
0,588  0,029  TRIM16 expression enhancer
0,582  0,024  PA2G4 expression inhibitor
0,591  0,033  HAPLN3 expression inhibitor
0,582  0,024  IL2RA expression inhibitor
0,595  0,038  IL10 expression enhancer
0,572  0,016  CALM1 expression enhancer
0,565  0,009  SPAG6 expression enhancer
0,569  0,013  ZFAND5 expression inhibitor
0,588  0,032  APOA1 expression inhibitor
0,578  0,024  YWHAH expression inhibitor
0,565  0,011  PTPRK expression inhibitor
0,572  0,018  WDR4 expression inhibitor
0,587  0,033  NOC3L expression inhibitor
0,569  0,016  E2F1 expression inhibitor
0,579  0,028  CLMN expression enhancer
0,565  0,013  SUMO1 expression inhibitor
0,571  0,021  CBX3 expression inhibitor
0,596  0,047  ID2 expression enhancer
0,595  0,047  PRKAR2B expression enhancer
0,572  0,025  POLE2 expression inhibitor
0,607  0,060  HIF1A expression enhancer
0,566  0,019  MYBL2 expression inhibitor
0,580  0,034  RPS19 expression inhibitor
0,580  0,034  SIRT1 expression inhibitor
0,579  0,034  ADAM17 expression inhibitor
0,579  0,034  CTBP1 expression inhibitor
0,573  0,029  FGFR2 expression enhancer
0,577  0,036  IER3 expression inhibitor
0,593  0,053  MYB expression enhancer
0,572  0,033  EPHB4 expression inhibitor
0,572  0,033  NMT1 expression inhibitor
0,608  0,072  HMGB1 expression inhibitor
0,562  0,027  COL4A1 expression inhibitor
0,563  0,028  FUS expression inhibitor
0,572  0,038  TIMP1 expression enhancer
0,555  0,022  TOB1 expression inhibitor
0,547  0,014  LYN expression enhancer
0,564  0,033  PPARGC1A expression enhancer
0,587  0,056  CASP3 expression enhancer
0,566  0,036  VAV3 expression inhibitor
0,554  0,024  ANAPC1 expression enhancer
0,541  0,013  RARB expression inhibitor
0,545  0,016  TPO expression enhancer
0,585  0,057  KIF23 expression enhancer
0,541  0,014  HMGB2 expression inhibitor
0,552  0,025  DLX4 expression inhibitor
0,573  0,046  GSTM2 expression inhibitor
0,563  0,036  ETS2 expression inhibitor
0,557  0,030  MTHFD2 expression inhibitor
0,560  0,035  DTYMK expression enhancer
0,546  0,021  JUN expression inhibitor
0,565  0,040  TGFB1 expression enhancer
0,600  0,077  ITGB1 expression enhancer
0,569  0,046  BIRC3 expression enhancer
0,542  0,019  BID expression inhibitor
0,545  0,023  FOXC1 expression enhancer
0,534  0,012  IGF1R expression enhancer
0,554  0,032  MCM7 expression inhibitor
0,571  0,050  ARL6IP5 expression enhancer
0,563  0,042  IL1B expression enhancer
0,548  0,027  NEDD9 expression inhibitor
0,563  0,042  CAV1 expression inhibitor
0,559  0,038  CPM expression enhancer
0,554  0,033  HNRPC expression inhibitor
0,549  0,028  PIM1 expression enhancer
0,563  0,044  MMP2 expression inhibitor
0,557  0,038  POR expression enhancer
0,533  0,015  CAPN2 expression inhibitor
0,536  0,017  HLA-E expression enhancer
0,549  0,031  ERBB4 expression inhibitor
0,541  0,023  MT1X expression inhibitor
0,544  0,027  ITGA6 expression inhibitor
0,567  0,052  TNF expression enhancer
0,559  0,045  DDIT4 expression enhancer
0,597  0,083  XPO1 expression inhibitor
0,563  0,049  CDK2 expression inhibitor
0,540  0,027  FEN1 expression inhibitor
0,575  0,063  CEP350 expression inhibitor
0,575  0,063  PDE8A expression inhibitor
0,541  0,030  RPS27L expression enhancer
0,556  0,046  PDCD4 expression inhibitor
0,555  0,046  GSTM3 expression inhibitor
0,544  0,035  TUBA1A expression inhibitor
0,562  0,054  TNFSF10 expression enhancer
0,552  0,044  CUTL1 expression inhibitor
0,545  0,038  TUBA4A expression enhancer
0,540  0,033  COL3A1 expression inhibitor
0,544  0,038  CEP57 expression inhibitor
0,511  0,007  ASTN2 expression enhancer
0,538  0,034  TOP2A expression inhibitor
0,565  0,063  MT1A expression enhancer
0,523  0,021  CYFIP2 expression enhancer
0,525  0,024  FOS expression inhibitor
0,556  0,055  KPNA1 expression enhancer
0,526  0,026  KIF15 expression inhibitor
0,527  0,028  SASH1 expression inhibitor
0,550  0,051  SEPT2 expression inhibitor
0,556  0,057  MMP15 expression inhibitor
0,550  0,052  RNF4 expression inhibitor
0,533  0,036  VCAM1 expression enhancer
0,544  0,047  EFEMP1 expression inhibitor
0,556  0,059  THBD expression enhancer
0,540  0,044  SF1 expression inhibitor
0,536  0,041  FAS expression inhibitor
0,519  0,024  STC2 expression enhancer
0,554  0,060  RASEF expression inhibitor
0,530  0,038  CD86 expression enhancer
0,499  0,008  CORO1C expression enhancer
0,538  0,047  SCARB1 expression inhibitor
0,536  0,046  STAT3 expression inhibitor
0,522  0,032  PGM2 expression enhancer
0,525  0,035  RRM2 expression inhibitor
0,528  0,040  RRBP1 expression enhancer
0,527  0,040  ISG15 expression enhancer
0,510  0,023  CYP17A1 expression enhancer
0,518  0,032  CDK6 expression inhibitor
0,502  0,016  C6ORF108 expression inhibitor
0,502  0,016  CASK expression inhibitor
0,502  0,016  MAP2K5 expression inhibitor
0,502  0,016  PPP1CA expression inhibitor
0,502  0,016  TCF3 expression inhibitor
0,539  0,053  TERT expression enhancer
0,533  0,048  HLA-G expression enhancer
0,512  0,029  TIMP1 expression inhibitor
0,543  0,061  NCOA2 expression enhancer
0,542  0,060  NSF expression inhibitor
0,522  0,040  PLD1 expression enhancer
0,529  0,048  JUND expression inhibitor
0,551  0,070  ZFP36 expression enhancer
0,502  0,021  PLCB1 expression enhancer
0,537  0,056  BIRC2 expression inhibitor
0,509  0,029  GFPT2 expression enhancer
0,518  0,038  NOLC1 expression inhibitor
0,518  0,040  TRAF3 expression enhancer
0,528  0,051  NAA15 expression enhancer
0,487  0,010  POLR2A expression enhancer
0,510  0,033  G0S2 expression enhancer
0,536  0,060  CASP9 expression enhancer
0,524  0,048  ASXL1 expression inhibitor
0,524  0,048  C11ORF68 expression enhancer
0,524  0,048  CAPN7 expression inhibitor
0,524  0,048  FAM208A expression inhibitor
0,524  0,048  NKTR expression inhibitor
0,524  0,048  RABGAP1 expression inhibitor
0,524  0,048  SETD2 expression inhibitor
0,524  0,048  TIA1 expression inhibitor
0,524  0,048  TTC3 expression inhibitor
0,501  0,025  KIAA0930 expression enhancer
0,505  0,029  ISYNA1 expression enhancer
0,490  0,014  PKP4 expression inhibitor
0,490  0,014  TUBGCP3 expression inhibitor
0,524  0,049  CCL5 expression inhibitor
0,520  0,046  YWHAE expression inhibitor
0,537  0,062  CCND2 expression enhancer
0,524  0,050  HIF1A expression inhibitor
0,483  0,009  BRAF expression inhibitor
0,501  0,027  NME2 expression inhibitor
0,513  0,039  SLC6A2 expression inhibitor
0,506  0,033  SF3B5 expression enhancer
0,510  0,036  TNNT1 expression inhibitor
0,524  0,052  SPP1 expression enhancer
0,507  0,035  KLHL24 expression inhibitor
0,518  0,048  CDC16 expression inhibitor
0,503  0,033  ALPL expression enhancer
0,498  0,029  SKP2 expression inhibitor
0,480  0,011  ASAH1 expression inhibitor
0,485  0,017  TRIM24 expression inhibitor
0,527  0,059  MACF1 expression inhibitor
0,509  0,042  CDH1 expression enhancer
0,544  0,079  EIF2S1 expression inhibitor
0,475  0,009  NBL1 expression enhancer
0,495  0,030  TP53I3 expression enhancer
0,511  0,046  DDX42 expression enhancer
0,523  0,058  CDK4 expression inhibitor
0,483  0,018  CEBPG expression inhibitor
0,495  0,031  BDNF expression inhibitor
0,518  0,055  TMPRSS2 expression inhibitor
0,510  0,047  CREB1 expression inhibitor
0,530  0,067  PDE9A expression inhibitor
0,522  0,061  NR3C1 expression inhibitor
0,518  0,057  MGMT expression enhancer
0,499  0,039  NR1H2 expression inhibitor
0,489  0,028  CYP11A1 expression enhancer
0,517  0,057  ICAM1 expression enhancer
0,508  0,049  ELOVL5 expression inhibitor
0,493  0,033  SMAD3 expression enhancer
0,522  0,063  MSMO1 expression enhancer
0,513  0,055  DUSP5 expression enhancer
0,502  0,044  EDN1 expression inhibitor
0,491  0,034  CSF2 expression enhancer
0,496  0,039  SOX9 expression inhibitor
0,513  0,057  NAV1 expression inhibitor
0,495  0,040  GATA2 expression enhancer
0,481  0,026  CDKN2C expression inhibitor
0,469  0,014  SLC16A1 expression inhibitor
0,542  0,088  CREBBP expression inhibitor
0,508  0,054  SLC3A2 expression enhancer
0,476  0,022  DNMT1 expression inhibitor
0,488  0,033  RECQL expression inhibitor
0,514  0,060  GAS6 expression enhancer
0,498  0,044  PTN expression enhancer
0,475  0,021  GARS expression inhibitor
0,490  0,038  DAPK1 expression inhibitor
0,484  0,032  EHD1 expression enhancer
0,515  0,064  GSTA1 expression enhancer
0,479  0,028  TMSB4X expression enhancer
0,517  0,066  AGRN expression enhancer
0,481  0,031  EPAS1 expression enhancer
0,511  0,060  PCDH8 expression enhancer
0,481  0,031  LAMB3 expression enhancer
0,503  0,053  CDC25C expression inhibitor
0,478  0,029  SNAI1 expression enhancer
0,483  0,034  DFFB expression inhibitor
0,512  0,064  CDC25B expression enhancer
0,497  0,049  EPHA4 expression enhancer
0,493  0,046  PELI1 expression inhibitor
0,491  0,044  SELE expression enhancer
0,471  0,024  TK1 expression enhancer
0,505  0,061  NT5DC2 expression enhancer
0,505  0,061  RAI14 expression enhancer
0,505  0,061  RFTN1 expression enhancer
0,500  0,056  CITED2 expression inhibitor
0,472  0,028  LAMC2 expression enhancer
0,449  0,005  RAP1A expression enhancer
0,482  0,039  CCL2 expression enhancer
0,479  0,036  EFNB2 expression inhibitor
0,476  0,034  BTG2 expression enhancer
0,456  0,014  IVNS1ABP expression inhibitor
0,519  0,078  BAX expression enhancer
0,476  0,035  APOA1 expression enhancer
0,464  0,023  BAD expression enhancer
0,489  0,049  TM4SF1 expression enhancer
0,444  0,004  RHOB expression enhancer
0,478  0,039  ANXA1 expression inhibitor
0,473  0,034  EGR3 expression inhibitor
0,511  0,073  C3 expression enhancer
0,459  0,021  ACAN expression enhancer
0,467  0,030  HSPA2 expression enhancer
0,452  0,016  MET expression enhancer
0,515  0,079  ABCC5 expression enhancer
0,504  0,068  RAD51AP1 expression enhancer
0,477  0,041  IL1A expression enhancer
0,452  0,017  CITED2 expression enhancer
0,474  0,039  NR5A2 expression enhancer
0,474  0,039  ZBTB10 expression inhibitor
0,456  0,022  GATA1 expression enhancer
0,471  0,039  HMGN2 expression inhibitor
0,461  0,030  MDFI expression inhibitor
0,461  0,030  SYMPK expression inhibitor
0,494  0,065  DHRS2 expression enhancer
0,500  0,071  PDCD4 expression enhancer
0,478  0,050  ALDH1A3 expression inhibitor
0,489  0,061  AKT1 expression enhancer
0,512  0,084  FOS expression enhancer
0,458  0,030  CEBPD expression enhancer
0,447  0,020  MND1 expression inhibitor
0,468  0,041  PPARG expression enhancer
0,485  0,058  IL4 expression enhancer
0,448  0,022  BTG1 expression inhibitor
0,484  0,059  CSE1L expression inhibitor
0,447  0,022  HIVEP1 expression enhancer
0,439  0,015  NDC80 expression inhibitor
0,498  0,074  CEACAM1 expression enhancer
0,505  0,081  EIF2S1 expression enhancer
0,450  0,026  SLC31A1 expression enhancer
0,464  0,041  NGFR expression enhancer
0,451  0,027  CA2 expression enhancer
0,465  0,042  SLC17A2 expression inhibitor
0,445  0,023  TGFB3 expression enhancer
0,435  0,013  CPT1A expression enhancer
0,469  0,047  BUB1B expression enhancer
0,452  0,030  LAMA3 expression enhancer
0,440  0,018  CDCA3 expression inhibitor
0,444  0,024  SMARCC1 expression inhibitor
0,446  0,026  GINS2 expression inhibitor
0,451  0,031  PPP1R3C expression inhibitor
0,432  0,013  LINC00467 expression enhancer
0,432  0,013  PHF17 expression inhibitor
0,466  0,048  F2R expression enhancer
0,477  0,059  ASNS expression inhibitor
0,457  0,040  HS3ST3A1 expression enhancer
0,517  0,100  CYR61 expression enhancer
0,443  0,026  EIF4E expression inhibitor
0,447  0,031  TGFA expression enhancer
0,476  0,060  RAD51C expression enhancer
0,476  0,060  SMC4 expression enhancer
0,476  0,060  ZWINT expression enhancer
0,463  0,047  ST3GAL1 expression enhancer
0,440  0,025  IGF2 expression enhancer
0,491  0,077  NPM3 expression inhibitor
0,491  0,077  PTEN expression inhibitor
0,464  0,050  AKR1C2 expression enhancer
0,450  0,036  APOBEC3B expression enhancer
0,438  0,025  ASRGL1 expression enhancer
0,454  0,041  BAG5 expression inhibitor
0,427  0,015  APOE expression enhancer
0,437  0,026  NKX3-1 expression enhancer
0,480  0,069  STRBP expression inhibitor
0,484  0,073  ABHD3 expression enhancer
0,446  0,036  IVL expression inhibitor
0,447  0,037  NCF1 expression enhancer
0,453  0,044  ME1 expression enhancer
0,457  0,050  CBLB expression inhibitor
0,435  0,028  KEAP1 expression enhancer
0,479  0,072  TNFSF10 expression inhibitor
0,468  0,062  WISP2 expression inhibitor
0,434  0,028  PHLDA1 expression enhancer
0,464  0,059  AKR1C1 expression enhancer
0,421  0,016  GSTA4 expression enhancer
0,443  0,038  BMP2 expression enhancer
0,435  0,030  C22ORF29 expression enhancer
0,435  0,030  ETNK2 expression enhancer
0,446  0,041  PI4KA expression inhibitor
0,446  0,041  VCAN expression inhibitor
0,430  0,026  RCC2 expression inhibitor
0,426  0,022  KLK7 expression enhancer
0,502  0,098  TMEM158 expression enhancer
0,448  0,045  RSAD2 expression enhancer
0,458  0,056  KLK6 expression enhancer
0,458  0,056  PADI3 expression enhancer
0,485  0,082  KRCC1 expression enhancer
0,433  0,031  LGALS3 expression enhancer
0,464  0,062  EIF3B expression inhibitor
0,428  0,026  S100A8 expression enhancer
0,470  0,068  SNAI2 expression inhibitor
0,424  0,023  IFIT3 expression enhancer
0,477  0,076  CCND1 expression inhibitor
0,441  0,041  GCLM expression enhancer
0,419  0,020  SLC30A5 expression inhibitor
0,470  0,074  PPARD expression enhancer
0,412  0,016  CXCR4 expression enhancer
0,413  0,017  ETS1 expression inhibitor
0,464  0,068  SERPINE1 expression enhancer
0,440  0,044  IGFBP2 expression inhibitor
0,424  0,029  CEBPD expression inhibitor
0,424  0,029  HADH expression enhancer
0,424  0,029  MELK expression enhancer
0,424  0,029  TFF3 expression enhancer
0,437  0,041  CD36 expression enhancer
0,456  0,062  GRPEL1 expression inhibitor
0,437  0,043  GPX2 expression enhancer
0,429  0,036  AP1S2 expression enhancer
0,432  0,039  TNFRSF25 expression inhibitor
0,472  0,079  VEGFA expression enhancer
0,442  0,049  CCNE1 expression inhibitor
0,448  0,055  KLF10 expression inhibitor
0,448  0,055  KPNB1 expression enhancer
0,477  0,086  ALCAM expression inhibitor
0,414  0,022  ATG5 expression inhibitor
0,464  0,074  PPARD expression inhibitor
0,434  0,044  CDK2 expression enhancer
0,427  0,037  BRF1 expression inhibitor
0,414  0,025  SOX11 expression inhibitor
0,436  0,049  MAD1L1 expression enhancer
0,413  0,026  BCAT1 expression inhibitor
0,401  0,014  WHSC1 expression inhibitor
0,466  0,079  BCL2L1 expression inhibitor
0,442  0,057  MDK expression enhancer
0,404  0,020  LGALS1 expression inhibitor
0,448  0,064  DDIT3 expression enhancer
0,416  0,032  GPR142 expression enhancer
0,425  0,042  MAFF expression enhancer
0,446  0,063  CD14 expression enhancer
0,482  0,099  VEGFA expression inhibitor
0,407  0,025  ABCG2 expression inhibitor
0,407  0,025  TULP3 expression inhibitor
0,436  0,054  MITF expression enhancer
0,430  0,048  CSNK1D expression inhibitor
0,430  0,048  SPATA20 expression enhancer
0,415  0,034  IGFBP2 expression enhancer
0,411  0,030  MGST1 expression inhibitor
0,450  0,070  TNFRSF21 expression enhancer
0,418  0,038  RXRA expression enhancer
0,437  0,058  NKX3-1 expression inhibitor
0,451  0,071  FOXO1 expression enhancer
0,423  0,043  PTEN expression enhancer
0,435  0,056  DLEU2 expression enhancer
0,473  0,094  PNKD expression inhibitor
0,411  0,033  CCL4 expression enhancer
0,433  0,055  AREG expression enhancer
0,431  0,054  TK1 expression inhibitor
0,425  0,049  TUBB3 expression enhancer
0,441  0,065  FAM49A expression enhancer
0,427  0,050  BAX expression inhibitor
0,447  0,070  NPM1 expression inhibitor
0,401  0,025  EID1 expression enhancer
0,416  0,041  S100A11 expression enhancer
0,405  0,030  CBS expression inhibitor
0,433  0,060  KLK3 expression inhibitor
0,452  0,079  ABCB1 expression enhancer
0,407  0,036  DUSP10 expression enhancer
0,430  0,061  GRN expression enhancer
0,426  0,057  CYP17A1 expression inhibitor
0,409  0,040  OLFM1 expression enhancer
0,455  0,086  CP expression enhancer
0,450  0,082  CDCA5 expression enhancer
0,414  0,046  GALNT1 expression inhibitor
0,427  0,060  PIM1 expression inhibitor
0,427  0,061  PIK3CD expression inhibitor
0,402  0,035  MCM2 expression enhancer
0,405  0,039  CTPS expression inhibitor
0,422  0,057  FASN expression inhibitor
0,413  0,048  IL9 expression inhibitor
0,407  0,043  ESR1 expression enhancer
0,419  0,057  AHSA1 expression enhancer
0,412  0,050  RRM2 expression enhancer
0,435  0,073  PTGS2 expression inhibitor
0,401  0,039  BFSP2 expression enhancer
0,401  0,039  EGLN3 expression enhancer
0,401  0,041  PPAP2C expression inhibitor
0,441  0,080  AGPS expression inhibitor
0,437  0,076  ATM expression enhancer
0,446  0,086  RND3 expression inhibitor
0,409  0,049  SHBG expression enhancer
0,416  0,056  IGFBP4 expression enhancer
0,410  0,051  UBE2C expression enhancer
0,406  0,049  NFKBIA expression enhancer
0,411  0,055  ABCG1 expression enhancer
0,435  0,082  HSPA1A expression inhibitor
0,413  0,061  ATF3 expression enhancer
0,411  0,060  BORA expression inhibitor
0,415  0,064  INCENP expression inhibitor
0,410  0,061  CDK1 expression inhibitor
0,403  0,054  SLC7A11 expression enhancer
0,426  0,078  DCC expression enhancer
0,402  0,054  TNFRSF10B expression inhibitor
0,433  0,085  ABCC3 expression inhibitor
0,419  0,072  PAK2 expression inhibitor
0,409  0,064  TXNIP expression inhibitor
0,413  0,068  DEPTOR expression enhancer
0,419  0,075  TPM4 expression inhibitor
0,406  0,068  PRDX6 expression enhancer
0,415  0,078  EZH1 expression enhancer
0,401  0,065  BRD2 expression enhancer
0,401  0,065  NENF expression enhancer
0,401  0,065  SRRM2 expression inhibitor
0,401  0,065  ZCCHC2 expression inhibitor
0,402  0,066  EI24 expression enhancer
0,413  0,078  CDKN2A expression enhancer
0,413  0,081  JAK2 expression inhibitor
0,413  0,081  TBC1D1 expression inhibitor
0,413  0,083  AHR expression enhancer
0,401  0,081  VIM expression inhibitor
0,427  0,110  SREBF2 expression inhibitor
0,428  0,115  SERPINB5 expression enhancer
0,408  0,103  IL6 expression enhancer
0,401  0,106  BRCA1 expression enhancer
0,403  0,109  CDKN1A expression enhancer
0,409  0,120  TP53TG1 expression enhancer
0,421  0,140  FYTTD1 expression inhibitor
0,421  0,140  MST4 expression inhibitor
0,421  0,140  TRAK2 expression inhibitor
0,421  0,140  USP32 expression inhibitor
0,416  0,161  SLC2A4 expression enhancer
0,404  0,151  KLK2 expression inhibitor

>  <Mechanisms>
0,907  0,004  Aldehyde oxidase inhibitor
0,918  0,017  Transferase stimulant
0,898  0,004  Feruloyl esterase inhibitor
0,895  0,005  Beta-adrenergic receptor kinase inhibitor
0,895  0,005  G-protein-coupled receptor kinase inhibitor
0,894  0,004  Monodehydroascorbate reductase (NADH) inhibitor
0,850  0,003  L-glucuronate reductase inhibitor
0,832  0,003  Alcohol dehydrogenase (NADP+) inhibitor
0,835  0,006  Dehydro-L-gulonate decarboxylase inhibitor
0,815  0,004  Aspartate-phenylpyruvate transaminase inhibitor
0,820  0,015  Alkenylglycerophosphocholine hydrolase inhibitor
0,807  0,003  GABA aminotransferase inhibitor
0,806  0,003  Nicotinamidase inhibitor
0,814  0,017  Polyporopepsin inhibitor
0,813  0,018  Chlordecone reductase inhibitor
0,792  0,006  Venombin AB inhibitor
0,810  0,029  Ubiquinol-cytochrome-c reductase inhibitor
0,783  0,004  3-Phytase inhibitor
0,786  0,009  Fucosterol-epoxide lyase inhibitor
0,780  0,003  Aldehyde dehydrogenase (NADP+) inhibitor
0,783  0,008  Complement factor D inhibitor
0,776  0,003  Aspartyl aminopeptidase inhibitor
0,776  0,004  Aryldialkylphosphatase inhibitor
0,784  0,020  Methylenetetrahydrofolate reductase (NADPH) inhibitor
0,768  0,005  Aryl-acylamidase inhibitor
0,762  0,003  Acylphosphatase inhibitor
0,760  0,003  Polygalacturonase inhibitor
0,757  0,002  Vomilenine glucosyltransferase inhibitor
0,753  0,004  Uroporphyrinogen-III synthase inhibitor
0,752  0,004  Di-trans,poly-cis-decaprenylcistransferase inhibitor
0,753  0,005  Phosphatase inhibitor
0,751  0,004  Pyruvate decarboxylase inhibitor
0,751  0,005  Allyl-alcohol dehydrogenase inhibitor
0,749  0,003  Nitrilase inhibitor
0,741  0,002  Aldehyde dehydrogenase inhibitor
0,735  0,003  Aryl-alcohol dehydrogenase inhibitor
0,746  0,014  Omptin inhibitor
0,741  0,013  Fragilysin inhibitor
0,730  0,003  Succinate-semialdehyde dehydrogenase [NAD(P)+] inhibitor
0,741  0,019  Glucose oxidase inhibitor
0,763  0,044  Membrane integrity agonist
0,723  0,005  Spermicide
0,739  0,022  Pro-opiomelanocortin converting enzyme inhibitor
0,723  0,009  Lipid metabolism regulator
0,719  0,007  Centromere associated protein inhibitor
0,719  0,011  Prolyl aminopeptidase inhibitor
0,734  0,027  Sugar-phosphatase inhibitor
0,718  0,011  2-Hydroxymuconate-semialdehyde hydrolase inhibitor
0,725  0,023  Acylcarnitine hydrolase inhibitor
0,707  0,005  Glyoxylate reductase inhibitor
0,705  0,003  Lactate 2-monooxygenase inhibitor
0,704  0,004  Poly(3-hydroxybutyrate) depolymerase inhibitor
0,700  0,002  (S)-2-hydroxy-acid oxidase inhibitor
0,699  0,004  Mannan endo-1,6-alpha-mannosidase inhibitor
0,696  0,003  Benzoate 4-monooxygenase inhibitor
0,703  0,011  Linoleate diol synthase inhibitor
0,689  0,004  Dolichyl-phosphatase inhibitor
0,703  0,019  Arginine 2-monooxygenase inhibitor
0,692  0,015  Macrophage colony stimulating factor agonist
0,681  0,005  Malate dehydrogenase inhibitor
0,679  0,004  Snapalysin inhibitor
0,676  0,004  Aminomuconate-semialdehyde dehydrogenase inhibitor
0,676  0,005  Nitrite reductase (NO-forming) inhibitor
0,673  0,003  Catechol 1,2-dioxygenase inhibitor
0,671  0,002  4-Hydroxybenzoate 3-monooxygenase inhibitor
0,670  0,004  Arylesterase inhibitor
0,673  0,007  Prostaglandin-A1 DELTA-isomerase inhibitor
0,673  0,009  NADH kinase inhibitor
0,670  0,008  Anesthetic general
0,666  0,005  Glycopeptide alpha-N-acetylgalactosaminidase inhibitor
0,664  0,004  Quinoprotein glucose dehydrogenase inhibitor
0,665  0,007  Malate dehydrogenase (acceptor) inhibitor
0,661  0,003  Ferredoxin-nitrite reductase inhibitor
0,662  0,004  2-Oxoglutarate decarboxylase inhibitor
0,669  0,013  Caspase 3 stimulant
0,663  0,010  IgA-specific metalloendopeptidase inhibitor
0,656  0,004  Aminoacylase inhibitor
0,675  0,023  Alkylacetylglycerophosphatase inhibitor
0,663  0,011  Biotinidase inhibitor
0,666  0,016  Bisphosphoglycerate phosphatase inhibitor
0,666  0,017  Lipoprotein lipase inhibitor
0,668  0,021  UDP-N-acetylglucosamine 4-epimerase inhibitor
0,650  0,004  Phosphoenolpyruvate-protein phosphotransferase inhibitor
0,651  0,009  Phosphoinositide 5-phosphatase inhibitor
0,648  0,006  Transketolase inhibitor
0,659  0,017  Manganese peroxidase inhibitor
0,647  0,008  Shikimate O-hydroxycinnamoyltransferase inhibitor
0,643  0,005  Phosphopantothenoylcysteine decarboxylase inhibitor
0,650  0,012  Endopeptidase So inhibitor
0,655  0,020  2-Hydroxyquinoline 8-monooxygenase inhibitor
0,665  0,033  NADPH peroxidase inhibitor
0,642  0,014  Lysostaphin inhibitor
0,642  0,017  Acetylesterase inhibitor
0,647  0,027  Carboxypeptidase Taq inhibitor
0,624  0,005  Lactaldehyde reductase inhibitor
0,638  0,022  Dimethylargininase inhibitor
0,631  0,017  Platelet aggregation stimulant
0,632  0,018  Methylamine-glutamate N-methyltransferase inhibitor
0,611  0,003  Diiodophenylpyruvate reductase inhibitor
0,616  0,009  Glutarate-semialdehyde dehydrogenase inhibitor
0,616  0,015  Alkenylglycerophosphoethanolamine hydrolase inhibitor
0,611  0,013  D-lactaldehyde dehydrogenase inhibitor
0,603  0,005  Monophenol monooxygenase inhibitor
0,608  0,011  Leukotriene-B4 20-monooxygenase inhibitor
0,608  0,014  Dextranase inhibitor
0,622  0,030  Glutathione thiolesterase inhibitor
0,598  0,006  Aminocarboxymuconate-semialdehyde decarboxylase inhibitor
0,617  0,026  Exoribonuclease II inhibitor
0,606  0,016  Methylumbelliferyl-acetate deacetylase inhibitor
0,611  0,021  Formaldehyde transketolase inhibitor
0,599  0,012  Xylan endo-1,3-beta-xylosidase inhibitor
0,616  0,030  Proteasome ATPase inhibitor
0,595  0,009  N-Acyl-D-aspartate deacylase inhibitor
0,592  0,006  Mannose isomerase inhibitor
0,598  0,012  Arylmalonate decarboxylase inhibitor
0,601  0,016  Insulin growth factor agonist
0,601  0,016  Insulin like growth factor 1 agonist
0,586  0,003  8-Amino-7-oxononanoate synthase inhibitor
0,590  0,009  Sarcosine oxidase inhibitor
0,603  0,022  Acetylcholine neuromuscular blocking agent
0,605  0,025  Fatty-acyl-CoA synthase inhibitor
0,582  0,005  Gly-X carboxypeptidase inhibitor
0,585  0,010  Peptidoglycan glycosyltransferase inhibitor
0,587  0,013  Long-chain-aldehyde dehydrogenase inhibitor
0,581  0,009  Rhamnulose-1-phosphate aldolase inhibitor
0,575  0,004  Hydroxymethylbilane synthase inhibitor
0,587  0,016  N-formylmethionyl-peptidase inhibitor
0,597  0,030  Lysine 2,3-aminomutase inhibitor
0,573  0,008  Mannitol-1-phosphatase inhibitor
0,585  0,024  ADP-thymidine kinase inhibitor
0,577  0,017  N-benzyloxycarbonylglycine hydrolase inhibitor
0,582  0,023  3-Hydroxybenzoate 6-monooxygenase inhibitor
0,562  0,003  D-2-hydroxy-acid dehydrogenase inhibitor
0,562  0,004  2,2-Dialkylglycine decarboxylase (pyruvate) inhibitor
0,565  0,008  N-carbamoyl-L-amino-acid hydrolase inhibitor
0,579  0,024  Pullulanase inhibitor
0,558  0,004  Betaine-aldehyde dehydrogenase inhibitor
0,558  0,005  Pyruvate dehydrogenase (lipoamide) inhibitor
0,569  0,017  Aspartate-ammonia ligase inhibitor
0,575  0,022  Phenol O-methyltransferase inhibitor
0,572  0,024  Cholesterol antagonist
0,566  0,019  Galanin receptor antagonist
0,556  0,010  D-xylulose reductase inhibitor
0,553  0,010  Caspase 8 stimulant
0,553  0,011  Carboxypeptidase D inhibitor
0,540  0,005  Acid phosphatase inhibitor
0,538  0,003  Succinate-semialdehyde dehydrogenase inhibitor
0,544  0,010  Cyanoalanine nitrilase inhibitor
0,540  0,006  Phosphoenolpyruvate mutase inhibitor
0,557  0,025  Arylsulfate sulfotransferase inhibitor
0,567  0,035  Glucan endo-1,3-beta-D-glucosidase inhibitor
0,535  0,004  Leucine dehydrogenase inhibitor
0,564  0,034  Peptide agonist
0,541  0,012  Gluconolactonase inhibitor
0,532  0,003  Tyrosine-ester sulfotransferase inhibitor
0,535  0,008  Nucleoside-diphosphatase inhibitor
0,557  0,030  Cl--transporting ATPase inhibitor
0,533  0,008  Catalase inhibitor
0,554  0,031  Peptidyl-dipeptidase Dcp inhibitor
0,530  0,008  Levansucrase inhibitor
0,526  0,006  Glutamate dehydrogenase [NAD(P)+] inhibitor
0,537  0,018  Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase inhibitor
0,537  0,019  Cutinase inhibitor
0,559  0,041  Glucan endo-1,6-beta-glucosidase inhibitor
0,586  0,069  Glycosylphosphatidylinositol phospholipase D inhibitor
0,603  0,086  Membrane permeability inhibitor
0,527  0,011  Horrilysin inhibitor
0,529  0,013  Hypocalcaemic
0,520  0,005  Aldehyde dehydrogenase (NAD+) inhibitor
0,519  0,004  NAD+ synthase (glutamine-hydrolysing) inhibitor
0,521  0,006  Formate dehydrogenase inhibitor
0,523  0,009  Oryzin inhibitor
0,522  0,009  CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase inhibitor
0,532  0,019  Sulfite reductase inhibitor
0,517  0,005  N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase inhibitor
0,522  0,010  Galactose oxidase inhibitor
0,514  0,004  Aureolysin inhibitor
0,518  0,008  Glutathione dehydrogenase (ascorbate) inhibitor
0,518  0,010  Pectate lyase inhibitor
0,529  0,021  1-Alkylglycerophosphocholine O-acetyltransferase inhibitor
0,559  0,051  Lysase inhibitor
0,513  0,006  Acyloxyacyl hydrolase inhibitor
0,514  0,007  Pyruvate dehydrogenase inhibitor
0,519  0,012  Galactolipase inhibitor
0,509  0,006  Glucan 1,4-beta-glucosidase inhibitor
0,540  0,038  Alkane 1-monooxygenase inhibitor
0,509  0,007  Bisphosphoglycerate mutase inhibitor
0,516  0,015  Phosphatidylglycerophosphatase inhibitor
0,507  0,007  Acetate-CoA ligase inhibitor
0,521  0,021  NADPH-ferrihemoprotein reductase inhibitor
0,515  0,016  Acylaminoacyl-peptidase inhibitor
0,531  0,033  Gluconate 5-dehydrogenase inhibitor
0,523  0,026  All-trans-retinyl-palmitate hydrolase inhibitor
0,502  0,006  Dihydroxy-acid dehydratase inhibitor
0,521  0,024  Renal tissue kallikrein inhibitor
0,510  0,014  Glycerol-3-phosphate dehydrogenase inhibitor
0,501  0,006  Serine 3-dehydrogenase inhibitor
0,511  0,017  Phosphatidylcholine-sterol O-acyltransferase inhibitor
0,527  0,033  Superoxide dismutase inhibitor
0,498  0,004  Phenol 2-monooxygenase inhibitor
0,520  0,026  Creatininase inhibitor
0,494  0,005  Aspartate-tRNA ligase inhibitor
0,493  0,003  Proline dehydrogenase inhibitor
0,490  0,004  Peroxisome proliferator-activated receptor gamma agonist
0,489  0,004  Isocitrate dehydrogenase (NADP+) inhibitor
0,509  0,024  Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase inhibitor
0,499  0,016  Cyclomaltodextrinase inhibitor
0,519  0,036  Peroxidase inhibitor
0,513  0,030  Glutamine-phenylpyruvate transaminase inhibitor
0,520  0,038  Adenomatous polyposis treatment
0,488  0,009  Inorganic diphosphatase inhibitor
0,496  0,017  Lipid peroxidase inhibitor
0,492  0,014  Phenylacetate-CoA ligase inhibitor
0,480  0,002  Phosphomevalonate kinase inhibitor
0,515  0,038  Hydrogen dehydrogenase inhibitor
0,490  0,013  Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase inhibitor
0,503  0,027  tRNA-pseudouridine synthase I inhibitor
0,479  0,005  Expectorant
0,484  0,011  Glycerol 2-dehydrogenase (NADP+) inhibitor
0,481  0,010  Nitrate reductase inhibitor
0,489  0,018  Membrane permeability enhancer
0,492  0,023  Enteropeptidase inhibitor
0,508  0,039  Ecdysone 20-monooxygenase inhibitor
0,473  0,004  Peroxisome proliferator-activated receptor agonist
0,499  0,030  Mannan endo-1,4-beta-mannosidase inhibitor
0,473  0,004  Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) inhibitor
0,472  0,004  Tauropine dehydrogenase inhibitor
0,476  0,007  Glucan 1,6-alpha-glucosidase inhibitor
0,489  0,021  Glucan 1,4-alpha-maltotetraohydrolase inhibitor
0,478  0,011  Ubiquitin thiolesterase inhibitor
0,486  0,019  Fructan beta-fructosidase inhibitor
0,486  0,019  4-Coumarate-CoA ligase inhibitor
0,490  0,024  Threonine aldolase inhibitor
0,477  0,014  4-Hydroxyglutamate transaminase inhibitor
0,482  0,021  Poly(beta-D-mannuronate) lyase inhibitor
0,469  0,010  N-acetylneuraminate synthase inhibitor
0,468  0,010  Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase inhibitor
0,468  0,010  N-acetyllactosamine synthase inhibitor
0,480  0,023  4-Hydroxyphenylacetate 3-monooxygenase inhibitor
0,471  0,014  Licheninase inhibitor
0,485  0,029  Galanin receptor 2 antagonist
0,464  0,010  CYP2A6 inhibitor
0,476  0,021  Opheline kinase inhibitor
0,476  0,021  Taurocyamine kinase inhibitor
0,462  0,008  3-Isopropylmalate dehydratase inhibitor
0,463  0,010  Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase inhibitor
0,467  0,014  2-Hydroxy-3-oxoadipate synthase inhibitor
0,456  0,004  D-lactate dehydrogenase (cytochrome) inhibitor
0,478  0,026  Aspergillopepsin I inhibitor
0,456  0,004  Alanine dehydrogenase inhibitor
0,474  0,024  Alcohol dehydrogenase (acceptor) inhibitor
0,494  0,046  Nitrate reductase (cytochrome) inhibitor
0,469  0,021  Sulfite dehydrogenase inhibitor
0,459  0,012  Peptide-tryptophan 2,3-dioxygenase inhibitor
0,468  0,022  Carbon-monoxide dehydrogenase inhibitor
0,491  0,045  Polyamine-transporting ATPase inhibitor
0,450  0,005  Glycerol dehydratase inhibitor
0,451  0,006  Peptidylamidoglycolate lyase inhibitor
0,474  0,029  Urethanase inhibitor
0,463  0,018  4-Hydroxymandelate oxidase inhibitor
0,459  0,015  Protein-Npi-phosphohistidine-sugar phosphotransferase inhibitor
0,452  0,008  Aryl sulfotransferase inhibitor
0,461  0,017  Leukotriene-C4 synthase inhibitor
0,461  0,017  N-(long-chain-acyl)ethanolamine deacylase inhibitor
0,462  0,019  Methanol dehydrogenase inhibitor
0,475  0,033  S-formylglutathione hydrolase inhibitor
0,448  0,006  Creatinase inhibitor
0,451  0,010  Alpha-amylase inhibitor
0,451  0,010  Amylase inhibitor
0,447  0,007  Acetoin dehydrogenase inhibitor
0,466  0,026  Peptide alpha-N-acetyltransferase inhibitor
0,464  0,024  Sulfite oxidase inhibitor
0,447  0,008  Prunasin beta-glucosidase inhibitor
0,452  0,014  6-Pyruvoyltetrahydropterin synthase inhibitor
0,447  0,009  tRNA nucleotidyltransferase inhibitor
0,450  0,013  Serralysin inhibitor
0,440  0,003  L-lactate dehydrogenase (cytochrome) inhibitor
0,467  0,030  4-Hydroxyproline epimerase inhibitor
0,448  0,012  3-Carboxyethylcatechol 2,3-dioxygenase inhibitor
0,453  0,019  Clavaminate synthase inhibitor
0,451  0,017  Sorbitol-6-phosphate 2-dehydrogenase inhibitor
0,443  0,009  Xaa-Pro dipeptidyl-peptidase inhibitor
0,461  0,028  Dolichyl-diphosphooligosaccharide-protein glycotransferase inhibitor
0,455  0,023  Glyoxylate oxidase inhibitor
0,453  0,021  Opine dehydrogenase inhibitor
0,452  0,020  Aldehyde dehydrogenase (pyrroloquinoline-quinone) inhibitor
0,449  0,017  Dimethylmaleate hydratase inhibitor
0,466  0,035  Chenodeoxycholoyltaurine hydrolase inhibitor
0,491  0,059  Benzoate-CoA ligase inhibitor
0,458  0,028  S-alkylcysteine lyase inhibitor
0,445  0,018  2,3,4,5-Tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase inhibitor
0,435  0,008  Glycine C-acetyltransferase inhibitor
0,435  0,008  Alpha-N-arabinofuranosidase inhibitor
0,433  0,007  Thiosulfate sulfurtransferase inhibitor
0,440  0,014  Alpha-N-acetylglucosaminidase inhibitor
0,450  0,024  H+-exporting ATPase inhibitor
0,444  0,018  Myeloblastin inhibitor
0,431  0,006  Formaldehyde dehydrogenase inhibitor
0,449  0,025  Phosphatidate phosphatase inhibitor
0,440  0,018  2-Oxoaldehyde dehydrogenase (NADP+) inhibitor
0,429  0,008  Isopenicillin-N synthase inhibitor
0,457  0,036  Cyclohexanone monooxygenase inhibitor
0,445  0,026  Carnitinamidase inhibitor
0,447  0,028  Corticosteroid side-chain-isomerase inhibitor
0,437  0,019  Sphinganine-1-phosphate aldolase inhibitor
0,456  0,038  Hydroxylamine oxidase inhibitor
0,427  0,010  Lombricine kinase inhibitor
0,459  0,042  Protein-glutamate methylesterase inhibitor
0,425  0,009  Fumarate reductase (NADH) inhibitor
0,441  0,026  DNA-(apurinic or apyrimidinic site) lyase inhibitor
0,466  0,052  Erythropoiesis stimulant
0,443  0,030  Thiol oxidase inhibitor
0,422  0,010  Alkylglycerophosphoethanolamine phosphodiesterase inhibitor
0,447  0,036  Mitochondrial processing peptidase inhibitor
0,416  0,006  (S)-3-amino-2-methylpropionate transaminase inhibitor
0,449  0,039  Cytochrome P450 stimulant
0,421  0,011  2-Enoate reductase inhibitor
0,412  0,003  L-fuconate dehydratase inhibitor
0,412  0,004  O-acetylhomoserine aminocarboxypropyltransferase inhibitor
0,461  0,053  Thromboxane B2 antagonist
0,427  0,019  Protein-tyrosine sulfotransferase inhibitor
0,425  0,017  4-Chlorophenylacetate 3,4-dioxygenase inhibitor
0,418  0,011  Arylformamidase inhibitor
0,432  0,025  Cyclohexyl-isocyanide hydratase inhibitor
0,441  0,035  (R)-Pantolactone dehydrogenase (flavin) inhibitor
0,432  0,028  Levanase inhibitor
0,449  0,045  Phosphatidylserine decarboxylase inhibitor
0,411  0,009  Gamma-butyrobetaine dioxygenase inhibitor
0,424  0,021  4-Nitrophenylphosphatase inhibitor
0,452  0,050  Transforming growth factor agonist
0,411  0,011  Penicillin amidase inhibitor
0,447  0,047  Prostaglandin-E2 9-reductase inhibitor
0,426  0,027  Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase inhibitor
0,413  0,014  Acetate kinase inhibitor
0,413  0,015  3-Demethylubiquinone-9 3-O-methyltransferase inhibitor
0,408  0,011  Pyruvate dehydrogenase (cytochrome) inhibitor
0,408  0,011  Trans-2-enoyl-CoA reductase (NAD+) inhibitor
0,438  0,041  Histidine kinase inhibitor
0,480  0,083  Platelet adhesion inhibitor
0,401  0,005  Porphobilinogen synthase inhibitor
0,451  0,055  Fibrolase inhibitor
0,469  0,074  Glyceryl-ether monooxygenase inhibitor
0,421  0,026  Phosphatidylinositol diacylglycerol-lyase inhibitor
0,402  0,008  Saccharopine dehydrogenase (NAD+, L-lysine-forming) inhibitor
0,434  0,041  Ferredoxin-NAD+ reductase inhibitor
0,434  0,041  Naphthalene 1,2-dioxygenase inhibitor
0,494  0,101  Kidney function stimulant
0,404  0,011  Thyroxine 5-deiodinase inhibitor
0,408  0,017  Signal peptidase I inhibitor
0,414  0,023  Procollagen N-endopeptidase inhibitor
0,409  0,020  Tryptophanamidase inhibitor
0,407  0,018  Mitochondrial intermediate peptidase inhibitor
0,451  0,062  Pterin deaminase inhibitor
0,402  0,015  Phospholipase C inhibitor
0,419  0,032  Chitosanase inhibitor
0,408  0,021  Envelysin inhibitor
0,426  0,040  IgA-specific serine endopeptidase inhibitor
0,462  0,077  Phospholipid-translocating ATPase inhibitor
0,405  0,020  Glycine dehydrogenase (decarboxylating) inhibitor
0,404  0,020  LGALS1 expression inhibitor
0,427  0,044  Glucan 1,4-alpha-maltotriohydrolase inhibitor
0,452  0,069  Oxygen scavenger
0,441  0,059  Sulfur reductase inhibitor
0,417  0,036  1-Acylglycerol-3-phosphate O-acyltransferase inhibitor
0,420  0,042  N-hydroxyarylamine O-acetyltransferase inhibitor
0,410  0,035  Pitrilysin inhibitor
0,423  0,049  Immunostimulant
0,411  0,037  Arylacetonitrilase inhibitor
0,420  0,047  Plastoquinol-plastocyanin reductase inhibitor
0,429  0,058  Alcohol O-acetyltransferase inhibitor
0,419  0,048  Gamma-guanidinobutyraldehyde dehydrogenase inhibitor
0,406  0,036  Aspergillus nuclease S1 inhibitor
0,407  0,038  CDP-diacylglycerol-serine O-phosphatidyltransferase inhibitor
0,436  0,070  Neurotransmitter antagonist
0,456  0,091  Collagen inhibitor
0,416  0,052  NAD(P)+-arginine ADP-ribosyltransferase inhibitor
0,466  0,103  Taurine dehydrogenase inhibitor
0,408  0,045  Limulus clotting factor C inhibitor
0,400  0,039  Myc inhibitor
0,429  0,074  Histamine release inhibitor
0,421  0,066  Beta glucuronidase inhibitor
0,424  0,071  Cyclic AMP agonist
0,431  0,086  27-Hydroxycholesterol 7alpha-monooxygenase inhibitor
0,401  0,061  L-glutamate oxidase inhibitor
0,425  0,094  NACHT, LRR and PYD domains-containing protein 3 inhibitor
0,404  0,081  Fibrinogen receptor antagonist
0,462  0,143  Vasodilator, cerebral
0,460  0,144  Transferase inhibitor
0,402  0,097  Penicillin binding protein antagonist
0,402  0,097  Penicillin-binding protein ampH inhibitor
0,419  0,116  Guanyl-specific ribonuclease T1 inhibitor
0,445  0,153  Mucomembranous protector

>  <Metabolism>
0,807  0,019  CYP2J substrate
0,771  0,003  Aldehyde oxidase substrate
0,710  0,010  CYP2C8 substrate
0,701  0,017  CYP2C substrate
0,697  0,021  CYP2 substrate
0,690  0,024  GST A substrate
0,711  0,055  CYP2C12 substrate
0,650  0,008  CYP2F1 substrate
0,624  0,017  CYP2A substrate
0,623  0,015  CYP2A6 substrate
0,608  0,010  CYP2E1 substrate
0,602  0,011  CYP2E substrate
0,573  0,002  Alcohol dehydrogenase substrate
0,579  0,015  UGT1A9 substrate
0,524  0,013  UGT1A6 substrate
0,556  0,047  CYP3A2 substrate
0,541  0,034  CYP3A1 substrate
0,500  0,001  Aldehyde dehydrogenase 1 substrate
0,530  0,032  CYP2B6 substrate
0,546  0,053  CYP3A4 substrate
0,515  0,027  CYP2A4 substrate
0,539  0,051  CYP3A substrate
0,509  0,027  CYP2C19 substrate
0,469  0,009  CYP2A3 substrate
0,459  0,000  Aldehyde dehydrogenase 3 substrate
0,464  0,010  CYP2A6 inhibitor
0,478  0,028  CYP2B substrate
0,444  0,002  Aldehyde dehydrogenase substrate
0,457  0,030  CYP2C11 substrate
0,459  0,033  CYP1A2 substrate
0,471  0,046  CYP2C9 substrate
0,462  0,040  CYP2B5 substrate
0,437  0,019  UGT2B4 substrate
0,444  0,035  CYP4A11 substrate
0,452  0,051  CYP2D16 substrate
0,412  0,014  UGT1A10 substrate
0,408  0,010  UGT2B28 substrate
0,419  0,023  CYP1A1 substrate
0,433  0,040  CYP1A substrate
0,432  0,041  CYP1 substrate
0,401  0,010  UGT1A7 substrate
0,407  0,029  CYP4A substrate
0,425  0,067  CYP2A1 substrate

>  <Toxicity>
0,851  0,003  Eye irritation, weak
0,838  0,004  Skin irritative effect
0,816  0,017  Hemolysis
0,805  0,013  Muscle weakness
0,795  0,004  Skin irritation, high
0,773  0,004  Skin irritation, moderate
0,787  0,020  Weakness
0,771  0,008  Hypomagnesemia
0,765  0,018  Hematemesis
0,757  0,022  Respiratory failure
0,738  0,005  Fatty liver
0,723  0,005  Spermicide
0,729  0,014  Non mutagenic, Salmonella
0,748  0,044  Lichenoid eruption
0,733  0,030  Reproductive dysfunction
0,698  0,008  Carcinogenic
0,720  0,038  Ulcer, aphthous
0,680  0,010  Sensitization
0,685  0,016  Ototoxicity
0,681  0,021  Immunotoxin
0,702  0,044  Toxic
0,688  0,036  Toxic, vascular
0,688  0,039  Hyponatremia
0,677  0,042  Drowsiness
0,635  0,009  Carcinogenic, mouse, female
0,675  0,059  Stroke
0,623  0,010  Carcinogenic, mouse
0,645  0,040  Gastrointestinal hemorrhage
0,632  0,029  Scleroderma
0,646  0,043  Hypercholesterolemic
0,655  0,063  Cerebral hemorrhage
0,638  0,046  Ulcer, esophageal
0,601  0,011  Carcinogenic, rat, male
0,615  0,027  Pseudoporphyria
0,642  0,060  Renal insufficiency
0,589  0,008  Eye irritation, moderate
0,632  0,056  Sleep disturbance
0,585  0,012  Carcinogenic, mouse, male
0,574  0,006  Carcinogenic, group 2B
0,659  0,092  Shivering
0,634  0,069  Hyperactivity
0,601  0,039  Acidosis, metabolic
0,594  0,034  Fibrosis, interstitial
0,608  0,059  Toxic, respiration
0,596  0,054  Ectropion
0,615  0,074  Myocardial ischemia
0,544  0,013  Carcinogenic, rat
0,571  0,046  Ataxia
0,529  0,013  Hypocalcaemic
0,582  0,067  Lymphocytosis
0,524  0,019  Ulceration
0,579  0,084  Anemia, hemolytic
0,537  0,044  Teratogen
0,549  0,063  Convulsant
0,550  0,067  Pure red cell aplasia
0,525  0,043  Hyperuricemia
0,505  0,027  Acidosis, lactic
0,557  0,084  Toxic, gastrointestinal
0,514  0,046  Embryotoxic
0,504  0,038  ANCA-positive vasculitis
0,545  0,087  Alopecia (hair loss)
0,509  0,051  Aseptic meningitis
0,504  0,058  Allergic contact dermatitis
0,492  0,049  Nephrotic syndrome
0,448  0,019  Eye irritation, high
0,447  0,028  Bullous pemphigoid
0,452  0,034  Ophthalmoplegia
0,448  0,031  Anemia, sideroblastic
0,428  0,012  Renal papillary necrosis
0,490  0,076  Hepatic necrosis
0,512  0,099  Withdrawal
0,473  0,067  Allergic dermatitis
0,421  0,017  Carcinogenic, group 3
0,435  0,035  Cytotoxic
0,496  0,107  Fibrillation, atrial
0,402  0,014  Skin irritation, weak
0,461  0,075  Raynaud's phenomenon
0,441  0,055  Palpitation
0,463  0,079  Dyskinesia
0,452  0,068  Colic
0,452  0,069  Serum sickness
0,417  0,040  Myasthenia Gravis
0,476  0,105  Cardiogenic shock
0,423  0,054  Fasciculation
0,453  0,085  Enterocolitis
0,477  0,110  Optic neuropathy
0,452  0,089  Hirsutism
0,413  0,051  Ulcer, peptic
0,416  0,061  Renal colic
0,426  0,082  Splenomegaly
0,416  0,073  Gastrointestinal disturbance
0,437  0,095  Cataract
0,422  0,087  Interstitial nephritis
0,456  0,121  Bone marrow suppression
0,443  0,110  Nephritis
0,436  0,104  Hepatotoxic
0,413  0,084  Panic
0,403  0,076  Adrenal cortex hypoplasia
0,439  0,118  Purpura
0,432  0,115  Diarrhea
0,426  0,109  Edema
0,433  0,143  Optic neuritis
0,406  0,126  Galactorrhea
0,434  0,157  Hyperreflexia
0,416  0,140  Hyperglycemic
0,435  0,175  Neuritis
0,434  0,186  Ejaculation dysfunction

>  <Murcko.CdId>
957

>  <Murcko.Mol Weight>
78.1118

>  <Murcko.Formula>
C6H6

>  <Murcko.AKOS_NUMBER>
AKOS016012143

>  <Murcko.IntegerID>
956

$$$$

  Mrv0541 04281317412D          

 14 14  0  0  0  0            999 V2000
    2.6217    0.1578    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5552    1.5788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2436   -0.5734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6840   -1.2714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1730    0.8476    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1107    2.2768    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5067   -1.2382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9429   -1.9320    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3778    1.6162    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3059   -1.9985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4127   -0.6025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3503    0.8185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4832   -2.0359    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0387   -1.3379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  5  1  0  0  0  0
  3  1  1  0  0  0  0
  4  3  1  0  0  0  0
  5  1  1  0  0  0  0
  6  2  2  0  0  0  0
  7  4  1  0  0  0  0
  8  7  2  0  0  0  0
  9  2  1  0  0  0  0
 10  4  2  0  0  0  0
 11  3  2  0  0  0  0
 12  5  1  0  0  0  0
 13 14  2  0  0  0  0
 14 11  1  0  0  0  0
 10 13  1  0  0  0  0
M  END
>  <CdId>
963

>  <Mol Weight>
194.184

>  <Formula>
C10H10O4

>  <AKOS_NUMBER>
AKOS016035534

>  <Lipinski's Rule of Five>
0

>  <XLogP (text field)>
0.78

>  <PASS_MNA_NEW_COUNT>
0

>  <PASS_RESULT_COUNT>
   31 of   464 Possible Pharmacological Effects at Pa > 0.400
  354 of  3850 Possible Mechanisms of Action at Pa > 0.400
  100 of   321 Possible Toxic and Adverse Effects at Pa > 0.400
    5 of   118 Possible Antitargets at Pa > 0.400
   28 of   195 Possible Metabolism-Related Actions at Pa > 0.400
  644 of  1610 Possible Gene Expression Regulation at Pa > 0.400
    0 of    68 Possible Transporters-Related Actions at Pa > 0.400

>  <Effects>
0,936  0,003  Skin irritation, inactive
0,716  0,005  Antidiabetic
0,708  0,014  Apoptosis agonist
0,702  0,011  Lipid metabolism regulator
0,679  0,016  Respiratory analeptic
0,636  0,015  Analeptic
0,614  0,006  Antidiabetic (type 2)
0,617  0,013  Antihypercholesterolemic
0,647  0,047  Antiseborrheic
0,653  0,054  Neuroprotector
0,629  0,057  Fibrinolytic
0,518  0,005  Expectorant
0,523  0,032  Antihypoxic
0,523  0,037  Leukopoiesis stimulant
0,510  0,035  Hypolipemic
0,484  0,023  Anesthetic general
0,502  0,050  Alopecia treatment
0,470  0,025  Eye irritation, inactive
0,446  0,013  Antiinflammatory, intestinal
0,438  0,013  Sclerosant
0,456  0,038  Antifungal
0,457  0,056  Erythropoiesis stimulant
0,458  0,069  Preneoplastic conditions treatment
0,422  0,040  Menopausal disorders treatment
0,474  0,115  Kidney function stimulant
0,422  0,067  Vasoprotector
0,418  0,089  Cytoprotectant
0,457  0,161  Antieczematic
0,408  0,114  Antinephrotoxic
0,441  0,168  Vasodilator, cerebral
0,421  0,187  Antibacterial activity enhancer

>  <Antitargets>
0,767  0,044  Ubiquinol-cytochrome-c reductase inhibitor
0,708  0,004  GABA aminotransferase inhibitor
0,524  0,009  Catalase inhibitor
0,523  0,034  Superoxide dismutase inhibitor
0,519  0,036  Peroxidase inhibitor

>  <Gene_Expression>
0,904  0,004  ID1 expression inhibitor
0,859  0,004  FGF2 expression inhibitor
0,852  0,010  PPARA expression inhibitor
0,846  0,011  SERPINB5 expression inhibitor
0,835  0,007  FUBP1 expression inhibitor
0,853  0,032  HSPD1 expression inhibitor
0,811  0,008  CLMP expression inhibitor
0,842  0,039  LPL expression enhancer
0,809  0,008  DDX18 expression inhibitor
0,799  0,003  PPARA expression enhancer
0,824  0,028  NAA15 expression inhibitor
0,809  0,018  ITGB6 expression inhibitor
0,799  0,011  NASP expression inhibitor
0,796  0,010  TNS3 expression enhancer
0,792  0,008  CDKN1C expression inhibitor
0,786  0,009  HMGA1 expression inhibitor
0,786  0,011  CPE expression inhibitor
0,801  0,027  GPX1 expression inhibitor
0,791  0,026  TOP1 expression inhibitor
0,769  0,009  CPNE1 expression enhancer
0,780  0,021  ILF3 expression inhibitor
0,759  0,005  FGFR3 expression inhibitor
0,759  0,007  CARS expression inhibitor
0,757  0,005  SCARB1 expression enhancer
0,755  0,006  CCNA2 expression enhancer
0,780  0,033  DUSP4 expression enhancer
0,762  0,016  TNFRSF21 expression inhibitor
0,762  0,020  PRKCA expression enhancer
0,775  0,034  CXCR1 expression enhancer
0,761  0,020  NBN expression inhibitor
0,753  0,013  MAFB expression inhibitor
0,745  0,005  CYB5A expression enhancer
0,764  0,026  EZH2 expression inhibitor
0,743  0,011  GNL3 expression inhibitor
0,745  0,013  NEIL3 expression inhibitor
0,743  0,012  HMBS expression inhibitor
0,764  0,033  MYL6 expression enhancer
0,740  0,009  SUV420H1 expression inhibitor
0,760  0,029  MAPT expression enhancer
0,748  0,019  MYBL1 expression enhancer
0,753  0,025  CNN1 expression enhancer
0,738  0,014  PRRX1 expression inhibitor
0,735  0,012  EDN1 expression enhancer
0,743  0,021  COL2A1 expression enhancer
0,757  0,035  STAR expression enhancer
0,746  0,026  CD44 expression inhibitor
0,726  0,007  CALM3 expression enhancer
0,742  0,023  JAG1 expression inhibitor
0,741  0,022  NOM1 expression inhibitor
0,735  0,016  ORC4 expression enhancer
0,725  0,007  BNIP3 expression inhibitor
0,726  0,012  DFFA expression inhibitor
0,751  0,037  PDXK expression inhibitor
0,740  0,028  MMP7 expression enhancer
0,733  0,023  TFDP2 expression inhibitor
0,730  0,020  MCM6 expression enhancer
0,731  0,021  IL18 expression inhibitor
0,728  0,024  NAT1 expression enhancer
0,730  0,027  C10ORF116 expression enhancer
0,736  0,035  SUZ12 expression inhibitor
0,723  0,022  ETV5 expression inhibitor
0,707  0,007  NOS1 expression inhibitor
0,716  0,018  WFDC2 expression enhancer
0,726  0,029  APOM expression enhancer
0,703  0,009  SP2 expression inhibitor
0,697  0,009  CRABP2 expression inhibitor
0,723  0,036  SRPK1 expression inhibitor
0,707  0,020  PKM2 expression enhancer
0,723  0,037  SFPQ expression enhancer
0,704  0,018  PCNA expression enhancer
0,725  0,041  FGFR1 expression inhibitor
0,710  0,030  FILIP1L expression inhibitor
0,684  0,005  SPAG6 expression enhancer
0,700  0,023  TNFRSF11A expression enhancer
0,702  0,027  TRAK2 expression enhancer
0,711  0,036  ATP1B3 expression inhibitor
0,697  0,022  PTGR1 expression enhancer
0,686  0,012  PSAT1 expression inhibitor
0,692  0,019  FOSL1 expression enhancer
0,703  0,034  GAS6 expression inhibitor
0,671  0,005  IFNG expression inhibitor
0,692  0,027  TP53 expression enhancer
0,684  0,019  PRSS23 expression enhancer
0,690  0,032  ITGB2 expression enhancer
0,662  0,005  PICALM expression inhibitor
0,678  0,023  ZNF91 expression inhibitor
0,703  0,048  TXNRD1 expression inhibitor
0,685  0,032  IGFBP6 expression inhibitor
0,684  0,030  TMSB4X expression inhibitor
0,669  0,016  SIDT2 expression enhancer
0,658  0,005  UGT1A1 expression enhancer
0,662  0,013  CDK5 expression enhancer
0,694  0,046  OAS2 expression enhancer
0,671  0,023  LYN expression inhibitor
0,665  0,017  ADD3 expression enhancer
0,657  0,010  MMP9 expression inhibitor
0,664  0,018  MMP2 expression enhancer
0,669  0,028  MAPK8 expression inhibitor
0,668  0,027  SLC16A4 expression enhancer
0,671  0,032  CCNE2 expression inhibitor
0,654  0,016  HMGA1 expression enhancer
0,650  0,013  DEK expression inhibitor
0,646  0,009  MFAP4 expression inhibitor
0,659  0,025  IGF2 expression inhibitor
0,655  0,023  LAMC1 expression enhancer
0,657  0,026  BAD expression inhibitor
0,646  0,016  JUNB expression inhibitor
0,638  0,012  IFI30 expression enhancer
0,643  0,017  TRAM1 expression inhibitor
0,650  0,026  ELL2 expression enhancer
0,656  0,032  EPRS expression inhibitor
0,705  0,082  RAD23B expression inhibitor
0,635  0,012  CCNK expression inhibitor
0,637  0,015  FTL expression enhancer
0,635  0,014  ATR expression inhibitor
0,635  0,014  EFNA4 expression inhibitor
0,635  0,014  MARK3 expression inhibitor
0,635  0,014  SMAD1 expression inhibitor
0,628  0,008  SUMO1 expression inhibitor
0,632  0,013  SCML1 expression enhancer
0,632  0,013  SEPHS1 expression inhibitor
0,636  0,018  PML expression inhibitor
0,638  0,020  ADSL expression inhibitor
0,641  0,024  PTGS2 expression enhancer
0,672  0,056  MSH6 expression inhibitor
0,633  0,017  BMP1 expression inhibitor
0,630  0,014  IL6ST expression inhibitor
0,628  0,013  MDK expression inhibitor
0,619  0,003  ABCG5 expression enhancer
0,619  0,003  CYP7A1 expression enhancer
0,633  0,020  EZR expression inhibitor
0,633  0,020  GAK expression inhibitor
0,633  0,020  TERF1 expression inhibitor
0,630  0,017  PLA2G2A expression enhancer
0,617  0,005  POLR2A expression enhancer
0,631  0,018  NR4A2 expression inhibitor
0,646  0,037  IL1RN expression inhibitor
0,613  0,005  ASTN2 expression enhancer
0,637  0,030  CLDN4 expression enhancer
0,624  0,018  CYP4A11 expression enhancer
0,631  0,024  MLF1 expression enhancer
0,636  0,031  PMEPA1 expression inhibitor
0,648  0,046  PLIN2 expression enhancer
0,617  0,014  PLAGL1 expression enhancer
0,629  0,028  ESR1 expression inhibitor
0,627  0,026  PIK3R2 expression inhibitor
0,626  0,026  ITGB7 expression enhancer
0,648  0,048  AHR expression inhibitor
0,616  0,018  ID3 expression inhibitor
0,619  0,022  FOXD1 expression inhibitor
0,610  0,015  TOB1 expression inhibitor
0,647  0,051  PHB expression inhibitor
0,637  0,043  IFNGR1 expression enhancer
0,606  0,014  MT1F expression inhibitor
0,615  0,023  MAP2K1 expression enhancer
0,605  0,014  C5ORF32 expression enhancer
0,605  0,014  FAH expression enhancer
0,605  0,014  RRAS expression enhancer
0,605  0,014  SH3BGRL3 expression enhancer
0,629  0,039  SATB1 expression inhibitor
0,640  0,050  STAT1 expression inhibitor
0,627  0,040  ACTA2 expression inhibitor
0,616  0,030  SLC1A1 expression enhancer
0,641  0,056  CD36 expression inhibitor
0,654  0,069  MAPK8 expression enhancer
0,609  0,025  NPTX2 expression enhancer
0,640  0,064  PLAU expression inhibitor
0,602  0,026  CYB5R2 expression enhancer
0,594  0,020  WAS expression enhancer
0,601  0,027  SCARB1 expression inhibitor
0,615  0,041  SLC16A2 expression enhancer
0,601  0,027  TRIM16 expression enhancer
0,589  0,016  WDR4 expression inhibitor
0,607  0,035  FKBP8 expression inhibitor
0,581  0,009  PTPRK expression inhibitor
0,625  0,053  GTF2F1 expression inhibitor
0,599  0,029  CTTN expression inhibitor
0,599  0,029  ATP2A2 expression enhancer
0,590  0,022  YWHAH expression inhibitor
0,631  0,064  JUN expression enhancer
0,587  0,021  PARG expression enhancer
0,595  0,029  HLA-F expression enhancer
0,615  0,049  CASP3 expression enhancer
0,602  0,036  NOL5A expression inhibitor
0,608  0,043  PRKAR2B expression enhancer
0,594  0,030  HLA-C expression enhancer
0,606  0,042  KPNA1 expression enhancer
0,611  0,048  NR4A2 expression enhancer
0,577  0,013  CSDA expression inhibitor
0,596  0,032  HAPLN3 expression inhibitor
0,604  0,042  THBS1 expression enhancer
0,581  0,021  PRDX2 expression enhancer
0,622  0,062  FANCC expression inhibitor
0,603  0,043  TNF expression enhancer
0,599  0,040  IL6 expression inhibitor
0,574  0,016  BID expression inhibitor
0,572  0,017  TNF expression inhibitor
0,580  0,025  DDX24 expression inhibitor
0,613  0,060  UNG expression inhibitor
0,570  0,018  MYBL2 expression inhibitor
0,579  0,027  MTHFD2 expression inhibitor
0,576  0,024  POLE2 expression inhibitor
0,594  0,042  BIRC3 expression enhancer
0,570  0,019  IMPDH2 expression enhancer
0,568  0,017  CALM1 expression enhancer
0,618  0,068  NFKB1 expression enhancer
0,585  0,035  VAT1 expression enhancer
0,583  0,033  NOC3L expression inhibitor
0,592  0,044  IL1A expression inhibitor
0,580  0,031  HLA-B expression enhancer
0,595  0,047  ID2 expression enhancer
0,561  0,014  ZFAND5 expression inhibitor
0,580  0,033  ADAM17 expression inhibitor
0,580  0,033  CTBP1 expression inhibitor
0,572  0,026  PA2G4 expression inhibitor
0,584  0,039  MEGF9 expression inhibitor
0,556  0,012  CD47 expression inhibitor
0,574  0,029  FGFR2 expression enhancer
0,563  0,020  MT1X expression inhibitor
0,560  0,017  REL expression enhancer
0,573  0,032  MYB expression inhibitor
0,602  0,061  HIF1A expression enhancer
0,560  0,020  JUN expression inhibitor
0,608  0,068  VDR expression enhancer
0,581  0,043  HSPA1A expression enhancer
0,562  0,024  ITGA6 expression inhibitor
0,556  0,021  FOXC1 expression enhancer
0,565  0,030  MCM7 expression inhibitor
0,558  0,026  NEDD9 expression inhibitor
0,560  0,028  ACPP expression enhancer
0,566  0,036  VAV3 expression inhibitor
0,594  0,063  GADD45A expression inhibitor
0,548  0,019  MT1H expression inhibitor
0,557  0,028  HSP27 expression enhancer
0,557  0,030  SESN1 expression inhibitor
0,559  0,032  HNRPC expression inhibitor
0,586  0,060  CEP350 expression inhibitor
0,586  0,060  PDE8A expression inhibitor
0,573  0,047  PRTN3 expression enhancer
0,567  0,041  CAV1 expression inhibitor
0,550  0,025  ANAPC1 expression enhancer
0,542  0,017  HLA-E expression enhancer
0,554  0,029  CYP11A1 expression inhibitor
0,550  0,026  TGFBI expression enhancer
0,578  0,055  PPPDE1 expression inhibitor
0,556  0,036  ELOVL5 expression inhibitor
0,551  0,031  IL2RA expression inhibitor
0,534  0,014  RARB expression inhibitor
0,546  0,026  FEN1 expression inhibitor
0,556  0,037  DAB2 expression enhancer
0,556  0,037  STAT3 expression inhibitor
0,538  0,019  CYFIP2 expression enhancer
0,552  0,034  TUBA1A expression inhibitor
0,540  0,022  PLA2G16 expression enhancer
0,540  0,022  TCEB3 expression inhibitor
0,547  0,029  RPS27L expression enhancer
0,554  0,036  TUBA4A expression enhancer
0,565  0,047  SEPT2 expression inhibitor
0,561  0,044  SOX9 expression enhancer
0,557  0,041  APOA1 expression inhibitor
0,537  0,022  E2F1 expression inhibitor
0,537  0,022  SPARC expression inhibitor
0,554  0,039  POR expression enhancer
0,540  0,025  SASH1 expression inhibitor
0,537  0,025  KIF15 expression inhibitor
0,541  0,029  CBX3 expression inhibitor
0,575  0,067  PLAUR expression enhancer
0,542  0,033  COL3A1 expression inhibitor
0,541  0,033  FUS expression inhibitor
0,548  0,040  RPS19 expression inhibitor
0,548  0,040  SIRT1 expression inhibitor
0,540  0,034  COL4A1 expression inhibitor
0,534  0,028  CDKN1B expression inhibitor
0,520  0,014  C6ORF108 expression inhibitor
0,520  0,014  CASK expression inhibitor
0,520  0,014  MAP2K5 expression inhibitor
0,520  0,014  PPP1CA expression inhibitor
0,520  0,014  TCF3 expression inhibitor
0,539  0,035  EDN1 expression inhibitor
0,578  0,074  STAT5B expression enhancer
0,543  0,039  YWHAE expression inhibitor
0,566  0,062  KPNA2 expression inhibitor
0,522  0,020  TPO expression enhancer
0,547  0,047  IL10 expression enhancer
0,580  0,080  BST2 expression enhancer
0,552  0,052  RNF4 expression inhibitor
0,528  0,028  ALPL expression enhancer
0,545  0,046  CUTL1 expression inhibitor
0,536  0,037  ISG15 expression enhancer
0,541  0,043  JUND expression inhibitor
0,563  0,065  MYB expression enhancer
0,547  0,049  CALR expression inhibitor
0,537  0,040  CEP57 expression inhibitor
0,556  0,059  THBD expression enhancer
0,523  0,027  GFPT2 expression enhancer
0,517  0,023  KIAA0930 expression enhancer
0,518  0,024  FOS expression inhibitor
0,528  0,034  MYC expression enhancer
0,510  0,018  LYN expression enhancer
0,531  0,039  PLD1 expression enhancer
0,531  0,039  EPHB4 expression inhibitor
0,531  0,039  NMT1 expression inhibitor
0,517  0,027  ISYNA1 expression enhancer
0,533  0,043  IER3 expression inhibitor
0,532  0,043  FAS expression inhibitor
0,504  0,016  IGF1R expression enhancer
0,524  0,036  RRM2 expression inhibitor
0,547  0,060  PDE9A expression inhibitor
0,538  0,051  TIMP1 expression enhancer
0,523  0,037  NOLC1 expression inhibitor
0,540  0,054  GSTM2 expression inhibitor
0,538  0,053  ARL6IP5 expression enhancer
0,517  0,033  CLMN expression enhancer
0,526  0,043  DTYMK expression enhancer
0,529  0,046  CBX1 expression inhibitor
0,522  0,040  ETS2 expression inhibitor
0,499  0,017  CEBPG expression inhibitor
0,497  0,016  TRIM24 expression inhibitor
0,550  0,068  KIF23 expression enhancer
0,505  0,024  CYP17A1 expression enhancer
0,499  0,018  HMGB2 expression inhibitor
0,534  0,053  PPARD expression inhibitor
0,522  0,043  CREB1 expression inhibitor
0,518  0,038  SLC6A2 expression inhibitor
0,530  0,050  NAA15 expression enhancer
0,526  0,048  ASXL1 expression inhibitor
0,526  0,048  C11ORF68 expression enhancer
0,526  0,048  CAPN7 expression inhibitor
0,526  0,048  FAM208A expression inhibitor
0,526  0,048  NKTR expression inhibitor
0,526  0,048  RABGAP1 expression inhibitor
0,526  0,048  SETD2 expression inhibitor
0,526  0,048  TIA1 expression inhibitor
0,526  0,048  TTC3 expression inhibitor
0,535  0,057  BIRC2 expression inhibitor
0,510  0,033  G0S2 expression enhancer
0,535  0,059  MAF expression enhancer
0,493  0,019  CAPN2 expression inhibitor
0,518  0,044  DDX42 expression enhancer
0,501  0,027  APOA1 expression enhancer
0,508  0,035  KLHL24 expression inhibitor
0,529  0,056  PRKDC expression inhibitor
0,516  0,043  VCAM1 expression enhancer
0,493  0,020  BAD expression enhancer
0,492  0,020  GARS expression inhibitor
0,540  0,069  BAX expression enhancer
0,525  0,054  NAV1 expression inhibitor
0,521  0,051  HIF1A expression inhibitor
0,528  0,059  MACF1 expression inhibitor
0,497  0,028  HOXA10 expression enhancer
0,500  0,032  TIMP1 expression inhibitor
0,499  0,031  DFFB expression inhibitor
0,496  0,029  SKP2 expression inhibitor
0,519  0,051  IL1B expression enhancer
0,504  0,037  ERBB4 expression inhibitor
0,498  0,032  RECQL expression inhibitor
0,478  0,013  SLC16A1 expression inhibitor
0,496  0,030  EHD1 expression enhancer
0,529  0,063  CASP9 expression enhancer
0,510  0,045  RRBP1 expression enhancer
0,500  0,036  CDK6 expression inhibitor
0,498  0,035  SF3B5 expression enhancer
0,489  0,027  SNAI1 expression enhancer
0,514  0,052  HLA-G expression enhancer
0,496  0,035  PIM1 expression enhancer
0,530  0,069  TNFSF10 expression enhancer
0,473  0,012  IVNS1ABP expression inhibitor
0,529  0,070  SPATA13 expression enhancer
0,520  0,061  MMP2 expression inhibitor
0,495  0,036  DAPK1 expression inhibitor
0,486  0,027  HSPA2 expression enhancer
0,489  0,032  BDNF expression inhibitor
0,492  0,037  CCL2 expression enhancer
0,484  0,030  EPAS1 expression enhancer
0,493  0,039  PGM2 expression enhancer
0,498  0,045  PELI1 expression inhibitor
0,509  0,056  EFEMP1 expression inhibitor
0,498  0,044  PPARGC1A expression enhancer
0,521  0,068  CCND2 expression enhancer
0,518  0,065  AGRN expression enhancer
0,484  0,031  NGFR expression enhancer
0,505  0,053  SF1 expression inhibitor
0,492  0,042  TOP2A expression inhibitor
0,515  0,064  GSTA1 expression enhancer
0,520  0,069  C3 expression enhancer
0,496  0,046  TM4SF1 expression enhancer
0,494  0,045  PTN expression enhancer
0,477  0,030  NME2 expression inhibitor
0,457  0,010  CORO1C expression enhancer
0,511  0,064  CDC25B expression enhancer
0,483  0,036  TP53I3 expression enhancer
0,474  0,027  CDKN2C expression inhibitor
0,481  0,037  DLX4 expression inhibitor
0,510  0,065  NR3C1 expression inhibitor
0,504  0,059  DDIT4 expression enhancer
0,461  0,018  MND1 expression inhibitor
0,470  0,027  PLCB1 expression enhancer
0,460  0,018  PKP4 expression inhibitor
0,460  0,018  TUBGCP3 expression inhibitor
0,529  0,086  TMEM158 expression enhancer
0,475  0,033  LAMB3 expression enhancer
0,505  0,065  MGMT expression enhancer
0,480  0,040  IL1A expression enhancer
0,477  0,038  CSF2 expression enhancer
0,455  0,016  CDCA3 expression inhibitor
0,450  0,012  LINC00467 expression enhancer
0,450  0,012  PHF17 expression inhibitor
0,519  0,081  FOS expression enhancer
0,477  0,039  SLC17A2 expression inhibitor
0,485  0,048  TRAF3 expression enhancer
0,488  0,052  CPM expression enhancer
0,491  0,055  TGFB1 expression enhancer
0,450  0,014  NDC80 expression inhibitor
0,492  0,056  IL4 expression enhancer
0,457  0,022  SMARCC1 expression inhibitor
0,456  0,022  ACAN expression enhancer
0,493  0,059  AKT1 expression enhancer
0,457  0,025  GINS2 expression inhibitor
0,447  0,014  ASAH1 expression inhibitor
0,502  0,070  CDK2 expression inhibitor
0,459  0,027  LGALS3 expression enhancer
0,458  0,026  TK1 expression enhancer
0,464  0,034  NCF1 expression enhancer
0,475  0,045  TNNT1 expression inhibitor
0,500  0,070  PDCD4 expression enhancer
0,456  0,027  DNMT1 expression inhibitor
0,478  0,050  ALDH1A3 expression inhibitor
0,492  0,063  SPP1 expression enhancer
0,475  0,047  F2R expression enhancer
0,485  0,057  CDC16 expression inhibitor
0,440  0,012  NBL1 expression enhancer
0,438  0,011  BRAF expression inhibitor
0,477  0,050  CD86 expression enhancer
0,443  0,016  MET expression enhancer
0,447  0,022  HIVEP1 expression enhancer
0,470  0,045  CBLB expression inhibitor
0,496  0,072  MMP15 expression inhibitor
0,458  0,034  APOBEC3B expression enhancer
0,507  0,084  MT1A expression enhancer
0,495  0,073  TERT expression enhancer
0,463  0,041  HMGN2 expression inhibitor
0,460  0,039  BTG2 expression enhancer
0,461  0,040  EFNB2 expression inhibitor
0,475  0,055  EPHA4 expression enhancer
0,483  0,062  CITED2 expression inhibitor
0,495  0,075  CEACAM1 expression enhancer
0,480  0,060  CSE1L expression inhibitor
0,443  0,024  GATA1 expression enhancer
0,467  0,048  BUB1B expression enhancer
0,460  0,040  SMAD3 expression enhancer
0,467  0,048  NR1H2 expression inhibitor
0,437  0,018  CITED2 expression enhancer
0,487  0,069  PDCD4 expression inhibitor
0,431  0,013  CXCR4 expression enhancer
0,477  0,060  RAD51C expression enhancer
0,477  0,060  SMC4 expression enhancer
0,477  0,060  ZWINT expression enhancer
0,444  0,027  SLC31A1 expression enhancer
0,469  0,052  SELE expression enhancer
0,443  0,026  EIF4E expression inhibitor
0,466  0,050  AKR1C2 expression enhancer
0,442  0,026  KEAP1 expression enhancer
0,492  0,077  NPM3 expression inhibitor
0,492  0,077  PTEN expression inhibitor
0,471  0,057  AKR1C1 expression enhancer
0,438  0,025  ASRGL1 expression enhancer
0,497  0,084  EIF2S1 expression enhancer
0,487  0,074  CDK4 expression inhibitor
0,425  0,014  CPT1A expression enhancer
0,471  0,060  EIF3B expression inhibitor
0,504  0,093  ZFP36 expression enhancer
0,426  0,015  GSTA4 expression enhancer
0,447  0,037  STC2 expression enhancer
0,475  0,065  TMPRSS2 expression inhibitor
0,432  0,023  BCAT1 expression inhibitor
0,511  0,102  CREBBP expression inhibitor
0,437  0,028  PHLDA1 expression enhancer
0,416  0,007  RAP1A expression enhancer
0,421  0,012  WHSC1 expression inhibitor
0,433  0,026  S100A8 expression enhancer
0,480  0,073  ICAM1 expression enhancer
0,430  0,023  BTG1 expression inhibitor
0,486  0,082  KRCC1 expression enhancer
0,438  0,034  DENND5A expression enhancer
0,473  0,069  DHRS2 expression enhancer
0,479  0,075  RAD51AP1 expression enhancer
0,472  0,068  SNAI2 expression inhibitor
0,445  0,041  PI4KA expression inhibitor
0,445  0,041  VCAN expression inhibitor
0,437  0,034  LAMC2 expression enhancer
0,470  0,069  CCL5 expression inhibitor
0,413  0,012  PNN expression inhibitor
0,442  0,042  GPX2 expression enhancer
0,405  0,005  RHOB expression enhancer
0,442  0,043  BAG5 expression inhibitor
0,476  0,076  CCND1 expression inhibitor
0,440  0,041  EGR3 expression inhibitor
0,438  0,039  MAFF expression enhancer
0,425  0,027  IGF2 expression enhancer
0,430  0,032  C22ORF29 expression enhancer
0,430  0,032  ETNK2 expression enhancer
0,471  0,074  TNFSF10 expression inhibitor
0,417  0,020  SLC30A5 expression inhibitor
0,423  0,027  RCC2 expression inhibitor
0,468  0,072  NT5DC2 expression enhancer
0,468  0,072  RAI14 expression enhancer
0,468  0,072  RFTN1 expression enhancer
0,465  0,071  DUSP5 expression enhancer
0,416  0,022  EID1 expression enhancer
0,447  0,054  PIM1 expression inhibitor
0,447  0,054  PIK3CD expression inhibitor
0,415  0,022  ATG5 expression inhibitor
0,429  0,037  LAMA3 expression enhancer
0,439  0,047  NR5A2 expression enhancer
0,439  0,047  ZBTB10 expression inhibitor
0,429  0,037  BIRC5 expression enhancer
0,452  0,060  CD14 expression enhancer
0,458  0,067  TNFRSF21 expression enhancer
0,427  0,036  MYNN expression inhibitor
0,458  0,068  SLC3A2 expression enhancer
0,438  0,048  ANXA1 expression inhibitor
0,437  0,047  CYP11A1 expression enhancer
0,434  0,045  HS3ST3A1 expression enhancer
0,426  0,037  MDFI expression inhibitor
0,426  0,037  SYMPK expression inhibitor
0,461  0,074  GSTM3 expression inhibitor
0,451  0,065  CDC25C expression inhibitor
0,443  0,057  CDH1 expression enhancer
0,412  0,026  SOX11 expression inhibitor
0,473  0,088  ALCAM expression inhibitor
0,424  0,039  PPP1R3C expression inhibitor
0,411  0,025  IFIT3 expression enhancer
0,419  0,034  TGFA expression enhancer
0,412  0,028  TGFB3 expression enhancer
0,416  0,032  GPR142 expression enhancer
0,455  0,071  AGPS expression inhibitor
0,463  0,080  RASEF expression inhibitor
0,415  0,032  CCL4 expression enhancer
0,426  0,044  IL9 expression inhibitor
0,460  0,079  PCDH8 expression enhancer
0,433  0,052  GATA2 expression enhancer
0,428  0,048  TUBB3 expression enhancer
0,419  0,040  S100A11 expression enhancer
0,412  0,033  MCM2 expression enhancer
0,416  0,037  CTPS expression inhibitor
0,431  0,053  SOX9 expression inhibitor
0,437  0,060  MDK expression enhancer
0,415  0,038  AP1S2 expression enhancer
0,421  0,044  GALNT1 expression inhibitor
0,426  0,049  CSNK1D expression inhibitor
0,426  0,049  SPATA20 expression enhancer
0,431  0,054  TK1 expression inhibitor
0,458  0,082  ABHD3 expression enhancer
0,478  0,103  HMGB1 expression inhibitor
0,431  0,058  ST3GAL1 expression enhancer
0,482  0,108  XPO1 expression inhibitor
0,460  0,087  NCOA2 expression enhancer
0,404  0,033  TNFRSF1A expression inhibitor
0,401  0,032  SH2D4A expression inhibitor
0,412  0,044  SULF2 expression enhancer
0,479  0,112  ITGB1 expression enhancer
0,416  0,049  BMP2 expression enhancer
0,460  0,094  NSF expression inhibitor
0,423  0,057  MITF expression enhancer
0,406  0,041  MYLIP expression enhancer
0,400  0,035  NKX3-1 expression enhancer
0,425  0,060  INCENP expression inhibitor
0,439  0,075  ATM expression enhancer
0,434  0,072  ASNS expression inhibitor
0,403  0,041  CEBPD expression enhancer
0,416  0,055  RSAD2 expression enhancer
0,427  0,066  KLK6 expression enhancer
0,427  0,066  PADI3 expression enhancer
0,413  0,054  CDK2 expression enhancer
0,414  0,054  MAD1L1 expression enhancer
0,457  0,097  SREBF2 expression inhibitor
0,443  0,084  STRBP expression inhibitor
0,420  0,062  GRN expression enhancer
0,428  0,070  PAK2 expression inhibitor
0,422  0,064  DEPTOR expression enhancer
0,431  0,074  WISP2 expression inhibitor
0,416  0,058  AHSA1 expression enhancer
0,400  0,043  CDCA8 expression inhibitor
0,419  0,063  NKX3-1 expression inhibitor
0,406  0,049  GCLM expression enhancer
0,410  0,054  IGFBP2 expression inhibitor
0,411  0,056  BAX expression inhibitor
0,407  0,053  TNFRSF10B expression inhibitor
0,434  0,081  SERPINE1 expression enhancer
0,425  0,072  GRPEL1 expression inhibitor
0,405  0,052  UBE2C expression enhancer
0,430  0,078  AHR expression enhancer
0,437  0,085  CDCA5 expression enhancer
0,408  0,056  TMSB4X expression enhancer
0,436  0,085  MSMO1 expression enhancer
0,403  0,051  IGFBP5 expression enhancer
0,406  0,055  PPARG expression enhancer
0,415  0,065  KLF10 expression inhibitor
0,444  0,094  VEGFA expression enhancer
0,422  0,074  TPM4 expression inhibitor
0,425  0,076  JAK2 expression inhibitor
0,425  0,076  TBC1D1 expression inhibitor
0,403  0,055  ME1 expression enhancer
0,426  0,078  FOXO1 expression enhancer
0,411  0,065  KPNB1 expression enhancer
0,440  0,094  BCL2L1 expression inhibitor
0,418  0,073  FAM49A expression enhancer
0,401  0,056  CTNNA1 expression inhibitor
0,406  0,062  BORA expression inhibitor
0,468  0,125  CYR61 expression enhancer
0,404  0,063  CCNE1 expression inhibitor
0,445  0,105  PNKD expression inhibitor
0,403  0,064  FASN expression inhibitor
0,420  0,082  IL4R expression enhancer
0,402  0,064  BRD2 expression enhancer
0,402  0,064  NENF expression enhancer
0,402  0,064  SRRM2 expression inhibitor
0,402  0,064  ZCCHC2 expression inhibitor
0,412  0,075  VIM expression inhibitor
0,410  0,074  TAOK3 expression inhibitor
0,414  0,079  DDIT3 expression enhancer
0,405  0,071  C1S expression enhancer
0,416  0,084  GAS6 expression enhancer
0,402  0,070  PRDX6 expression enhancer
0,403  0,071  KLK3 expression inhibitor
0,446  0,115  VEGFA expression inhibitor
0,404  0,077  MAOB expression enhancer
0,405  0,081  CDKN2A expression enhancer
0,415  0,092  PPARD expression enhancer
0,409  0,086  DCC expression enhancer
0,413  0,091  PTGS2 expression inhibitor
0,421  0,100  CP expression enhancer
0,433  0,113  SERPINB5 expression enhancer
0,415  0,096  ABCC3 expression inhibitor
0,430  0,115  ABCC5 expression enhancer
0,409  0,096  ABCB1 expression enhancer
0,401  0,090  PRNP expression enhancer
0,411  0,102  IL6 expression enhancer
0,402  0,097  CEACAM6 expression enhancer
0,415  0,115  TP53TG1 expression enhancer
0,404  0,111  EIF2S1 expression inhibitor
0,405  0,113  S100A4 expression enhancer
0,408  0,121  POLE2 expression enhancer
0,401  0,153  KLK2 expression inhibitor

>  <Mechanisms>
0,918  0,003  Monodehydroascorbate reductase (NADH) inhibitor
0,899  0,004  Feruloyl esterase inhibitor
0,896  0,005  Beta-adrenergic receptor kinase inhibitor
0,896  0,005  G-protein-coupled receptor kinase inhibitor
0,900  0,026  Transferase stimulant
0,856  0,003  L-glucuronate reductase inhibitor
0,840  0,006  Prolyl aminopeptidase inhibitor
0,837  0,006  Dehydro-L-gulonate decarboxylase inhibitor
0,834  0,014  Methylenetetrahydrofolate reductase (NADPH) inhibitor
0,825  0,008  Aldehyde oxidase inhibitor
0,819  0,004  Aspartate-phenylpyruvate transaminase inhibitor
0,801  0,006  Venombin AB inhibitor
0,798  0,002  Aminomuconate-semialdehyde dehydrogenase inhibitor
0,798  0,003  Polygalacturonase inhibitor
0,783  0,004  Aryl-acylamidase inhibitor
0,771  0,003  Aspartyl aminopeptidase inhibitor
0,773  0,005  3-Phytase inhibitor
0,772  0,005  Centromere associated protein inhibitor
0,763  0,003  Nicotinamidase inhibitor
0,778  0,021  Alkenylglycerophosphocholine hydrolase inhibitor
0,757  0,003  Acylphosphatase inhibitor
0,747  0,003  Ferredoxin-nitrite reductase inhibitor
0,748  0,004  Aldehyde dehydrogenase (NADP+) inhibitor
0,748  0,006  Phosphatase inhibitor
0,746  0,005  Allyl-alcohol dehydrogenase inhibitor
0,745  0,004  Uroporphyrinogen-III synthase inhibitor
0,758  0,017  Glucose oxidase inhibitor
0,766  0,026  Polyporopepsin inhibitor
0,744  0,004  Aryldialkylphosphatase inhibitor
0,752  0,013  Omptin inhibitor
0,745  0,012  Complement factor D inhibitor
0,736  0,004  Alcohol dehydrogenase (NADP+) inhibitor
0,732  0,004  Malate dehydrogenase inhibitor
0,736  0,012  Fucosterol-epoxide lyase inhibitor
0,767  0,044  Ubiquinol-cytochrome-c reductase inhibitor
0,751  0,029  Chlordecone reductase inhibitor
0,731  0,011  2-Hydroxymuconate-semialdehyde hydrolase inhibitor
0,740  0,022  Pro-opiomelanocortin converting enzyme inhibitor
0,727  0,014  Fragilysin inhibitor
0,713  0,005  Glyoxylate reductase inhibitor
0,710  0,005  Pyruvate decarboxylase inhibitor
0,710  0,004  Di-trans,poly-cis-decaprenylcistransferase inhibitor
0,708  0,003  Lactate 2-monooxygenase inhibitor
0,708  0,004  GABA aminotransferase inhibitor
0,702  0,011  Lipid metabolism regulator
0,707  0,019  Arginine 2-monooxygenase inhibitor
0,687  0,004  Dolichyl-phosphatase inhibitor
0,696  0,014  Macrophage colony stimulating factor agonist
0,686  0,006  Malate dehydrogenase (acceptor) inhibitor
0,686  0,007  Spermicide
0,679  0,003  Vomilenine glucosyltransferase inhibitor
0,704  0,033  Sugar-phosphatase inhibitor
0,693  0,027  Acylcarnitine hydrolase inhibitor
0,674  0,009  IgA-specific metalloendopeptidase inhibitor
0,673  0,013  Caspase 3 stimulant
0,660  0,004  Aminoacylase inhibitor
0,658  0,003  Aldehyde dehydrogenase inhibitor
0,659  0,004  Mannan endo-1,6-alpha-mannosidase inhibitor
0,668  0,016  Bisphosphoglycerate phosphatase inhibitor
0,653  0,002  4-Hydroxybenzoate 3-monooxygenase inhibitor
0,654  0,004  Succinate-semialdehyde dehydrogenase [NAD(P)+] inhibitor
0,702  0,054  Membrane integrity agonist
0,650  0,004  Nitrilase inhibitor
0,659  0,014  Linoleate diol synthase inhibitor
0,649  0,006  Transketolase inhibitor
0,658  0,017  Manganese peroxidase inhibitor
0,651  0,012  Endopeptidase So inhibitor
0,641  0,005  Phosphopantothenoylcysteine decarboxylase inhibitor
0,635  0,005  Arylesterase inhibitor
0,639  0,009  Prostaglandin-A1 DELTA-isomerase inhibitor
0,633  0,005  Snapalysin inhibitor
0,630  0,005  Quinoprotein glucose dehydrogenase inhibitor
0,640  0,015  Biotinidase inhibitor
0,632  0,011  NADH kinase inhibitor
0,623  0,003  Aryl-alcohol dehydrogenase inhibitor
0,624  0,005  2-Oxoglutarate decarboxylase inhibitor
0,619  0,007  Glycopeptide alpha-N-acetylgalactosaminidase inhibitor
0,638  0,028  Alkylacetylglycerophosphatase inhibitor
0,626  0,018  Acetylesterase inhibitor
0,632  0,027  UDP-N-acetylglucosamine 4-epimerase inhibitor
0,616  0,011  Arylmalonate decarboxylase inhibitor
0,604  0,005  Phosphoenolpyruvate-protein phosphotransferase inhibitor
0,623  0,024  Lipoprotein lipase inhibitor
0,626  0,029  Glutathione thiolesterase inhibitor
0,600  0,005  Poly(3-hydroxybutyrate) depolymerase inhibitor
0,606  0,011  Leukotriene-B4 20-monooxygenase inhibitor
0,607  0,014  N-formylmethionyl-peptidase inhibitor
0,601  0,010  Shikimate O-hydroxycinnamoyltransferase inhibitor
0,601  0,012  Phosphoinositide 5-phosphatase inhibitor
0,604  0,016  Methylumbelliferyl-acetate deacetylase inhibitor
0,602  0,016  Insulin growth factor agonist
0,602  0,016  Insulin like growth factor 1 agonist
0,607  0,023  Platelet aggregation stimulant
0,597  0,014  D-lactaldehyde dehydrogenase inhibitor
0,622  0,041  NADPH peroxidase inhibitor
0,591  0,010  Nitrite reductase (NO-forming) inhibitor
0,602  0,022  Acetylcholine neuromuscular blocking agent
0,643  0,065  Membrane permeability inhibitor
0,584  0,006  Cyanoalanine nitrilase inhibitor
0,595  0,018  Lysostaphin inhibitor
0,583  0,007  N-carbamoyl-L-amino-acid hydrolase inhibitor
0,581  0,007  Lactaldehyde reductase inhibitor
0,578  0,005  Gly-X carboxypeptidase inhibitor
0,587  0,014  Galanin receptor antagonist
0,599  0,027  Dimethylargininase inhibitor
0,605  0,035  Carboxypeptidase Taq inhibitor
0,590  0,022  3-Hydroxybenzoate 6-monooxygenase inhibitor
0,571  0,004  8-Amino-7-oxononanoate synthase inhibitor
0,588  0,023  Methylamine-glutamate N-methyltransferase inhibitor
0,569  0,004  Hydroxymethylbilane synthase inhibitor
0,580  0,015  NADPH-ferrihemoprotein reductase inhibitor
0,574  0,011  Glutarate-semialdehyde dehydrogenase inhibitor
0,570  0,008  Mannose isomerase inhibitor
0,597  0,035  Proteasome ATPase inhibitor
0,556  0,004  2,2-Dialkylglycine decarboxylase (pyruvate) inhibitor
0,570  0,017  N-benzyloxycarbonylglycine hydrolase inhibitor
0,572  0,020  Alkenylglycerophosphoethanolamine hydrolase inhibitor
0,571  0,023  Phenol O-methyltransferase inhibitor
0,549  0,005  Phosphoenolpyruvate mutase inhibitor
0,576  0,032  Exoribonuclease II inhibitor
0,549  0,005  Glutathione dehydrogenase (ascorbate) inhibitor
0,545  0,005  Pyruvate dehydrogenase (lipoamide) inhibitor
0,565  0,025  Pullulanase inhibitor
0,566  0,027  Formaldehyde transketolase inhibitor
0,553  0,016  Enteropeptidase inhibitor
0,547  0,010  Sarcosine oxidase inhibitor
0,544  0,007  Levansucrase inhibitor
0,568  0,032  Fatty-acyl-CoA synthase inhibitor
0,563  0,029  Adenomatous polyposis treatment
0,538  0,004  Catechol 1,2-dioxygenase inhibitor
0,539  0,004  Benzoate 4-monooxygenase inhibitor
0,545  0,011  Carboxypeptidase D inhibitor
0,544  0,012  N-Acyl-D-aspartate deacylase inhibitor
0,531  0,003  (S)-2-hydroxy-acid oxidase inhibitor
0,542  0,015  Xylan endo-1,3-beta-xylosidase inhibitor
0,562  0,037  Lysine 2,3-aminomutase inhibitor
0,533  0,008  Aminocarboxymuconate-semialdehyde decarboxylase inhibitor
0,541  0,018  Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase inhibitor
0,558  0,035  Alkane 1-monooxygenase inhibitor
0,538  0,019  Cutinase inhibitor
0,556  0,038  2-Hydroxyquinoline 8-monooxygenase inhibitor
0,528  0,011  Mannitol-1-phosphatase inhibitor
0,524  0,009  Catalase inhibitor
0,518  0,003  D-2-hydroxy-acid dehydrogenase inhibitor
0,518  0,005  Expectorant
0,540  0,027  Arylsulfate sulfotransferase inhibitor
0,518  0,006  Glutamate dehydrogenase [NAD(P)+] inhibitor
0,526  0,016  Galanin receptor 2 antagonist
0,537  0,030  ADP-thymidine kinase inhibitor
0,515  0,012  Rhamnulose-1-phosphate aldolase inhibitor
0,575  0,072  Glycosylphosphatidylinositol phospholipase D inhibitor
0,542  0,038  Peptide agonist
0,529  0,026  All-trans-retinyl-palmitate hydrolase inhibitor
0,520  0,018  Peptidoglycan glycosyltransferase inhibitor
0,505  0,004  Peroxisome proliferator-activated receptor gamma agonist
0,531  0,031  Cholesterol antagonist
0,520  0,021  Aspartate-ammonia ligase inhibitor
0,503  0,006  Acid phosphatase inhibitor
0,503  0,008  Inorganic diphosphatase inhibitor
0,499  0,004  Peroxisome proliferator-activated receptor agonist
0,538  0,043  Glucan endo-1,3-beta-D-glucosidase inhibitor
0,510  0,016  Caspase 8 stimulant
0,498  0,004  Leucine dehydrogenase inhibitor
0,514  0,020  Sulfite reductase inhibitor
0,499  0,006  Dihydroxy-acid dehydratase inhibitor
0,509  0,017  Acylaminoacyl-peptidase inhibitor
0,504  0,013  D-xylulose reductase inhibitor
0,525  0,035  Peptidyl-dipeptidase Dcp inhibitor
0,523  0,034  Superoxide dismutase inhibitor
0,535  0,046  Glucan endo-1,6-beta-glucosidase inhibitor
0,492  0,005  Aspartate-tRNA ligase inhibitor
0,502  0,015  Gluconolactonase inhibitor
0,501  0,015  Glycerol-3-phosphate dehydrogenase inhibitor
0,490  0,005  NAD+ synthase (glutamine-hydrolysing) inhibitor
0,489  0,005  N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase inhibitor
0,519  0,036  Peroxidase inhibitor
0,491  0,009  Nucleoside-diphosphatase inhibitor
0,500  0,020  Glucan 1,4-alpha-maltotetraohydrolase inhibitor
0,485  0,005  Aureolysin inhibitor
0,483  0,005  Phenol 2-monooxygenase inhibitor
0,482  0,004  Isocitrate dehydrogenase (NADP+) inhibitor
0,487  0,014  4-Hydroxyglutamate transaminase inhibitor
0,487  0,014  Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase inhibitor
0,521  0,048  Aldose reductase-like protein inhibitor
0,483  0,011  Glycerol 2-dehydrogenase (NADP+) inhibitor
0,485  0,013  Galactose oxidase inhibitor
0,481  0,010  N-acetylneuraminate synthase inhibitor
0,474  0,005  Diiodophenylpyruvate reductase inhibitor
0,488  0,020  Opheline kinase inhibitor
0,488  0,020  Taurocyamine kinase inhibitor
0,506  0,038  Cl--transporting ATPase inhibitor
0,480  0,013  Oryzin inhibitor
0,477  0,011  Pectate lyase inhibitor
0,475  0,009  Bisphosphoglycerate mutase inhibitor
0,473  0,008  Acyloxyacyl hydrolase inhibitor
0,488  0,023  Dextranase inhibitor
0,472  0,008  Pyruvate dehydrogenase inhibitor
0,477  0,015  Horrilysin inhibitor
0,490  0,028  1-Alkylglycerophosphocholine O-acetyltransferase inhibitor
0,484  0,023  Anesthetic general
0,487  0,027  Urethanase inhibitor
0,470  0,012  Ubiquitin thiolesterase inhibitor
0,499  0,041  Ecdysone 20-monooxygenase inhibitor
0,515  0,057  Guanyl-specific ribonuclease T1 inhibitor
0,462  0,005  Glycerol dehydratase inhibitor
0,512  0,056  Platelet adhesion inhibitor
0,477  0,021  Phosphatidylcholine-sterol O-acyltransferase inhibitor
0,462  0,007  Serine 3-dehydrogenase inhibitor
0,459  0,004  Tauropine dehydrogenase inhibitor
0,464  0,010  Glucan 1,4-beta-glucosidase inhibitor
0,476  0,022  Hypocalcaemic
0,462  0,008  Glucan 1,6-alpha-glucosidase inhibitor
0,460  0,008  Monophenol monooxygenase inhibitor
0,460  0,009  Acetate-CoA ligase inhibitor
0,481  0,031  Renal tissue kallikrein inhibitor
0,473  0,024  Membrane permeability enhancer
0,459  0,011  Nitrate reductase inhibitor
0,489  0,041  Gluconate 5-dehydrogenase inhibitor
0,452  0,005  Peptidylamidoglycolate lyase inhibitor
0,472  0,025  Threonine aldolase inhibitor
0,479  0,033  Chenodeoxycholoyltaurine hydrolase inhibitor
0,473  0,026  S-alkylcysteine lyase inhibitor
0,487  0,041  Prostaglandin-E2 9-reductase inhibitor
0,470  0,025  Alcohol dehydrogenase (acceptor) inhibitor
0,461  0,016  Myeloblastin inhibitor
0,456  0,012  Serralysin inhibitor
0,451  0,008  Prunasin beta-glucosidase inhibitor
0,451  0,008  Aryl sulfotransferase inhibitor
0,443  0,000  Pyridoxamine-pyruvate transaminase inhibitor
0,462  0,020  Cyclomaltodextrinase inhibitor
0,448  0,007  Acetoin dehydrogenase inhibitor
0,486  0,045  Hydrogen dehydrogenase inhibitor
0,464  0,025  Long-chain-aldehyde dehydrogenase inhibitor
0,462  0,023  4-Coumarate-CoA ligase inhibitor
0,468  0,030  Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase inhibitor
0,444  0,009  Xaa-Pro dipeptidyl-peptidase inhibitor
0,445  0,009  2-Enoate reductase inhibitor
0,439  0,004  Proline dehydrogenase inhibitor
0,461  0,026  Peptide alpha-N-acetyltransferase inhibitor
0,460  0,027  Corticosteroid side-chain-isomerase inhibitor
0,437  0,005  Alanine dehydrogenase inhibitor
0,442  0,011  Alpha-amylase inhibitor
0,442  0,011  Amylase inhibitor
0,436  0,004  Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) inhibitor
0,444  0,013  Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase inhibitor
0,444  0,013  N-acetyllactosamine synthase inhibitor
0,434  0,005  Betaine-aldehyde dehydrogenase inhibitor
0,467  0,038  Mannan endo-1,4-beta-mannosidase inhibitor
0,437  0,009  3-Isopropylmalate dehydratase inhibitor
0,464  0,038  Glutamine-phenylpyruvate transaminase inhibitor
0,429  0,003  L-lactate dehydrogenase (cytochrome) inhibitor
0,432  0,007  Saccharopine dehydrogenase (NAD+, L-lysine-forming) inhibitor
0,447  0,023  Fructan beta-fructosidase inhibitor
0,440  0,017  Protein-Npi-phosphohistidine-sugar phosphotransferase inhibitor
0,444  0,022  Opine dehydrogenase inhibitor
0,426  0,005  Tyrosine-ester sulfotransferase inhibitor
0,445  0,023  Cyclohexyl-isocyanide hydratase inhibitor
0,455  0,035  tRNA-pseudouridine synthase I inhibitor
0,446  0,027  4-Hydroxyphenylacetate 3-monooxygenase inhibitor
0,425  0,006  Formaldehyde dehydrogenase inhibitor
0,435  0,017  CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase inhibitor
0,441  0,023  Leukotriene-C4 synthase inhibitor
0,452  0,035  Creatininase inhibitor
0,432  0,016  Ferredoxin hydrogenase inhibitor
0,449  0,033  N-hydroxyarylamine O-acetyltransferase inhibitor
0,445  0,030  Thiol oxidase inhibitor
0,425  0,011  Arylformamidase inhibitor
0,440  0,026  Poly(beta-D-mannuronate) lyase inhibitor
0,418  0,005  D-lactate dehydrogenase (cytochrome) inhibitor
0,439  0,025  H+-exporting ATPase inhibitor
0,427  0,014  3-Demethylubiquinone-9 3-O-methyltransferase inhibitor
0,440  0,028  Sulfite oxidase inhibitor
0,426  0,017  Licheninase inhibitor
0,448  0,040  Hydroxylamine oxidase inhibitor
0,426  0,018  2-Hydroxy-3-oxoadipate synthase inhibitor
0,448  0,041  S-formylglutathione hydrolase inhibitor
0,434  0,027  Carnitinamidase inhibitor
0,470  0,063  Benzoate-CoA ligase inhibitor
0,414  0,010  Thiamine pyridinylase inhibitor
0,415  0,011  Pyruvate dehydrogenase (cytochrome) inhibitor
0,415  0,011  Trans-2-enoyl-CoA reductase (NAD+) inhibitor
0,476  0,072  Lysase inhibitor
0,428  0,025  4-Hydroxymandelate oxidase inhibitor
0,436  0,034  Dolichyl-diphosphooligosaccharide-protein glycotransferase inhibitor
0,411  0,010  Formate dehydrogenase inhibitor
0,431  0,029  Sulfite dehydrogenase inhibitor
0,457  0,056  Erythropoiesis stimulant
0,419  0,018  Galactolipase inhibitor
0,421  0,021  Phenylacetate-CoA ligase inhibitor
0,428  0,028  Carbon-monoxide dehydrogenase inhibitor
0,422  0,024  Phosphatidylglycerophosphatase inhibitor
0,404  0,007  (S)-3-amino-2-methylpropionate transaminase inhibitor
0,452  0,055  Beta glucuronidase inhibitor
0,404  0,008  Creatinase inhibitor
0,417  0,021  Sorbitol-6-phosphate 2-dehydrogenase inhibitor
0,435  0,039  IgA-specific serine endopeptidase inhibitor
0,420  0,024  Clavaminate synthase inhibitor
0,409  0,013  Glutaminase inhibitor
0,451  0,057  Nitrate reductase (cytochrome) inhibitor
0,436  0,042  Histidine kinase inhibitor
0,421  0,027  Formate-dihydrofolate ligase inhibitor
0,408  0,014  Acetate kinase inhibitor
0,403  0,010  Glycine C-acetyltransferase inhibitor
0,431  0,040  Mitochondrial processing peptidase inhibitor
0,404  0,013  tRNA nucleotidyltransferase inhibitor
0,413  0,022  2,3,4,5-Tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase inhibitor
0,452  0,061  Histamine release inhibitor
0,445  0,055  Polyamine-transporting ATPase inhibitor
0,412  0,022  Dimethylmaleate hydratase inhibitor
0,409  0,020  Tryptophanamidase inhibitor
0,418  0,028  Glyoxylate oxidase inhibitor
0,404  0,018  Alpha-N-acetylglucosaminidase inhibitor
0,410  0,026  Methanol dehydrogenase inhibitor
0,401  0,018  Signal peptidase I inhibitor
0,417  0,037  Arylacetonitrilase inhibitor
0,415  0,036  1-Acylglycerol-3-phosphate O-acyltransferase inhibitor
0,422  0,043  Protein-glutamate methylesterase inhibitor
0,402  0,026  4-Nitrophenylphosphatase inhibitor
0,424  0,049  Phosphatidylserine decarboxylase inhibitor
0,422  0,047  Cytochrome P450 stimulant
0,407  0,033  Mydriatic
0,418  0,043  Limulus clotting factor C inhibitor
0,443  0,073  Oxygen scavenger
0,405  0,036  Pitrilysin inhibitor
0,410  0,042  Aspergillopepsin I inhibitor
0,421  0,053  Insulin promoter
0,402  0,034  DNA-(apurinic or apyrimidinic site) lyase inhibitor
0,419  0,052  NAD(P)+-arginine ADP-ribosyltransferase inhibitor
0,403  0,038  Isopenicillin-N epimerase inhibitor
0,404  0,040  X-methyl-His dipeptidase inhibitor
0,419  0,059  5 Hydroxytryptamine release inhibitor
0,474  0,115  Kidney function stimulant
0,419  0,068  Fibrolase inhibitor
0,449  0,098  Collagen inhibitor
0,427  0,078  Thromboxane B2 antagonist
0,401  0,053  Gamma-guanidinobutyraldehyde dehydrogenase inhibitor
0,410  0,065  Alcohol O-acetyltransferase inhibitor
0,418  0,075  Fibrinogen receptor antagonist
0,481  0,141  Mucomembranous protector
0,431  0,093  Phospholipid-translocating ATPase inhibitor
0,416  0,082  Transforming growth factor agonist
0,410  0,075  Protein-tyrosine phosphatase alpha inhibitor
0,409  0,077  Pterin deaminase inhibitor
0,426  0,096  Glyceryl-ether monooxygenase inhibitor
0,418  0,089  Cytoprotectant
0,414  0,092  Penicillin binding protein antagonist
0,414  0,092  Penicillin-binding protein ampH inhibitor
0,419  0,099  NACHT, LRR and PYD domains-containing protein 3 inhibitor
0,403  0,091  Neurotransmitter antagonist
0,408  0,098  Thioredoxin inhibitor
0,403  0,104  27-Hydroxycholesterol 7alpha-monooxygenase inhibitor
0,411  0,128  Taurine dehydrogenase inhibitor
0,441  0,168  Vasodilator, cerebral
0,408  0,183  Transferase inhibitor

>  <Metabolism>
0,807  0,019  CYP2J substrate
0,683  0,025  GST A substrate
0,622  0,011  CYP2F1 substrate
0,609  0,019  CYP2C8 substrate
0,553  0,004  Aldehyde oxidase substrate
0,568  0,032  CYP2C substrate
0,589  0,075  CYP2C12 substrate
0,510  0,023  UGT1A9 substrate
0,522  0,042  CYP2 substrate
0,522  0,063  CYP3A2 substrate
0,458  0,018  UGT1A6 substrate
0,477  0,037  CYP2A6 substrate
0,455  0,016  UGT2B4 substrate
0,489  0,053  CYP3A1 substrate
0,469  0,037  CYP2A4 substrate
0,433  0,004  Alcohol dehydrogenase substrate
0,472  0,044  CYP2D16 substrate
0,448  0,034  CYP4A11 substrate
0,453  0,041  CYP2A substrate
0,410  0,010  UGT2B28 substrate
0,402  0,005  Aldehyde dehydrogenase 2 substrate
0,418  0,025  CYP2E1 substrate
0,403  0,010  UGT2B17 substrate
0,403  0,016  CYP2A3 substrate
0,413  0,026  CYP2E substrate
0,416  0,039  CYP2C11 substrate
0,407  0,084  CYP3A substrate
0,407  0,087  CYP3A4 substrate

>  <Toxicity>
0,850  0,003  Eye irritation, weak
0,826  0,010  Hematemesis
0,804  0,004  Skin irritative effect
0,769  0,004  Skin irritation, moderate
0,778  0,023  Hemolysis
0,767  0,026  Ulcer, aphthous
0,769  0,033  Stroke
0,727  0,031  Reproductive dysfunction
0,712  0,022  Gastrointestinal hemorrhage
0,701  0,014  Ototoxicity
0,686  0,007  Spermicide
0,716  0,039  Cerebral hemorrhage
0,709  0,033  Hyponatremia
0,682  0,009  Sensitization
0,689  0,018  Hypomagnesemia
0,699  0,029  Ulcer, esophageal
0,677  0,025  Teratogen
0,696  0,045  Toxic
0,711  0,061  Lichenoid eruption
0,666  0,024  Immunotoxin
0,685  0,048  Myocardial ischemia
0,660  0,025  Muscle weakness
0,656  0,027  Embryotoxic
0,622  0,008  Skin irritation, high
0,644  0,038  Weakness
0,648  0,042  Hypercholesterolemic
0,632  0,033  Acidosis, metabolic
0,653  0,056  Renal insufficiency
0,651  0,064  Hyperactivity
0,598  0,011  Carcinogenic, rat, male
0,672  0,087  Shivering
0,595  0,015  Fatty liver
0,618  0,049  Convulsant
0,606  0,038  Scleroderma
0,574  0,006  Carcinogenic, group 2B
0,575  0,013  Carcinogenic
0,599  0,043  Respiratory failure
0,607  0,059  Toxic, respiration
0,542  0,016  Ulceration
0,539  0,014  Carcinogenic, rat
0,564  0,041  Pseudoporphyria
0,592  0,080  Anemia, hemolytic
0,570  0,067  Drowsiness
0,560  0,063  Toxic, vascular
0,556  0,065  Ectropion
0,508  0,018  Carcinogenic, mouse
0,516  0,031  Non mutagenic, Salmonella
0,551  0,067  Pure red cell aplasia
0,495  0,018  Carcinogenic, mouse, female
0,501  0,028  Acidosis, lactic
0,507  0,037  ANCA-positive vasculitis
0,523  0,053  Fibrosis, interstitial
0,476  0,022  Hypocalcaemic
0,506  0,058  Allergic dermatitis
0,454  0,009  Renal papillary necrosis
0,534  0,094  Lymphocytosis
0,459  0,021  Carcinogenic, mouse, male
0,532  0,094  Fibrillation, atrial
0,513  0,083  Sleep disturbance
0,481  0,055  Nephrotic syndrome
0,496  0,073  Hepatic necrosis
0,441  0,019  Eye irritation, high
0,475  0,053  Hyperuricemia
0,431  0,016  Carcinogenic, group 3
0,475  0,062  Aseptic meningitis
0,483  0,076  Ataxia
0,473  0,067  Raynaud's phenomenon
0,433  0,029  Bullous pemphigoid
0,423  0,024  Henoch-Schonlein purpura
0,435  0,042  Ophthalmoplegia
0,434  0,043  Ulcer, peptic
0,460  0,070  Splenomegaly
0,436  0,047  Fasciculation
0,446  0,060  Gastrointestinal disturbance
0,441  0,055  Palpitation
0,407  0,033  Mydriatic
0,444  0,077  Allergic contact dermatitis
0,485  0,119  Alopecia (hair loss)
0,404  0,040  Cytotoxic
0,458  0,100  Nephritis
0,434  0,080  Interstitial nephritis
0,466  0,116  Hyperglycemic
0,434  0,086  Hematuria
0,428  0,088  Serum sickness
0,449  0,112  Purpura
0,454  0,122  Cardiogenic shock
0,485  0,160  Dysesthesia
0,424  0,101  Cataract
0,456  0,133  Withdrawal
0,401  0,083  Dyspnea
0,431  0,115  Diarrhea
0,425  0,109  Edema
0,429  0,113  Hirsutism
0,447  0,132  Optic neuropathy
0,435  0,122  Toxic, gastrointestinal
0,437  0,128  Bone marrow suppression
0,415  0,119  Galactorrhea
0,406  0,119  Enterocolitis
0,422  0,184  Neuritis
0,402  0,171  Optic neuritis

>  <Murcko.CdId>
963

>  <Murcko.Mol Weight>
78.1118

>  <Murcko.Formula>
C6H6

>  <Murcko.AKOS_NUMBER>
AKOS016035534

>  <Murcko.IntegerID>
962

$$$$

  Mrv0541 04281317412D          

 17 18  0  0  0  0            999 V2000
    1.9103   -0.5299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4228    0.1368    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4228   -1.2007    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6353   -0.1174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6353   -0.9424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0772   -1.3632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7353   -0.5299    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2189    1.5243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5022    1.1118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0772    0.2951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5022    0.2868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9397    1.1118    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7897   -0.1257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6728    0.9243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6811   -1.9799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7897   -0.9507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2189    2.3493    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  3  1  1  0  0  0  0
  4  2  1  0  0  0  0
  5  3  1  0  0  0  0
  6  5  2  0  0  0  0
  7  1  2  0  0  0  0
  8  9  1  0  0  0  0
  9 11  2  0  0  0  0
 10  4  2  0  0  0  0
 11 13  1  0  0  0  0
 12  8  2  0  0  0  0
 13 10  1  0  0  0  0
 14  2  1  0  0  0  0
 15  3  1  0  0  0  0
 16  6  1  0  0  0  0
 17  8  1  0  0  0  0
  5  4  1  0  0  0  0
 16 13  2  0  0  0  0
M  END
>  <CdId>
3511

>  <Mol Weight>
232.2353

>  <Formula>
C12H12N2O3

>  <AKOS_NUMBER>
AKOS000114131

>  <Lipinski's Rule of Five>
0

>  <XLogP (text field)>
-0.0

>  <PASS_MNA_NEW_COUNT>
0

>  <PASS_RESULT_COUNT>
   34 of   464 Possible Pharmacological Effects at Pa > 0.400
  147 of  3850 Possible Mechanisms of Action at Pa > 0.400
  127 of   321 Possible Toxic and Adverse Effects at Pa > 0.400
    3 of   118 Possible Antitargets at Pa > 0.400
   24 of   195 Possible Metabolism-Related Actions at Pa > 0.400
  449 of  1610 Possible Gene Expression Regulation at Pa > 0.400
    1 of    68 Possible Transporters-Related Actions at Pa > 0.400

>  <Effects>
0,793  0,004  Vasodilator, cerebral
0,787  0,021  Antieczematic
0,679  0,014  Kidney function stimulant
0,655  0,007  Cell adhesion molecule inhibitor
0,647  0,013  Antihypoxic
0,613  0,009  Antimutagenic
0,603  0,006  Antihelmintic (Nematodes)
0,606  0,020  Lipid metabolism regulator
0,585  0,024  Vasodilator, peripheral
0,575  0,023  Antibacterial activity enhancer
0,570  0,023  Radiosensitizer
0,576  0,030  Preneoplastic conditions treatment
0,563  0,021  Antinephrotoxic
0,559  0,022  Antipruritic
0,553  0,022  Antipruritic, allergic
0,541  0,032  Leukopoiesis stimulant
0,512  0,043  Potassium sparing diuretic
0,499  0,038  Erythropoiesis stimulant
0,473  0,022  Muscular dystrophy treatment
0,450  0,005  Intermittent claudication treatment
0,513  0,069  Mucositis treatment
0,469  0,028  Antipsoriatic
0,483  0,045  Vasoprotector
0,444  0,020  Antipyretic
0,450  0,032  Antiulcerative
0,443  0,030  Anesthetic general
0,435  0,029  Eye irritation, inactive
0,447  0,043  Dermatologic
0,441  0,042  Antiallergic
0,434  0,042  Antithrombotic
0,493  0,136  Neuroprotector
0,436  0,082  Cytoprotectant
0,455  0,137  Fibrinolytic
0,415  0,173  Antiischemic, cerebral

>  <Antitargets>
0,560  0,028  Superoxide dismutase inhibitor
0,607  0,104  Ubiquinol-cytochrome-c reductase inhibitor
0,432  0,037  GABA aminotransferase inhibitor

>  <Gene_Expression>
0,876  0,011  PHB expression inhibitor
0,863  0,006  C10ORF116 expression enhancer
0,853  0,007  KPNA1 expression enhancer
0,846  0,003  CTPS expression inhibitor
0,841  0,004  SLC16A2 expression enhancer
0,837  0,002  MGST1 expression inhibitor
0,841  0,007  TMSB4X expression inhibitor
0,839  0,009  S100A8 expression inhibitor
0,832  0,005  RRBP1 expression enhancer
0,836  0,009  CCNE2 expression inhibitor
0,834  0,008  ABCB10 expression inhibitor
0,832  0,007  VIM expression inhibitor
0,837  0,013  PDXK expression inhibitor
0,824  0,004  CCND2 expression enhancer
0,824  0,006  CDK4 expression inhibitor
0,835  0,017  CXCR1 expression enhancer
0,820  0,018  ARL6IP5 expression enhancer
0,803  0,001  UQCRC2 expression inhibitor
0,823  0,025  XPO1 expression inhibitor
0,817  0,019  EIF2S1 expression inhibitor
0,805  0,011  EIF3B expression inhibitor
0,805  0,012  TNFAIP2 expression enhancer
0,798  0,006  HLA-F expression enhancer
0,797  0,011  IGFBP6 expression inhibitor
0,789  0,005  NOLC1 expression inhibitor
0,813  0,029  CD36 expression inhibitor
0,803  0,020  OAS2 expression enhancer
0,783  0,007  MCM7 expression inhibitor
0,798  0,023  SFPQ expression enhancer
0,782  0,012  PLIN2 expression enhancer
0,786  0,023  BIRC2 expression inhibitor
0,795  0,035  NAA15 expression inhibitor
0,771  0,011  PRTN3 expression enhancer
0,768  0,013  PDCD4 expression enhancer
0,805  0,051  LPL expression enhancer
0,766  0,014  FUBP1 expression inhibitor
0,798  0,049  HSPD1 expression inhibitor
0,760  0,011  CDKN1B expression inhibitor
0,757  0,009  KPNA2 expression inhibitor
0,754  0,010  IL12B expression inhibitor
0,764  0,026  JUN expression enhancer
0,746  0,009  PML expression inhibitor
0,758  0,025  CEACAM1 expression enhancer
0,743  0,009  VAT1 expression enhancer
0,740  0,007  TPM4 expression inhibitor
0,736  0,005  NPM1 expression inhibitor
0,747  0,016  DDX18 expression inhibitor
0,756  0,026  ILF3 expression inhibitor
0,764  0,035  GPX1 expression inhibitor
0,738  0,012  POLE2 expression inhibitor
0,759  0,034  MYL6 expression enhancer
0,750  0,026  MMP7 expression enhancer
0,730  0,007  YWHAE expression inhibitor
0,732  0,012  CTNNA1 expression inhibitor
0,734  0,016  SDCBP expression enhancer
0,745  0,027  CNN1 expression enhancer
0,736  0,019  IFNGR1 expression enhancer
0,735  0,022  ITGB2 expression enhancer
0,714  0,006  TOB1 expression inhibitor
0,715  0,009  ERMP1 expression enhancer
0,715  0,009  GAP43 expression enhancer
0,715  0,009  MSX2 expression enhancer
0,729  0,024  NOM1 expression inhibitor
0,725  0,022  ETV5 expression inhibitor
0,712  0,008  PLA2G2A expression enhancer
0,719  0,016  SAT expression enhancer
0,724  0,022  AHR expression enhancer
0,736  0,034  SRPK1 expression inhibitor
0,713  0,012  ADD3 expression enhancer
0,706  0,008  POR expression enhancer
0,715  0,018  WFDC2 expression enhancer
0,711  0,017  SOX9 expression enhancer
0,709  0,015  PRDX1 expression inhibitor
0,716  0,023  NASP expression inhibitor
0,697  0,005  RCC2 expression inhibitor
0,701  0,012  TK1 expression inhibitor
0,704  0,016  HSPE1 expression inhibitor
0,700  0,014  TOP2A expression inhibitor
0,704  0,021  PKM2 expression enhancer
0,700  0,017  FKBP8 expression inhibitor
0,693  0,011  FGFR3 expression inhibitor
0,691  0,010  CRABP2 expression inhibitor
0,695  0,014  CCL5 expression inhibitor
0,698  0,017  VAV3 expression inhibitor
0,693  0,013  SIDT2 expression enhancer
0,689  0,013  EI24 expression enhancer
0,698  0,022  NOL5A expression inhibitor
0,688  0,013  MYB expression inhibitor
0,704  0,029  CD38 expression enhancer
0,690  0,016  TRIM16 expression enhancer
0,700  0,027  ID2 expression enhancer
0,718  0,045  STAR expression enhancer
0,678  0,010  PDK4 expression enhancer
0,687  0,020  MITF expression enhancer
0,709  0,042  MAPT expression enhancer
0,687  0,023  GRN expression enhancer
0,676  0,013  TIMP1 expression enhancer
0,692  0,029  COL2A1 expression enhancer
0,681  0,022  IGF2 expression inhibitor
0,683  0,025  ITGB1 expression inhibitor
0,687  0,030  MCM6 expression enhancer
0,670  0,014  TNPO2 expression inhibitor
0,654  0,003  EIF4G2 expression inhibitor
0,670  0,019  STRBP expression inhibitor
0,657  0,007  HMGB2 expression inhibitor
0,671  0,022  CD86 expression enhancer
0,674  0,026  TNS3 expression enhancer
0,655  0,007  PSAP expression enhancer
0,691  0,045  EZH2 expression inhibitor
0,665  0,020  KPNB1 expression inhibitor
0,660  0,015  HSP27 expression enhancer
0,676  0,032  FGF2 expression inhibitor
0,653  0,013  DEK expression inhibitor
0,648  0,007  GINS2 expression inhibitor
0,671  0,032  TFDP2 expression inhibitor
0,651  0,013  FUS expression inhibitor
0,648  0,010  IMPDH2 expression enhancer
0,658  0,022  CASP9 expression enhancer
0,642  0,008  CDK1 expression inhibitor
0,644  0,011  MYBL2 expression inhibitor
0,647  0,015  SCARB1 expression enhancer
0,671  0,038  CASP3 expression enhancer
0,660  0,028  MAF expression enhancer
0,651  0,022  CAV1 expression inhibitor
0,650  0,024  PRRX1 expression inhibitor
0,656  0,033  CDKN1A expression enhancer
0,666  0,043  STAT1 expression inhibitor
0,643  0,023  TNFSF10 expression enhancer
0,633  0,014  SPARC expression inhibitor
0,646  0,028  DDIT4 expression enhancer
0,623  0,005  NARS expression inhibitor
0,650  0,035  FN1 expression inhibitor
0,649  0,034  THBS1 expression enhancer
0,629  0,015  CSE1L expression inhibitor
0,653  0,042  CD44 expression inhibitor
0,654  0,044  GSTA1 expression enhancer
0,633  0,022  CDKN1C expression inhibitor
0,615  0,004  HDAC3 expression inhibitor
0,614  0,005  TMSB4X expression enhancer
0,646  0,036  FOS expression enhancer
0,620  0,012  REL expression enhancer
0,637  0,030  IL6 expression inhibitor
0,622  0,015  CD14 expression enhancer
0,654  0,048  SERPINB5 expression enhancer
0,616  0,012  CBX3 expression inhibitor
0,607  0,004  ENO1 expression inhibitor
0,628  0,025  EGFR expression inhibitor
0,628  0,026  ITGB7 expression enhancer
0,620  0,018  CDK5 expression enhancer
0,617  0,016  FTL expression enhancer
0,625  0,024  CDH1 expression enhancer
0,608  0,009  IVL expression inhibitor
0,621  0,023  CYB5R2 expression enhancer
0,632  0,035  SLC16A4 expression enhancer
0,617  0,020  PSAT1 expression inhibitor
0,619  0,027  LAMC1 expression enhancer
0,624  0,032  CDK2 expression inhibitor
0,595  0,005  POLD3 expression inhibitor
0,630  0,041  TP53 expression enhancer
0,608  0,019  FEN1 expression inhibitor
0,607  0,020  ISG15 expression enhancer
0,616  0,029  NR3C1 expression inhibitor
0,608  0,023  RB1 expression enhancer
0,619  0,034  PPARD expression inhibitor
0,592  0,008  BARD1 expression inhibitor
0,606  0,022  STAT3 expression inhibitor
0,604  0,022  RRM2 expression inhibitor
0,603  0,022  NR4A2 expression inhibitor
0,592  0,014  PTGS2 expression inhibitor
0,592  0,014  ABCG1 expression enhancer
0,610  0,035  CCND1 expression inhibitor
0,586  0,011  BTG2 expression enhancer
0,632  0,057  SUZ12 expression inhibitor
0,591  0,017  FASN expression inhibitor
0,602  0,027  PPARGC1A expression enhancer
0,591  0,020  WAS expression enhancer
0,581  0,013  RAD51AP1 expression inhibitor
0,634  0,067  PLAU expression inhibitor
0,571  0,004  RYBP expression inhibitor
0,589  0,023  CDKN2A expression enhancer
0,610  0,045  IL18 expression inhibitor
0,580  0,017  DNMT3A expression inhibitor
0,590  0,026  GATA2 expression enhancer
0,577  0,017  NCF1 expression enhancer
0,596  0,037  TP53TG1 expression enhancer
0,582  0,024  PA2G4 expression inhibitor
0,599  0,041  BIRC3 expression enhancer
0,569  0,012  MDK expression enhancer
0,575  0,019  EHD1 expression enhancer
0,570  0,015  UGT1A1 expression enhancer
0,618  0,065  ITGA3 expression enhancer
0,571  0,019  ISYNA1 expression enhancer
0,575  0,024  INCENP expression inhibitor
0,578  0,028  AREG expression enhancer
0,597  0,047  THBD expression enhancer
0,563  0,013  ITGA6 expression enhancer
0,627  0,077  MAPK8 expression enhancer
0,554  0,005  SLC16A1 expression inhibitor
0,567  0,018  BGLAP expression inhibitor
0,562  0,014  TPO expression enhancer
0,555  0,007  FABP4 expression enhancer
0,581  0,033  DFFA expression inhibitor
0,588  0,043  RNF4 expression inhibitor
0,595  0,050  VEGFA expression inhibitor
0,580  0,036  ICAM1 expression enhancer
0,556  0,014  CYP11A1 expression enhancer
0,571  0,030  FGFR2 expression enhancer
0,579  0,040  CLDN4 expression enhancer
0,542  0,004  KIF2C expression inhibitor
0,563  0,024  G0S2 expression enhancer
0,552  0,014  SUMO1 expression inhibitor
0,545  0,008  CYP3A7 expression inhibitor
0,569  0,032  TFDP1 expression inhibitor
0,570  0,034  DAB2 expression enhancer
0,541  0,005  ENTPD5 expression inhibitor
0,568  0,032  PLD1 expression enhancer
0,576  0,040  SLC3A2 expression enhancer
0,548  0,015  EPAS1 expression enhancer
0,552  0,019  RPL7A expression inhibitor
0,575  0,044  PTGR1 expression enhancer
0,580  0,049  TRAK2 expression enhancer
0,551  0,021  SKP2 expression inhibitor
0,572  0,042  VEGFA expression enhancer
0,574  0,044  BCL2 expression inhibitor
0,564  0,036  CBX1 expression inhibitor
0,553  0,027  NFKBIA expression enhancer
0,538  0,016  BAK1 expression enhancer
0,559  0,042  BCL2L1 expression inhibitor
0,550  0,035  HLA-B expression enhancer
0,554  0,039  MGMT expression enhancer
0,520  0,006  CDKN2B expression enhancer
0,523  0,010  UGT2B15 expression enhancer
0,534  0,021  TNFSF11 expression inhibitor
0,527  0,015  PTPRK expression inhibitor
0,516  0,004  EIF4A1 expression inhibitor
0,526  0,015  PPP1R3C expression inhibitor
0,584  0,073  TOP1 expression inhibitor
0,523  0,012  DNMT1 expression inhibitor
0,525  0,016  PPARG expression inhibitor
0,514  0,006  ODC1 expression inhibitor
0,556  0,048  PPARD expression enhancer
0,530  0,023  JUN expression inhibitor
0,581  0,074  PDIA3 expression enhancer
0,533  0,028  TGFBI expression enhancer
0,550  0,045  ESR1 expression inhibitor
0,509  0,005  EIF4EBP2 expression inhibitor
0,551  0,048  MMP2 expression inhibitor
0,521  0,020  S100P expression enhancer
0,538  0,037  HLA-C expression enhancer
0,536  0,035  COL4A1 expression inhibitor
0,510  0,010  EIF4E expression inhibitor
0,532  0,032  CCL2 expression enhancer
0,522  0,024  TUBB3 expression enhancer
0,500  0,003  ARPC3 expression inhibitor
0,522  0,026  FOXC1 expression enhancer
0,543  0,048  NEIL3 expression inhibitor
0,507  0,013  COL1A1 expression enhancer
0,501  0,007  NBL1 expression enhancer
0,528  0,035  THBS1 expression inhibitor
0,511  0,018  SOX4 expression inhibitor
0,526  0,036  MMP2 expression enhancer
0,496  0,005  EEF2 expression inhibitor
0,506  0,017  NAT1 expression inhibitor
0,491  0,004  YBX1 expression inhibitor
0,534  0,047  AKT1 expression enhancer
0,524  0,038  ATF3 expression enhancer
0,526  0,041  BRCA1 expression enhancer
0,525  0,041  DDIT3 expression enhancer
0,493  0,009  SLC30A5 expression inhibitor
0,503  0,019  BTG1 expression enhancer
0,525  0,043  FAM49A expression enhancer
0,513  0,032  PPARG expression enhancer
0,492  0,012  CDKN1C expression enhancer
0,492  0,013  SOX11 expression inhibitor
0,536  0,057  TNFSF10 expression inhibitor
0,545  0,067  BAX expression enhancer
0,534  0,056  PCNA expression enhancer
0,527  0,051  IL10 expression enhancer
0,495  0,019  LYN expression enhancer
0,548  0,073  BAD expression inhibitor
0,480  0,006  COL4A2 expression inhibitor
0,478  0,003  SNRPB expression inhibitor
0,495  0,021  RXRA expression enhancer
0,541  0,068  PRKAR2B expression enhancer
0,544  0,071  PNKD expression inhibitor
0,492  0,020  GARS expression inhibitor
0,528  0,057  ABCB1 expression enhancer
0,514  0,044  MAP2K1 expression enhancer
0,522  0,052  CUTL1 expression inhibitor
0,487  0,017  NKX3-1 expression enhancer
0,520  0,050  SERPINE1 expression enhancer
0,502  0,032  TIMP1 expression inhibitor
0,523  0,054  TMPRSS2 expression inhibitor
0,486  0,017  EIF5A expression inhibitor
0,495  0,027  FOS expression inhibitor
0,475  0,006  PFN1 expression inhibitor
0,479  0,011  LGALS1 expression inhibitor
0,523  0,058  NAT1 expression enhancer
0,498  0,033  SMAD3 expression enhancer
0,496  0,031  E2F1 expression inhibitor
0,528  0,063  EDN1 expression enhancer
0,468  0,004  ARPC2 expression inhibitor
0,488  0,024  APOD expression enhancer
0,497  0,035  PIM1 expression enhancer
0,507  0,046  TUBA4A expression enhancer
0,511  0,053  FAS expression inhibitor
0,474  0,015  RRM2B expression enhancer
0,477  0,019  SLC7A1 expression inhibitor
0,471  0,014  CDCA3 expression inhibitor
0,519  0,063  ABHD3 expression enhancer
0,484  0,028  CYP17A1 expression enhancer
0,472  0,017  IFNG expression inhibitor
0,488  0,032  TNF expression inhibitor
0,546  0,092  SERPINB5 expression inhibitor
0,477  0,024  DUSP10 expression enhancer
0,486  0,033  IGFBP2 expression inhibitor
0,456  0,005  RHOB expression inhibitor
0,487  0,036  CLMN expression enhancer
0,491  0,040  SERPINA3 expression enhancer
0,527  0,076  MYBL1 expression enhancer
0,469  0,018  PLAT expression enhancer
0,487  0,037  MYC expression enhancer
0,494  0,045  TRAF3 expression enhancer
0,479  0,032  SP1 expression inhibitor
0,468  0,021  CCL4 expression enhancer
0,453  0,008  KRT10 expression inhibitor
0,496  0,054  CDC25C expression inhibitor
0,465  0,025  CALU expression inhibitor
0,514  0,073  KRCC1 expression enhancer
0,458  0,018  MND1 expression inhibitor
0,486  0,047  CDKN1A expression inhibitor
0,483  0,044  BMP1 expression inhibitor
0,450  0,014  NDC80 expression inhibitor
0,465  0,029  PIR expression enhancer
0,531  0,096  ITGB1 expression enhancer
0,466  0,031  BMP2 expression enhancer
0,484  0,050  EDN1 expression inhibitor
0,490  0,057  IL4 expression enhancer
0,493  0,059  HIF1A expression inhibitor
0,435  0,004  ILF2 expression inhibitor
0,516  0,084  PLAUR expression enhancer
0,461  0,030  FLT1 expression inhibitor
0,491  0,062  DUSP5 expression enhancer
0,481  0,053  ADSL expression inhibitor
0,452  0,025  NOS1 expression inhibitor
0,523  0,097  CYR61 expression enhancer
0,482  0,056  EZH1 expression enhancer
0,515  0,088  HIF1A expression enhancer
0,436  0,011  SAP18 expression inhibitor
0,469  0,044  TP53I3 expression enhancer
0,452  0,027  TNFRSF11B expression enhancer
0,486  0,064  ID1 expression inhibitor
0,448  0,026  BAD expression enhancer
0,473  0,051  HMGA1 expression inhibitor
0,461  0,040  APOA1 expression enhancer
0,456  0,035  CYFIP2 expression enhancer
0,465  0,046  SUV420H1 expression inhibitor
0,434  0,015  CRYAB expression enhancer
0,448  0,028  TK1 expression enhancer
0,442  0,024  SLC5A5 expression enhancer
0,451  0,033  HSPA2 expression enhancer
0,460  0,043  CCNE1 expression inhibitor
0,472  0,055  IL2RA expression inhibitor
0,500  0,084  GAS6 expression inhibitor
0,441  0,025  IGF2 expression enhancer
0,432  0,017  SLA expression enhancer
0,475  0,060  IL1B expression enhancer
0,475  0,061  MLF1 expression enhancer
0,493  0,079  NSF expression inhibitor
0,418  0,005  RARA expression enhancer
0,460  0,047  CDK6 expression inhibitor
0,440  0,027  KEAP1 expression enhancer
0,420  0,007  SRSF3 expression inhibitor
0,484  0,072  APOA1 expression inhibitor
0,464  0,053  CYP4A11 expression enhancer
0,414  0,004  NACA expression inhibitor
0,413  0,006  OCLN expression enhancer
0,478  0,073  GSTM2 expression inhibitor
0,478  0,074  SCARB1 expression inhibitor
0,476  0,073  JUND expression inhibitor
0,425  0,022  SOCS2 expression enhancer
0,476  0,074  MSMO1 expression enhancer
0,437  0,035  BRF1 expression inhibitor
0,452  0,050  MAFB expression inhibitor
0,440  0,040  MMP9 expression inhibitor
0,422  0,022  KLK7 expression enhancer
0,447  0,050  SF3B5 expression enhancer
0,401  0,004  SOD1 expression inhibitor
0,435  0,038  PLAGL1 expression enhancer
0,466  0,070  CASP9 expression inhibitor
0,450  0,055  ABLIM1 expression enhancer
0,417  0,024  IFIT3 expression enhancer
0,435  0,043  WDR4 expression inhibitor
0,417  0,026  IL2 expression inhibitor
0,439  0,048  HMGA1 expression enhancer
0,406  0,017  GSN expression enhancer
0,406  0,017  CXCR4 expression enhancer
0,446  0,058  PRDX2 expression enhancer
0,430  0,042  ID3 expression enhancer
0,420  0,032  RARB expression inhibitor
0,452  0,065  GNL3 expression inhibitor
0,429  0,045  GPX2 expression enhancer
0,433  0,050  HMGN2 expression inhibitor
0,403  0,022  MET expression enhancer
0,506  0,126  DUSP4 expression enhancer
0,452  0,073  SNAI2 expression inhibitor
0,452  0,073  CPE expression inhibitor
0,447  0,071  HSPA1A expression enhancer
0,402  0,026  CEBPG expression inhibitor
0,413  0,038  LAMC2 expression enhancer
0,408  0,033  RAN expression inhibitor
0,441  0,069  TGFB1 expression enhancer
0,444  0,073  CTTN expression inhibitor
0,422  0,051  KLHL24 expression inhibitor
0,432  0,061  CASP2 expression enhancer
0,482  0,111  KLK2 expression inhibitor
0,430  0,066  CYP11A1 expression inhibitor
0,458  0,095  HMBS expression inhibitor
0,437  0,077  CREB1 expression inhibitor
0,446  0,086  ORC4 expression enhancer
0,409  0,049  JUNB expression inhibitor
0,424  0,065  CLMP expression inhibitor
0,416  0,059  PSRC1 expression inhibitor
0,405  0,050  GCLM expression enhancer
0,423  0,069  DDX24 expression inhibitor
0,450  0,097  EPRS expression inhibitor
0,417  0,064  KLF10 expression inhibitor
0,421  0,070  EPHA4 expression enhancer
0,408  0,057  BAX expression inhibitor
0,401  0,051  PTEN expression enhancer
0,455  0,110  FGFR1 expression inhibitor
0,408  0,068  PMEPA1 expression inhibitor
0,433  0,096  NBN expression inhibitor
0,429  0,094  SPP1 expression enhancer
0,428  0,094  PDCD4 expression inhibitor
0,430  0,100  ELL2 expression enhancer
0,432  0,101  TNF expression enhancer
0,407  0,083  JAK2 expression inhibitor
0,407  0,083  TBC1D1 expression inhibitor
0,406  0,083  SLC2A3 expression inhibitor
0,407  0,091  CALR expression inhibitor
0,419  0,109  NPM3 expression inhibitor
0,419  0,109  PTEN expression inhibitor
0,440  0,131  ZFP36 expression enhancer
0,404  0,104  ATP2A2 expression enhancer
0,419  0,123  FANCC expression inhibitor
0,420  0,135  TXNRD1 expression inhibitor
0,406  0,123  FILIP1L expression inhibitor
0,414  0,174  VDR expression enhancer

>  <Mechanisms>
0,850  0,007  Feruloyl esterase inhibitor
0,818  0,014  Mucomembranous protector
0,793  0,004  Vasodilator, cerebral
0,760  0,012  Aldose reductase-like protein inhibitor
0,745  0,026  Penicillin binding protein antagonist
0,745  0,026  Penicillin-binding protein ampH inhibitor
0,735  0,049  Membrane integrity agonist
0,715  0,033  Membrane permeability inhibitor
0,709  0,033  Glycosylphosphatidylinositol phospholipase D inhibitor
0,679  0,014  Kidney function stimulant
0,691  0,029  NADPH peroxidase inhibitor
0,663  0,014  Insulysin inhibitor
0,655  0,007  Cell adhesion molecule inhibitor
0,649  0,005  Catechol oxidase inhibitor
0,646  0,014  Oxygen scavenger
0,615  0,006  4-Hydroxyglutamate transaminase inhibitor
0,615  0,009  N-methylhydantoinase (ATP-hydrolysing) inhibitor
0,619  0,020  Platelet aggregation stimulant
0,609  0,020  Gastrin inhibitor
0,606  0,020  Lipid metabolism regulator
0,610  0,026  Dimethylargininase inhibitor
0,612  0,033  Carboxypeptidase Taq inhibitor
0,586  0,010  Pyruvate decarboxylase inhibitor
0,596  0,022  Methylamine-glutamate N-methyltransferase inhibitor
0,577  0,008  Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase inhibitor
0,586  0,018  X-methyl-His dipeptidase inhibitor
0,571  0,004  Benzoylformate decarboxylase inhibitor
0,589  0,024  (R)-6-hydroxynicotine oxidase inhibitor
0,585  0,024  Vasodilator, peripheral
0,560  0,008  6-Pyruvoyltetrahydropterin synthase inhibitor
0,559  0,010  4-Coumarate-CoA ligase inhibitor
0,585  0,036  Beta-adrenergic receptor kinase inhibitor
0,585  0,036  G-protein-coupled receptor kinase inhibitor
0,559  0,022  Antipruritic
0,560  0,028  Superoxide dismutase inhibitor
0,593  0,062  Chlordecone reductase inhibitor
0,546  0,017  4-Hydroxyphenylacetate 3-monooxygenase inhibitor
0,549  0,026  Aspartate-phenylpyruvate transaminase inhibitor
0,519  0,006  Retinoic acid metabolism inhibitor
0,514  0,004  Fumarate reductase (NADH) inhibitor
0,550  0,044  Phospholipid-translocating ATPase inhibitor
0,534  0,029  Beta glucuronidase inhibitor
0,607  0,104  Ubiquinol-cytochrome-c reductase inhibitor
0,547  0,047  Macrophage colony stimulating factor agonist
0,548  0,056  Oxidoreductase inhibitor
0,514  0,022  Reductant
0,511  0,022  NADH kinase inhibitor
0,513  0,025  Glyoxylate reductase inhibitor
0,500  0,014  Allyl-alcohol dehydrogenase inhibitor
0,504  0,019  Glucan 1,4-alpha-maltotetraohydrolase inhibitor
0,512  0,028  Lysostaphin inhibitor
0,498  0,016  Prenyl-diphosphatase inhibitor
0,524  0,043  Lipoprotein lipase inhibitor
0,479  0,004  Phospholipase A-2-activating protein inhibitor
0,495  0,023  Arylmalonate decarboxylase inhibitor
0,475  0,004  Diphosphomevalonate decarboxylase inhibitor
0,527  0,058  Proteasome ATPase inhibitor
0,504  0,035  Histamine release inhibitor
0,512  0,043  Potassium sparing diuretic
0,479  0,011  LGALS1 expression inhibitor
0,498  0,032  Nucleotide metabolism regulator
0,481  0,018  Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase inhibitor
0,499  0,038  Erythropoiesis stimulant
0,484  0,025  Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase inhibitor
0,500  0,044  Fibrinogen receptor antagonist
0,528  0,075  Sugar-phosphatase inhibitor
0,496  0,048  Fatty-acyl-CoA synthase inhibitor
0,478  0,030  N-formylmethionyl-peptidase inhibitor
0,470  0,026  S-alkylcysteine lyase inhibitor
0,463  0,020  Gluconolactonase inhibitor
0,486  0,045  Hydrogen dehydrogenase inhibitor
0,493  0,053  Cyclic AMP antagonist
0,494  0,054  2-Hydroxyquinoline 8-monooxygenase inhibitor
0,442  0,004  4-Hydroxybenzoate 3-monooxygenase inhibitor
0,472  0,036  Insulin promoter
0,477  0,043  HIV rev inhibitor
0,486  0,052  Pterin deaminase inhibitor
0,481  0,048  Neurotransmitter antagonist
0,456  0,027  Alcohol dehydrogenase (acceptor) inhibitor
0,464  0,038  Glutamine-phenylpyruvate transaminase inhibitor
0,436  0,011  Sulfur dioxygenase inhibitor
0,428  0,007  Ferrochelatase inhibitor
0,483  0,062  UDP-N-acetylglucosamine 4-epimerase inhibitor
0,428  0,007  Benzoate 4-monooxygenase inhibitor
0,435  0,014  6-Carboxyhexanoate-CoA ligase inhibitor
0,435  0,014  Biotin-CoA ligase inhibitor
0,435  0,014  Homoaconitate hydratase inhibitor
0,435  0,014  Triacetate-lactonase inhibitor
0,464  0,045  Formaldehyde transketolase inhibitor
0,447  0,029  Aspartate-ammonia ligase inhibitor
0,449  0,033  (R)-Pantolactone dehydrogenase (flavin) inhibitor
0,462  0,047  Cholesterol antagonist
0,443  0,030  Anesthetic general
0,479  0,070  Acylcarnitine hydrolase inhibitor
0,459  0,051  Biotinidase inhibitor
0,427  0,020  Horrilysin inhibitor
0,467  0,061  Lysine 2,3-aminomutase inhibitor
0,428  0,023  Bothrolysin inhibitor
0,442  0,040  All-trans-retinyl-palmitate hydrolase inhibitor
0,435  0,035  Arylacetonitrilase inhibitor
0,427  0,028  Phosphatidylcholine-sterol O-acyltransferase inhibitor
0,407  0,011  Thyroxine 5-deiodinase inhibitor
0,463  0,067  Venombin AB inhibitor
0,437  0,041  Cyclohexanone monooxygenase inhibitor
0,435  0,039  Prostaglandin-A1 DELTA-isomerase inhibitor
0,428  0,033  Nitrite reductase (NO-forming) inhibitor
0,432  0,037  GABA aminotransferase inhibitor
0,417  0,025  Methanol dehydrogenase inhibitor
0,446  0,054  Exoribonuclease II inhibitor
0,404  0,013  2-Enoate reductase inhibitor
0,415  0,024  Glutarate-semialdehyde dehydrogenase inhibitor
0,410  0,020  GABA C receptor agonist
0,437  0,047  (S)-6-hydroxynicotine oxidase inhibitor
0,413  0,024  Meprin B inhibitor
0,439  0,050  Phenol O-methyltransferase inhibitor
0,414  0,026  Ethanolamine-phosphate cytidylyltransferase inhibitor
0,403  0,015  TRPA1 agonist
0,455  0,068  Galanin receptor antagonist
0,443  0,058  Fibrolase inhibitor
0,409  0,026  Polyadenylate-binding protein 1 inhibitor
0,429  0,046  ADP-thymidine kinase inhibitor
0,406  0,023  Dimethylmaleate hydratase inhibitor
0,470  0,088  Nicotinic alpha2beta2 receptor antagonist
0,442  0,060  Fragilysin inhibitor
0,403  0,024  DNA-3-methyladenine glycosylase I inhibitor
0,431  0,053  Complement factor 1s inhibitor
0,407  0,029  Fructan beta-fructosidase inhibitor
0,436  0,064  Arginine 2-monooxygenase inhibitor
0,414  0,043  RNA-directed RNA polymerase inhibitor
0,415  0,044  Mitochondrial processing peptidase inhibitor
0,466  0,096  Platelet adhesion inhibitor
0,402  0,032  Poly(beta-D-mannuronate) lyase inhibitor
0,404  0,034  N-acylmannosamine kinase inhibitor
0,432  0,078  Alkylacetylglycerophosphatase inhibitor
0,436  0,082  Cytoprotectant
0,411  0,059  Gluconate 5-dehydrogenase inhibitor
0,412  0,062  Manganese peroxidase inhibitor
0,403  0,054  Prostaglandin-E2 9-reductase inhibitor
0,418  0,073  Glutathione thiolesterase inhibitor
0,447  0,102  Omptin inhibitor
0,401  0,061  L-glutamate oxidase inhibitor
0,405  0,067  Endopeptidase So inhibitor
0,427  0,090  Glucan endo-1,3-beta-D-glucosidase inhibitor
0,404  0,070  Galanin receptor 2 antagonist
0,405  0,106  Anorexiant
0,433  0,154  Polyporopepsin inhibitor
0,466  0,198  Transferase stimulant

>  <Metabolism>
0,744  0,036  CYP2J substrate
0,640  0,012  CYP1A2 substrate
0,596  0,021  CYP2C8 substrate
0,600  0,039  GST A substrate
0,570  0,013  CYP2E1 substrate
0,553  0,006  CYP4A substrate
0,559  0,014  CYP2E substrate
0,560  0,022  CYP2A6 substrate
0,532  0,023  CYP1 substrate
0,519  0,017  CYP4A11 substrate
0,512  0,016  CYP2C18 substrate
0,519  0,025  CYP1A substrate
0,527  0,034  CYP2C9 substrate
0,489  0,011  CYP2C10 substrate
0,534  0,057  CYP3A2 substrate
0,517  0,042  CYP3A1 substrate
0,499  0,033  CYP2A substrate
0,448  0,022  CYP4A1 inhibitor
0,423  0,014  FMO3 substrate
0,448  0,068  CYP2B6 inhibitor
0,411  0,043  CYP2E1 inducer
0,405  0,038  CYP2C19 inducer
0,403  0,056  CYP3A3 substrate
0,417  0,109  CYP2C8 inhibitor

>  <Toxicity>
0,918  0,004  Hyperactivity
0,811  0,004  Skin irritation, corrasive
0,815  0,021  Pure red cell aplasia
0,719  0,012  Psychoses
0,754  0,057  Shivering
0,705  0,022  Akathisia
0,714  0,039  Ulcer, aphthous
0,689  0,019  Urine discoloration
0,697  0,029  Alopecia (hair loss)
0,687  0,019  Aseptic meningitis
0,674  0,016  Parkinsonism
0,654  0,035  Hematemesis
0,666  0,055  Myocardial ischemia
0,610  0,008  Ulcer, gastric
0,642  0,041  Gastrointestinal hemorrhage
0,634  0,036  Weight gain
0,607  0,009  Ulcer, peptic
0,642  0,044  Hypercholesterolemic
0,643  0,049  Photophobia
0,609  0,037  Desquamation
0,619  0,051  Diarrhea
0,642  0,077  Bone marrow suppression
0,622  0,064  Hyperreflexia
0,615  0,064  Hypoxia
0,593  0,056  Withdrawal
0,612  0,075  Anemia, hemolytic
0,571  0,034  Enterocolitis
0,595  0,060  Hemolysis
0,593  0,067  Muscle rigidity
0,576  0,054  Acidosis
0,543  0,029  Systemic lupus erythematosus
0,588  0,079  Renal insufficiency
0,523  0,019  Ulceration
0,547  0,046  Allergic dermatitis
0,559  0,058  Lethargy
0,544  0,045  Hypothermic
0,541  0,043  Keratopathy
0,557  0,064  Optic neuritis
0,566  0,075  Hyperglycemic
0,597  0,105  Ejaculation dysfunction
0,548  0,056  Edema
0,557  0,067  Extrapyramidal effect
0,551  0,065  Optic neuropathy
0,531  0,051  Hyperkinesia
0,551  0,077  Aggression
0,557  0,086  Neuritis
0,542  0,076  Drowsiness
0,523  0,060  Neurotoxic
0,521  0,059  Acidosis, metabolic
0,535  0,075  Proteinuria
0,543  0,085  Dry eye
0,505  0,047  Hirsutism
0,508  0,052  Keratitis
0,548  0,096  Eye pain
0,529  0,079  Gait disturbance
0,511  0,061  Ototoxicity
0,473  0,027  Lacrimal secretion stimulant
0,503  0,057  Pancytopenia
0,537  0,093  Fibrillation, atrial
0,523  0,080  Sleep disturbance
0,473  0,030  Sensitization
0,465  0,029  Ophthalmoplegia
0,531  0,099  Stroke
0,536  0,106  Hemorrhage
0,475  0,053  Serum sickness
0,525  0,103  Nystagmus
0,535  0,116  Cerebral hemorrhage
0,448  0,030  Cleft palate
0,510  0,094  Hepatitis
0,521  0,112  Hyponatremia
0,480  0,076  Cataract
0,465  0,067  Parotid gland enlargement
0,487  0,090  Toxic epidermal necrolysis
0,490  0,099  Insomnia
0,478  0,092  Inflammation
0,455  0,077  Fibrosis, interstitial
0,489  0,112  Hot flush
0,451  0,074  Apnea
0,466  0,093  Hypotension
0,470  0,097  Nasal congestion
0,474  0,102  Hypotonia
0,478  0,110  Asthma
0,463  0,097  Status epilepticus
0,452  0,094  Cyanosis
0,468  0,111  Cardiogenic shock
0,465  0,109  Hyperbilirubinemia
0,450  0,097  Respiratory impairment
0,453  0,100  Hepatic necrosis
0,455  0,106  Drug eruption
0,462  0,117  Mania
0,475  0,136  Lymphocytosis
0,435  0,096  Agitation
0,448  0,113  Purpura
0,429  0,096  Dystonia
0,427  0,093  Respiratory failure
0,449  0,120  Anxiety
0,440  0,111  Nephritis
0,410  0,081  Cholestasis
0,410  0,085  Photoallergy dermatitis
0,410  0,085  Panic
0,420  0,102  Choreoathetosis
0,403  0,097  Postural (orthostatic) hypotension
0,420  0,118  Ectropion
0,433  0,132  Jaundice
0,412  0,112  Colitis
0,428  0,130  Malaise
0,410  0,112  Neutropenia
0,405  0,106  Anorexiant
0,432  0,134  Xerostomia
0,433  0,137  Stomatitis
0,418  0,124  Ocular toxicity
0,447  0,155  Electrolyte imbalance
0,427  0,138  Vasculitis
0,405  0,117  Nephrotic syndrome
0,442  0,155  Pancreatitis
0,423  0,136  Scleroderma
0,421  0,141  Chills
0,434  0,162  Erectile dysfunction
0,407  0,138  Vision disturbance
0,409  0,145  Diplopia
0,411  0,149  Constipation
0,433  0,171  Leukocytosis
0,407  0,146  Enuresis
0,400  0,145  Toxic, respiration
0,404  0,176  Myalgia
0,402  0,191  Arthralgia
0,404  0,194  Myocardial infarction

>  <Transporter>
0,588  0,024  Basolateral Na-K-Cl symporter inhibitor

>  <Murcko.CdId>
3511

>  <Murcko.Mol Weight>
134.1353

>  <Murcko.Formula>
C7H6N2O

>  <Murcko.AKOS_NUMBER>
AKOS000114131

>  <Murcko.IntegerID>
3510

$$$$

  Mrv0541 04281317412D          

 16 16  0  0  0  0            999 V2000
    2.6285   -0.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8039   -0.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6700   -0.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3915    0.2681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0824    0.2681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1546   -0.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0408    0.2681    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5669    0.2681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6700    0.9827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0408   -1.1613    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1546    0.9827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0824   -1.1613    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9070    0.2681    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3193    0.9827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9070   -1.1613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1440    0.9827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  3  6  2  0  0  0  0
  4  2  2  0  0  0  0
  5  9  2  0  0  0  0
  6  8  1  0  0  0  0
  7  1  2  0  0  0  0
  8  4  1  0  0  0  0
  9 11  1  0  0  0  0
 10  1  1  0  0  0  0
 11  8  2  0  0  0  0
 12  3  1  0  0  0  0
 13  5  1  0  0  0  0
 14 13  1  0  0  0  0
 15 12  1  0  0  0  0
 16 14  1  0  0  0  0
  3  5  1  0  0  0  0
M  END
>  <CdId>
4453

>  <Mol Weight>
222.2372

>  <Formula>
C12H14O4

>  <AKOS_NUMBER>
AKOS000109189

>  <Lipinski's Rule of Five>
0

>  <XLogP (text field)>
1.52

>  <PASS_MNA_NEW_COUNT>
0

>  <PASS_RESULT_COUNT>
   68 of   464 Possible Pharmacological Effects at Pa > 0.400
  192 of  3850 Possible Mechanisms of Action at Pa > 0.400
  151 of   321 Possible Toxic and Adverse Effects at Pa > 0.400
    6 of   118 Possible Antitargets at Pa > 0.400
   59 of   195 Possible Metabolism-Related Actions at Pa > 0.400
  592 of  1610 Possible Gene Expression Regulation at Pa > 0.400
    1 of    68 Possible Transporters-Related Actions at Pa > 0.400

>  <Effects>
0,870  0,002  Choleretic
0,834  0,004  Eye irritation, inactive
0,832  0,003  Preneoplastic conditions treatment
0,804  0,004  Antimutagenic
0,798  0,005  Vasoprotector
0,781  0,005  Anesthetic general
0,771  0,006  Fibrinolytic
0,754  0,008  Lipid metabolism regulator
0,771  0,025  Antieczematic
0,740  0,005  Vasodilator, cerebral
0,729  0,004  Antipyretic
0,725  0,005  Carminative
0,714  0,005  Antiseptic
0,725  0,021  Mucositis treatment
0,695  0,008  Antihypoxic
0,688  0,006  Cytoprotectant
0,698  0,040  Neuroprotector
0,652  0,010  Antihypercholesterolemic
0,643  0,016  Vasodilator, peripheral
0,615  0,004  Expectorant
0,620  0,009  Antipruritic, allergic
0,611  0,013  Vasodilator, coronary
0,603  0,011  Antiulcerative
0,640  0,048  Antiseborrheic
0,587  0,007  Antihelmintic (Nematodes)
0,565  0,003  Antinephritic
0,571  0,014  Antipsoriatic
0,571  0,015  Hepatoprotectant
0,570  0,017  Cardiovascular analeptic
0,573  0,020  Antipruritic
0,564  0,012  Chemopreventive
0,536  0,005  Antiinflammatory, intestinal
0,559  0,031  Antibacterial activity enhancer
0,537  0,024  Antisecretoric
0,528  0,019  Antiviral (Influenza)
0,533  0,024  Antithrombotic
0,541  0,034  Apoptosis agonist
0,514  0,014  Cell adhesion molecule inhibitor
0,533  0,034  Leukopoiesis stimulant
0,543  0,045  Antiinflammatory
0,516  0,025  Antiallergic
0,522  0,035  Radiosensitizer
0,505  0,027  Spasmolytic
0,497  0,020  Anticarcinogenic
0,502  0,025  Radioprotector
0,480  0,004  Intermittent claudication treatment
0,493  0,022  Vasodilator
0,502  0,032  Dermatologic
0,494  0,025  Antiprotozoal (Leishmania)
0,476  0,019  Antimyopathies
0,498  0,043  Antianginal
0,465  0,014  Chemoprotective
0,465  0,017  Antituberculosic
0,447  0,010  Sweetener
0,462  0,025  Antimycobacterial
0,471  0,042  Hypolipemic
0,433  0,006  Antiinflammatory, ophthalmic
0,438  0,024  Proliferative diseases treatment
0,463  0,061  Antinociceptive
0,423  0,021  Spasmolytic, Papaverin-like
0,407  0,009  Antidote
0,466  0,067  Antinephrotoxic
0,415  0,017  Pediculicide
0,415  0,018  Antitussive
0,409  0,016  Sclerosant
0,406  0,018  Anesthetic
0,427  0,058  Respiratory analeptic
0,437  0,091  Antineoplastic

>  <Antitargets>
0,822  0,026  Ubiquinol-cytochrome-c reductase inhibitor
0,753  0,009  Superoxide dismutase inhibitor
0,658  0,005  GABA aminotransferase inhibitor
0,452  0,016  CYP1A2 inhibitor
0,424  0,012  Phospholipase C inhibitor
0,452  0,045  Peroxidase inhibitor

>  <Gene_Expression>
0,962  0,002  SFPQ expression enhancer
0,962  0,004  CASP3 expression enhancer
0,948  0,005  CD36 expression inhibitor
0,941  0,003  CXCR1 expression enhancer
0,934  0,002  COL2A1 expression enhancer
0,931  0,006  FN1 expression inhibitor
0,928  0,005  ITGB1 expression enhancer
0,921  0,002  TRIM16 expression enhancer
0,919  0,004  SUZ12 expression inhibitor
0,912  0,003  PLAU expression inhibitor
0,912  0,006  GPX1 expression inhibitor
0,901  0,002  FUS expression inhibitor
0,906  0,009  BIRC2 expression inhibitor
0,897  0,004  CDKN1B expression inhibitor
0,898  0,008  PHB expression inhibitor
0,883  0,002  CASP9 expression enhancer
0,884  0,005  CCNE2 expression inhibitor
0,881  0,003  FTL expression enhancer
0,881  0,003  MCM7 expression inhibitor
0,880  0,004  IL18 expression inhibitor
0,879  0,006  CALR expression inhibitor
0,878  0,007  PLAUR expression enhancer
0,884  0,022  HSPD1 expression inhibitor
0,862  0,003  NR4A2 expression inhibitor
0,862  0,005  CDK4 expression inhibitor
0,864  0,007  NFKBIA expression enhancer
0,864  0,010  TNFSF10 expression inhibitor
0,856  0,005  CCND1 expression inhibitor
0,858  0,009  JUN expression enhancer
0,862  0,016  XPO1 expression inhibitor
0,850  0,007  CCL2 expression enhancer
0,851  0,008  STAT1 expression inhibitor
0,855  0,013  EIF2S1 expression inhibitor
0,848  0,007  PMEPA1 expression inhibitor
0,843  0,003  CDK1 expression inhibitor
0,847  0,014  SERPINB5 expression enhancer
0,835  0,005  IFNGR1 expression enhancer
0,837  0,008  TMSB4X expression inhibitor
0,840  0,013  MAPT expression enhancer
0,834  0,008  KPNA1 expression enhancer
0,840  0,015  ARL6IP5 expression enhancer
0,827  0,003  YWHAE expression inhibitor
0,845  0,023  NAA15 expression inhibitor
0,828  0,006  WFDC2 expression enhancer
0,835  0,014  CEACAM1 expression enhancer
0,828  0,009  SNAI2 expression inhibitor
0,854  0,036  LPL expression enhancer
0,822  0,005  CDH1 expression enhancer
0,825  0,008  PRKDC expression inhibitor
0,823  0,008  PPARD expression inhibitor
0,820  0,007  DDX18 expression inhibitor
0,815  0,004  KLHL24 expression inhibitor
0,820  0,008  NASP expression inhibitor
0,819  0,008  PPARGC1A expression enhancer
0,823  0,014  MMP7 expression enhancer
0,813  0,004  TRAF3 expression enhancer
0,816  0,008  NOL5A expression inhibitor
0,828  0,023  MAPK8 expression enhancer
0,817  0,013  CDKN1A expression enhancer
0,810  0,006  TOP2A expression inhibitor
0,814  0,014  BCL2L1 expression inhibitor
0,811  0,015  ILF3 expression inhibitor
0,817  0,022  MYL6 expression enhancer
0,804  0,010  CDC25C expression inhibitor
0,803  0,009  MCM6 expression enhancer
0,797  0,006  PCNA expression enhancer
0,794  0,009  DDIT3 expression enhancer
0,796  0,012  FOS expression enhancer
0,790  0,007  HLA-F expression enhancer
0,797  0,014  CD38 expression enhancer
0,787  0,003  MMP9 expression inhibitor
0,790  0,006  KPNA2 expression inhibitor
0,786  0,004  DEK expression inhibitor
0,789  0,007  VEGFA expression inhibitor
0,791  0,010  PDCD4 expression enhancer
0,789  0,012  EIF3B expression inhibitor
0,800  0,024  STAR expression enhancer
0,783  0,007  EI24 expression enhancer
0,782  0,009  IL6 expression inhibitor
0,778  0,006  NOLC1 expression inhibitor
0,775  0,005  CDK6 expression inhibitor
0,773  0,003  STAT3 expression inhibitor
0,786  0,017  BIRC3 expression enhancer
0,775  0,007  RRBP1 expression enhancer
0,777  0,013  TNS3 expression enhancer
0,765  0,003  DUSP10 expression enhancer
0,776  0,014  TMPRSS2 expression inhibitor
0,764  0,004  HMGB2 expression inhibitor
0,775  0,014  ETV5 expression inhibitor
0,780  0,020  MSMO1 expression enhancer
0,777  0,020  CNN1 expression enhancer
0,760  0,004  NPM1 expression inhibitor
0,766  0,011  DUSP5 expression enhancer
0,767  0,013  SLC3A2 expression enhancer
0,775  0,020  CD44 expression inhibitor
0,759  0,006  H1FX expression inhibitor
0,765  0,013  MITF expression enhancer
0,758  0,006  HMGA1 expression enhancer
0,763  0,011  PKM2 expression enhancer
0,764  0,013  ABCB10 expression inhibitor
0,764  0,013  AKR1C1 expression enhancer
0,765  0,017  THBS1 expression enhancer
0,777  0,029  PDXK expression inhibitor
0,759  0,012  JAK2 expression inhibitor
0,759  0,012  TBC1D1 expression inhibitor
0,752  0,005  FOS expression inhibitor
0,751  0,003  SRSF2 expression enhancer
0,761  0,015  S100A8 expression inhibitor
0,759  0,013  EGFR expression inhibitor
0,754  0,009  CCL5 expression inhibitor
0,749  0,005  TIMP1 expression enhancer
0,749  0,005  TNFSF11 expression inhibitor
0,758  0,016  FUBP1 expression inhibitor
0,751  0,009  KLF10 expression inhibitor
0,755  0,014  SDCBP expression enhancer
0,745  0,004  CD14 expression enhancer
0,761  0,021  C10ORF116 expression enhancer
0,751  0,013  PRRX1 expression inhibitor
0,752  0,014  SERPINE1 expression enhancer
0,755  0,017  TNFAIP2 expression enhancer
0,749  0,013  MYC expression enhancer
0,745  0,009  ATF3 expression enhancer
0,741  0,006  CRABP2 expression inhibitor
0,739  0,005  CDKN2A expression enhancer
0,737  0,004  BAD expression enhancer
0,747  0,019  IGFBP6 expression inhibitor
0,757  0,030  SRPK1 expression inhibitor
0,741  0,015  CASP9 expression inhibitor
0,728  0,005  PTGS2 expression inhibitor
0,726  0,004  BTG2 expression enhancer
0,760  0,039  DUSP4 expression enhancer
0,735  0,014  HSPE1 expression inhibitor
0,750  0,030  EZH2 expression inhibitor
0,732  0,013  GATA2 expression enhancer
0,725  0,006  TIMP1 expression inhibitor
0,731  0,014  ESR1 expression inhibitor
0,729  0,012  CTNNA1 expression inhibitor
0,726  0,010  MMP2 expression inhibitor
0,729  0,014  LAMC1 expression enhancer
0,719  0,006  TOB1 expression inhibitor
0,722  0,011  DAB2 expression enhancer
0,724  0,014  EDN1 expression enhancer
0,730  0,020  BCL2 expression inhibitor
0,722  0,013  POLE2 expression inhibitor
0,717  0,009  PSAT1 expression inhibitor
0,722  0,017  IGF2 expression inhibitor
0,719  0,013  ATM expression enhancer
0,723  0,018  GRN expression enhancer
0,725  0,021  IL10 expression enhancer
0,713  0,009  CASP2 expression enhancer
0,709  0,006  TNF expression inhibitor
0,718  0,016  ITGB7 expression enhancer
0,703  0,008  CDK5 expression enhancer
0,714  0,019  PRTN3 expression enhancer
0,707  0,013  TGFA expression enhancer
0,718  0,026  ITGB2 expression enhancer
0,715  0,023  BAX expression enhancer
0,706  0,015  CDK2 expression inhibitor
0,706  0,015  PRDX1 expression inhibitor
0,710  0,019  CD86 expression enhancer
0,697  0,008  ALPL expression enhancer
0,705  0,016  FKBP8 expression inhibitor
0,703  0,016  CDKN1C expression inhibitor
0,698  0,012  CDKN1A expression inhibitor
0,712  0,026  PLIN2 expression enhancer
0,693  0,007  BGLAP expression inhibitor
0,693  0,008  NHLRC2 expression inhibitor
0,701  0,016  KPNB1 expression inhibitor
0,702  0,017  VAV3 expression inhibitor
0,723  0,038  OAS2 expression enhancer
0,695  0,010  HOXA10 expression enhancer
0,709  0,024  TP53 expression enhancer
0,688  0,003  HDAC3 expression inhibitor
0,692  0,009  SCARB1 expression enhancer
0,695  0,013  PML expression inhibitor
0,696  0,014  ADD3 expression enhancer
0,694  0,013  SIDT2 expression enhancer
0,701  0,020  SPP1 expression enhancer
0,690  0,010  ERMP1 expression enhancer
0,690  0,010  GAP43 expression enhancer
0,690  0,010  MSX2 expression enhancer
0,695  0,015  GPX2 expression enhancer
0,703  0,024  ETS2 expression inhibitor
0,701  0,023  ASNS expression inhibitor
0,700  0,024  ABCB1 expression enhancer
0,701  0,025  THBD expression enhancer
0,680  0,005  CYP17A1 expression enhancer
0,685  0,011  TXNRD1 expression enhancer
0,686  0,012  CBX1 expression inhibitor
0,689  0,015  MMP2 expression enhancer
0,687  0,013  TNPO2 expression inhibitor
0,680  0,007  REL expression enhancer
0,689  0,016  VAT1 expression enhancer
0,699  0,028  TFDP2 expression inhibitor
0,696  0,025  TNFRSF21 expression inhibitor
0,683  0,012  HSP27 expression enhancer
0,691  0,024  SLC16A2 expression enhancer
0,701  0,033  VDR expression enhancer
0,695  0,030  MYBL1 expression enhancer
0,676  0,010  HMOX1 expression enhancer
0,688  0,023  SLC16A4 expression enhancer
0,671  0,007  GCLM expression enhancer
0,677  0,013  FEN1 expression inhibitor
0,671  0,007  MGMT expression enhancer
0,733  0,070  RAD23B expression inhibitor
0,703  0,040  CYR61 expression enhancer
0,688  0,027  TNF expression enhancer
0,673  0,012  PLA2G2A expression enhancer
0,667  0,007  CCNE1 expression inhibitor
0,672  0,012  TNFRSF10B expression inhibitor
0,668  0,008  IMPDH2 expression enhancer
0,666  0,008  FLT1 expression inhibitor
0,673  0,015  CYB5R2 expression enhancer
0,675  0,018  DFFA expression inhibitor
0,660  0,005  HIST1H2BD expression enhancer
0,659  0,005  E2F1 expression inhibitor
0,657  0,003  ENO1 expression inhibitor
0,675  0,022  IFRD1 expression inhibitor
0,673  0,020  TP53TG1 expression enhancer
0,664  0,012  SPARC expression inhibitor
0,658  0,007  CBX3 expression inhibitor
0,663  0,013  TPM4 expression inhibitor
0,660  0,011  PDK4 expression enhancer
0,679  0,032  FGF2 expression inhibitor
0,653  0,008  FAS expression inhibitor
0,674  0,029  KLK2 expression inhibitor
0,663  0,021  HLA-B expression enhancer
0,649  0,009  PPARG expression inhibitor
0,651  0,012  WAS expression enhancer
0,646  0,007  SUMO1 expression inhibitor
0,643  0,004  NARS expression inhibitor
0,658  0,021  IL12B expression inhibitor
0,641  0,004  TMSB4X expression enhancer
0,654  0,019  TNFSF10 expression enhancer
0,652  0,017  MYB expression inhibitor
0,632  0,003  AKR1B1 expression inhibitor
0,634  0,010  ABCG1 expression enhancer
0,652  0,030  MAF expression enhancer
0,648  0,026  SOX9 expression enhancer
0,627  0,006  BAK1 expression enhancer
0,649  0,031  PPARA expression inhibitor
0,641  0,022  TUBA4A expression enhancer
0,661  0,043  HIF1A expression enhancer
0,650  0,033  ZFP36 expression enhancer
0,650  0,036  TRAK2 expression enhancer
0,630  0,016  TGFBI expression enhancer
0,633  0,020  TK1 expression inhibitor
0,638  0,024  EZH1 expression enhancer
0,641  0,030  CLDN4 expression enhancer
0,616  0,005  ABCG2 expression inhibitor
0,633  0,025  HLA-C expression enhancer
0,630  0,023  CLMN expression enhancer
0,624  0,018  FGFR3 expression inhibitor
0,615  0,010  SP1 expression inhibitor
0,626  0,022  MAP2K1 expression enhancer
0,637  0,035  HSPA1A expression enhancer
0,631  0,031  CCND2 expression enhancer
0,613  0,014  JUN expression inhibitor
0,638  0,041  IL6 expression enhancer
0,615  0,018  PA2G4 expression inhibitor
0,646  0,051  POLE2 expression enhancer
0,616  0,022  POR expression enhancer
0,628  0,033  HMBS expression inhibitor
0,598  0,005  LGALS1 expression inhibitor
0,603  0,009  LYN expression enhancer
0,602  0,009  BMP2 expression enhancer
0,597  0,004  EIF4G2 expression inhibitor
0,603  0,010  PSAP expression enhancer
0,628  0,035  IL4 expression enhancer
0,602  0,010  IGF2 expression enhancer
0,614  0,022  THBS1 expression inhibitor
0,611  0,020  EDN1 expression inhibitor
0,622  0,031  IL1B expression enhancer
0,620  0,030  FOSL1 expression enhancer
0,593  0,004  SLC16A1 expression inhibitor
0,612  0,023  AREG expression enhancer
0,619  0,030  HIF1A expression inhibitor
0,599  0,011  IGF1R expression inhibitor
0,593  0,006  MGST1 expression inhibitor
0,607  0,022  NKX3-1 expression inhibitor
0,601  0,017  SLC7A11 expression enhancer
0,604  0,020  CSE1L expression inhibitor
0,608  0,024  EGR1 expression inhibitor
0,603  0,019  G0S2 expression enhancer
0,647  0,063  MSH6 expression inhibitor
0,602  0,019  MAP2K3 expression enhancer
0,614  0,032  PPARD expression enhancer
0,589  0,009  CYP11A1 expression enhancer
0,622  0,043  DHRS2 expression enhancer
0,591  0,012  APOA1 expression enhancer
0,583  0,006  FABP4 expression enhancer
0,583  0,006  SRSF5 expression inhibitor
0,617  0,040  AGRN expression enhancer
0,578  0,005  NOTCH1 expression inhibitor
0,593  0,022  CYP11A1 expression inhibitor
0,588  0,017  ISYNA1 expression enhancer
0,588  0,018  CTPS expression inhibitor
0,595  0,025  RB1 expression enhancer
0,632  0,064  SERPINB5 expression inhibitor
0,594  0,028  EPHA4 expression enhancer
0,577  0,012  BTG1 expression enhancer
0,577  0,013  CD36 expression enhancer
0,600  0,036  MAPK8 expression inhibitor
0,586  0,023  KLK3 expression inhibitor
0,566  0,004  RYBP expression inhibitor
0,580  0,018  FOXC1 expression enhancer
0,598  0,037  NEIL3 expression inhibitor
0,571  0,011  CXCL2 expression inhibitor
0,573  0,013  RAD51AP1 expression inhibitor
0,564  0,005  NBL1 expression enhancer
0,569  0,010  TP53I3 expression enhancer
0,564  0,006  POLD3 expression inhibitor
0,568  0,010  RXRA expression enhancer
0,616  0,059  UNG expression inhibitor
0,580  0,026  ASCL1 expression enhancer
0,597  0,044  RAD51AP1 expression enhancer
0,557  0,004  ODC1 expression inhibitor
0,569  0,019  CA2 expression enhancer
0,558  0,007  MET expression enhancer
0,563  0,013  IVL expression inhibitor
0,574  0,026  PIM1 expression enhancer
0,569  0,021  RSAD2 expression enhancer
0,565  0,017  CSF2 expression enhancer
0,551  0,006  ZFHX3 expression inhibitor
0,555  0,012  NAT1 expression inhibitor
0,579  0,036  ICAM1 expression enhancer
0,583  0,040  CPE expression inhibitor
0,602  0,060  GADD45A expression inhibitor
0,581  0,040  DDIT4 expression enhancer
0,562  0,022  BAX expression inhibitor
0,552  0,014  ITGA6 expression enhancer
0,556  0,018  UGT1A1 expression enhancer
0,549  0,014  RCC2 expression inhibitor
0,557  0,022  FASN expression inhibitor
0,546  0,012  BCAT1 expression inhibitor
0,540  0,007  RXRA expression inhibitor
0,546  0,016  NOS1 expression inhibitor
0,563  0,034  MAFB expression inhibitor
0,561  0,033  PLD1 expression enhancer
0,585  0,057  KIF23 expression enhancer
0,542  0,016  ZFAND5 expression inhibitor
0,532  0,006  SLC30A5 expression inhibitor
0,575  0,049  ACTA2 expression inhibitor
0,554  0,028  RPS27L expression enhancer
0,536  0,011  BARD1 expression inhibitor
0,546  0,021  CCNK expression inhibitor
0,596  0,071  ITGA3 expression enhancer
0,565  0,041  CCNA2 expression enhancer
0,537  0,014  PTPRK expression inhibitor
0,547  0,027  NEDD9 expression inhibitor
0,586  0,067  AHR expression inhibitor
0,528  0,009  SOX11 expression inhibitor
0,545  0,028  IL8 expression enhancer
0,530  0,012  EIF5A expression inhibitor
0,530  0,014  RARB expression inhibitor
0,528  0,012  NKX3-1 expression enhancer
0,533  0,017  APOD expression enhancer
0,557  0,042  TXNIP expression inhibitor
0,523  0,011  NRIP1 expression enhancer
0,522  0,011  IFIT3 expression enhancer
0,518  0,007  APOE expression enhancer
0,526  0,015  CEBPG expression inhibitor
0,534  0,024  DNMT3A expression inhibitor
0,544  0,035  ISG15 expression enhancer
0,517  0,008  EP300 expression inhibitor
0,542  0,034  COL4A1 expression inhibitor
0,549  0,042  CLMP expression inhibitor
0,538  0,030  UBE2C expression enhancer
0,513  0,006  UQCRC2 expression inhibitor
0,532  0,025  EHD1 expression enhancer
0,532  0,027  SMAD3 expression enhancer
0,532  0,028  TOP2A expression enhancer
0,514  0,011  CYP3A7 expression inhibitor
0,548  0,045  CUTL1 expression inhibitor
0,566  0,064  FILIP1L expression inhibitor
0,538  0,037  BRCA1 expression enhancer
0,576  0,075  TOP1 expression inhibitor
0,515  0,014  CCL4 expression enhancer
0,522  0,021  LAMC2 expression enhancer
0,504  0,005  ELF3 expression enhancer
0,503  0,005  EIF4A1 expression inhibitor
0,503  0,005  RARB expression enhancer
0,554  0,056  ID2 expression enhancer
0,510  0,013  COL1A1 expression enhancer
0,578  0,081  TXNRD1 expression inhibitor
0,513  0,018  GARS expression inhibitor
0,509  0,014  S100A8 expression enhancer
0,515  0,023  BID expression inhibitor
0,505  0,015  PLAU expression enhancer
0,532  0,043  PCAF expression enhancer
0,542  0,054  ORC4 expression enhancer
0,539  0,052  VEGFA expression enhancer
0,506  0,019  VWF expression enhancer
0,504  0,017  TNFRSF11B expression enhancer
0,525  0,039  ABLIM1 expression enhancer
0,516  0,031  PRDX6 expression enhancer
0,510  0,025  NCF1 expression enhancer
0,522  0,037  FGFR2 expression enhancer
0,491  0,006  CD74 expression inhibitor
0,503  0,018  KEAP1 expression enhancer
0,497  0,014  DHRS3 expression enhancer
0,499  0,017  SLC7A1 expression inhibitor
0,487  0,007  SAP18 expression inhibitor
0,491  0,012  CDKN1C expression enhancer
0,485  0,008  ENTPD5 expression inhibitor
0,482  0,004  KIF2C expression inhibitor
0,523  0,046  PTGS2 expression enhancer
0,485  0,008  CDKN2B expression enhancer
0,549  0,072  BAD expression inhibitor
0,500  0,025  TPO expression enhancer
0,500  0,025  EPAS1 expression enhancer
0,532  0,059  CDC25B expression enhancer
0,505  0,033  JUNB expression inhibitor
0,505  0,033  PPARG expression enhancer
0,528  0,057  GSTM2 expression inhibitor
0,517  0,048  GNL3 expression inhibitor
0,494  0,025  CYP1A1 expression inhibitor
0,507  0,040  CYP4A11 expression enhancer
0,472  0,005  SRSF3 expression inhibitor
0,483  0,017  IL2 expression inhibitor
0,484  0,018  ACAN expression enhancer
0,498  0,033  HMGN2 expression inhibitor
0,562  0,097  ITGB6 expression inhibitor
0,496  0,031  MDK expression enhancer
0,538  0,074  GAS6 expression inhibitor
0,480  0,019  TGFB3 expression enhancer
0,496  0,037  CARS expression inhibitor
0,529  0,069  JAG1 expression inhibitor
0,491  0,032  IGFBP2 expression inhibitor
0,519  0,061  RNF4 expression inhibitor
0,479  0,021  GINS2 expression inhibitor
0,474  0,016  MND1 expression inhibitor
0,481  0,023  PPP1R3C expression inhibitor
0,478  0,021  DNMT1 expression inhibitor
0,503  0,047  ADSL expression inhibitor
0,466  0,011  GSN expression enhancer
0,490  0,035  IL6ST expression inhibitor
0,517  0,063  NR3C1 expression inhibitor
0,462  0,008  EIF4EBP2 expression inhibitor
0,468  0,015  CDCA3 expression inhibitor
0,484  0,030  ID3 expression enhancer
0,474  0,020  GATA1 expression enhancer
0,457  0,004  SNRPB expression inhibitor
0,485  0,033  MYBL2 expression inhibitor
0,468  0,016  RELA expression inhibitor
0,463  0,012  NOS2 expression inhibitor
0,458  0,010  IL24 expression inhibitor
0,471  0,025  MCM2 expression enhancer
0,455  0,008  KRT10 expression inhibitor
0,478  0,032  SKP2 expression inhibitor
0,459  0,014  KRAS expression inhibitor
0,471  0,027  ESR1 expression enhancer
0,456  0,013  NDC80 expression inhibitor
0,489  0,047  VIM expression inhibitor
0,458  0,016  UGT2B15 expression enhancer
0,451  0,009  ABCG5 expression enhancer
0,451  0,009  CYP7A1 expression enhancer
0,503  0,062  MEGF9 expression inhibitor
0,478  0,037  DLX4 expression inhibitor
0,460  0,019  PLAT expression enhancer
0,454  0,013  GSTA4 expression enhancer
0,461  0,021  SOX4 expression inhibitor
0,485  0,046  RRM2 expression inhibitor
0,480  0,042  PARG expression enhancer
0,445  0,007  UBE2M expression inhibitor
0,470  0,032  AR expression inhibitor
0,472  0,034  IL4 expression inhibitor
0,443  0,005  PSMD3 expression inhibitor
0,455  0,018  KLK7 expression enhancer
0,478  0,041  ERBB4 expression inhibitor
0,449  0,012  TFF1 expression enhancer
0,453  0,016  C6ORF48 expression inhibitor
0,441  0,005  TGM2 expression enhancer
0,511  0,076  NR4A2 expression enhancer
0,440  0,004  PABPC1 expression inhibitor
0,440  0,004  RPS27 expression inhibitor
0,440  0,004  UBA52 expression inhibitor
0,458  0,026  RAN expression inhibitor
0,443  0,012  CPT1A expression enhancer
0,497  0,065  CAV1 expression inhibitor
0,475  0,044  SERPINA3 expression enhancer
0,436  0,006  YBX1 expression inhibitor
0,448  0,018  SOCS2 expression enhancer
0,433  0,004  RARA expression enhancer
0,443  0,016  FGFR1 expression enhancer
0,507  0,080  EIF2S1 expression enhancer
0,453  0,027  TK1 expression enhancer
0,495  0,069  GSTA1 expression enhancer
0,469  0,043  SF3B5 expression enhancer
0,448  0,023  SLC5A5 expression enhancer
0,462  0,038  TUBB3 expression enhancer
0,464  0,041  NGFR expression enhancer
0,484  0,061  CPNE1 expression enhancer
0,473  0,051  HMGA1 expression inhibitor
0,467  0,045  SUV420H1 expression inhibitor
0,450  0,033  BRF1 expression inhibitor
0,455  0,041  BAG5 expression inhibitor
0,487  0,073  ELL2 expression enhancer
0,440  0,027  EIF4E expression inhibitor
0,450  0,037  MAFF expression enhancer
0,474  0,061  MLF1 expression enhancer
0,459  0,049  CALM3 expression enhancer
0,458  0,047  SOX9 expression inhibitor
0,475  0,065  AHR expression enhancer
0,419  0,010  EEF2 expression inhibitor
0,430  0,020  PTHLH expression inhibitor
0,424  0,016  CRYAB expression enhancer
0,446  0,040  RECQL expression inhibitor
0,417  0,012  PFN1 expression inhibitor
0,410  0,005  TIMP2 expression inhibitor
0,456  0,053  AKR1C2 expression enhancer
0,413  0,011  NQO1 expression enhancer
0,464  0,062  TGFB1 expression enhancer
0,447  0,045  TGFBR2 expression enhancer
0,438  0,037  S100P expression enhancer
0,407  0,007  RHOB expression inhibitor
0,430  0,031  IGFBP2 expression enhancer
0,472  0,077  SDC1 expression enhancer
0,453  0,059  SELE expression enhancer
0,447  0,053  INCENP expression inhibitor
0,413  0,020  TCF12 expression enhancer
0,434  0,041  PIR expression enhancer
0,421  0,029  WWP2 expression inhibitor
0,475  0,083  TERT expression enhancer
0,421  0,029  CYP3A4 expression enhancer
0,419  0,028  CDKN2C expression enhancer
0,499  0,108  CREBBP expression inhibitor
0,474  0,082  NBN expression inhibitor
0,450  0,059  DDX24 expression inhibitor
0,484  0,094  MT1A expression enhancer
0,411  0,021  CITED2 expression enhancer
0,492  0,103  APOM expression enhancer
0,415  0,028  ACSL3 expression inhibitor
0,497  0,110  BST2 expression enhancer
0,404  0,017  CXCR4 expression enhancer
0,457  0,074  TNFRSF11A expression enhancer
0,493  0,110  PDIA3 expression enhancer
0,402  0,020  ASAH1 expression inhibitor
0,420  0,037  CEBPD expression enhancer
0,461  0,079  PDCD4 expression inhibitor
0,413  0,031  MFAP4 expression inhibitor
0,431  0,051  FOXA1 expression inhibitor
0,463  0,085  PRKCA expression enhancer
0,425  0,049  PPARA expression enhancer
0,470  0,095  HSP90B1 expression enhancer
0,414  0,040  CLGN expression inhibitor
0,446  0,072  FOXO1 expression enhancer
0,437  0,064  TUBA1A expression inhibitor
0,431  0,059  SLC1A1 expression enhancer
0,434  0,063  PRDX2 expression enhancer
0,428  0,059  ST3GAL1 expression enhancer
0,438  0,072  PRSS23 expression enhancer
0,468  0,102  NOM1 expression inhibitor
0,445  0,080  ATP2A2 expression enhancer
0,418  0,053  LAMB3 expression enhancer
0,423  0,061  SP2 expression inhibitor
0,410  0,050  SCML1 expression enhancer
0,410  0,050  SEPHS1 expression inhibitor
0,406  0,045  C5ORF32 expression enhancer
0,406  0,045  FAH expression enhancer
0,406  0,045  RRAS expression enhancer
0,406  0,045  SH3BGRL3 expression enhancer
0,427  0,068  BUB1B expression enhancer
0,407  0,049  PTEN expression enhancer
0,431  0,074  RAD51C expression enhancer
0,431  0,074  SMC4 expression enhancer
0,431  0,074  ZWINT expression enhancer
0,444  0,089  SPATA13 expression enhancer
0,425  0,072  SLC2A3 expression inhibitor
0,431  0,079  PTGR1 expression enhancer
0,418  0,066  SAT expression enhancer
0,410  0,058  ACPP expression enhancer
0,410  0,058  SASH1 expression inhibitor
0,400  0,050  PLA2G16 expression enhancer
0,400  0,050  TCEB3 expression inhibitor
0,435  0,092  RND3 expression inhibitor
0,435  0,095  CD58 expression inhibitor
0,436  0,096  SCARB1 expression inhibitor
0,417  0,079  IL2RA expression inhibitor
0,431  0,094  VCAM1 expression enhancer
0,437  0,101  APOA1 expression inhibitor
0,409  0,076  FAM49A expression enhancer
0,405  0,072  NPTX2 expression enhancer
0,427  0,094  ABHD3 expression enhancer
0,414  0,084  DDX42 expression enhancer
0,402  0,074  CPM expression enhancer
0,425  0,114  IL1RN expression inhibitor
0,404  0,104  PCDH8 expression enhancer
0,429  0,135  TMEM158 expression enhancer
0,404  0,119  EPRS expression inhibitor
0,405  0,131  FGFR1 expression inhibitor
0,411  0,142  GTF2F1 expression inhibitor

>  <Mechanisms>
0,970  0,001  Feruloyl esterase inhibitor
0,930  0,005  Membrane integrity agonist
0,892  0,004  Linoleate diol synthase inhibitor
0,867  0,001  Fumarate reductase (NADH) inhibitor
0,862  0,010  Chlordecone reductase inhibitor
0,836  0,011  Mucomembranous protector
0,820  0,007  Membrane permeability inhibitor
0,821  0,011  Beta-adrenergic receptor kinase inhibitor
0,821  0,011  G-protein-coupled receptor kinase inhibitor
0,822  0,026  Ubiquinol-cytochrome-c reductase inhibitor
0,785  0,002  4-Coumarate-CoA ligase inhibitor
0,781  0,005  Anesthetic general
0,759  0,003  1-Acylglycerol-3-phosphate O-acyltransferase inhibitor
0,754  0,008  Lipid metabolism regulator
0,753  0,009  Superoxide dismutase inhibitor
0,740  0,005  Vasodilator, cerebral
0,739  0,005  Insulysin inhibitor
0,731  0,005  Beta-carotene 15,15'-monooxygenase inhibitor
0,727  0,004  Perilipin-5 inhibitor
0,721  0,002  Diphosphomevalonate decarboxylase inhibitor
0,710  0,004  1-Acylglycerol-3-phosphate O-acyltransferase ABHD5 inhibitor
0,708  0,004  Perilipin-1 inhibitor
0,705  0,006  Reductant
0,709  0,011  Caspase 3 stimulant
0,694  0,004  Benzoylformate decarboxylase inhibitor
0,707  0,019  Arginine 2-monooxygenase inhibitor
0,688  0,006  Cytoprotectant
0,703  0,031  Alkenylglycerophosphocholine hydrolase inhibitor
0,662  0,002  Aryl sulfotransferase inhibitor
0,658  0,004  Benzoate 4-monooxygenase inhibitor
0,658  0,005  GABA aminotransferase inhibitor
0,659  0,008  Steroid N-acetylglucosaminyltransferase inhibitor
0,661  0,013  Prolyl aminopeptidase inhibitor
0,659  0,012  Cholesterol antagonist
0,649  0,005  Galanin receptor antagonist
0,655  0,013  Lysostaphin inhibitor
0,645  0,005  Free radical scavenger
0,665  0,025  Aldose reductase-like protein inhibitor
0,644  0,007  Pyruvate decarboxylase inhibitor
0,744  0,108  Transferase stimulant
0,643  0,016  Vasodilator, peripheral
0,629  0,005  Dolichyl-phosphatase inhibitor
0,639  0,015  Oxygen scavenger
0,620  0,003  Vanillyl-alcohol oxidase inhibitor
0,642  0,025  Aldehyde oxidase inhibitor
0,618  0,003  Retinoic acid metabolism inhibitor
0,615  0,004  Expectorant
0,643  0,035  Methylenetetrahydrofolate reductase (NADPH) inhibitor
0,610  0,003  Shikimate 5-dehydrogenase inhibitor
0,612  0,009  Nitrite reductase (NO-forming) inhibitor
0,606  0,008  Di-trans,poly-cis-decaprenylcistransferase inhibitor
0,611  0,013  Vasodilator, coronary
0,598  0,005  LGALS1 expression inhibitor
0,599  0,006  Catechol oxidase inhibitor
0,607  0,021  Gastrin inhibitor
0,589  0,005  Polygalacturonase inhibitor
0,586  0,004  Histone acetyltransferase inhibitor
0,630  0,048  Sugar-phosphatase inhibitor
0,586  0,008  Mannitol-1-phosphatase inhibitor
0,583  0,006  Galanin receptor 2 antagonist
0,577  0,007  Aminocarboxymuconate-semialdehyde decarboxylase inhibitor
0,599  0,032  Macrophage colony stimulating factor agonist
0,592  0,028  Platelet aggregation stimulant
0,571  0,015  Hepatoprotectant
0,571  0,015  Histamine release inhibitor
0,571  0,016  (-)-(4S)-limonene synthase inhibitor
0,573  0,020  Antipruritic
0,613  0,064  Polyporopepsin inhibitor
0,557  0,010  Aryldialkylphosphatase inhibitor
0,569  0,026  Ecdysone 20-monooxygenase inhibitor
0,588  0,046  Mannotetraose 2-alpha-N-acetylglucosaminyltransferase inhibitor
0,551  0,012  Lipid peroxidase inhibitor
0,571  0,033  Fragilysin inhibitor
0,547  0,010  Gonadotropin antagonist
0,554  0,017  1-Alkylglycerophosphocholine O-acetyltransferase inhibitor
0,604  0,075  NACHT, LRR and PYD domains-containing protein 1 inhibitor
0,538  0,011  Mediator release inhibitor
0,566  0,039  Guanyl-specific ribonuclease T1 inhibitor
0,530  0,003  4-Hydroxybenzoate 3-monooxygenase inhibitor
0,569  0,042  5 Hydroxytryptamine release stimulant
0,565  0,043  Carboxypeptidase Taq inhibitor
0,527  0,006  3-Demethylubiquinone-9 3-O-methyltransferase inhibitor
0,523  0,006  Monophenol monooxygenase inhibitor
0,553  0,038  2-Hydroxyquinoline 8-monooxygenase inhibitor
0,541  0,027  Beta glucuronidase inhibitor
0,526  0,012  Nav1.6 sodium channel blocker
0,538  0,024  All-trans-retinyl-palmitate hydrolase inhibitor
0,525  0,014  Prenyl-diphosphatase inhibitor
0,535  0,027  Arylsulfate sulfotransferase inhibitor
0,534  0,026  Nucleotide metabolism regulator
0,507  0,003  Protein-tyrosine phosphatase LC-PTP inhibitor
0,514  0,014  Cell adhesion molecule inhibitor
0,517  0,021  Plastoquinol-plastocyanin reductase inhibitor
0,497  0,002  CpG DNA methylase inhibitor
0,517  0,025  tRNA-pseudouridine synthase I inhibitor
0,546  0,057  Oxidoreductase inhibitor
0,528  0,045  Platelet adhesion inhibitor
0,528  0,048  Venombin AB inhibitor
0,510  0,031  Alkenylglycerophosphoethanolamine hydrolase inhibitor
0,484  0,005  Prephenate dehydrogenase inhibitor
0,495  0,017  Shikimate O-hydroxycinnamoyltransferase inhibitor
0,484  0,008  HIV-2 integrase inhibitor
0,503  0,028  Creatininase inhibitor
0,497  0,023  Peptidoglycan glycosyltransferase inhibitor
0,493  0,022  Vasodilator
0,507  0,040  MAP kinase stimulant
0,497  0,030  Insulin promoter
0,489  0,024  N-hydroxyarylamine O-acetyltransferase inhibitor
0,499  0,033  Alcohol O-acetyltransferase inhibitor
0,510  0,046  Lipoprotein lipase inhibitor
0,493  0,035  Thromboxane B2 antagonist
0,495  0,037  3-Hydroxybenzoate 6-monooxygenase inhibitor
0,480  0,023  Long-chain-aldehyde dehydrogenase inhibitor
0,477  0,022  Caspase 8 stimulant
0,500  0,047  Fatty-acyl-CoA synthase inhibitor
0,473  0,020  Cyanoalanine nitrilase inhibitor
0,490  0,037  Phenol O-methyltransferase inhibitor
0,465  0,014  Glycine dehydrogenase (decarboxylating) inhibitor
0,491  0,041  Cl--transporting ATPase inhibitor
0,466  0,017  Formate-dihydrofolate ligase inhibitor
0,494  0,046  Fibrinogen receptor antagonist
0,487  0,038  Fucosterol-epoxide lyase inhibitor
0,533  0,086  Phosphatase inhibitor
0,456  0,010  SV40 T antigen inhibitor
0,446  0,003  Phosphomevalonate kinase inhibitor
0,454  0,012  3-Carboxyethylcatechol 2,3-dioxygenase inhibitor
0,446  0,005  Histidine decarboxylase inhibitor
0,466  0,026  Peptide alpha-N-acetyltransferase inhibitor
0,475  0,036  Malate dehydrogenase (acceptor) inhibitor
0,448  0,016  Glutathione dehydrogenase (ascorbate) inhibitor
0,452  0,021  Phosphatidylglycerophosphatase inhibitor
0,498  0,069  NADPH peroxidase inhibitor
0,470  0,043  Histamine release stimulant
0,435  0,008  Thyroxine 5-deiodinase inhibitor
0,431  0,006  Transcription factor NF kappa B inhibitor
0,443  0,018  Phenylacetate-CoA ligase inhibitor
0,457  0,035  Leukotriene-B4 20-monooxygenase inhibitor
0,470  0,049  Exoribonuclease II inhibitor
0,478  0,057  Lysine 2,3-aminomutase inhibitor
0,447  0,028  Dextranase inhibitor
0,434  0,017  Vanilloid 1 agonist
0,468  0,051  Hydrogen dehydrogenase inhibitor
0,431  0,016  Aminomuconate-semialdehyde dehydrogenase inhibitor
0,458  0,044  Complement factor 1s inhibitor
0,467  0,054  Pin1 inhibitor
0,424  0,012  Phospholipase C inhibitor
0,482  0,070  General pump inhibitor
0,487  0,076  Proteasome ATPase inhibitor
0,441  0,030  NADH kinase inhibitor
0,474  0,065  UDP-N-acetylglucosamine 4-epimerase inhibitor
0,452  0,045  Peroxidase inhibitor
0,421  0,015  Malate dehydrogenase inhibitor
0,433  0,031  Monodehydroascorbate reductase (NADH) inhibitor
0,449  0,049  Gluconate 5-dehydrogenase inhibitor
0,409  0,011  Penicillin amidase inhibitor
0,414  0,019  4-Hydroxyglutamate transaminase inhibitor
0,417  0,024  Clavaminate synthase inhibitor
0,413  0,020  4-Hydroxybenzoate nonaprenyltransferase inhibitor
0,459  0,068  Alkylacetylglycerophosphatase inhibitor
0,422  0,034  Calcium regulator
0,432  0,046  Cyclic AMP phosphodiesterase inhibitor
0,409  0,026  Hydroxylamine reductase (NADH) inhibitor
0,408  0,024  Uroporphyrinogen-III synthase inhibitor
0,417  0,033  4-Methoxybenzoate monooxygenase (O-demethylating) inhibitor
0,457  0,076  Penicillin binding protein antagonist
0,457  0,076  Penicillin-binding protein ampH inhibitor
0,412  0,032  Leukotriene-C4 synthase inhibitor
0,485  0,105  Glycosylphosphatidylinositol phospholipase D inhibitor
0,439  0,063  Dimethylargininase inhibitor
0,453  0,079  Lysase inhibitor
0,451  0,078  Glucan endo-1,3-beta-D-glucosidase inhibitor
0,434  0,061  Membrane integrity antagonist
0,452  0,080  Anorexiant
0,406  0,038  Urethanase inhibitor
0,456  0,091  Collagen inhibitor
0,414  0,049  Cytochrome P450 stimulant
0,406  0,042  Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase inhibitor
0,406  0,050  Cyclohexanone monooxygenase inhibitor
0,411  0,060  Aspartate-phenylpyruvate transaminase inhibitor
0,403  0,052  ADP-thymidine kinase inhibitor
0,408  0,060  HIV rev inhibitor
0,403  0,056  Methylamine-glutamate N-methyltransferase inhibitor
0,413  0,078  Cyclic AMP agonist
0,429  0,094  Glyceryl-ether monooxygenase inhibitor
0,407  0,072  Dehydro-L-gulonate decarboxylase inhibitor
0,406  0,071  Nitrate reductase (cytochrome) inhibitor
0,422  0,102  Insulin growth factor agonist
0,422  0,102  Insulin like growth factor 1 agonist
0,410  0,092  Acylcarnitine hydrolase inhibitor
0,429  0,111  Omptin inhibitor
0,406  0,135  Acetylcholine neuromuscular blocking agent
0,421  0,172  Transferase inhibitor

>  <Metabolism>
0,780  0,002  CYP2E1 inducer
0,809  0,034  CYP2C12 substrate
0,763  0,007  CYP2C8 substrate
0,766  0,014  GST A substrate
0,760  0,008  CYP2A substrate
0,758  0,007  CYP2A6 substrate
0,758  0,010  CYP2B6 substrate
0,741  0,037  CYP2J substrate
0,707  0,003  CYP4A substrate
0,709  0,007  CYP2E substrate
0,705  0,007  CYP2E1 substrate
0,696  0,003  CYP4 substrate
0,694  0,004  CYP2C18 substrate
0,655  0,015  CYP2C9 substrate
0,645  0,023  CYP2C substrate
0,608  0,007  CYP4A11 substrate
0,597  0,005  FMO1 substrate
0,609  0,019  CYP2C8 inhibitor
0,593  0,015  CYP2F1 substrate
0,577  0,008  CYP1A inducer
0,583  0,022  UDP-glucuronosyltransferase substrate
0,551  0,005  UGT1A7 substrate
0,560  0,018  CYP2C19 substrate
0,548  0,006  UGT1A10 substrate
0,557  0,019  CYP1A2 substrate
0,550  0,025  CYP2B5 substrate
0,537  0,026  CYP2D6 substrate
0,515  0,005  CYP2C6 substrate
0,533  0,028  CYP2A1 substrate
0,518  0,018  UGT1A substrate
0,522  0,025  CYP2A4 substrate
0,530  0,041  CYP2 substrate
0,495  0,009  UGT1A3 substrate
0,534  0,057  CYP3A2 substrate
0,485  0,012  CYP1A inhibitor
0,502  0,031  CYP2D substrate
0,471  0,002  CYP4A1 substrate
0,480  0,016  GST P substrate
0,489  0,027  CYP2B substrate
0,465  0,004  CYP1A1 inhibitor
0,459  0,003  CYP4F2 substrate
0,483  0,030  CYP1A substrate
0,479  0,031  CYP1 substrate
0,463  0,014  UGT2B4 substrate
0,491  0,052  CYP3A1 substrate
0,452  0,016  CYP1A2 inhibitor
0,461  0,030  CYP2C11 substrate
0,451  0,021  CYP3A7 substrate
0,442  0,017  GST M substrate
0,440  0,016  GST P1-1 substrate
0,473  0,056  CYP2B6 inhibitor
0,426  0,016  Peroxidase substrate
0,429  0,022  CYP1A1 substrate
0,421  0,017  UGT1A1 substrate
0,448  0,053  CYP3A5 substrate
0,411  0,036  CYP2C9 inducer
0,448  0,074  CYP3A4 substrate
0,402  0,043  CYP2D2 inhibitor
0,407  0,084  CYP3A substrate

>  <Toxicity>
0,826  0,004  Irritation
0,780  0,016  Hyponatremia
0,784  0,022  Hemolysis
0,758  0,004  Ulcer, gastric
0,761  0,009  Hypercholesterolemic
0,758  0,020  Alopecia (hair loss)
0,747  0,013  Non mutagenic, Salmonella
0,731  0,018  Gastrointestinal hemorrhage
0,714  0,005  Fatty liver
0,716  0,008  Sensitization
0,685  0,004  Ulcer, peptic
0,695  0,030  Ulcer, esophageal
0,678  0,019  Hypomagnesemia
0,660  0,005  Ulceration
0,694  0,050  Eye pain
0,683  0,040  Diarrhea
0,674  0,039  Toxic, vascular
0,699  0,067  Lichenoid eruption
0,670  0,040  Photophobia
0,644  0,018  Cataract
0,628  0,005  Skin irritation, moderate
0,653  0,036  Neurotoxic
0,640  0,030  Optic neuritis
0,651  0,044  Ocular toxicity
0,638  0,033  Optic neuropathy
0,631  0,026  Fibrosis, interstitial
0,650  0,051  Hot flush
0,647  0,065  Anemia, hemolytic
0,601  0,029  Panic
0,638  0,070  Cerebral hemorrhage
0,619  0,062  Hypoxia
0,590  0,034  Pseudoporphyria
0,611  0,060  Sleep disturbance
0,613  0,067  Hemorrhage
0,601  0,059  Drowsiness
0,637  0,099  Shivering
0,562  0,028  Urine discoloration
0,580  0,053  Proteinuria
0,585  0,063  Dry eye
0,598  0,078  Electrolyte imbalance
0,569  0,052  Hematemesis
0,593  0,077  Renal insufficiency
0,558  0,048  Apnea
0,590  0,083  Myocardial ischemia
0,566  0,063  Hepatotoxic
0,576  0,076  Ulcer, aphthous
0,567  0,068  Hepatitis
0,575  0,077  Neuritis
0,568  0,072  Erectile dysfunction
0,549  0,053  Weight loss
0,507  0,014  Skin irritative effect
0,558  0,073  Pancreatitis
0,503  0,017  Ophthalmoplegia
0,488  0,007  Hypoglycemic
0,560  0,080  Muscle rigidity
0,525  0,048  Parkinsonism
0,490  0,018  Carcinogenic, mouse, male
0,560  0,089  Chest pain
0,535  0,074  Weakness
0,509  0,052  Keratitis
0,477  0,021  Carcinogenic, mouse
0,538  0,083  Toxic, respiration
0,480  0,026  Lacrimal secretion stimulant
0,540  0,092  Rhinitis
0,511  0,064  Anemia
0,531  0,088  Myocardial infarction
0,499  0,056  Keratopathy
0,501  0,059  Hypothermic
0,501  0,063  Muscle weakness
0,491  0,053  Dyspnea
0,446  0,010  Renal papillary necrosis
0,505  0,070  Nephritis
0,504  0,070  Edema
0,529  0,097  Psychosexual disorder
0,488  0,058  Hirsutism
0,487  0,066  Colitis
0,476  0,055  Glaucoma
0,499  0,079  Hypotension
0,505  0,089  Psychoses
0,455  0,039  Fasciculation
0,523  0,108  Arthralgia
0,455  0,045  Pulmonary edema
0,503  0,093  Asthma
0,491  0,081  Toxic
0,495  0,086  Extrapyramidal effect
0,495  0,088  Scleroderma
0,491  0,088  Nasal congestion
0,500  0,098  Toxic, gastrointestinal
0,457  0,056  Teratogen
0,475  0,074  Hematuria
0,461  0,064  Immunotoxin
0,452  0,058  Gastrointestinal disturbance
0,481  0,089  Bronchoconstrictor
0,423  0,032  Cardiodepressant
0,522  0,139  Ejaculation dysfunction
0,475  0,093  Inflammation
0,473  0,091  Behavioral disturbance
0,480  0,099  Hypotonia
0,454  0,075  Ototoxicity
0,491  0,115  Myalgia
0,473  0,099  Toxic epidermal necrolysis
0,405  0,031  Henoch-Schonlein purpura
0,452  0,080  Anorexiant
0,483  0,111  Sexual dysfunction
0,454  0,083  Acidosis, metabolic
0,491  0,122  Heart failure
0,437  0,069  Systemic lupus erythematosus
0,475  0,108  Malaise
0,468  0,101  Memory impairment
0,472  0,106  Insomnia
0,422  0,061  Embryotoxic
0,444  0,085  Respiratory failure
0,402  0,047  Myasthenia Gravis
0,440  0,088  Neutropenia
0,470  0,124  Withdrawal
0,462  0,116  Vasculitis
0,456  0,115  Erythema
0,430  0,092  Nephrotic syndrome
0,465  0,130  Dyspepsia
0,419  0,086  Aseptic meningitis
0,423  0,089  Postural (orthostatic) hypotension
0,453  0,122  Hyperglycemic
0,402  0,073  Dysphoria
0,431  0,103  Depression
0,417  0,088  Allergic dermatitis
0,462  0,135  Reproductive dysfunction
0,451  0,125  Cardiogenic shock
0,447  0,122  Syncope
0,463  0,139  Nystagmus
0,422  0,107  Nephrotoxic
0,428  0,120  Hematotoxic
0,418  0,117  Galactorrhea
0,435  0,135  Osteoporosis
0,424  0,126  Drug eruption
0,432  0,134  Xerostomia
0,418  0,125  Amnesia
0,422  0,130  Vision disturbance
0,421  0,129  Gait disturbance
0,426  0,136  Hyperbilirubinemia
0,407  0,118  Acidosis
0,437  0,151  Abdominal pain
0,423  0,139  Aggression
0,418  0,135  Stroke
0,414  0,137  Purpura
0,422  0,146  Shock
0,404  0,139  Allergic reaction
0,411  0,149  Constipation
0,402  0,145  Nightmare
0,406  0,154  Chills
0,401  0,149  Anxiety
0,400  0,152  Consciousness alteration

>  <Transporter>
0,538  0,035  Basolateral Na-K-Cl symporter inhibitor

>  <Murcko.CdId>
4453

>  <Murcko.Mol Weight>
78.1118

>  <Murcko.Formula>
C6H6

>  <Murcko.AKOS_NUMBER>
AKOS000109189

>  <Murcko.IntegerID>
4452

$$$$

  Mrv0541 04281317412D          

 12 12  0  0  0  0            999 V2000
    6.7875   -6.8042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2167   -6.8042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5000   -6.3917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0667   -6.3917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7917   -7.6292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2167   -7.6375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3542   -6.8042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9375   -6.3917    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0792   -8.0417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3542   -7.6292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0750   -5.5667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0792   -8.8667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  3  1  0  0  0  0
  3  1  1  0  0  0  0
  4  1  2  0  0  0  0
  5  1  1  0  0  0  0
  6  2  2  0  0  0  0
  7  4  1  0  0  0  0
  8  2  1  0  0  0  0
  9  5  2  0  0  0  0
 10  9  1  0  0  0  0
 11  4  1  0  0  0  0
 12  9  1  0  0  0  0
 10  7  2  0  0  0  0
M  END
>  <CdId>
6631

>  <Mol Weight>
163.2163

>  <Formula>
C10H13NO

>  <AKOS_NUMBER>
AKOS005134226

>  <Lipinski's Rule of Five>
0

>  <XLogP (text field)>
1.30

>  <PASS_MNA_NEW_COUNT>
0

>  <PASS_RESULT_COUNT>
   29 of   464 Possible Pharmacological Effects at Pa > 0.400
  181 of  3850 Possible Mechanisms of Action at Pa > 0.400
  203 of   321 Possible Toxic and Adverse Effects at Pa > 0.400
    3 of   118 Possible Antitargets at Pa > 0.400
   11 of   195 Possible Metabolism-Related Actions at Pa > 0.400
  407 of  1610 Possible Gene Expression Regulation at Pa > 0.400
    0 of    68 Possible Transporters-Related Actions at Pa > 0.400

>  <Effects>
0,750  0,009  Antidyskinetic
0,724  0,033  Antiseborrheic
0,695  0,010  Kidney function stimulant
0,692  0,026  Fibrinolytic
0,578  0,018  Potassium sparing diuretic
0,573  0,024  Antibacterial activity enhancer
0,557  0,028  Leukopoiesis stimulant
0,539  0,026  Erythropoiesis stimulant
0,559  0,056  Mucositis treatment
0,507  0,032  Antinociceptive
0,509  0,047  Alopecia treatment
0,498  0,038  Antihypoxic
0,473  0,023  Leukopoiesis inhibitor
0,461  0,022  Carminative
0,479  0,046  Vasoprotector
0,432  0,012  Acaricide
0,498  0,083  Acute neurologic disorders treatment
0,442  0,031  Antimyopathies
0,428  0,023  Skeletal muscle relaxant
0,403  0,025  Antipyretic
0,505  0,129  Neuroprotector
0,436  0,063  Antianginal
0,447  0,074  Preneoplastic conditions treatment
0,447  0,078  Cytoprotectant
0,418  0,057  Anticonvulsant
0,443  0,093  Ovulation inhibitor
0,417  0,106  Antinephrotoxic
0,459  0,166  Nootropic
0,410  0,156  Antineurotic

>  <Antitargets>
0,811  0,029  Ubiquinol-cytochrome-c reductase inhibitor
0,461  0,047  Superoxide dismutase inhibitor
0,403  0,047  GABA aminotransferase inhibitor

>  <Gene_Expression>
0,784  0,017  C10ORF116 expression enhancer
0,747  0,014  SLC16A2 expression enhancer
0,738  0,009  PRNP expression enhancer
0,727  0,009  HSP27 expression enhancer
0,718  0,008  CRABP2 expression inhibitor
0,728  0,021  IFNGR1 expression enhancer
0,718  0,012  MAOB expression enhancer
0,722  0,030  ABCC5 expression enhancer
0,732  0,043  PDXK expression inhibitor
0,697  0,009  SLC6A2 expression inhibitor
0,735  0,049  CXCR1 expression enhancer
0,690  0,012  ITGA6 expression inhibitor
0,698  0,022  PTGR1 expression enhancer
0,708  0,037  GSTA1 expression enhancer
0,689  0,024  PRTN3 expression enhancer
0,710  0,046  STAT5B expression enhancer
0,718  0,055  NAA15 expression inhibitor
0,686  0,024  MACF1 expression inhibitor
0,690  0,038  APOM expression enhancer
0,689  0,036  CD44 expression inhibitor
0,688  0,036  GTF2F1 expression inhibitor
0,683  0,035  NOM1 expression inhibitor
0,683  0,034  PLIN2 expression enhancer
0,694  0,049  MYL6 expression enhancer
0,687  0,041  ILF3 expression inhibitor
0,654  0,009  PRDX6 expression enhancer
0,715  0,074  LPL expression enhancer
0,673  0,033  FGF2 expression inhibitor
0,657  0,016  SESN2 expression enhancer
0,682  0,044  CNN1 expression enhancer
0,643  0,006  CYP17A1 expression inhibitor
0,690  0,054  GPX1 expression inhibitor
0,670  0,035  DHRS2 expression enhancer
0,672  0,037  ITGB2 expression enhancer
0,654  0,025  GSTM3 expression inhibitor
0,651  0,033  DDX18 expression inhibitor
0,655  0,039  IGFBP6 expression inhibitor
0,621  0,006  DENND5A expression enhancer
0,645  0,033  PKM2 expression enhancer
0,634  0,022  CTTN expression inhibitor
0,664  0,054  PLAU expression inhibitor
0,631  0,021  ADD3 expression enhancer
0,646  0,038  TMSB4X expression inhibitor
0,627  0,020  POR expression enhancer
0,662  0,055  SERPINB5 expression inhibitor
0,621  0,015  PPP2CB expression enhancer
0,613  0,008  IFIT1 expression enhancer
0,654  0,052  SUZ12 expression inhibitor
0,633  0,031  CCND2 expression enhancer
0,630  0,028  EFEMP1 expression inhibitor
0,662  0,061  ITGB6 expression inhibitor
0,624  0,024  PLA2G4A expression enhancer
0,631  0,033  GSTM2 expression inhibitor
0,622  0,028  WISP2 expression inhibitor
0,648  0,056  FANCC expression inhibitor
0,613  0,021  HS6ST2 expression inhibitor
0,649  0,058  BST2 expression enhancer
0,610  0,020  JUNB expression inhibitor
0,611  0,021  TM4SF1 expression enhancer
0,649  0,061  TXNRD1 expression inhibitor
0,644  0,061  OAS2 expression enhancer
0,631  0,052  SRPK1 expression inhibitor
0,619  0,041  ACTA2 expression inhibitor
0,640  0,062  MAPT expression enhancer
0,602  0,026  JUND expression inhibitor
0,613  0,037  TNFRSF11A expression enhancer
0,586  0,011  ST7 expression inhibitor
0,615  0,041  C3 expression enhancer
0,600  0,027  ALDH1A3 expression inhibitor
0,594  0,023  SP2 expression inhibitor
0,604  0,033  NR3C1 expression inhibitor
0,588  0,018  SASH1 expression inhibitor
0,624  0,055  AHR expression inhibitor
0,600  0,032  VAT1 expression enhancer
0,577  0,009  MAP3K8 expression enhancer
0,607  0,040  BIRC3 expression enhancer
0,584  0,018  TNFAIP3 expression enhancer
0,600  0,036  FKBP8 expression inhibitor
0,611  0,048  JAG1 expression inhibitor
0,591  0,031  ASXL1 expression inhibitor
0,591  0,031  C11ORF68 expression enhancer
0,591  0,031  CAPN7 expression inhibitor
0,591  0,031  FAM208A expression inhibitor
0,591  0,031  NKTR expression inhibitor
0,591  0,031  RABGAP1 expression inhibitor
0,591  0,031  SETD2 expression inhibitor
0,591  0,031  TIA1 expression inhibitor
0,591  0,031  TTC3 expression inhibitor
0,563  0,005  IFIT2 expression enhancer
0,594  0,037  PDCD4 expression inhibitor
0,596  0,039  WFDC2 expression enhancer
0,634  0,079  DUSP4 expression enhancer
0,582  0,029  DDX42 expression enhancer
0,556  0,004  HIVEP2 expression enhancer
0,584  0,033  RPS19 expression inhibitor
0,584  0,033  SIRT1 expression inhibitor
0,584  0,034  CDC16 expression inhibitor
0,582  0,033  ADAM17 expression inhibitor
0,582  0,033  CTBP1 expression inhibitor
0,590  0,044  IL1A expression inhibitor
0,592  0,047  EPRS expression inhibitor
0,576  0,031  CD86 expression enhancer
0,567  0,023  ANXA1 expression inhibitor
0,603  0,059  PLAUR expression enhancer
0,587  0,044  MAF expression enhancer
0,575  0,033  AKR1C1 expression enhancer
0,577  0,036  SF1 expression inhibitor
0,566  0,026  CYP11A1 expression inhibitor
0,568  0,028  SCARB1 expression enhancer
0,615  0,076  STAR expression enhancer
0,584  0,047  ITGB1 expression inhibitor
0,565  0,027  PELI1 expression inhibitor
0,543  0,006  PELI1 expression enhancer
0,541  0,007  BCL2A1 expression enhancer
0,573  0,039  CPNE1 expression enhancer
0,554  0,020  EGR3 expression inhibitor
0,565  0,033  CEP57 expression inhibitor
0,589  0,058  FILIP1L expression inhibitor
0,560  0,029  IL2RA expression inhibitor
0,574  0,044  NT5DC2 expression enhancer
0,574  0,044  RAI14 expression enhancer
0,574  0,044  RFTN1 expression enhancer
0,533  0,004  FILIP1L expression enhancer
0,582  0,054  NBN expression inhibitor
0,584  0,056  MYB expression enhancer
0,560  0,032  TUBA1A expression inhibitor
0,580  0,053  CDCA5 expression enhancer
0,553  0,027  NFKBIA expression enhancer
0,577  0,051  ID2 expression enhancer
0,553  0,030  BMP1 expression inhibitor
0,588  0,065  GADD45A expression inhibitor
0,534  0,015  CAPN2 expression inhibitor
0,569  0,051  TNFSF10 expression enhancer
0,563  0,045  TMPRSS2 expression inhibitor
0,550  0,035  CREB1 expression inhibitor
0,561  0,047  AHR expression enhancer
0,554  0,044  IGF2 expression inhibitor
0,563  0,053  TRAK2 expression enhancer
0,529  0,020  ALDH4A1 expression inhibitor
0,565  0,057  ETV5 expression inhibitor
0,576  0,070  HIF1A expression enhancer
0,574  0,068  CD36 expression inhibitor
0,530  0,023  IGFBP5 expression inhibitor
0,576  0,071  UNG expression inhibitor
0,555  0,052  NAT1 expression enhancer
0,548  0,046  STRBP expression inhibitor
0,579  0,078  HMGB1 expression inhibitor
0,611  0,111  HSPD1 expression inhibitor
0,564  0,064  BAD expression inhibitor
0,567  0,069  SERPINB5 expression enhancer
0,533  0,036  EZR expression inhibitor
0,533  0,036  GAK expression inhibitor
0,533  0,036  TERF1 expression inhibitor
0,578  0,082  VDR expression enhancer
0,542  0,048  CAV1 expression inhibitor
0,516  0,023  PPARA expression enhancer
0,544  0,051  NOS2 expression enhancer
0,533  0,042  SIDT2 expression enhancer
0,544  0,053  SEPT2 expression inhibitor
0,550  0,060  IL6 expression inhibitor
0,539  0,049  HSPA1A expression inhibitor
0,538  0,048  CLDN4 expression enhancer
0,522  0,032  ST3GAL1 expression enhancer
0,536  0,048  NOL5A expression inhibitor
0,522  0,034  PRDX2 expression enhancer
0,537  0,050  ID1 expression inhibitor
0,513  0,026  MDK expression enhancer
0,531  0,045  NOC3L expression inhibitor
0,512  0,026  SLC7A11 expression enhancer
0,531  0,046  ATP2A2 expression enhancer
0,530  0,046  ATM expression enhancer
0,502  0,018  PIR expression enhancer
0,518  0,036  SUV420H1 expression inhibitor
0,564  0,082  NFKB1 expression enhancer
0,483  0,002  HNRPLL expression enhancer
0,521  0,041  HMGA1 expression inhibitor
0,519  0,040  KPNB1 expression enhancer
0,538  0,059  CASP9 expression enhancer
0,535  0,056  RNF4 expression inhibitor
0,531  0,053  PSMC1 expression enhancer
0,516  0,039  DDX24 expression inhibitor
0,536  0,060  NPM3 expression inhibitor
0,536  0,060  PTEN expression inhibitor
0,487  0,014  IFIT3 expression enhancer
0,509  0,037  INCENP expression inhibitor
0,533  0,063  SLC16A4 expression enhancer
0,531  0,065  ALCAM expression inhibitor
0,518  0,053  NAA15 expression enhancer
0,510  0,045  COL4A1 expression inhibitor
0,556  0,092  EZH2 expression inhibitor
0,517  0,053  HAPLN3 expression inhibitor
0,466  0,003  RAB8B expression enhancer
0,501  0,039  MTHFD2 expression inhibitor
0,501  0,041  CDK5 expression enhancer
0,506  0,047  CYB5R2 expression enhancer
0,462  0,003  STX11 expression enhancer
0,503  0,043  SAT expression enhancer
0,515  0,056  IL1R1 expression inhibitor
0,511  0,053  FAS expression inhibitor
0,527  0,069  KRCC1 expression enhancer
0,496  0,039  PIM1 expression inhibitor
0,532  0,076  MCM6 expression enhancer
0,502  0,047  HLA-F expression enhancer
0,511  0,056  CPE expression inhibitor
0,456  0,003  ZCCHC2 expression enhancer
0,497  0,044  PTN expression enhancer
0,508  0,056  CUTL1 expression inhibitor
0,494  0,042  PLA2G2A expression enhancer
0,485  0,034  IGFBP2 expression inhibitor
0,523  0,074  EIF2S1 expression enhancer
0,474  0,025  SST expression inhibitor
0,500  0,053  MAP1B expression enhancer
0,506  0,060  STAT3 expression inhibitor
0,518  0,072  IL1RN expression inhibitor
0,505  0,060  TNS3 expression enhancer
0,497  0,053  PRRX1 expression inhibitor
0,508  0,064  CDK4 expression inhibitor
0,495  0,051  DTYMK expression enhancer
0,507  0,064  TFDP2 expression inhibitor
0,487  0,045  CTSD expression inhibitor
0,505  0,065  ORC4 expression enhancer
0,473  0,033  PLA2G16 expression enhancer
0,473  0,033  TCEB3 expression inhibitor
0,521  0,083  MMP7 expression enhancer
0,488  0,050  HSD11B2 expression enhancer
0,474  0,037  CSNK1D expression inhibitor
0,474  0,037  SPATA20 expression enhancer
0,479  0,043  WAS expression enhancer
0,482  0,046  KLF10 expression inhibitor
0,475  0,039  CSF2 expression enhancer
0,449  0,015  SOD2 expression inhibitor
0,451  0,018  HERPUD1 expression inhibitor
0,495  0,064  SOX9 expression enhancer
0,483  0,052  PA2G4 expression inhibitor
0,475  0,047  AKR1C2 expression enhancer
0,440  0,012  CXCR4 expression enhancer
0,499  0,071  IL18 expression inhibitor
0,474  0,048  PSAT1 expression inhibitor
0,473  0,048  MCM7 expression inhibitor
0,476  0,052  LAMC1 expression enhancer
0,451  0,028  CDK1 expression enhancer
0,470  0,047  ITGB7 expression enhancer
0,469  0,046  TFDP1 expression inhibitor
0,451  0,028  CSDA expression inhibitor
0,469  0,046  CALM3 expression enhancer
0,467  0,045  YWHAH expression inhibitor
0,468  0,047  TNNT1 expression inhibitor
0,501  0,080  THBD expression enhancer
0,473  0,052  HIST1H4B expression inhibitor
0,462  0,042  ME1 expression enhancer
0,466  0,048  BORA expression inhibitor
0,456  0,038  ISYNA1 expression enhancer
0,469  0,051  C1S expression enhancer
0,458  0,040  RPL7A expression inhibitor
0,451  0,034  CLDN5 expression enhancer
0,491  0,074  CDK2 expression inhibitor
0,465  0,049  BRD2 expression enhancer
0,465  0,049  NENF expression enhancer
0,465  0,049  SRRM2 expression inhibitor
0,465  0,049  ZCCHC2 expression inhibitor
0,454  0,039  COL5A2 expression inhibitor
0,455  0,041  BAG5 expression inhibitor
0,445  0,031  TGOLN2 expression inhibitor
0,444  0,029  BTG1 expression enhancer
0,483  0,070  NASP expression inhibitor
0,514  0,101  CYR61 expression enhancer
0,477  0,064  VCAM1 expression enhancer
0,479  0,067  DDIT4 expression enhancer
0,449  0,038  TMSB4X expression enhancer
0,451  0,042  CDKN1B expression inhibitor
0,450  0,042  SMAD3 expression enhancer
0,469  0,061  ISG15 expression enhancer
0,458  0,052  ASAH1 expression enhancer
0,478  0,073  CDC25B expression enhancer
0,467  0,063  FUBP1 expression inhibitor
0,460  0,056  TRIM16 expression enhancer
0,442  0,038  DPP4 expression enhancer
0,482  0,078  MGMT expression enhancer
0,506  0,104  ITGB1 expression enhancer
0,468  0,065  HSPA1A expression enhancer
0,419  0,017  AKR1B10 expression enhancer
0,465  0,064  MYB expression inhibitor
0,436  0,035  REL expression enhancer
0,452  0,052  HNRPC expression inhibitor
0,446  0,046  HMGN2 expression inhibitor
0,472  0,073  CCNE2 expression inhibitor
0,442  0,042  GPX2 expression enhancer
0,472  0,073  MEGF9 expression inhibitor
0,488  0,090  MYBL1 expression enhancer
0,448  0,050  CDKN1C expression inhibitor
0,479  0,082  CCNA2 expression enhancer
0,497  0,100  TOP1 expression inhibitor
0,462  0,065  HLA-G expression enhancer
0,447  0,050  SF3B5 expression enhancer
0,429  0,033  PTPRK expression inhibitor
0,445  0,048  ALDOA expression enhancer
0,457  0,061  GRPEL1 expression inhibitor
0,440  0,046  FEN1 expression inhibitor
0,447  0,054  AHRR expression enhancer
0,439  0,046  HSBP1 expression inhibitor
0,486  0,094  PRKAR2B expression enhancer
0,484  0,093  SFPQ expression enhancer
0,447  0,056  CDH1 expression enhancer
0,476  0,086  HMBS expression inhibitor
0,445  0,055  NR1H2 expression inhibitor
0,434  0,044  TPO expression enhancer
0,478  0,089  EDN1 expression enhancer
0,469  0,080  CP expression enhancer
0,470  0,082  COL2A1 expression enhancer
0,425  0,039  PPP1R3C expression inhibitor
0,486  0,100  KPNA2 expression inhibitor
0,416  0,031  LRP8 expression inhibitor
0,448  0,064  FUS expression inhibitor
0,430  0,047  TUBB3 expression enhancer
0,478  0,096  MT1A expression enhancer
0,431  0,049  MYBL2 expression inhibitor
0,453  0,072  NEIL3 expression inhibitor
0,455  0,074  NAV1 expression inhibitor
0,410  0,029  GARS expression inhibitor
0,469  0,089  NR4A2 expression enhancer
0,442  0,062  CYP4A11 expression enhancer
0,425  0,046  IGFBP5 expression enhancer
0,453  0,074  CALR expression inhibitor
0,405  0,026  CTH expression inhibitor
0,444  0,065  MAP2K1 expression enhancer
0,461  0,083  ICAM1 expression enhancer
0,435  0,057  IL1A expression enhancer
0,426  0,048  POLE2 expression inhibitor
0,431  0,054  TK1 expression inhibitor
0,426  0,050  CARS expression inhibitor
0,444  0,069  DFFA expression inhibitor
0,439  0,064  VIM expression inhibitor
0,455  0,080  SPP1 expression enhancer
0,426  0,053  IMPDH2 expression enhancer
0,453  0,080  TNFSF10 expression inhibitor
0,423  0,050  PDAP1 expression inhibitor
0,454  0,081  PCDH8 expression enhancer
0,448  0,076  OS9 expression enhancer
0,430  0,059  DLEU2 expression enhancer
0,446  0,075  YWHAE expression inhibitor
0,410  0,041  RXRA expression enhancer
0,429  0,061  FOSL1 expression enhancer
0,401  0,035  ITPR1 expression inhibitor
0,414  0,048  ATR expression inhibitor
0,414  0,048  EFNA4 expression inhibitor
0,414  0,048  MARK3 expression inhibitor
0,414  0,048  SMAD1 expression inhibitor
0,409  0,044  JUN expression inhibitor
0,435  0,070  CDC25C expression inhibitor
0,416  0,052  DEK expression inhibitor
0,433  0,070  GNL3 expression inhibitor
0,411  0,049  CCNC expression inhibitor
0,468  0,107  STAT1 expression inhibitor
0,440  0,080  DUSP5 expression enhancer
0,421  0,062  EPHA3 expression inhibitor
0,410  0,050  FOXC1 expression enhancer
0,434  0,075  MVP expression enhancer
0,427  0,068  MAPK8 expression inhibitor
0,435  0,077  SNAI2 expression inhibitor
0,432  0,074  DAB2 expression enhancer
0,436  0,079  AKT1 expression enhancer
0,414  0,057  EPAS1 expression enhancer
0,419  0,064  ANAPC1 expression enhancer
0,405  0,051  EHD1 expression enhancer
0,420  0,067  NPTX2 expression enhancer
0,402  0,050  NCF1 expression enhancer
0,402  0,050  RECQL expression inhibitor
0,417  0,065  S100A10 expression enhancer
0,401  0,051  PTEN expression enhancer
0,421  0,074  TIMP3 expression enhancer
0,428  0,082  CBX1 expression inhibitor
0,401  0,054  TGFBI expression enhancer
0,465  0,120  JUN expression enhancer
0,409  0,064  EPHB4 expression inhibitor
0,409  0,064  NMT1 expression inhibitor
0,440  0,097  VEGFA expression enhancer
0,441  0,098  BIRC2 expression inhibitor
0,403  0,060  ALPL expression enhancer
0,418  0,076  IL4 expression enhancer
0,414  0,074  ADSL expression inhibitor
0,411  0,070  IER3 expression inhibitor
0,451  0,113  CASP3 expression enhancer
0,436  0,099  TNF expression enhancer
0,407  0,070  SERPINE2 expression enhancer
0,409  0,075  RRM2 expression inhibitor
0,430  0,097  PRKCA expression enhancer
0,417  0,084  MLF1 expression enhancer
0,412  0,079  CD14 expression enhancer
0,448  0,116  BAX expression enhancer
0,404  0,072  DEPTOR expression enhancer
0,406  0,076  TUBA4A expression enhancer
0,429  0,100  ELL2 expression enhancer
0,408  0,082  ASNS expression inhibitor
0,406  0,084  PRSS23 expression enhancer
0,405  0,084  JAK2 expression inhibitor
0,405  0,084  TBC1D1 expression inhibitor
0,428  0,108  APOA1 expression inhibitor
0,445  0,128  ZFP36 expression enhancer
0,404  0,096  CEACAM6 expression enhancer
0,424  0,117  TERT expression enhancer
0,401  0,097  TNFRSF21 expression enhancer
0,414  0,110  BCL2L1 expression inhibitor
0,408  0,105  PCNA expression enhancer
0,423  0,126  VEGFA expression inhibitor
0,409  0,114  MMP2 expression inhibitor
0,409  0,121  KPNA1 expression enhancer
0,401  0,123  CD38 expression enhancer

>  <Mechanisms>
0,864  0,005  NACHT, LRR and PYD domains-containing protein 1 inhibitor
0,797  0,008  Omptin inhibitor
0,844  0,057  Transferase stimulant
0,811  0,029  Ubiquinol-cytochrome-c reductase inhibitor
0,793  0,020  Mucomembranous protector
0,773  0,004  Endopeptidase So inhibitor
0,772  0,006  Glutamine-phenylpyruvate transaminase inhibitor
0,760  0,007  Macrophage colony stimulating factor agonist
0,759  0,009  Venombin AB inhibitor
0,733  0,009  Polyamine-transporting ATPase inhibitor
0,725  0,010  Fatty-acyl-CoA synthase inhibitor
0,718  0,005  Insulin promoter
0,737  0,031  Polyporopepsin inhibitor
0,695  0,010  Kidney function stimulant
0,677  0,014  2-Hydroxymuconate-semialdehyde hydrolase inhibitor
0,680  0,017  Dimethylargininase inhibitor
0,671  0,015  Pterin deaminase inhibitor
0,666  0,024  Complement factor D inhibitor
0,668  0,032  Pro-opiomelanocortin converting enzyme inhibitor
0,653  0,019  Muramoyltetrapeptide carboxypeptidase inhibitor
0,643  0,014  Limulus clotting factor C inhibitor
0,650  0,024  UDP-N-acetylglucosamine 4-epimerase inhibitor
0,634  0,010  Cathepsin T inhibitor
0,633  0,017  Hydrogen dehydrogenase inhibitor
0,627  0,012  Aspartate-ammonia ligase inhibitor
0,629  0,017  Oxygen scavenger
0,618  0,011  Mannan endo-1,4-beta-mannosidase inhibitor
0,621  0,015  Fibrolase inhibitor
0,621  0,026  Fragilysin inhibitor
0,607  0,024  Insulysin inhibitor
0,630  0,048  Sugar-phosphatase inhibitor
0,582  0,003  Sodium channel blocker class Ib
0,593  0,018  All-trans-retinyl-palmitate hydrolase inhibitor
0,612  0,041  Acylcarnitine hydrolase inhibitor
0,597  0,026  Phosphatidylserine decarboxylase inhibitor
0,576  0,008  Gingipain K inhibitor
0,578  0,018  Potassium sparing diuretic
0,562  0,004  Picornain 3C inhibitor
0,589  0,033  Arginine 2-monooxygenase inhibitor
0,567  0,013  Alanine-tRNA ligase inhibitor
0,586  0,032  Lysine 2,3-aminomutase inhibitor
0,568  0,018  Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase inhibitor
0,574  0,026  L-glutamate oxidase inhibitor
0,566  0,018  N-formylmethionyl-peptidase inhibitor
0,601  0,056  Taurine dehydrogenase inhibitor
0,551  0,010  Chitosanase inhibitor
0,566  0,027  Biotinidase inhibitor
0,565  0,028  Gluconate 5-dehydrogenase inhibitor
0,551  0,017  Peptide alpha-N-acetyltransferase inhibitor
0,607  0,073  Membrane integrity agonist
0,554  0,026  MAP kinase stimulant
0,555  0,030  Adenomatous polyposis treatment
0,552  0,030  Insulin growth factor agonist
0,552  0,030  Insulin like growth factor 1 agonist
0,541  0,022  Methylumbelliferyl-acetate deacetylase inhibitor
0,596  0,078  Transferase inhibitor
0,532  0,018  Benzodiazepine omega receptor agonist
0,531  0,018  Aspergillopepsin I inhibitor
0,539  0,026  Erythropoiesis stimulant
0,520  0,008  Urease inhibitor
0,525  0,015  Albendazole monooxygenase inhibitor
0,545  0,036  Exoribonuclease II inhibitor
0,537  0,029  Methylamine-glutamate N-methyltransferase inhibitor
0,540  0,032  Cl--transporting ATPase inhibitor
0,573  0,067  Chlordecone reductase inhibitor
0,557  0,054  NADPH peroxidase inhibitor
0,523  0,020  N-benzyloxycarbonylglycine hydrolase inhibitor
0,515  0,013  Arylesterase inhibitor
0,547  0,047  Acetylcholine neuromuscular blocking agent
0,538  0,038  Platelet adhesion inhibitor
0,520  0,020  (R)-Pantolactone dehydrogenase (flavin) inhibitor
0,531  0,032  Formaldehyde transketolase inhibitor
0,542  0,048  Platelet aggregation stimulant
0,509  0,022  HERG 1 channel blocker
0,530  0,047  Anorexiant
0,504  0,027  Renal tissue kallikrein inhibitor
0,498  0,023  S-alkylcysteine lyase inhibitor
0,512  0,038  Ecdysone 20-monooxygenase inhibitor
0,507  0,034  Phenol O-methyltransferase inhibitor
0,511  0,038  Pin1 inhibitor
0,503  0,032  NAD(P)+-arginine ADP-ribosyltransferase inhibitor
0,505  0,035  3-Hydroxybenzoate 6-monooxygenase inhibitor
0,509  0,041  Cyclic AMP antagonist
0,521  0,053  Phospholipid-translocating ATPase inhibitor
0,517  0,051  Glucan endo-1,3-beta-D-glucosidase inhibitor
0,488  0,022  Isopenicillin-N epimerase inhibitor
0,500  0,037  Linoleate diol synthase inhibitor
0,506  0,044  Alkane 1-monooxygenase inhibitor
0,498  0,035  Sulfur reductase inhibitor
0,507  0,051  Collagen inhibitor
0,470  0,016  D-alanine 2-hydroxymethyltransferase inhibitor
0,497  0,044  Protein-tyrosine phosphatase alpha inhibitor
0,504  0,055  Alkylacetylglycerophosphatase inhibitor
0,461  0,012  N-Acyl-D-amino-acid deacylase inhibitor
0,481  0,032  Chenodeoxycholoyltaurine hydrolase inhibitor
0,497  0,050  Glucose oxidase inhibitor
0,461  0,014  DNA-3-methyladenine glycosylase I inhibitor
0,517  0,071  Nicotinic alpha2beta2 receptor antagonist
0,489  0,044  Neurotransmitter antagonist
0,463  0,019  Glycolate dehydrogenase inhibitor
0,483  0,050  Fibrinogen receptor antagonist
0,495  0,065  Penicillin binding protein antagonist
0,495  0,065  Penicillin-binding protein ampH inhibitor
0,452  0,023  Carboxypeptidase D inhibitor
0,451  0,023  Mannose isomerase inhibitor
0,442  0,014  Serine-pyruvate transaminase inhibitor
0,446  0,019  Yeast ribonuclease inhibitor
0,441  0,015  Phenylalanine(histidine) transaminase inhibitor
0,426  0,004  Renilla-luciferin 2-monooxygenase inhibitor
0,444  0,024  Cyclohexyl-isocyanide hydratase inhibitor
0,458  0,038  Arylsulfate sulfotransferase inhibitor
0,427  0,008  Aspergillopepsin II inhibitor
0,473  0,054  Lipoprotein lipase inhibitor
0,458  0,040  Centromere associated protein inhibitor
0,421  0,003  Tyrosine kinase stimulant
0,444  0,027  Glucan 1,4-alpha-maltotetraohydrolase inhibitor
0,436  0,019  Sphinganine-1-phosphate aldolase inhibitor
0,436  0,019  Glucuronate isomerase inhibitor
0,439  0,022  Neuropeptide Y2 antagonist
0,473  0,058  Glutathione thiolesterase inhibitor
0,461  0,047  Superoxide dismutase inhibitor
0,445  0,031  Arylmalonate decarboxylase inhibitor
0,452  0,039  Glucan 1,4-alpha-maltotriohydrolase inhibitor
0,427  0,015  Gamma-glutamyltransferase inhibitor
0,463  0,053  Nitrate reductase (cytochrome) inhibitor
0,435  0,028  2-Haloacid dehalogenase inhibitor
0,445  0,038  Ferredoxin-NAD+ reductase inhibitor
0,445  0,038  Naphthalene 1,2-dioxygenase inhibitor
0,437  0,032  Pitrilysin inhibitor
0,446  0,041  S-formylglutathione hydrolase inhibitor
0,451  0,048  Aspartate-phenylpyruvate transaminase inhibitor
0,418  0,015  Subtilisin inhibitor
0,412  0,012  Prunasin beta-glucosidase inhibitor
0,465  0,067  27-Hydroxycholesterol 7alpha-monooxygenase inhibitor
0,416  0,019  GABA C receptor agonist
0,429  0,032  NADH kinase inhibitor
0,424  0,028  Opheline kinase inhibitor
0,424  0,028  Taurocyamine kinase inhibitor
0,466  0,070  Thioredoxin inhibitor
0,500  0,105  DNA ligase 1 inhibitor
0,410  0,016  Nardilysin inhibitor
0,464  0,070  Carboxypeptidase Taq inhibitor
0,443  0,049  5 Hydroxytryptamine release inhibitor
0,468  0,074  Lysase inhibitor
0,425  0,032  (-)-(4S)-limonene synthase inhibitor
0,411  0,019  Glycine dehydrogenase (decarboxylating) inhibitor
0,410  0,020  Oxidizing agent
0,419  0,028  H+-exporting ATPase inhibitor
0,421  0,031  4-Hydroxyphenylacetate 3-monooxygenase inhibitor
0,430  0,040  Prostaglandin-A1 DELTA-isomerase inhibitor
0,414  0,027  DELTA14-sterol reductase inhibitor
0,418  0,032  Adenylyl-sulfate reductase inhibitor
0,433  0,048  Fucosterol-epoxide lyase inhibitor
0,410  0,028  Diamine N-acetyltransferase inhibitor
0,446  0,063  Dehydro-L-gulonate decarboxylase inhibitor
0,426  0,045  Acetylesterase inhibitor
0,438  0,060  Membrane integrity antagonist
0,401  0,026  Taurine-2-oxoglutarate transaminase inhibitor
0,409  0,034  Sulfite oxidase inhibitor
0,438  0,063  Cyclic AMP agonist
0,427  0,053  Peptidyl-dipeptidase Dcp inhibitor
0,440  0,067  Glucan endo-1,6-beta-glucosidase inhibitor
0,402  0,030  Fructan beta-fructosidase inhibitor
0,411  0,039  Malate oxidase inhibitor
0,409  0,038  Enteropeptidase inhibitor
0,417  0,047  Plastoquinol-plastocyanin reductase inhibitor
0,447  0,078  Cytoprotectant
0,442  0,074  Alkenylglycerophosphocholine hydrolase inhibitor
0,424  0,058  Manganese peroxidase inhibitor
0,421  0,056  HIV rev inhibitor
0,435  0,070  Histamine release inhibitor
0,413  0,049  ADP-thymidine kinase inhibitor
0,456  0,093  Gastrin inhibitor
0,438  0,078  Galanin receptor antagonist
0,403  0,047  GABA aminotransferase inhibitor
0,447  0,092  Oxidoreductase inhibitor
0,422  0,070  Histamine release stimulant
0,492  0,153  Membrane permeability inhibitor
0,438  0,126  Glycosylphosphatidylinositol phospholipase D inhibitor
0,459  0,166  Nootropic
0,438  0,158  Phosphatase inhibitor

>  <Metabolism>
0,722  0,043  CYP2J substrate
0,640  0,067  CYP2C12 substrate
0,521  0,011  CYP4A1 inhibitor
0,495  0,024  FMO1 substrate
0,501  0,035  CYP2D16 substrate
0,481  0,037  CYP2A8 substrate
0,461  0,039  CYP2F1 substrate
0,474  0,064  GST A substrate
0,459  0,063  CYP2B6 inhibitor
0,419  0,033  CYP2C9 inducer
0,430  0,048  CYP2B5 substrate

>  <Toxicity>
0,830  0,037  Bone marrow suppression
0,814  0,022  Hyperactivity
0,758  0,005  Cardiogenic shock
0,736  0,016  Apnea
0,752  0,057  Shivering
0,721  0,037  Ulcer, aphthous
0,700  0,024  Dry eye
0,701  0,028  Ulcer, esophageal
0,696  0,027  Memory impairment
0,684  0,023  Withdrawal
0,707  0,047  Eye pain
0,691  0,035  Hypoxia
0,664  0,010  Acneiform eruption
0,714  0,060  Lichenoid eruption
0,678  0,030  Hypercholesterolemic
0,678  0,031  Postural (orthostatic) hypotension
0,675  0,030  Lymphocytosis
0,668  0,032  Aggression
0,662  0,027  Proteinuria
0,656  0,021  Fibrosis, interstitial
0,660  0,034  Hematemesis
0,672  0,050  Renal insufficiency
0,664  0,042  Photophobia
0,632  0,012  Systemic lupus erythematosus
0,663  0,047  Hyponatremia
0,670  0,057  Cerebral hemorrhage
0,634  0,024  Hypersexuality
0,669  0,061  Stroke
0,648  0,042  Euphoria
0,650  0,046  Heart failure
0,646  0,043  Psychomotor impairment
0,632  0,032  Asthma
0,621  0,022  Colitis
0,649  0,062  Myocardial ischemia
0,650  0,064  Anemia, hemolytic
0,641  0,062  Rhinitis
0,589  0,013  Bullous pemphigoid
0,626  0,051  Pancreatitis
0,619  0,045  Lethargy
0,608  0,037  Scleroderma
0,600  0,031  Pseudoporphyria
0,602  0,039  Desquamation
0,615  0,054  Xerostomia
0,583  0,023  ANCA-positive vasculitis
0,621  0,061  Hot flush
0,610  0,050  Ectropion
0,632  0,074  Dysesthesia
0,624  0,070  Electrolyte imbalance
0,598  0,044  Drug eruption
0,584  0,031  Keratitis
0,586  0,034  Allergic dermatitis
0,598  0,051  Weakness
0,589  0,043  Bradycardic
0,577  0,033  Panic
0,600  0,057  Hepatitis
0,575  0,035  Hypomagnesemia
0,601  0,061  Toxic, respiration
0,561  0,024  Raynaud's phenomenon
0,574  0,041  Coma
0,565  0,038  Pancytopenia
0,587  0,061  Pure red cell aplasia
0,587  0,060  Erectile dysfunction
0,594  0,073  Hyperreflexia
0,595  0,074  Hemorrhage
0,547  0,026  Interstitial nephritis
0,589  0,070  Dyspepsia
0,583  0,067  Malaise
0,544  0,030  Adrenal cortex hypoplasia
0,589  0,078  Chest pain
0,554  0,043  Nephritis
0,532  0,022  Anemia, sideroblastic
0,549  0,040  Keratopathy
0,583  0,078  Nystagmus
0,553  0,050  Respiratory impairment
0,545  0,042  Aseptic meningitis
0,574  0,072  Alopecia (hair loss)
0,567  0,064  Enuresis
0,567  0,067  Gastrointestinal hemorrhage
0,548  0,049  Depression
0,532  0,034  Eosinophilia
0,568  0,070  Myocardial infarction
0,531  0,042  Hyperuricemia
0,572  0,086  Arthralgia
0,557  0,071  Vasculitis
0,503  0,018  Carcinogenic, rat, male
0,547  0,063  Amnesia
0,528  0,045  Choreoathetosis
0,530  0,047  Anorexiant
0,558  0,075  Constipation
0,491  0,016  Carcinogenic, rat, female
0,555  0,082  Vertigo
0,507  0,037  Cholestasis
0,502  0,035  Serum sickness
0,495  0,029  Demyelination
0,536  0,071  Nightmare
0,544  0,080  Allergic reaction
0,518  0,055  Tremor
0,531  0,071  Jaundice
0,528  0,071  Hyperbilirubinemia
0,535  0,077  Psychoses
0,498  0,042  Dysphoria
0,489  0,034  Urine discoloration
0,548  0,096  Abdominal pain
0,463  0,017  Pemphigus
0,511  0,068  Edema
0,513  0,070  Anaphylaxis
0,520  0,078  Status epilepticus
0,519  0,078  Tachycardiac
0,529  0,093  Mania
0,519  0,088  Insomnia
0,500  0,069  Ataxia
0,513  0,084  Anxiety
0,511  0,082  Vision disturbance
0,506  0,078  Confusion
0,513  0,085  Purpura
0,505  0,079  Ocular toxicity
0,521  0,098  Hiccups
0,520  0,101  Psychosexual disorder
0,454  0,034  Thrombocytopoiesis inhibitor
0,501  0,083  Toxic epidermal necrolysis
0,506  0,088  Erythema
0,506  0,089  Pruritus
0,468  0,052  Laryngospasm
0,501  0,087  Urticaria
0,515  0,102  Myalgia
0,508  0,096  Stomatitis
0,443  0,031  Cleft palate
0,460  0,049  Visual acuity impairment
0,439  0,029  Vasopressor
0,449  0,039  Methemoglobinemia
0,496  0,090  Consciousness alteration
0,479  0,074  Agitation
0,463  0,059  Hallucinogen
0,472  0,072  Muscle weakness
0,468  0,069  Yawning
0,490  0,091  Thrombophlebitis
0,492  0,094  Hemolysis
0,498  0,100  Nausea
0,507  0,110  Reproductive dysfunction
0,421  0,024  Carcinogenic, rat
0,440  0,045  Fasciculation
0,490  0,096  Drowsiness
0,462  0,069  Splenomegaly
0,466  0,074  Hyperthermic
0,467  0,076  Enterocolitis
0,496  0,107  Fibrillation, atrial
0,491  0,105  Thrombocytopenia
0,458  0,072  Allergic contact dermatitis
0,476  0,092  Bronchoconstrictor
0,467  0,085  Acidosis
0,461  0,080  Dyskinesia
0,462  0,086  Weight loss
0,478  0,103  Emetic
0,434  0,062  Porphyria
0,460  0,089  Galactorrhea
0,468  0,098  Inflammation
0,424  0,067  Chorea
0,415  0,060  Peripheral neuropathy
0,452  0,100  Hypertensive
0,450  0,099  Extrapyramidal effect
0,435  0,087  Nephrotic syndrome
0,462  0,114  Headache
0,415  0,067  Acidosis, lactic
0,484  0,136  Neuritis
0,467  0,121  Shock
0,443  0,101  Arrhythmogenic
0,460  0,119  Hyperglycemic
0,452  0,111  Sensory disturbance
0,430  0,092  Respiratory failure
0,463  0,126  Migraine
0,448  0,112  Gait disturbance
0,451  0,116  Erythema multiforme
0,438  0,104  Leukopenia
0,407  0,077  Gastrointestinal disturbance
0,432  0,108  Paralysis
0,442  0,119  Excitability
0,458  0,136  Muscle rigidity
0,436  0,116  Hematotoxic
0,412  0,093  Agranulocytosis
0,437  0,121  Dizziness
0,441  0,126  Syncope
0,462  0,148  Leukocytosis
0,426  0,112  Behavioral disturbance
0,434  0,122  Dermatitis
0,475  0,163  Ejaculation dysfunction
0,403  0,092  Neurotoxic
0,428  0,120  Sleep disturbance
0,437  0,134  Osteoporosis
0,430  0,127  Pain
0,421  0,122  Hirsutism
0,409  0,114  Parotid gland enlargement
0,420  0,126  Hepatic necrosis
0,418  0,128  Toxic, gastrointestinal
0,402  0,113  Cataract
0,404  0,116  Anorgasmia
0,401  0,120  Neutropenia
0,420  0,139  Exanthema
0,408  0,128  Injection site pain
0,411  0,131  Necrosis
0,408  0,146  Diplopia
0,416  0,158  Optic neuritis
0,402  0,147  Paranoia
0,404  0,155  Chills

>  <Murcko.CdId>
6631

>  <Murcko.Mol Weight>
78.1118

>  <Murcko.Formula>
C6H6

>  <Murcko.AKOS_NUMBER>
AKOS005134226

>  <Murcko.IntegerID>
6630

$$$$

  Mrv0541 04281317412D          

 10 10  0  0  0  0            999 V2000
    0.7146    0.4173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0004    0.8289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7146   -0.4140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7112    0.4090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7112   -0.4140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0004   -0.8256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0087    1.6519    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4221    0.8206    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4255   -0.8256    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0004   -1.6486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  2  0  0  0  0
  3  1  1  0  0  0  0
  4  2  1  0  0  0  0
  5  6  1  0  0  0  0
  6  3  2  0  0  0  0
  7  2  1  0  0  0  0
  8  4  1  0  0  0  0
  9  3  1  0  0  0  0
 10  6  1  0  0  0  0
  4  5  2  0  0  0  0
M  END
>  <CdId>
6692

>  <Mol Weight>
156.613

>  <Formula>
C7H9ClN2

>  <AKOS_NUMBER>
AKOS000114358

>  <Lipinski's Rule of Five>
0

>  <XLogP (text field)>
0.59

>  <PASS_MNA_NEW_COUNT>
0

>  <PASS_RESULT_COUNT>
   33 of   464 Possible Pharmacological Effects at Pa > 0.400
  197 of  3850 Possible Mechanisms of Action at Pa > 0.400
  220 of   321 Possible Toxic and Adverse Effects at Pa > 0.400
    6 of   118 Possible Antitargets at Pa > 0.400
   31 of   195 Possible Metabolism-Related Actions at Pa > 0.400
  658 of  1610 Possible Gene Expression Regulation at Pa > 0.400
    1 of    68 Possible Transporters-Related Actions at Pa > 0.400

>  <Effects>
0,728  0,032  Antiseborrheic
0,662  0,010  Leukopoiesis stimulant
0,655  0,025  Antidyskinetic
0,640  0,010  Antiinfective
0,615  0,007  Antiseptic
0,590  0,014  Antinephrotoxic
0,568  0,020  Potassium sparing diuretic
0,538  0,005  Loop diuretic
0,535  0,005  Diuretic inhibitor
0,541  0,017  Eye irritation, inactive
0,530  0,013  Skin irritation, inactive
0,528  0,013  Antiparasitic
0,591  0,078  Neuroprotector
0,513  0,003  Antihelmintic (Fasciola)
0,537  0,027  Erythropoiesis stimulant
0,509  0,005  Antiprotozoal (Coccidial)
0,579  0,084  Fibrinolytic
0,532  0,038  Alopecia treatment
0,548  0,067  Kidney function stimulant
0,473  0,008  Antihelmintic
0,512  0,048  Preneoplastic conditions treatment
0,464  0,009  Acaricide
0,542  0,093  Antineurotic
0,496  0,075  Mucositis treatment
0,456  0,049  Respiratory analeptic
0,439  0,033  Dementia treatment
0,463  0,062  Lipid metabolism regulator
0,415  0,023  Acidifying agent non gastric
0,464  0,079  Ovulation inhibitor
0,436  0,060  Antihypoxic
0,428  0,054  Anticonvulsant
0,418  0,095  Antinociceptive
0,440  0,160  Antibacterial activity enhancer

>  <Antitargets>
0,872  0,011  Ubiquinol-cytochrome-c reductase inhibitor
0,556  0,004  Aryl hydrocarbon receptor agonist
0,471  0,026  GABA aminotransferase inhibitor
0,455  0,045  Peroxidase inhibitor
0,418  0,015  5 Hydroxytryptamine 2B agonist
0,406  0,064  Superoxide dismutase inhibitor

>  <Gene_Expression>
0,871  0,004  PLIN2 expression enhancer
0,842  0,014  SERPINB5 expression enhancer
0,831  0,004  MAOB expression enhancer
0,836  0,012  ABCC5 expression enhancer
0,824  0,005  MT1H expression enhancer
0,826  0,009  ID2 expression enhancer
0,814  0,007  PRKAR2B expression enhancer
0,812  0,008  VIM expression inhibitor
0,814  0,011  TIMP3 expression enhancer
0,808  0,005  GSTM3 expression inhibitor
0,806  0,006  IL1A expression inhibitor
0,811  0,013  CNN1 expression enhancer
0,803  0,014  APOM expression enhancer
0,798  0,011  IGFBP6 expression inhibitor
0,790  0,004  DFFB expression inhibitor
0,800  0,015  IL4 expression enhancer
0,791  0,009  ITGB1 expression inhibitor
0,789  0,008  SLC16A2 expression enhancer
0,779  0,009  PKM2 expression enhancer
0,789  0,020  BST2 expression enhancer
0,791  0,022  OAS2 expression enhancer
0,773  0,009  EFEMP1 expression inhibitor
0,771  0,007  PLA2G4A expression enhancer
0,774  0,012  IFNGR1 expression enhancer
0,775  0,017  NAT1 expression enhancer
0,769  0,011  SAT expression enhancer
0,772  0,015  ETV5 expression inhibitor
0,755  0,013  IGF2 expression inhibitor
0,755  0,013  NT5DC2 expression enhancer
0,755  0,013  RAI14 expression enhancer
0,755  0,013  RFTN1 expression enhancer
0,767  0,027  MAPT expression enhancer
0,747  0,009  NOS2 expression enhancer
0,745  0,008  TM4SF1 expression enhancer
0,739  0,005  POR expression enhancer
0,746  0,013  SOX9 expression enhancer
0,736  0,005  PELI1 expression inhibitor
0,746  0,016  SPP1 expression enhancer
0,782  0,054  HSPD1 expression inhibitor
0,747  0,022  JAG1 expression inhibitor
0,743  0,019  AHR expression enhancer
0,734  0,011  ATP2A2 expression enhancer
0,726  0,004  CIRBP expression inhibitor
0,741  0,023  CDCA5 expression enhancer
0,731  0,017  PRTN3 expression enhancer
0,753  0,038  ITGB1 expression enhancer
0,724  0,014  NPM3 expression inhibitor
0,724  0,014  PTEN expression inhibitor
0,723  0,014  WISP2 expression inhibitor
0,718  0,009  CREB1 expression inhibitor
0,728  0,019  TNFRSF11A expression enhancer
0,750  0,042  DUSP4 expression enhancer
0,720  0,012  STRBP expression inhibitor
0,724  0,017  SLC16A4 expression enhancer
0,719  0,013  NOC3L expression inhibitor
0,710  0,006  S100A10 expression enhancer
0,725  0,022  IL1RN expression inhibitor
0,716  0,014  CTSD expression inhibitor
0,716  0,014  CDKN1C expression inhibitor
0,727  0,026  GTF2F1 expression inhibitor
0,723  0,022  IL18 expression inhibitor
0,719  0,020  ALCAM expression inhibitor
0,714  0,015  CEACAM6 expression enhancer
0,729  0,030  PLAUR expression enhancer
0,725  0,027  FILIP1L expression inhibitor
0,710  0,012  IGFBP5 expression enhancer
0,715  0,018  WFDC2 expression enhancer
0,708  0,011  CYB5R2 expression enhancer
0,711  0,017  ITGB7 expression enhancer
0,707  0,014  VAT1 expression enhancer
0,713  0,021  F2R expression enhancer
0,705  0,013  HAPLN3 expression inhibitor
0,725  0,035  EZH2 expression inhibitor
0,695  0,007  HSBP1 expression inhibitor
0,731  0,044  PDXK expression inhibitor
0,692  0,004  AMHR2 expression inhibitor
0,694  0,008  IL9 expression inhibitor
0,690  0,004  LRP6 expression enhancer
0,691  0,008  AHRR expression enhancer
0,720  0,037  CYR61 expression enhancer
0,691  0,008  CSNK1D expression inhibitor
0,691  0,008  SPATA20 expression enhancer
0,695  0,014  MTHFD2 expression inhibitor
0,691  0,010  PLA2G2A expression enhancer
0,696  0,023  TNS3 expression enhancer
0,718  0,045  STAR expression enhancer
0,680  0,009  EIF2B4 expression enhancer
0,695  0,026  THBD expression enhancer
0,696  0,029  CDC25B expression enhancer
0,696  0,031  PRKCA expression enhancer
0,680  0,015  C1S expression enhancer
0,672  0,007  CCNC expression inhibitor
0,685  0,022  NEIL3 expression inhibitor
0,690  0,031  DHRS2 expression enhancer
0,681  0,024  HLA-G expression enhancer
0,665  0,009  DPP4 expression enhancer
0,693  0,037  AHR expression inhibitor
0,712  0,057  NAA15 expression inhibitor
0,664  0,010  EGR3 expression inhibitor
0,686  0,032  EIF2S1 expression enhancer
0,665  0,012  FTL expression enhancer
0,699  0,047  CD36 expression inhibitor
0,686  0,036  C10ORF116 expression enhancer
0,660  0,011  ANAPC1 expression enhancer
0,669  0,020  GNL3 expression inhibitor
0,661  0,015  PSAT1 expression inhibitor
0,694  0,050  STAT5B expression enhancer
0,665  0,022  MAFB expression inhibitor
0,677  0,034  NBN expression inhibitor
0,669  0,029  C3 expression enhancer
0,659  0,018  TNFSF10 expression enhancer
0,650  0,012  ST3GAL1 expression enhancer
0,655  0,018  POLE2 expression inhibitor
0,657  0,020  TRIM16 expression enhancer
0,653  0,017  PTN expression enhancer
0,646  0,011  PI4KA expression inhibitor
0,646  0,011  VCAN expression inhibitor
0,659  0,025  BAD expression inhibitor
0,643  0,010  REL expression enhancer
0,650  0,019  GRPEL1 expression inhibitor
0,644  0,015  CRABP2 expression inhibitor
0,694  0,064  CXCR1 expression enhancer
0,661  0,034  FN1 expression inhibitor
0,680  0,052  MYL6 expression enhancer
0,644  0,017  MVP expression enhancer
0,668  0,041  HIF1A expression enhancer
0,638  0,011  PLA2G16 expression enhancer
0,638  0,011  TCEB3 expression inhibitor
0,653  0,028  CPE expression inhibitor
0,632  0,007  PPL expression inhibitor
0,637  0,012  PAICS expression enhancer
0,628  0,005  RHOC expression enhancer
0,652  0,028  GSTM2 expression inhibitor
0,646  0,024  CD86 expression enhancer
0,640  0,018  DDX42 expression enhancer
0,635  0,013  PPP2CB expression enhancer
0,658  0,036  KRCC1 expression enhancer
0,678  0,057  GPX1 expression inhibitor
0,642  0,021  NPTX2 expression enhancer
0,699  0,078  LPL expression enhancer
0,646  0,026  HSPA1A expression inhibitor
0,631  0,015  ME1 expression enhancer
0,637  0,022  PLD1 expression enhancer
0,634  0,023  HSD11B2 expression enhancer
0,618  0,008  EPB41L2 expression inhibitor
0,630  0,021  KLK6 expression enhancer
0,630  0,021  PADI3 expression enhancer
0,621  0,014  KIAA0930 expression enhancer
0,632  0,025  CAV1 expression inhibitor
0,611  0,004  PIR expression enhancer
0,630  0,027  PRSS23 expression enhancer
0,620  0,019  SCARB1 expression enhancer
0,611  0,010  CYP17A1 expression enhancer
0,623  0,026  HLA-B expression enhancer
0,623  0,026  TFDP1 expression inhibitor
0,614  0,019  ISG15 expression enhancer
0,620  0,025  TUBA4A expression enhancer
0,604  0,010  PPARA expression enhancer
0,644  0,050  ILF3 expression inhibitor
0,620  0,027  LAMC1 expression enhancer
0,601  0,008  LRP8 expression inhibitor
0,618  0,025  ASXL1 expression inhibitor
0,618  0,025  C11ORF68 expression enhancer
0,618  0,025  CAPN7 expression inhibitor
0,618  0,025  FAM208A expression inhibitor
0,618  0,025  NKTR expression inhibitor
0,618  0,025  RABGAP1 expression inhibitor
0,618  0,025  SETD2 expression inhibitor
0,618  0,025  TIA1 expression inhibitor
0,618  0,025  TTC3 expression inhibitor
0,626  0,034  IL10 expression enhancer
0,623  0,031  FKBP8 expression inhibitor
0,626  0,035  MACF1 expression inhibitor
0,604  0,014  EPHA3 expression inhibitor
0,599  0,010  SH2D4A expression inhibitor
0,613  0,024  MYB expression inhibitor
0,598  0,009  IFIT1 expression enhancer
0,609  0,019  ITGA6 expression inhibitor
0,600  0,011  ALDH4A1 expression inhibitor
0,606  0,018  ADIPOR2 expression inhibitor
0,643  0,054  VDR expression enhancer
0,602  0,016  AOX1 expression enhancer
0,593  0,008  DNASE2 expression inhibitor
0,610  0,026  WIPI1 expression enhancer
0,601  0,017  PPARG expression enhancer
0,589  0,006  AKR1B10 expression enhancer
0,634  0,052  SRPK1 expression inhibitor
0,618  0,035  SEPT2 expression inhibitor
0,623  0,043  MYB expression enhancer
0,614  0,034  ELL2 expression enhancer
0,615  0,036  ID1 expression inhibitor
0,611  0,033  PCDH8 expression enhancer
0,593  0,015  HMGN2 expression inhibitor
0,592  0,015  PSRC1 expression inhibitor
0,595  0,018  IL6ST expression inhibitor
0,601  0,025  CEP57 expression inhibitor
0,605  0,031  SERPINE2 expression enhancer
0,587  0,013  BIK expression enhancer
0,591  0,018  ODZ3 expression inhibitor
0,591  0,018  TBC1D9 expression inhibitor
0,599  0,027  DAB2 expression enhancer
0,591  0,021  FEN1 expression inhibitor
0,597  0,027  MAP2K1 expression enhancer
0,603  0,033  NR3C1 expression inhibitor
0,593  0,023  SLC6A2 expression inhibitor
0,603  0,034  TERT expression enhancer
0,601  0,032  JAK2 expression inhibitor
0,601  0,032  TBC1D1 expression inhibitor
0,607  0,037  TNFRSF21 expression inhibitor
0,589  0,020  AP1S2 expression enhancer
0,579  0,010  PARP14 expression enhancer
0,588  0,021  NR5A2 expression enhancer
0,588  0,021  ZBTB10 expression inhibitor
0,627  0,061  FANCC expression inhibitor
0,595  0,033  SF1 expression inhibitor
0,585  0,024  SP2 expression inhibitor
0,590  0,029  BORA expression inhibitor
0,577  0,016  C5ORF32 expression enhancer
0,577  0,016  FAH expression enhancer
0,577  0,016  RRAS expression enhancer
0,577  0,016  SH3BGRL3 expression enhancer
0,600  0,040  CCND2 expression enhancer
0,603  0,044  NCOA2 expression enhancer
0,586  0,028  MMP2 expression enhancer
0,602  0,044  PDE9A expression inhibitor
0,571  0,013  S100P expression enhancer
0,579  0,022  TGFBI expression enhancer
0,581  0,024  CYP11A1 expression inhibitor
0,579  0,022  NR1H2 expression inhibitor
0,565  0,009  SHMT2 expression inhibitor
0,572  0,017  MDK expression inhibitor
0,563  0,007  MT1A expression inhibitor
0,586  0,031  CTTN expression inhibitor
0,574  0,020  SF3B5 expression enhancer
0,587  0,033  SLC1A1 expression enhancer
0,586  0,033  RPS19 expression inhibitor
0,586  0,033  SIRT1 expression inhibitor
0,576  0,023  SLC17A2 expression inhibitor
0,586  0,033  CDC16 expression inhibitor
0,569  0,017  NCF1 expression enhancer
0,570  0,019  IMPDH2 expression enhancer
0,581  0,031  JUND expression inhibitor
0,609  0,059  STAT1 expression inhibitor
0,561  0,012  CD47 expression inhibitor
0,563  0,014  GARS expression inhibitor
0,596  0,049  VEGFA expression inhibitor
0,606  0,060  ITGB2 expression enhancer
0,563  0,017  RPL7A expression inhibitor
0,592  0,046  DDX18 expression inhibitor
0,563  0,018  MT1F expression inhibitor
0,586  0,041  PTGR1 expression enhancer
0,614  0,069  NFKB1 expression enhancer
0,604  0,060  GADD45A expression inhibitor
0,558  0,016  CYP17A1 expression inhibitor
0,550  0,008  ALDH1A1 expression enhancer
0,560  0,018  DHCR24 expression enhancer
0,566  0,024  RRM2 expression enhancer
0,557  0,015  NEK4 expression inhibitor
0,612  0,070  SERPINB5 expression inhibitor
0,577  0,036  AKT1 expression enhancer
0,604  0,064  SUZ12 expression inhibitor
0,550  0,011  TMSB4X expression enhancer
0,584  0,046  TFDP2 expression inhibitor
0,557  0,019  LDOC1 expression inhibitor
0,557  0,019  RPRM expression inhibitor
0,585  0,047  ACTA2 expression inhibitor
0,572  0,035  ADAM17 expression inhibitor
0,572  0,035  CTBP1 expression inhibitor
0,558  0,021  IGFBP2 expression inhibitor
0,568  0,032  ALDH1A3 expression inhibitor
0,561  0,027  PIM1 expression enhancer
0,582  0,048  TNF expression enhancer
0,558  0,026  GPX2 expression enhancer
0,561  0,029  CLMN expression enhancer
0,586  0,055  ZFP36 expression enhancer
0,562  0,032  HIST1H4B expression inhibitor
0,556  0,027  YWHAH expression inhibitor
0,547  0,019  HNRNPH2 expression inhibitor
0,541  0,013  SLC31A1 expression enhancer
0,555  0,028  HSP27 expression enhancer
0,566  0,041  NAA15 expression enhancer
0,581  0,056  TP53 expression enhancer
0,556  0,033  TUBA1A expression inhibitor
0,551  0,029  UBE2C expression enhancer
0,531  0,010  MND1 expression inhibitor
0,544  0,023  TNFAIP3 expression enhancer
0,574  0,054  GSTA1 expression enhancer
0,565  0,046  PSMC1 expression enhancer
0,573  0,053  EPRS expression inhibitor
0,549  0,031  IL2RA expression inhibitor
0,533  0,016  ST7 expression inhibitor
0,550  0,033  HS6ST2 expression inhibitor
0,535  0,019  CYB5A expression enhancer
0,523  0,007  PELI1 expression enhancer
0,603  0,088  SLC2A4 expression enhancer
0,532  0,018  BFSP2 expression enhancer
0,532  0,018  EGLN3 expression enhancer
0,524  0,011  CTH expression inhibitor
0,569  0,056  TMSB4X expression inhibitor
0,542  0,030  RPS27L expression enhancer
0,525  0,013  CCL4 expression enhancer
0,519  0,007  PRUNE2 expression inhibitor
0,534  0,023  CSF2 expression enhancer
0,527  0,016  CBS expression inhibitor
0,545  0,034  ADD3 expression enhancer
0,533  0,022  TUBB3 expression enhancer
0,553  0,044  CPNE1 expression enhancer
0,515  0,007  NBL1 expression enhancer
0,537  0,029  ASAH1 expression enhancer
0,547  0,039  SIDT2 expression enhancer
0,517  0,010  AATK expression enhancer
0,517  0,010  C5AR1 expression inhibitor
0,517  0,010  CBL expression enhancer
0,517  0,010  CCL16 expression inhibitor
0,517  0,010  CCR5 expression enhancer
0,517  0,010  CKS1 expression inhibitor
0,517  0,010  GDF1 expression enhancer
0,517  0,010  GRO2 expression inhibitor
0,517  0,010  IFNAR1 expression inhibitor
0,517  0,010  IGHM expression inhibitor
0,517  0,010  IL3RA expression inhibitor
0,517  0,010  MST1 expression inhibitor
0,517  0,010  NFKBIE expression inhibitor
0,517  0,010  PLD expression inhibitor
0,517  0,010  PLD2 expression enhancer
0,517  0,010  POU2F1 expression enhancer
0,517  0,010  PSMB6 expression inhibitor
0,517  0,010  PTAFR expression inhibitor
0,517  0,010  RPS25 expression enhancer
0,517  0,010  SLC9A3R2 expression inhibitor
0,517  0,010  SMAD9 expression enhancer
0,517  0,010  STAT2 expression inhibitor
0,517  0,010  STK25 expression enhancer
0,517  0,010  UGP2 expression enhancer
0,526  0,019  NEU4 expression enhancer
0,526  0,019  SH3GL2 expression inhibitor
0,539  0,032  EGR1 expression inhibitor
0,522  0,016  PPP1R3C expression inhibitor
0,536  0,030  DEPTOR expression enhancer
0,540  0,036  KPNB1 expression enhancer
0,547  0,044  MAPK8 expression inhibitor
0,536  0,033  BMP1 expression inhibitor
0,516  0,014  GPR142 expression enhancer
0,548  0,046  IL1R1 expression inhibitor
0,535  0,034  LYN expression inhibitor
0,555  0,056  BIK expression inhibitor
0,537  0,037  CDH1 expression enhancer
0,518  0,020  PHGDH expression inhibitor
0,533  0,036  EZR expression inhibitor
0,533  0,036  GAK expression inhibitor
0,533  0,036  TERF1 expression inhibitor
0,526  0,029  CXCR7 expression inhibitor
0,514  0,019  CLGN expression inhibitor
0,527  0,032  MT2A expression enhancer
0,515  0,019  IRF7 expression enhancer
0,519  0,024  PTPRM expression enhancer
0,574  0,080  HMGB1 expression inhibitor
0,503  0,009  BCL2A1 expression enhancer
0,518  0,024  CTPS expression inhibitor
0,517  0,024  SPARC expression inhibitor
0,537  0,044  TXNIP expression inhibitor
0,540  0,048  ICAM1 expression enhancer
0,505  0,013  IFNG expression inhibitor
0,553  0,061  UGCG expression enhancer
0,516  0,025  GALNT1 expression inhibitor
0,502  0,011  MANSC1 expression inhibitor
0,560  0,071  MMP7 expression enhancer
0,539  0,050  CDKN1A expression enhancer
0,497  0,009  HOMER1 expression inhibitor
0,497  0,009  TNIK expression inhibitor
0,497  0,009  TRIB3 expression inhibitor
0,511  0,025  SC5DL expression enhancer
0,499  0,013  HSD17B1 expression enhancer
0,509  0,023  EZR expression enhancer
0,505  0,021  SST expression inhibitor
0,516  0,032  PDAP1 expression inhibitor
0,507  0,023  CYP11A1 expression enhancer
0,517  0,036  PRDX2 expression enhancer
0,504  0,024  MT1H expression inhibitor
0,513  0,032  G0S2 expression enhancer
0,511  0,032  SESN1 expression inhibitor
0,495  0,016  TRPV2 expression enhancer
0,509  0,031  IL1A expression enhancer
0,524  0,045  VAV3 expression inhibitor
0,550  0,072  NOM1 expression inhibitor
0,534  0,057  THBS1 expression enhancer
0,512  0,036  ERBB4 expression inhibitor
0,492  0,016  HIVEP1 expression enhancer
0,502  0,027  ID3 expression enhancer
0,526  0,051  FUBP1 expression inhibitor
0,486  0,012  CD59 expression enhancer
0,491  0,018  ASRGL1 expression enhancer
0,486  0,014  ZBTB1 expression enhancer
0,482  0,011  SOD2 expression inhibitor
0,531  0,061  MAF expression enhancer
0,495  0,025  LAMC2 expression enhancer
0,529  0,060  TRAK2 expression enhancer
0,498  0,029  COL5A2 expression inhibitor
0,492  0,023  HLA-E expression enhancer
0,490  0,022  INPP4B expression inhibitor
0,487  0,019  GATA1 expression enhancer
0,483  0,017  IL2 expression inhibitor
0,516  0,050  ATM expression enhancer
0,525  0,059  TNFSF10 expression inhibitor
0,483  0,017  S100A8 expression enhancer
0,519  0,054  STAT3 expression inhibitor
0,507  0,042  DDX24 expression inhibitor
0,494  0,030  MT1X expression inhibitor
0,488  0,024  LGALS3 expression enhancer
0,509  0,047  FOSL1 expression enhancer
0,477  0,015  PKP4 expression inhibitor
0,477  0,015  TUBGCP3 expression inhibitor
0,518  0,057  MGMT expression enhancer
0,551  0,090  JUN expression enhancer
0,523  0,062  CP expression enhancer
0,482  0,021  LYN expression enhancer
0,493  0,034  UGT1A1 expression enhancer
0,516  0,058  MEGF9 expression inhibitor
0,477  0,019  CEBPG expression inhibitor
0,486  0,028  FOS expression inhibitor
0,513  0,055  HSPA1A expression enhancer
0,493  0,035  SASH1 expression inhibitor
0,506  0,048  IER3 expression inhibitor
0,476  0,018  MFN2 expression enhancer
0,476  0,018  NEIL2 expression enhancer
0,481  0,024  TGOLN2 expression inhibitor
0,519  0,062  CCNE2 expression inhibitor
0,492  0,036  ANXA1 expression inhibitor
0,507  0,051  MAP1B expression enhancer
0,522  0,067  COL2A1 expression enhancer
0,478  0,023  LAMA3 expression enhancer
0,481  0,026  OLFM1 expression enhancer
0,507  0,052  CDC25C expression inhibitor
0,473  0,020  IGF1R expression enhancer
0,507  0,054  CLDN4 expression enhancer
0,491  0,038  PRDX6 expression enhancer
0,467  0,015  WDR67 expression inhibitor
0,487  0,035  MDK expression enhancer
0,514  0,062  RNF4 expression inhibitor
0,484  0,034  E2F1 expression inhibitor
0,491  0,041  SOX9 expression inhibitor
0,457  0,008  CCL5 expression enhancer
0,480  0,030  TPO expression enhancer
0,505  0,057  BIRC3 expression enhancer
0,467  0,019  TRIM24 expression inhibitor
0,481  0,035  BGLAP expression inhibitor
0,479  0,033  KIF15 expression inhibitor
0,503  0,058  ESR1 expression inhibitor
0,488  0,044  BRD2 expression enhancer
0,488  0,044  NENF expression enhancer
0,488  0,044  SRRM2 expression inhibitor
0,488  0,044  ZCCHC2 expression inhibitor
0,474  0,029  CLDN5 expression enhancer
0,476  0,032  SKP2 expression inhibitor
0,462  0,018  TNFRSF1A expression inhibitor
0,523  0,079  MCM6 expression enhancer
0,463  0,020  XPA expression enhancer
0,483  0,041  TK1 expression inhibitor
0,458  0,018  PDZK1 expression inhibitor
0,505  0,064  CCND1 expression inhibitor
0,463  0,024  CEBPD expression inhibitor
0,463  0,024  HADH expression enhancer
0,463  0,024  MELK expression enhancer
0,463  0,024  TFF3 expression enhancer
0,466  0,027  PDK1 expression inhibitor
0,458  0,020  ACSL3 expression inhibitor
0,481  0,046  CDK5 expression enhancer
0,478  0,043  TFF1 expression inhibitor
0,454  0,020  PSPH expression inhibitor
0,499  0,065  ABCB1 expression enhancer
0,485  0,052  CDKN2A expression enhancer
0,523  0,090  UNG expression inhibitor
0,466  0,033  VEGF expression enhancer
0,506  0,074  FGF2 expression inhibitor
0,465  0,033  JUN expression inhibitor
0,494  0,062  NAV1 expression inhibitor
0,454  0,023  EIF4E expression inhibitor
0,473  0,044  WAS expression enhancer
0,457  0,029  RXRA expression enhancer
0,443  0,015  ERCC3 expression enhancer
0,541  0,115  PLAU expression inhibitor
0,494  0,069  VEGFA expression enhancer
0,452  0,027  C22ORF29 expression enhancer
0,452  0,027  ETNK2 expression enhancer
0,461  0,036  GCLM expression enhancer
0,507  0,083  IL6 expression inhibitor
0,468  0,044  TP53I3 expression enhancer
0,492  0,069  ORC4 expression enhancer
0,470  0,047  INCENP expression inhibitor
0,489  0,068  PDCD4 expression inhibitor
0,442  0,021  CDKN2C expression enhancer
0,455  0,034  SNAI1 expression enhancer
0,437  0,016  TIPARP expression enhancer
0,470  0,049  AKR1C2 expression enhancer
0,479  0,058  ASNS expression inhibitor
0,472  0,052  PRNP expression enhancer
0,445  0,026  IFI30 expression enhancer
0,478  0,059  NOL5A expression inhibitor
0,481  0,062  SERPINE1 expression enhancer
0,482  0,064  CUTL1 expression inhibitor
0,476  0,058  PRRX1 expression inhibitor
0,452  0,034  S100A11 expression enhancer
0,430  0,013  CXCR4 expression enhancer
0,456  0,039  ATR expression inhibitor
0,456  0,039  EFNA4 expression inhibitor
0,456  0,039  MARK3 expression inhibitor
0,456  0,039  SMAD1 expression inhibitor
0,458  0,042  TRAM1 expression inhibitor
0,439  0,023  NFE2L2 expression enhancer
0,420  0,005  CYP11B2 expression enhancer
0,478  0,064  VCAM1 expression enhancer
0,446  0,032  CEBPD expression enhancer
0,431  0,018  DOK4 expression enhancer
0,448  0,035  CSF3 expression enhancer
0,458  0,045  HMOX1 expression enhancer
0,492  0,080  CASP9 expression enhancer
0,435  0,023  HEY2 expression enhancer
0,436  0,025  CAPN2 expression inhibitor
0,492  0,081  EDN1 expression enhancer
0,452  0,042  NFKBIA expression enhancer
0,423  0,013  ALDH1A3 expression enhancer
0,465  0,055  SLC2A3 expression inhibitor
0,461  0,052  EPHB4 expression inhibitor
0,461  0,052  NMT1 expression inhibitor
0,440  0,030  PTPRK expression inhibitor
0,469  0,061  COL4A1 expression inhibitor
0,425  0,020  MGST1 expression enhancer
0,439  0,033  DNMT1 expression inhibitor
0,426  0,022  GALNT4 expression enhancer
0,454  0,050  TNNT1 expression inhibitor
0,455  0,051  PIM1 expression inhibitor
0,418  0,015  GSN expression enhancer
0,430  0,027  TACC1 expression inhibitor
0,420  0,016  ARHGAP18 expression inhibitor
0,420  0,016  RHBDD2 expression enhancer
0,478  0,079  CDK4 expression inhibitor
0,417  0,018  FAM105A expression enhancer
0,417  0,018  KRT6A expression enhancer
0,423  0,024  BCAT1 expression inhibitor
0,415  0,017  PRKCA expression inhibitor
0,464  0,066  SLC3A2 expression enhancer
0,445  0,048  COL3A1 expression inhibitor
0,471  0,073  NASP expression inhibitor
0,419  0,022  LPL expression inhibitor
0,458  0,062  DTYMK expression enhancer
0,430  0,036  ESR1 expression enhancer
0,461  0,068  YWHAE expression inhibitor
0,438  0,044  CDKN1B expression inhibitor
0,440  0,047  FGFR3 expression inhibitor
0,417  0,024  HIST1H2BD expression enhancer
0,415  0,023  MAP3K8 expression enhancer
0,434  0,042  ISYNA1 expression enhancer
0,432  0,040  MAFF expression enhancer
0,435  0,045  PDK4 expression enhancer
0,413  0,024  B4GALT5 expression inhibitor
0,413  0,024  TLE3 expression inhibitor
0,429  0,039  PLAGL1 expression enhancer
0,439  0,049  ALDOA expression enhancer
0,409  0,021  MET expression enhancer
0,452  0,064  PA2G4 expression inhibitor
0,440  0,051  SUV420H1 expression inhibitor
0,405  0,019  TGFB2 expression inhibitor
0,424  0,038  BRF1 expression inhibitor
0,431  0,044  SLC26A2 expression inhibitor
0,411  0,026  HERPUD1 expression inhibitor
0,419  0,034  CALM1 expression enhancer
0,430  0,046  SMAD3 expression enhancer
0,403  0,020  IVNS1ABP expression inhibitor
0,453  0,069  TNFRSF21 expression enhancer
0,442  0,058  PTPRE expression enhancer
0,452  0,069  MLF1 expression enhancer
0,434  0,052  TIMP1 expression inhibitor
0,411  0,030  ACAN expression enhancer
0,417  0,036  TNFSF11 expression inhibitor
0,434  0,054  CRH expression inhibitor
0,409  0,029  CYP1A2 expression enhancer
0,402  0,022  IFIT2 expression enhancer
0,409  0,029  CYP19A1 expression inhibitor
0,445  0,065  FUS expression inhibitor
0,431  0,051  BTG2 expression enhancer
0,441  0,062  HLA-F expression enhancer
0,442  0,064  ADSL expression inhibitor
0,423  0,045  EHD1 expression enhancer
0,437  0,060  HMGA1 expression inhibitor
0,419  0,043  TNFRSF25 expression inhibitor
0,423  0,046  JUNB expression inhibitor
0,472  0,096  MYBL1 expression enhancer
0,400  0,025  CDCA3 expression inhibitor
0,472  0,096  SFPQ expression enhancer
0,458  0,083  FAS expression inhibitor
0,478  0,104  KPNA2 expression inhibitor
0,403  0,029  SLC16A1 expression inhibitor
0,409  0,035  CSDA expression inhibitor
0,418  0,044  CCNK expression inhibitor
0,464  0,092  HMBS expression inhibitor
0,406  0,034  NKX3-1 expression enhancer
0,427  0,056  SERPINA3 expression enhancer
0,460  0,089  CDK2 expression inhibitor
0,412  0,042  PHYH expression enhancer
0,402  0,033  MGST1 expression inhibitor
0,462  0,092  CCNA2 expression enhancer
0,417  0,048  SCML1 expression enhancer
0,417  0,048  SEPHS1 expression inhibitor
0,440  0,070  DFFA expression inhibitor
0,408  0,039  TNFRSF11B expression enhancer
0,437  0,068  AKR1C1 expression enhancer
0,427  0,058  LMNA expression inhibitor
0,418  0,050  HPN expression enhancer
0,417  0,048  FOXC1 expression enhancer
0,429  0,063  PMEPA1 expression inhibitor
0,413  0,047  RECQL expression inhibitor
0,443  0,078  CSE1L expression inhibitor
0,416  0,052  IL4 expression inhibitor
0,417  0,053  ZNF114 expression enhancer
0,476  0,113  TXNRD1 expression inhibitor
0,406  0,043  RBMS1 expression inhibitor
0,405  0,042  CDCA8 expression inhibitor
0,421  0,059  PGM2 expression enhancer
0,426  0,063  PTGS2 expression enhancer
0,436  0,074  CD44 expression inhibitor
0,412  0,050  DLX4 expression inhibitor
0,416  0,055  EPAS1 expression enhancer
0,409  0,048  GFPT2 expression enhancer
0,403  0,042  PLCB1 expression enhancer
0,414  0,055  MYBL2 expression inhibitor
0,418  0,061  CALM3 expression enhancer
0,433  0,078  SNAI2 expression inhibitor
0,403  0,047  APOBEC3B expression enhancer
0,407  0,054  DEK expression inhibitor
0,407  0,056  BDNF expression inhibitor
0,408  0,058  IGFBP5 expression inhibitor
0,408  0,059  FOXD1 expression inhibitor
0,409  0,061  CDK1 expression inhibitor
0,427  0,078  TMPRSS2 expression inhibitor
0,412  0,065  NKX3-1 expression inhibitor
0,425  0,078  CBX3 expression inhibitor
0,420  0,075  CD14 expression enhancer
0,411  0,068  CLMP expression inhibitor
0,407  0,064  F2R expression inhibitor
0,411  0,069  CDKN1A expression inhibitor
0,429  0,088  AGPS expression inhibitor
0,421  0,085  CALR expression inhibitor
0,411  0,077  BUB1B expression enhancer
0,436  0,102  APOA1 expression inhibitor
0,447  0,113  INHBE expression enhancer
0,444  0,111  MT1A expression enhancer
0,406  0,076  IL1B expression enhancer
0,401  0,072  MCM7 expression inhibitor
0,427  0,104  NR4A2 expression enhancer
0,424  0,109  BIRC2 expression inhibitor
0,411  0,096  DDIT4 expression enhancer
0,432  0,125  FOS expression enhancer
0,412  0,111  BCL2L1 expression inhibitor
0,406  0,106  PCNA expression enhancer
0,401  0,106  IL6 expression enhancer
0,423  0,130  TOP1 expression inhibitor
0,407  0,122  KPNA1 expression enhancer
0,405  0,145  CASP3 expression enhancer

>  <Mechanisms>
0,896  0,006  DNA ligase 1 inhibitor
0,896  0,028  Transferase stimulant
0,872  0,011  Ubiquinol-cytochrome-c reductase inhibitor
0,857  0,005  NACHT, LRR and PYD domains-containing protein 1 inhibitor
0,808  0,006  Complement factor D inhibitor
0,784  0,006  HIV rev inhibitor
0,771  0,016  NADPH peroxidase inhibitor
0,751  0,009  IgA-specific serine endopeptidase inhibitor
0,729  0,003  Myeloblastin inhibitor
0,728  0,005  Laccase inhibitor
0,730  0,028  Glycosylphosphatidylinositol phospholipase D inhibitor
0,714  0,012  2-Hydroxymuconate-semialdehyde hydrolase inhibitor
0,728  0,028  Membrane permeability inhibitor
0,709  0,019  Omptin inhibitor
0,693  0,005  Thiol oxidase inhibitor
0,695  0,011  L-glutamate oxidase inhibitor
0,697  0,014  Phospholipid-translocating ATPase inhibitor
0,696  0,015  Cl--transporting ATPase inhibitor
0,683  0,018  Venombin AB inhibitor
0,700  0,040  Chlordecone reductase inhibitor
0,678  0,019  UDP-N-acetylglucosamine 4-epimerase inhibitor
0,674  0,015  Pterin deaminase inhibitor
0,690  0,034  Taurine dehydrogenase inhibitor
0,640  0,010  Antiinfective
0,672  0,053  Transferase inhibitor
0,629  0,011  Cytochrome P450 stimulant
0,625  0,017  Linoleate diol synthase inhibitor
0,627  0,022  Fatty-acyl-CoA synthase inhibitor
0,618  0,017  Acetylcholine neuromuscular blocking agent
0,614  0,015  Centromere associated protein inhibitor
0,601  0,005  Endothelial growth factor antagonist
0,616  0,020  Arylsulfate sulfotransferase inhibitor
0,600  0,008  Cyclic AMP antagonist
0,618  0,031  Oxidoreductase inhibitor
0,659  0,075  Mucomembranous protector
0,587  0,013  GABA C receptor rho-3 antagonist
0,579  0,011  Sulfite oxidase inhibitor
0,594  0,027  Phosphatidylserine decarboxylase inhibitor
0,618  0,051  Sugar-phosphatase inhibitor
0,588  0,022  Endopeptidase So inhibitor
0,607  0,041  Lysase inhibitor
0,588  0,027  Polyamine-transporting ATPase inhibitor
0,590  0,029  Nitrate reductase (cytochrome) inhibitor
0,572  0,012  N-hydroxyarylamine O-acetyltransferase inhibitor
0,579  0,020  Aryl-acylamidase inhibitor
0,588  0,031  Alkane 1-monooxygenase inhibitor
0,556  0,004  Aryl hydrocarbon receptor agonist
0,563  0,014  Na+-transporting two-sector ATPase inhibitor
0,568  0,020  Potassium sparing diuretic
0,605  0,067  Polyporopepsin inhibitor
0,571  0,035  Platelet aggregation stimulant
0,546  0,012  Albendazole monooxygenase inhibitor
0,538  0,005  Loop diuretic
0,535  0,005  Diuretic inhibitor
0,538  0,009  Taurine-2-oxoglutarate transaminase inhibitor
0,603  0,074  Membrane integrity agonist
0,549  0,024  Creatininase inhibitor
0,529  0,005  D-amino-acid dehydrogenase inhibitor
0,559  0,038  Arginine 2-monooxygenase inhibitor
0,563  0,050  Acylcarnitine hydrolase inhibitor
0,536  0,023  Female germline-specific tumor suppressor gld-1 inhibitor
0,537  0,027  Erythropoiesis stimulant
0,555  0,045  Carboxypeptidase Taq inhibitor
0,542  0,038  Insulysin inhibitor
0,548  0,045  Dehydro-L-gulonate decarboxylase inhibitor
0,539  0,038  Dimethylargininase inhibitor
0,515  0,014  Tetrahydroxynaphthalene reductase inhibitor
0,505  0,004  Thiamine pyridinylase inhibitor
0,540  0,041  Lysine 2,3-aminomutase inhibitor
0,502  0,004  Sodium channel blocker class Ib
0,536  0,044  Glucose oxidase inhibitor
0,523  0,032  Neurotransmitter antagonist
0,536  0,046  Thioredoxin inhibitor
0,514  0,024  Benzodiazepine omega receptor agonist
0,514  0,024  Leukotriene-B4 20-monooxygenase inhibitor
0,517  0,032  Aspartate-phenylpyruvate transaminase inhibitor
0,494  0,011  3-Hydroxybenzoate 4-monooxygenase inhibitor
0,511  0,028  All-trans-retinyl-palmitate hydrolase inhibitor
0,497  0,015  Neuropeptide Y2 antagonist
0,548  0,067  Kidney function stimulant
0,496  0,017  Pyruvate decarboxylase inhibitor
0,530  0,053  Macrophage colony stimulating factor agonist
0,523  0,046  2-Hydroxyquinoline 8-monooxygenase inhibitor
0,499  0,023  S-alkylcysteine lyase inhibitor
0,512  0,038  Galanin receptor antagonist
0,485  0,011  Aminomuconate-semialdehyde dehydrogenase inhibitor
0,494  0,021  Alanine-tRNA ligase inhibitor
0,508  0,037  Fibrolase inhibitor
0,489  0,018  Chitosanase inhibitor
0,498  0,028  Hydroxylamine oxidase inhibitor
0,509  0,039  Hydrogen dehydrogenase inhibitor
0,515  0,047  27-Hydroxycholesterol 7alpha-monooxygenase inhibitor
0,489  0,022  Cutinase inhibitor
0,497  0,035  Sulfur reductase inhibitor
0,488  0,029  Nucleoside oxidase (H2O2-forming) inhibitor
0,508  0,050  Collagen inhibitor
0,490  0,032  Mannan endo-1,4-beta-mannosidase inhibitor
0,481  0,027  (R)-Pantolactone dehydrogenase (flavin) inhibitor
0,464  0,010  Interleukin antagonist
0,453  0,002  Interleukin 10 antagonist
0,487  0,037  ADP-thymidine kinase inhibitor
0,470  0,024  4-Hydroxyphenylacetate 3-monooxygenase inhibitor
0,478  0,033  Limulus clotting factor C inhibitor
0,471  0,026  GABA aminotransferase inhibitor
0,478  0,035  Glutamine-phenylpyruvate transaminase inhibitor
0,461  0,019  RNA-directed RNA polymerase inhibitor
0,482  0,042  Gluconate 5-dehydrogenase inhibitor
0,453  0,014  CDP-4-dehydro-6-deoxyglucose reductase inhibitor
0,478  0,041  3-Hydroxybenzoate 6-monooxygenase inhibitor
0,445  0,011  G-protein coupled receptor 35 antagonist
0,442  0,008  N6-methyl-lysine oxidase inhibitor
0,460  0,026  N-benzyloxycarbonylglycine hydrolase inhibitor
0,460  0,027  Nav1.6 sodium channel blocker
0,491  0,058  NACHT, LRR and PYD domains-containing protein 3 inhibitor
0,506  0,074  Nicotinic alpha2beta2 receptor antagonist
0,488  0,059  Alkylacetylglycerophosphatase inhibitor
0,463  0,034  Plastoquinol-plastocyanin reductase inhibitor
0,461  0,034  tRNA-pseudouridine synthase I inhibitor
0,460  0,035  Ferredoxin-NAD+ reductase inhibitor
0,460  0,035  Naphthalene 1,2-dioxygenase inhibitor
0,433  0,009  5 Hydroxytryptamine 1E antagonist
0,480  0,057  Glucan endo-1,6-beta-glucosidase inhibitor
0,451  0,029  Enteropeptidase inhibitor
0,479  0,057  Glutathione thiolesterase inhibitor
0,460  0,039  Galanin receptor 2 antagonist
0,424  0,004  Granzyme A inhibitor
0,442  0,022  DELTA14-sterol reductase inhibitor
0,442  0,025  DNA-(apurinic or apyrimidinic site) lyase inhibitor
0,490  0,074  Gastrin inhibitor
0,455  0,040  Spermicide
0,432  0,017  Linoleoyl-CoA desaturase inhibitor
0,482  0,068  Penicillin binding protein antagonist
0,482  0,068  Penicillin-binding protein ampH inhibitor
0,431  0,019  DNA-3-methyladenine glycosylase I inhibitor
0,427  0,015  Botulin neurotoxin A light chain inhibitor
0,430  0,018  Chaperonin ATPase inhibitor
0,455  0,045  Peroxidase inhibitor
0,430  0,020  D-alanine 2-hydroxymethyltransferase inhibitor
0,435  0,027  Opheline kinase inhibitor
0,435  0,027  Taurocyamine kinase inhibitor
0,444  0,038  Lysostaphin inhibitor
0,473  0,068  Glucan endo-1,3-beta-D-glucosidase inhibitor
0,466  0,062  Calmodulin antagonist
0,418  0,015  5 Hydroxytryptamine 2B agonist
0,454  0,052  Exoribonuclease II inhibitor
0,463  0,062  Lipid metabolism regulator
0,432  0,031  Aspartate-ammonia ligase inhibitor
0,440  0,040  Chenodeoxycholoyltaurine hydrolase inhibitor
0,410  0,010  3-Chloro-D-alanine dehydrochlorinase inhibitor
0,439  0,040  Cyclohexanone monooxygenase inhibitor
0,431  0,033  NADPH-ferrihemoprotein reductase inhibitor
0,425  0,029  Transitional endoplasmic reticulum ATPase inhibitor
0,404  0,008  Aryl-alcohol dehydrogenase inhibitor
0,442  0,047  Methylamine-glutamate N-methyltransferase inhibitor
0,439  0,047  (S)-6-hydroxynicotine oxidase inhibitor
0,415  0,023  Acidifying agent non gastric
0,422  0,033  Isopenicillin-N epimerase inhibitor
0,408  0,020  Thiopurine S-methyltransferase inhibitor
0,446  0,059  Fragilysin inhibitor
0,451  0,065  (R)-6-hydroxynicotine oxidase inhibitor
0,415  0,031  Cytochrome-b5 reductase inhibitor
0,433  0,049  Malate dehydrogenase (acceptor) inhibitor
0,417  0,032  G-protein coupled receptor 55 antagonist
0,416  0,032  2-Haloacid dehalogenase inhibitor
0,426  0,043  Glyoxylate reductase inhibitor
0,428  0,045  Amine dehydrogenase inhibitor
0,411  0,031  Carbon-monoxide dehydrogenase inhibitor
0,418  0,040  Cathepsin T inhibitor
0,414  0,038  Malate oxidase inhibitor
0,400  0,025  Para amino benzoic acid antagonist
0,441  0,067  Tyrosine-protein kinase BMX inhibitor
0,427  0,053  Phenol O-methyltransferase inhibitor
0,403  0,030  Coccolysin inhibitor
0,421  0,051  NAD(P)+-arginine ADP-ribosyltransferase inhibitor
0,439  0,070  MAP kinase stimulant
0,417  0,049  Membrane permeability enhancer
0,427  0,062  Aldehyde oxidase inhibitor
0,420  0,056  Formaldehyde transketolase inhibitor
0,413  0,049  Gamma-guanidinobutyraldehyde dehydrogenase inhibitor
0,422  0,060  Platelet derived growth factor receptor kinase inhibitor
0,436  0,076  Oxygen scavenger
0,413  0,054  S-formylglutathione hydrolase inhibitor
0,406  0,049  Glucan 1,4-alpha-maltotriohydrolase inhibitor
0,400  0,045  N-formylmethionyl-peptidase inhibitor
0,415  0,060  Kinase inhibitor
0,413  0,060  Nucleotide metabolism regulator
0,439  0,087  Anorexiant
0,409  0,062  Cholesterol antagonist
0,406  0,064  Superoxide dismutase inhibitor
0,452  0,110  Platelet adhesion inhibitor
0,404  0,065  Manganese peroxidase inhibitor
0,417  0,081  Alkenylglycerophosphocholine hydrolase inhibitor
0,401  0,064  Adenomatous polyposis treatment
0,411  0,075  Protein-tyrosine phosphatase alpha inhibitor
0,402  0,068  Feruloyl esterase inhibitor
0,405  0,116  Insulin growth factor agonist
0,405  0,116  Insulin like growth factor 1 agonist

>  <Metabolism>
0,781  0,026  CYP2J substrate
0,705  0,007  CYP2A8 substrate
0,658  0,013  CYP1A substrate
0,653  0,013  CYP1 substrate
0,647  0,031  GST A substrate
0,574  0,006  CYP2G1 substrate
0,569  0,032  CYP2C8 inhibitor
0,548  0,032  CYP3A1 substrate
0,531  0,016  CYP2E1 substrate
0,529  0,016  CYP2E substrate
0,523  0,024  CYP1A2 substrate
0,507  0,016  CYP1A1 substrate
0,490  0,004  CYP2C3 substrate
0,514  0,029  CYP2A6 substrate
0,537  0,055  CYP3A2 substrate
0,464  0,013  CYP2E1 inhibitor
0,460  0,016  CYP2A5 substrate
0,459  0,030  CYP2C18 substrate
0,462  0,039  CYP2A substrate
0,464  0,047  CYP2D16 substrate
0,423  0,006  CYP2B2 substrate
0,451  0,043  CYP2B5 substrate
0,423  0,023  CYP7 inhibitor
0,403  0,008  CYP4A2 substrate
0,425  0,035  CYP2B substrate
0,405  0,022  CYP2B11 substrate
0,427  0,047  CYP2F1 substrate
0,447  0,069  CYP2B6 inhibitor
0,412  0,036  CYP2C9 inducer
0,401  0,053  CYP2B6 substrate
0,426  0,103  CYP2C12 substrate

>  <Toxicity>
0,907  0,004  Lichenoid eruption
0,896  0,004  Eye irritation, moderate
0,849  0,014  Pure red cell aplasia
0,837  0,010  Ulcer, aphthous
0,818  0,005  Hypomagnesemia
0,822  0,011  Hematemesis
0,810  0,009  Non mutagenic, Salmonella
0,800  0,004  Carcinogenic, group 3
0,806  0,012  Hyponatremia
0,801  0,007  Demyelination
0,809  0,023  Hyperactivity
0,824  0,038  Bone marrow suppression
0,799  0,022  Anemia, hemolytic
0,782  0,005  Methemoglobinemia
0,776  0,009  Allergic contact dermatitis
0,765  0,018  Anemia
0,731  0,009  Hematuria
0,724  0,004  Carcinogenic, group 2B
0,756  0,037  Stroke
0,723  0,006  Carcinogenic, mouse
0,721  0,006  Adrenal cortex hypoplasia
0,720  0,006  Carcinogenic, mouse, male
0,728  0,019  Weight loss
0,729  0,021  Extrapyramidal effect
0,708  0,006  Carcinogenic, mouse, female
0,717  0,021  Gastrointestinal hemorrhage
0,698  0,009  Visual acuity impairment
0,702  0,014  Hypersexuality
0,717  0,030  Psychomotor impairment
0,690  0,017  Hepatic necrosis
0,689  0,017  Hyperuricemia
0,684  0,020  Galactorrhea
0,680  0,022  Desquamation
0,683  0,027  Delirium
0,669  0,021  Cyanosis
0,666  0,022  Aseptic meningitis
0,673  0,034  Alopecia (hair loss)
0,646  0,017  Gastrointestinal disturbance
0,657  0,034  Postural (orthostatic) hypotension
0,656  0,038  Lethargy
0,656  0,045  Hemolysis
0,647  0,039  Enuresis
0,616  0,010  Carcinogenic, rat, male
0,662  0,057  Electrolyte imbalance
0,612  0,011  Bullous pemphigoid
0,655  0,056  Renal insufficiency
0,632  0,036  Weight gain
0,611  0,019  ANCA-positive vasculitis
0,604  0,012  Carcinogenic
0,641  0,058  Fibrillation, atrial
0,625  0,047  Lymphocytosis
0,641  0,065  Myocardial ischemia
0,607  0,033  Immunotoxin
0,614  0,047  Withdrawal
0,584  0,019  Nephrotic syndrome
0,583  0,019  Systemic lupus erythematosus
0,635  0,072  Dysesthesia
0,571  0,008  Fasciculation
0,580  0,017  Fatty liver
0,622  0,061  Hypoxia
0,583  0,025  Choreoathetosis
0,575  0,018  Myocarditis
0,604  0,049  Weakness
0,609  0,059  Hypercholesterolemic
0,581  0,033  Nephritis
0,601  0,057  Erythema
0,565  0,021  Interstitial nephritis
0,640  0,098  Shivering
0,631  0,090  Ejaculation dysfunction
0,562  0,023  Acneiform eruption
0,595  0,058  Erythema multiforme
0,561  0,026  Porphyria
0,575  0,040  Muscle weakness
0,588  0,056  Ectropion
0,546  0,015  Serum sickness
0,553  0,024  Photoallergy dermatitis
0,566  0,040  Glycosuria
0,558  0,032  Peripheral neuropathy
0,585  0,060  Diarrhea
0,537  0,014  Carcinogenic, rat
0,569  0,046  Apnea
0,568  0,049  Cardiogenic shock
0,560  0,042  Allergic dermatitis
0,593  0,075  Hemorrhage
0,527  0,014  Carcinogenic, rat, female
0,568  0,056  Acidosis
0,553  0,041  Embryotoxic
0,584  0,073  Neuritis
0,553  0,042  Teratogen
0,573  0,062  Psychoses
0,561  0,053  Edema
0,515  0,007  Mutagenic
0,578  0,070  Photophobia
0,558  0,057  Scleroderma
0,507  0,007  Mutagenic, Salmonella
0,555  0,059  Anorgasmia
0,538  0,043  Enterocolitis
0,508  0,014  Skin irritative effect
0,552  0,059  Akathisia
0,535  0,044  Keratopathy
0,548  0,060  Myoclonus
0,582  0,094  Cerebral hemorrhage
0,524  0,036  Hirsutism
0,536  0,049  Fibrosis, interstitial
0,552  0,067  Optic neuritis
0,529  0,045  Keratitis
0,506  0,025  Anemia, sideroblastic
0,558  0,078  Hyperglycemic
0,534  0,055  Acidosis, metabolic
0,530  0,056  Ataxia
0,548  0,077  Pancreatitis
0,530  0,059  Respiratory impairment
0,546  0,077  Hepatitis
0,561  0,092  Leukocytosis
0,540  0,073  Proteinuria
0,557  0,091  Paranoia
0,527  0,061  Dystonia
0,557  0,092  Eye pain
0,528  0,068  Nephrotoxic
0,546  0,087  Mania
0,539  0,080  Hematotoxic
0,540  0,083  Toxic, respiration
0,503  0,046  Chorea
0,476  0,022  Cleft palate
0,526  0,073  Jaundice
0,513  0,060  Cataract
0,478  0,026  Lacrimal secretion stimulant
0,506  0,055  Delusion
0,523  0,073  Hyperbilirubinemia
0,510  0,061  Pseudoporphyria
0,499  0,051  Panic
0,522  0,074  Akinesia
0,459  0,011  Carcinogenic, group 1
0,519  0,073  Confusion
0,504  0,063  Coma
0,521  0,081  Optic neuropathy
0,513  0,077  Toxic epidermal necrolysis
0,492  0,056  Parkinsonism
0,524  0,089  Dermatitis
0,486  0,052  Parotid gland enlargement
0,449  0,016  Henoch-Schonlein purpura
0,513  0,081  Diplopia
0,464  0,032  Thrombocytopoiesis inhibitor
0,530  0,098  Reproductive dysfunction
0,486  0,055  Dyspnea
0,531  0,101  Nystagmus
0,514  0,084  Osteoporosis
0,507  0,077  Drug eruption
0,502  0,073  Necrosis
0,518  0,089  Stomatitis
0,486  0,060  Raynaud's phenomenon
0,509  0,089  Asthma
0,514  0,095  Exanthema
0,459  0,042  Torticollis
0,484  0,068  Ototoxicity
0,518  0,102  Psychosexual disorder
0,479  0,064  Splenomegaly
0,455  0,040  Spermicide
0,498  0,088  Gait disturbance
0,467  0,057  Endocrine disruptor
0,422  0,012  Renal papillary necrosis
0,513  0,104  Muscle rigidity
0,486  0,086  Dysarthria
0,410  0,013  Skin irritation, weak
0,493  0,097  Emetic
0,482  0,086  Euphoria
0,483  0,095  Thrombophlebitis
0,467  0,082  Depression
0,453  0,069  Glaucoma
0,452  0,067  Eosinophilia
0,480  0,099  Hypotonia
0,477  0,098  Purpura
0,458  0,081  Dyskinesia
0,493  0,116  Erectile dysfunction
0,411  0,036  Oculogyric crisis
0,472  0,098  Bradycardic
0,452  0,080  Neutropenia
0,492  0,121  Heart failure
0,453  0,084  Colitis
0,466  0,098  Aphasia
0,449  0,083  Respiratory failure
0,471  0,106  Excitability
0,446  0,083  Hyperthermic
0,470  0,108  Toxic, gastrointestinal
0,441  0,080  Pancytopenia
0,465  0,105  Nightmare
0,481  0,122  Hyperreflexia
0,461  0,108  Consciousness alteration
0,425  0,072  Cholestasis
0,439  0,087  Anorexiant
0,446  0,099  Hepatotoxic
0,447  0,104  Urinary retention
0,434  0,094  Toxic
0,447  0,113  Drowsiness
0,441  0,111  Amnesia
0,452  0,123  Vasculitis
0,450  0,123  Thrombocytopenia
0,461  0,134  Myocardial infarction
0,454  0,131  Dry eye
0,419  0,097  Tremor
0,428  0,110  Paralysis
0,403  0,097  Agranulocytosis
0,422  0,116  Bronchoconstrictor
0,413  0,109  Hyperkinesia
0,429  0,126  Vision disturbance
0,434  0,132  Syncope
0,437  0,137  Sexual dysfunction
0,434  0,134  Aggression
0,428  0,130  Malaise
0,436  0,145  Rhinitis
0,433  0,145  Migraine
0,411  0,127  Memory impairment
0,423  0,147  Vertigo
0,401  0,132  Pruritus
0,417  0,149  Shock
0,423  0,162  Myalgia
0,411  0,151  Hiccups
0,418  0,166  Abdominal pain
0,405  0,173  Chest pain
0,406  0,188  Arthralgia

>  <Transporter>
0,517  0,040  Basolateral Na-K-Cl symporter inhibitor

>  <Murcko.CdId>
6692

>  <Murcko.Mol Weight>
78.1118

>  <Murcko.Formula>
C6H6

>  <Murcko.AKOS_NUMBER>
AKOS000114358

>  <Murcko.IntegerID>
6691

$$$$

  Mrv0541 04281317412D          

 15 16  0  0  0  0            999 V2000
    1.0520   -0.2733    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0478    0.5540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3370   -0.6848    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3821   -0.2733    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3287    0.9613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3821    0.5498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7629   -0.6806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0971    0.9613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0971   -0.6931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3287    1.7844    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4737   -0.2691    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7712   -1.5037    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8080    0.5415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8080   -0.2815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5271   -0.6931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  2  0  0  0  0
  3  1  1  0  0  0  0
  4  3  1  0  0  0  0
  5  2  1  0  0  0  0
  6  4  1  0  0  0  0
  7  1  1  0  0  0  0
  8  6  2  0  0  0  0
  9  4  2  0  0  0  0
 10  5  2  0  0  0  0
 11  7  2  0  0  0  0
 12  7  1  0  0  0  0
 13 14  2  0  0  0  0
 14  9  1  0  0  0  0
 15 14  1  0  0  0  0
  6  5  1  0  0  0  0
  8 13  1  0  0  0  0
M  END
>  <CdId>
7325

>  <Mol Weight>
204.1788

>  <Formula>
C11H8O4

>  <AKOS_NUMBER>
AKOS000296183

>  <Lipinski's Rule of Five>
0

>  <XLogP (text field)>
0.94

>  <PASS_MNA_NEW_COUNT>
0

>  <PASS_RESULT_COUNT>
   42 of   464 Possible Pharmacological Effects at Pa > 0.400
  298 of  3850 Possible Mechanisms of Action at Pa > 0.400
  122 of   321 Possible Toxic and Adverse Effects at Pa > 0.400
    4 of   118 Possible Antitargets at Pa > 0.400
   23 of   195 Possible Metabolism-Related Actions at Pa > 0.400
  712 of  1610 Possible Gene Expression Regulation at Pa > 0.400
    0 of    68 Possible Transporters-Related Actions at Pa > 0.400

>  <Effects>
0,866  0,002  Antiuremic
0,737  0,031  Antiseborrheic
0,691  0,009  Antiallergic
0,689  0,009  Antihypercholesterolemic
0,668  0,012  Antisecretoric
0,667  0,036  Fibrinolytic
0,633  0,004  Loop diuretic
0,666  0,058  Antieczematic
0,628  0,020  Cytoprotectant
0,604  0,010  Antimutagenic
0,569  0,019  Erythropoiesis stimulant
0,527  0,016  Carminative
0,567  0,057  Kidney function stimulant
0,519  0,020  Antiviral (Influenza)
0,495  0,005  Antiparkinsonian, tremor relieving
0,508  0,022  Antiinfective
0,517  0,033  Antipruritic, allergic
0,506  0,022  Antiulcerative
0,514  0,036  Vasoprotector
0,488  0,014  Antiseptic
0,459  0,002  Capillary fragility treatment
0,472  0,033  Spasmolytic
0,485  0,056  Antinephrotoxic
0,501  0,073  Mucositis treatment
0,459  0,034  Vasodilator, coronary
0,478  0,060  Alopecia treatment
0,466  0,061  Lipid metabolism regulator
0,430  0,025  Antiparasitic
0,405  0,009  Photosensitizer
0,427  0,040  Antiasthmatic
0,408  0,024  Cardioprotectant
0,413  0,044  Menopausal disorders treatment
0,426  0,061  Apoptosis agonist
0,410  0,055  Hypolipemic
0,432  0,082  Preneoplastic conditions treatment
0,435  0,085  Antidyskinetic
0,435  0,120  Acute neurologic disorders treatment
0,403  0,094  Antiinflammatory
0,440  0,151  Antiischemic, cerebral
0,435  0,178  Neuroprotector
0,430  0,175  Antibacterial activity enhancer
0,426  0,186  Vasodilator, cerebral

>  <Antitargets>
0,853  0,016  Ubiquinol-cytochrome-c reductase inhibitor
0,580  0,028  Peroxidase inhibitor
0,417  0,041  GABA aminotransferase inhibitor
0,415  0,061  Superoxide dismutase inhibitor

>  <Gene_Expression>
0,916  0,015  LPL expression enhancer
0,869  0,010  ARL6IP5 expression enhancer
0,865  0,018  NAA15 expression inhibitor
0,848  0,004  TUBA1A expression inhibitor
0,840  0,009  JAG1 expression inhibitor
0,842  0,018  TXNRD1 expression inhibitor
0,831  0,011  CD44 expression inhibitor
0,834  0,016  CYR61 expression enhancer
0,823  0,013  ILF3 expression inhibitor
0,817  0,012  C10ORF116 expression enhancer
0,818  0,019  SUZ12 expression inhibitor
0,820  0,023  GPX1 expression inhibitor
0,803  0,013  NBN expression inhibitor
0,811  0,023  CXCR1 expression enhancer
0,798  0,010  DDX18 expression inhibitor
0,811  0,029  CD36 expression inhibitor
0,786  0,013  NR4A2 expression enhancer
0,779  0,010  MAFB expression inhibitor
0,798  0,030  MAPK8 expression enhancer
0,783  0,017  IL4 expression enhancer
0,788  0,029  STAT5B expression enhancer
0,768  0,009  CPNE1 expression enhancer
0,766  0,007  EPHA4 expression enhancer
0,777  0,020  AHR expression inhibitor
0,769  0,013  TNS3 expression enhancer
0,764  0,011  VAV3 expression inhibitor
0,761  0,008  ADD3 expression enhancer
0,777  0,025  OAS2 expression enhancer
0,755  0,006  FTL expression enhancer
0,767  0,020  APOM expression enhancer
0,775  0,029  PDXK expression inhibitor
0,768  0,023  MMP7 expression enhancer
0,795  0,050  HSPD1 expression inhibitor
0,753  0,010  AKT1 expression enhancer
0,756  0,013  PRTN3 expression enhancer
0,758  0,017  IL1RN expression inhibitor
0,771  0,031  HMGB1 expression inhibitor
0,746  0,006  DDX42 expression enhancer
0,765  0,027  SERPINB5 expression inhibitor
0,764  0,026  JUN expression enhancer
0,769  0,032  STAR expression enhancer
0,748  0,013  PRRX1 expression inhibitor
0,759  0,025  CASP3 expression enhancer
0,752  0,022  HSPA1A expression enhancer
0,744  0,014  ITGB7 expression enhancer
0,747  0,018  F2R expression enhancer
0,744  0,016  CLMP expression inhibitor
0,731  0,005  TCF7 expression enhancer
0,740  0,016  PSMC1 expression enhancer
0,762  0,038  DUSP4 expression enhancer
0,751  0,029  UNG expression inhibitor
0,744  0,022  GTF2F1 expression inhibitor
0,738  0,016  MACF1 expression inhibitor
0,741  0,020  TMSB4X expression inhibitor
0,746  0,026  PLAU expression inhibitor
0,734  0,016  ORC4 expression enhancer
0,730  0,012  POLE2 expression inhibitor
0,733  0,017  SLC3A2 expression enhancer
0,728  0,013  HSPA1A expression inhibitor
0,726  0,011  MTHFD2 expression inhibitor
0,741  0,028  CNN1 expression enhancer
0,717  0,006  EGR3 expression inhibitor
0,731  0,022  IGFBP6 expression inhibitor
0,720  0,013  NOC3L expression inhibitor
0,717  0,010  TM4SF1 expression enhancer
0,714  0,008  DEK expression inhibitor
0,712  0,006  BGLAP expression inhibitor
0,734  0,029  POLE2 expression enhancer
0,722  0,018  HIF1A expression inhibitor
0,717  0,013  ALDH1A3 expression inhibitor
0,723  0,024  COL2A1 expression enhancer
0,738  0,039  MYL6 expression enhancer
0,721  0,022  MCM6 expression enhancer
0,724  0,027  FILIP1L expression inhibitor
0,710  0,014  HNRPC expression inhibitor
0,713  0,019  WFDC2 expression enhancer
0,713  0,019  CLDN4 expression enhancer
0,711  0,018  SERPINE1 expression enhancer
0,713  0,020  SESN1 expression inhibitor
0,722  0,029  BIRC2 expression inhibitor
0,713  0,023  AHR expression enhancer
0,699  0,010  SP2 expression inhibitor
0,718  0,030  STAT1 expression inhibitor
0,696  0,009  CDK5 expression enhancer
0,713  0,028  EIF2S1 expression enhancer
0,712  0,028  CD38 expression enhancer
0,712  0,029  PRKCA expression enhancer
0,708  0,025  IFNGR1 expression enhancer
0,700  0,017  GSTM3 expression inhibitor
0,693  0,012  FEN1 expression inhibitor
0,700  0,019  IGF2 expression inhibitor
0,716  0,036  GSTA1 expression enhancer
0,705  0,027  ACTA2 expression inhibitor
0,702  0,026  ETV5 expression inhibitor
0,692  0,016  ATM expression enhancer
0,712  0,037  SERPINB5 expression enhancer
0,691  0,018  FKBP8 expression inhibitor
0,687  0,016  RPS19 expression inhibitor
0,687  0,016  SIRT1 expression inhibitor
0,687  0,016  CDC16 expression inhibitor
0,686  0,020  IL6 expression inhibitor
0,691  0,025  TNFRSF21 expression inhibitor
0,690  0,025  TMPRSS2 expression inhibitor
0,694  0,028  FGF2 expression inhibitor
0,674  0,011  CALM3 expression enhancer
0,705  0,043  FANCC expression inhibitor
0,688  0,027  MT1A expression enhancer
0,674  0,014  TRAM1 expression inhibitor
0,688  0,029  CCNE2 expression inhibitor
0,672  0,014  BAG5 expression inhibitor
0,671  0,014  RECQL expression inhibitor
0,697  0,041  SRPK1 expression inhibitor
0,661  0,011  ME1 expression enhancer
0,668  0,018  ATP2A2 expression enhancer
0,674  0,027  MAPK8 expression inhibitor
0,666  0,020  TAOK3 expression inhibitor
0,661  0,015  PML expression inhibitor
0,657  0,013  SCARB1 expression enhancer
0,661  0,019  CTSD expression inhibitor
0,678  0,038  GADD45A expression inhibitor
0,663  0,025  DDIT4 expression enhancer
0,647  0,012  PPP2CB expression enhancer
0,663  0,028  PDCD4 expression enhancer
0,663  0,030  PDE9A expression inhibitor
0,650  0,018  GPX2 expression enhancer
0,651  0,024  ESR1 expression inhibitor
0,650  0,023  WISP2 expression inhibitor
0,657  0,030  PKM2 expression enhancer
0,644  0,019  KLF10 expression inhibitor
0,633  0,008  SUMO1 expression inhibitor
0,638  0,014  CSE1L expression inhibitor
0,642  0,017  IGFBP5 expression enhancer
0,653  0,030  MAF expression enhancer
0,657  0,038  IL6 expression enhancer
0,644  0,024  LAMC1 expression enhancer
0,641  0,022  NR3C1 expression inhibitor
0,643  0,025  EFEMP1 expression inhibitor
0,626  0,009  GARS expression inhibitor
0,646  0,029  NOL5A expression inhibitor
0,632  0,016  HMOX1 expression enhancer
0,656  0,042  ITGB2 expression enhancer
0,639  0,026  CUTL1 expression inhibitor
0,665  0,053  TOP1 expression inhibitor
0,635  0,024  DDIT3 expression enhancer
0,631  0,021  MYB expression inhibitor
0,664  0,055  MAPT expression enhancer
0,638  0,031  GSTM2 expression inhibitor
0,656  0,049  VDR expression enhancer
0,664  0,058  MSH6 expression inhibitor
0,629  0,027  CDK4 expression inhibitor
0,631  0,031  CPE expression inhibitor
0,636  0,037  NASP expression inhibitor
0,633  0,036  RAD51AP1 expression enhancer
0,631  0,034  FUBP1 expression inhibitor
0,617  0,020  NKX3-1 expression inhibitor
0,631  0,035  SLC16A4 expression enhancer
0,626  0,032  ASNS expression inhibitor
0,608  0,014  CEBPD expression enhancer
0,607  0,015  TNFAIP3 expression enhancer
0,617  0,025  SIDT2 expression enhancer
0,604  0,013  IL1A expression enhancer
0,599  0,008  IL4 expression inhibitor
0,611  0,021  HMGA1 expression enhancer
0,611  0,022  PTN expression enhancer
0,628  0,039  CDC25B expression enhancer
0,606  0,017  PRDX2 expression enhancer
0,613  0,025  NPTX2 expression enhancer
0,610  0,022  SESN2 expression enhancer
0,621  0,035  CALR expression inhibitor
0,618  0,033  NEIL3 expression inhibitor
0,614  0,029  SF1 expression inhibitor
0,636  0,051  PLAUR expression enhancer
0,609  0,025  COL3A1 expression inhibitor
0,606  0,023  TK1 expression inhibitor
0,598  0,016  GALNT1 expression inhibitor
0,625  0,042  DHRS2 expression enhancer
0,611  0,029  HAPLN3 expression inhibitor
0,621  0,040  SLC16A2 expression enhancer
0,605  0,025  ALDOA expression enhancer
0,628  0,049  NOM1 expression inhibitor
0,619  0,040  C3 expression enhancer
0,602  0,022  PSAT1 expression inhibitor
0,591  0,012  CYP17A1 expression enhancer
0,598  0,020  TNNT1 expression inhibitor
0,600  0,022  ACPP expression enhancer
0,584  0,007  LRP6 expression enhancer
0,597  0,020  MT2A expression enhancer
0,605  0,030  GNL3 expression inhibitor
0,592  0,017  CYP1A1 expression inhibitor
0,603  0,028  EPHB4 expression inhibitor
0,603  0,028  NMT1 expression inhibitor
0,601  0,027  GRPEL1 expression inhibitor
0,602  0,029  AKR1C1 expression enhancer
0,594  0,022  PA2G4 expression inhibitor
0,614  0,042  TNFSF10 expression inhibitor
0,610  0,039  IL1A expression inhibitor
0,582  0,011  PECAM1 expression inhibitor
0,600  0,029  PIK3R2 expression inhibitor
0,582  0,012  CEBPG expression inhibitor
0,590  0,020  PGM2 expression enhancer
0,611  0,043  VEGFA expression inhibitor
0,611  0,043  ID2 expression enhancer
0,591  0,024  MGMT expression enhancer
0,600  0,033  SPP1 expression enhancer
0,600  0,033  NAA15 expression enhancer
0,593  0,027  CDKN1C expression inhibitor
0,573  0,010  PTPRK expression inhibitor
0,622  0,059  SFPQ expression enhancer
0,578  0,018  CBR1 expression enhancer
0,598  0,039  CDK2 expression inhibitor
0,592  0,034  IL1R1 expression inhibitor
0,607  0,049  FOS expression enhancer
0,568  0,010  ACAN expression enhancer
0,585  0,028  STAT3 expression inhibitor
0,588  0,032  ADAM17 expression inhibitor
0,588  0,032  CTBP1 expression inhibitor
0,594  0,038  ELL2 expression enhancer
0,594  0,038  CCND1 expression inhibitor
0,585  0,029  DTYMK expression enhancer
0,579  0,023  SLC17A2 expression inhibitor
0,563  0,008  CTH expression inhibitor
0,604  0,049  MYB expression enhancer
0,585  0,030  TRIM16 expression enhancer
0,576  0,021  ANAPC1 expression enhancer
0,593  0,038  EDN1 expression enhancer
0,606  0,052  MYBL1 expression enhancer
0,594  0,040  SEPT2 expression inhibitor
0,578  0,025  AKR1C2 expression enhancer
0,583  0,030  POR expression enhancer
0,577  0,024  CRABP2 expression inhibitor
0,602  0,049  ZFP36 expression enhancer
0,586  0,035  VAT1 expression enhancer
0,562  0,011  TULP3 expression inhibitor
0,590  0,039  IL10 expression enhancer
0,557  0,007  HERPUD1 expression inhibitor
0,568  0,019  IMPDH2 expression enhancer
0,579  0,030  MAOB expression enhancer
0,616  0,068  BST2 expression enhancer
0,571  0,025  FGFR3 expression inhibitor
0,581  0,034  PTGS2 expression enhancer
0,561  0,014  SST expression inhibitor
0,593  0,047  TRAK2 expression enhancer
0,585  0,041  NAV1 expression inhibitor
0,565  0,021  SF3B5 expression enhancer
0,554  0,011  PICALM expression inhibitor
0,574  0,031  PPARGC1A expression enhancer
0,593  0,050  CDCA5 expression enhancer
0,574  0,031  CYB5R2 expression enhancer
0,612  0,070  EZH2 expression inhibitor
0,577  0,034  ASXL1 expression inhibitor
0,577  0,034  C11ORF68 expression enhancer
0,577  0,034  CAPN7 expression inhibitor
0,577  0,034  FAM208A expression inhibitor
0,577  0,034  NKTR expression inhibitor
0,577  0,034  RABGAP1 expression inhibitor
0,577  0,034  SETD2 expression inhibitor
0,577  0,034  TIA1 expression inhibitor
0,577  0,034  TTC3 expression inhibitor
0,609  0,068  ITGA3 expression enhancer
0,579  0,039  CDC25C expression inhibitor
0,578  0,038  PMEPA1 expression inhibitor
0,576  0,036  TIMP1 expression enhancer
0,580  0,040  SOX9 expression enhancer
0,546  0,009  HEY2 expression enhancer
0,546  0,011  TRPV2 expression enhancer
0,570  0,035  MLF1 expression enhancer
0,556  0,022  TIMP1 expression inhibitor
0,576  0,042  ID1 expression inhibitor
0,545  0,013  NAT1 expression inhibitor
0,588  0,056  KIF23 expression enhancer
0,561  0,029  SUV420H1 expression inhibitor
0,559  0,028  COL4A1 expression inhibitor
0,637  0,107  RAD23B expression inhibitor
0,557  0,028  PIK3CD expression inhibitor
0,557  0,028  PLA2G2A expression enhancer
0,538  0,010  SPAG6 expression enhancer
0,547  0,019  REL expression enhancer
0,571  0,043  FOXO1 expression enhancer
0,555  0,027  NFKBIA expression enhancer
0,559  0,032  FAS expression inhibitor
0,581  0,055  KPNA2 expression inhibitor
0,557  0,032  TRAF3 expression enhancer
0,550  0,026  EFNB2 expression inhibitor
0,534  0,010  CITED2 expression enhancer
0,559  0,035  TUBA4A expression enhancer
0,556  0,033  HSPE1 expression inhibitor
0,558  0,034  HMGA1 expression inhibitor
0,538  0,014  BTG1 expression inhibitor
0,579  0,057  TP53 expression enhancer
0,570  0,049  HMBS expression inhibitor
0,548  0,027  PARG expression enhancer
0,601  0,082  ITGB6 expression inhibitor
0,579  0,060  ABCC5 expression enhancer
0,563  0,045  PCDH8 expression enhancer
0,549  0,031  IL2RA expression inhibitor
0,566  0,049  GAS6 expression enhancer
0,554  0,037  DAB2 expression enhancer
0,548  0,032  CDKN1A expression inhibitor
0,570  0,054  EPRS expression inhibitor
0,544  0,028  WAS expression enhancer
0,556  0,040  SCARB1 expression inhibitor
0,543  0,028  NEDD9 expression inhibitor
0,535  0,020  MDK expression inhibitor
0,528  0,014  DENND5A expression enhancer
0,531  0,018  EPAS1 expression enhancer
0,548  0,035  PLD1 expression enhancer
0,535  0,022  UGT1A1 expression enhancer
0,546  0,033  EZR expression inhibitor
0,546  0,033  GAK expression inhibitor
0,546  0,033  TERF1 expression inhibitor
0,557  0,046  MMP2 expression inhibitor
0,568  0,058  BAX expression enhancer
0,536  0,026  MT1G expression enhancer
0,527  0,018  PLCB1 expression enhancer
0,544  0,034  ATF3 expression enhancer
0,545  0,036  MITF expression enhancer
0,582  0,073  PLIN2 expression enhancer
0,532  0,023  PLA2G16 expression enhancer
0,532  0,023  TCEB3 expression inhibitor
0,555  0,048  NT5DC2 expression enhancer
0,555  0,048  RAI14 expression enhancer
0,555  0,048  RFTN1 expression enhancer
0,526  0,020  LGALS3 expression enhancer
0,539  0,033  VCAM1 expression enhancer
0,531  0,025  HMGN2 expression inhibitor
0,547  0,042  PRSS23 expression enhancer
0,544  0,041  DFFA expression inhibitor
0,536  0,033  EGR1 expression inhibitor
0,530  0,028  PRDX6 expression enhancer
0,525  0,024  SLC7A11 expression enhancer
0,535  0,034  MMP2 expression enhancer
0,550  0,049  VEGFA expression enhancer
0,558  0,058  THBD expression enhancer
0,548  0,048  BCL2 expression inhibitor
0,517  0,018  PDK1 expression inhibitor
0,508  0,008  BCL2A1 expression enhancer
0,530  0,032  CARS expression inhibitor
0,533  0,035  DDX24 expression inhibitor
0,536  0,040  CEP57 expression inhibitor
0,519  0,023  TNFSF11 expression inhibitor
0,519  0,024  MDK expression enhancer
0,525  0,030  ANXA1 expression inhibitor
0,521  0,026  ISYNA1 expression enhancer
0,529  0,034  CYP11A1 expression inhibitor
0,520  0,026  WDR4 expression inhibitor
0,535  0,041  ELOVL5 expression inhibitor
0,548  0,054  THBS1 expression enhancer
0,532  0,039  BRCA1 expression enhancer
0,526  0,034  CBX3 expression inhibitor
0,523  0,032  UBE2C expression enhancer
0,542  0,050  CCNA2 expression enhancer
0,545  0,054  NAT1 expression enhancer
0,515  0,025  PLAGL1 expression enhancer
0,514  0,023  BTG2 expression enhancer
0,546  0,056  CASP9 expression enhancer
0,507  0,017  ITPR1 expression inhibitor
0,518  0,028  GFPT2 expression enhancer
0,534  0,045  RAD51C expression enhancer
0,534  0,045  SMC4 expression enhancer
0,534  0,045  ZWINT expression enhancer
0,524  0,036  CD14 expression enhancer
0,539  0,051  BIRC3 expression enhancer
0,499  0,013  ABCG2 expression inhibitor
0,510  0,024  KIAA0930 expression enhancer
0,538  0,052  TNFRSF11A expression enhancer
0,520  0,036  FOXD1 expression inhibitor
0,515  0,030  ITGA6 expression inhibitor
0,493  0,010  SLC16A1 expression inhibitor
0,511  0,028  KIF15 expression inhibitor
0,508  0,025  NCF1 expression enhancer
0,509  0,026  GCLM expression enhancer
0,518  0,037  RRM2 expression inhibitor
0,505  0,024  COLEC12 expression enhancer
0,513  0,032  G0S2 expression enhancer
0,522  0,042  MAP2K1 expression enhancer
0,504  0,024  MYNN expression inhibitor
0,500  0,022  RBMS1 expression inhibitor
0,523  0,045  YWHAE expression inhibitor
0,503  0,025  LAMB3 expression enhancer
0,517  0,040  HLA-B expression enhancer
0,503  0,027  HOXA10 expression enhancer
0,515  0,040  PELI1 expression inhibitor
0,509  0,034  CDK6 expression inhibitor
0,495  0,019  PARP1 expression enhancer
0,522  0,047  CTTN expression inhibitor
0,501  0,026  C5ORF32 expression enhancer
0,501  0,026  FAH expression enhancer
0,501  0,026  RRAS expression enhancer
0,501  0,026  SH3BGRL3 expression enhancer
0,513  0,038  PRNP expression enhancer
0,496  0,021  MFAP4 expression inhibitor
0,489  0,015  CCND1 expression enhancer
0,514  0,041  FUS expression inhibitor
0,506  0,033  ARF3 expression enhancer
0,482  0,010  POLR2A expression enhancer
0,493  0,023  CDKN2C expression inhibitor
0,507  0,037  DEPTOR expression enhancer
0,512  0,045  HLA-F expression enhancer
0,487  0,020  RARB expression inhibitor
0,481  0,014  KRT17 expression inhibitor
0,528  0,062  MSMO1 expression enhancer
0,492  0,026  MT1F expression inhibitor
0,486  0,021  FTH1 expression inhibitor
0,499  0,034  TGFBI expression enhancer
0,477  0,011  ASAH1 expression inhibitor
0,476  0,011  NOS2 expression inhibitor
0,516  0,052  CCL5 expression inhibitor
0,503  0,040  LMNA expression inhibitor
0,477  0,014  CDKN2C expression enhancer
0,519  0,056  ICAM1 expression enhancer
0,499  0,036  BUB1B expression enhancer
0,472  0,009  GPRC5C expression enhancer
0,480  0,018  HIVEP1 expression enhancer
0,494  0,033  SMAD3 expression enhancer
0,492  0,033  TXNRD1 expression enhancer
0,487  0,029  AR expression inhibitor
0,505  0,047  ISG15 expression enhancer
0,490  0,032  E2F1 expression inhibitor
0,513  0,056  BCL2L1 expression inhibitor
0,487  0,031  MMP9 expression inhibitor
0,488  0,032  IGFBP4 expression enhancer
0,475  0,020  ASRGL1 expression enhancer
0,485  0,030  SULF2 expression enhancer
0,527  0,072  SREBF2 expression inhibitor
0,478  0,023  TK1 expression enhancer
0,471  0,017  NRIP1 expression enhancer
0,466  0,012  LGALS1 expression inhibitor
0,514  0,062  RNF4 expression inhibitor
0,469  0,018  EIF4E expression inhibitor
0,483  0,033  FOXC1 expression enhancer
0,480  0,030  APOBEC3B expression enhancer
0,512  0,063  TFDP2 expression inhibitor
0,508  0,059  BRCA2 expression enhancer
0,516  0,067  MMP15 expression inhibitor
0,503  0,055  HLA-G expression enhancer
0,485  0,037  SASH1 expression inhibitor
0,506  0,059  PTGR1 expression enhancer
0,531  0,084  HIF1A expression enhancer
0,540  0,094  ITGB1 expression enhancer
0,517  0,070  CCND2 expression enhancer
0,506  0,060  CDKN1A expression enhancer
0,491  0,045  SLC6A2 expression inhibitor
0,514  0,068  IL18 expression inhibitor
0,465  0,020  MFN2 expression enhancer
0,465  0,020  NEIL2 expression enhancer
0,514  0,068  TNF expression enhancer
0,478  0,033  PDK4 expression enhancer
0,480  0,035  CSNK1D expression inhibitor
0,480  0,035  SPATA20 expression enhancer
0,471  0,026  RXRA expression enhancer
0,512  0,069  NPM3 expression inhibitor
0,512  0,069  PTEN expression inhibitor
0,500  0,057  FN1 expression inhibitor
0,467  0,024  DNMT1 expression inhibitor
0,480  0,037  IL6ST expression inhibitor
0,454  0,011  GADD45B expression enhancer
0,485  0,043  HLA-C expression enhancer
0,465  0,023  SLC31A1 expression enhancer
0,455  0,014  SLC30A5 expression inhibitor
0,511  0,071  NCOA2 expression enhancer
0,463  0,022  LRP8 expression inhibitor
0,475  0,034  SCML1 expression enhancer
0,475  0,034  SEPHS1 expression inhibitor
0,464  0,025  GPR30 expression inhibitor
0,478  0,039  FASN expression inhibitor
0,456  0,018  SOX11 expression inhibitor
0,524  0,086  BAD expression inhibitor
0,465  0,027  HLA-E expression enhancer
0,451  0,013  CRYAB expression enhancer
0,476  0,038  CCNE1 expression inhibitor
0,472  0,034  PPARA expression enhancer
0,474  0,037  LMCD1 expression enhancer
0,500  0,063  MEGF9 expression inhibitor
0,481  0,045  KLK3 expression inhibitor
0,498  0,063  PPARD expression inhibitor
0,452  0,017  CYP19A1 expression inhibitor
0,475  0,041  TP53I3 expression enhancer
0,468  0,034  TPO expression enhancer
0,454  0,020  PLAT expression enhancer
0,485  0,052  ADSL expression inhibitor
0,463  0,030  ID3 expression inhibitor
0,463  0,030  MDFI expression inhibitor
0,463  0,030  SYMPK expression inhibitor
0,470  0,037  BAG1 expression inhibitor
0,471  0,040  NR5A2 expression enhancer
0,471  0,040  ZBTB10 expression inhibitor
0,456  0,025  CEBPD expression inhibitor
0,456  0,025  HADH expression enhancer
0,456  0,025  MELK expression enhancer
0,456  0,025  TFF3 expression enhancer
0,501  0,070  TERT expression enhancer
0,449  0,019  SLC7A5 expression enhancer
0,436  0,008  LBR expression inhibitor
0,504  0,076  KRCC1 expression enhancer
0,454  0,027  C22ORF29 expression enhancer
0,454  0,027  ETNK2 expression enhancer
0,476  0,049  KPNB1 expression enhancer
0,459  0,033  BMP2 expression enhancer
0,463  0,037  PI4KA expression inhibitor
0,463  0,037  VCAN expression inhibitor
0,502  0,076  ALCAM expression inhibitor
0,489  0,063  DUSP5 expression enhancer
0,470  0,045  ST3GAL1 expression enhancer
0,520  0,095  NFKB1 expression enhancer
0,465  0,041  PPARG expression enhancer
0,487  0,065  SNAI2 expression inhibitor
0,452  0,029  ZFAND5 expression inhibitor
0,441  0,019  DHRS3 expression enhancer
0,463  0,041  NGFR expression enhancer
0,456  0,035  DPP4 expression enhancer
0,479  0,058  DCC expression enhancer
0,453  0,033  AP1S2 expression enhancer
0,467  0,046  FGFR2 expression enhancer
0,432  0,011  PON1 expression enhancer
0,469  0,049  PTGS2 expression inhibitor
0,430  0,010  KRT10 expression inhibitor
0,449  0,029  CYP1A1 expression enhancer
0,441  0,021  MND1 expression inhibitor
0,502  0,083  TNFSF10 expression enhancer
0,513  0,095  KLK2 expression inhibitor
0,453  0,035  STC2 expression enhancer
0,442  0,024  SMARCC1 expression inhibitor
0,503  0,085  PRKAR2B expression enhancer
0,440  0,023  NFE2L2 expression enhancer
0,478  0,063  CBX1 expression inhibitor
0,487  0,072  NOS2 expression enhancer
0,458  0,043  CYP17A1 expression inhibitor
0,460  0,046  ETS2 expression inhibitor
0,453  0,039  COL5A2 expression inhibitor
0,432  0,018  MET expression enhancer
0,480  0,066  PLA2G4A expression enhancer
0,445  0,032  MYLIP expression enhancer
0,443  0,030  COL1A1 expression inhibitor
0,450  0,038  HNRNPH2 expression inhibitor
0,440  0,027  INPP4B expression inhibitor
0,426  0,013  NBL1 expression enhancer
0,451  0,039  EHD1 expression enhancer
0,465  0,053  C1S expression enhancer
0,454  0,042  HSBP1 expression inhibitor
0,456  0,044  ALPL expression enhancer
0,431  0,020  MT1X expression enhancer
0,452  0,040  ATR expression inhibitor
0,452  0,040  EFNA4 expression inhibitor
0,452  0,040  MARK3 expression inhibitor
0,452  0,040  SMAD1 expression inhibitor
0,444  0,033  BIRC5 expression enhancer
0,456  0,045  DAPK1 expression inhibitor
0,438  0,027  BAD expression enhancer
0,460  0,050  NR1H2 expression inhibitor
0,461  0,052  SLC1A1 expression enhancer
0,438  0,029  SMG1 expression inhibitor
0,467  0,058  CDKN2A expression enhancer
0,450  0,042  BDNF expression inhibitor
0,452  0,045  LYN expression inhibitor
0,441  0,034  HIG2 expression inhibitor
0,441  0,034  SLTM expression inhibitor
0,441  0,034  ZBTB43 expression inhibitor
0,446  0,039  TMSB4X expression enhancer
0,456  0,049  TOP2A expression inhibitor
0,434  0,027  TNFRSF1B expression enhancer
0,443  0,036  IFIT1 expression enhancer
0,427  0,021  RHOC expression enhancer
0,456  0,051  BRD2 expression enhancer
0,456  0,051  NENF expression enhancer
0,456  0,051  SRRM2 expression inhibitor
0,456  0,051  ZCCHC2 expression inhibitor
0,428  0,022  RGS10 expression enhancer
0,436  0,030  HNRNPA2B1 expression enhancer
0,419  0,014  CD74 expression inhibitor
0,418  0,013  DHFR expression inhibitor
0,418  0,013  ROCK1 expression inhibitor
0,436  0,032  APLP2 expression inhibitor
0,436  0,031  POLR2C expression enhancer
0,450  0,047  HSP27 expression enhancer
0,448  0,045  APOA1 expression enhancer
0,454  0,052  BMP1 expression inhibitor
0,430  0,029  RACGAP1 expression enhancer
0,430  0,029  TRIP13 expression enhancer
0,482  0,080  SPATA13 expression enhancer
0,452  0,050  EI24 expression enhancer
0,469  0,068  CITED2 expression inhibitor
0,423  0,021  PPM1D expression enhancer
0,432  0,031  CSDA expression inhibitor
0,454  0,053  MCM7 expression inhibitor
0,454  0,053  RPS27L expression enhancer
0,414  0,014  NOTCH1 expression enhancer
0,446  0,046  MAD1L1 expression enhancer
0,461  0,061  TIMP3 expression enhancer
0,430  0,031  HSPA6 expression inhibitor
0,433  0,034  OLFM1 expression enhancer
0,430  0,032  TNFRSF11B expression enhancer
0,445  0,047  TOB1 expression inhibitor
0,461  0,063  TGFB1 expression enhancer
0,437  0,039  PTEN expression enhancer
0,451  0,053  NR4A2 expression inhibitor
0,444  0,049  AHSA1 expression enhancer
0,425  0,030  GPR142 expression enhancer
0,422  0,028  S100A8 expression enhancer
0,418  0,024  IFIT3 expression enhancer
0,477  0,084  KPNA1 expression enhancer
0,415  0,022  CDCA3 expression inhibitor
0,419  0,026  HMGB2 expression inhibitor
0,421  0,029  CHEK1 expression enhancer
0,437  0,046  TNFRSF10B expression inhibitor
0,422  0,031  CCNB2 expression enhancer
0,477  0,086  ITGB1 expression inhibitor
0,449  0,058  NOLC1 expression inhibitor
0,404  0,013  CYP1B1 expression inhibitor
0,449  0,059  KLK6 expression enhancer
0,449  0,059  PADI3 expression enhancer
0,423  0,033  DUSP10 expression enhancer
0,436  0,047  BAX expression inhibitor
0,433  0,045  RRM2 expression enhancer
0,456  0,068  CREB1 expression inhibitor
0,421  0,034  PHGDH expression inhibitor
0,421  0,033  NHLRC2 expression inhibitor
0,417  0,031  LYN expression enhancer
0,419  0,033  H1FX expression inhibitor
0,422  0,037  TGOLN2 expression inhibitor
0,411  0,026  BCAT1 expression inhibitor
0,405  0,020  DMXL1 expression inhibitor
0,405  0,020  TMEM59L expression inhibitor
0,452  0,067  MAP1B expression enhancer
0,425  0,041  TNFRSF25 expression inhibitor
0,460  0,076  ABCB1 expression enhancer
0,401  0,017  CXCR4 expression enhancer
0,403  0,019  FOXJ1 expression inhibitor
0,423  0,041  SNAI1 expression enhancer
0,406  0,024  MAP3K8 expression enhancer
0,414  0,033  CYB5A expression enhancer
0,425  0,044  BAK1 expression enhancer
0,431  0,051  TGFBR2 expression enhancer
0,448  0,068  MVP expression enhancer
0,401  0,022  DOK4 expression enhancer
0,460  0,082  JUND expression inhibitor
0,409  0,031  MGST1 expression inhibitor
0,419  0,041  PTPRM expression enhancer
0,442  0,064  EDN1 expression inhibitor
0,422  0,045  PIM1 expression enhancer
0,437  0,060  FOSL1 expression enhancer
0,400  0,026  KLK7 expression enhancer
0,445  0,071  NPM1 expression inhibitor
0,423  0,049  IGFBP2 expression inhibitor
0,443  0,070  JAK2 expression inhibitor
0,443  0,070  TBC1D1 expression inhibitor
0,442  0,069  EZH1 expression enhancer
0,456  0,084  CAV1 expression inhibitor
0,467  0,095  GAS6 expression inhibitor
0,430  0,059  EGFR expression inhibitor
0,402  0,031  IFI30 expression enhancer
0,421  0,050  CDK2 expression enhancer
0,432  0,062  SERPINE2 expression enhancer
0,405  0,035  MCM2 expression enhancer
0,411  0,041  BRF1 expression inhibitor
0,429  0,060  DLEU2 expression enhancer
0,403  0,034  RELA expression inhibitor
0,425  0,057  YWHAH expression inhibitor
0,403  0,036  CCL4 expression enhancer
0,406  0,038  CDK1 expression enhancer
0,445  0,078  ABCC3 expression inhibitor
0,424  0,057  AREG expression enhancer
0,427  0,061  GRN expression enhancer
0,408  0,042  AURKA expression enhancer
0,404  0,038  IRF7 expression enhancer
0,411  0,045  CLMN expression enhancer
0,419  0,054  MYBL2 expression inhibitor
0,441  0,077  IL4R expression enhancer
0,407  0,043  S100A11 expression enhancer
0,411  0,048  CYFIP2 expression enhancer
0,415  0,052  UGDH expression enhancer
0,480  0,118  CREBBP expression inhibitor
0,410  0,048  ITGA6 expression enhancer
0,418  0,056  CDK1 expression inhibitor
0,447  0,086  PCNA expression enhancer
0,425  0,065  BAZ2A expression inhibitor
0,407  0,047  CLDN5 expression enhancer
0,412  0,053  TNF expression inhibitor
0,412  0,054  KLHL24 expression inhibitor
0,407  0,050  SHBG expression enhancer
0,405  0,048  CCNK expression inhibitor
0,418  0,064  PIM1 expression inhibitor
0,444  0,090  CP expression enhancer
0,431  0,079  TNFRSF21 expression enhancer
0,411  0,060  CYP11A1 expression enhancer
0,409  0,059  SOX9 expression inhibitor
0,403  0,053  SKP2 expression inhibitor
0,402  0,054  NCAPG expression enhancer
0,402  0,054  PBK expression enhancer
0,402  0,057  TUBB3 expression enhancer
0,420  0,077  SDC2 expression enhancer
0,447  0,105  CEP350 expression inhibitor
0,447  0,105  PDE8A expression inhibitor
0,415  0,075  ATF3 expression inhibitor
0,463  0,125  PDIA3 expression enhancer
0,426  0,090  AGPS expression inhibitor
0,410  0,077  CYP4A11 expression enhancer
0,400  0,069  INCENP expression inhibitor
0,418  0,096  STRBP expression inhibitor
0,413  0,092  RASEF expression inhibitor
0,418  0,099  PDCD4 expression inhibitor
0,410  0,092  CEACAM6 expression enhancer
0,419  0,102  RND3 expression inhibitor
0,406  0,089  FOLH1 expression inhibitor
0,407  0,095  PPARD expression enhancer
0,405  0,095  SMAD4 expression inhibitor
0,416  0,106  ATP1B3 expression inhibitor
0,436  0,131  TMEM158 expression enhancer
0,425  0,122  KPNA1 expression inhibitor
0,413  0,117  TP53TG1 expression enhancer
0,402  0,111  RB1 expression enhancer
0,409  0,128  UGCG expression enhancer
0,403  0,128  APOA1 expression inhibitor

>  <Mechanisms>
0,975  0,001  Anaphylatoxin receptor antagonist
0,948  0,003  DNA ligase 1 inhibitor
0,921  0,002  5 Hydroxytryptamine release inhibitor
0,867  0,004  Alkane 1-monooxygenase inhibitor
0,869  0,009  Chlordecone reductase inhibitor
0,862  0,010  Penicillin binding protein antagonist
0,862  0,010  Penicillin-binding protein ampH inhibitor
0,852  0,003  Histamine release inhibitor
0,883  0,035  Transferase stimulant
0,853  0,016  Ubiquinol-cytochrome-c reductase inhibitor
0,848  0,025  Membrane integrity agonist
0,813  0,005  Nitrate reductase (cytochrome) inhibitor
0,805  0,006  2-Hydroxymuconate-semialdehyde hydrolase inhibitor
0,793  0,011  Membrane permeability inhibitor
0,776  0,004  Cholestanetriol 26-monooxygenase inhibitor
0,784  0,019  Sugar-phosphatase inhibitor
0,762  0,003  Mediator release inhibitor
0,771  0,013  Dehydro-L-gulonate decarboxylase inhibitor
0,758  0,010  Arylsulfate sulfotransferase inhibitor
0,739  0,004  Perilipin-5 inhibitor
0,742  0,008  Fatty-acyl-CoA synthase inhibitor
0,756  0,024  Methylenetetrahydrofolate reductase (NADPH) inhibitor
0,738  0,008  N-benzyloxycarbonylglycine hydrolase inhibitor
0,734  0,006  Ecdysone 20-monooxygenase inhibitor
0,739  0,013  Glutathione thiolesterase inhibitor
0,732  0,009  3-Hydroxybenzoate 6-monooxygenase inhibitor
0,716  0,004  1-Acylglycerol-3-phosphate O-acyltransferase ABHD5 inhibitor
0,724  0,013  UDP-N-acetylglucosamine 4-epimerase inhibitor
0,733  0,027  Alkenylglycerophosphocholine hydrolase inhibitor
0,704  0,004  Perilipin-1 inhibitor
0,702  0,004  Carbonyl reductase [NADPH] inhibitor
0,702  0,007  tRNA-pseudouridine synthase I inhibitor
0,698  0,004  Leukotriene-B4 20-monooxygenase inhibitor
0,701  0,008  Insulysin inhibitor
0,709  0,018  Arginine 2-monooxygenase inhibitor
0,730  0,043  Mucomembranous protector
0,696  0,012  Pterin deaminase inhibitor
0,685  0,005  Mannan endo-1,4-beta-mannosidase inhibitor
0,685  0,005  Gastrin inhibitor
0,696  0,018  Aldehyde oxidase inhibitor
0,665  0,009  NADH kinase inhibitor
0,673  0,019  Oxidoreductase inhibitor
0,662  0,017  27-Hydroxycholesterol 7alpha-monooxygenase inhibitor
0,646  0,005  1-Acylglycerol-3-phosphate O-acyltransferase inhibitor
0,642  0,006  Carbon-monoxide dehydrogenase inhibitor
0,658  0,024  Phosphatase inhibitor
0,650  0,016  Gluconate 5-dehydrogenase inhibitor
0,650  0,017  Bisphosphoglycerate phosphatase inhibitor
0,644  0,011  Ferredoxin-NAD+ reductase inhibitor
0,644  0,011  Naphthalene 1,2-dioxygenase inhibitor
0,633  0,004  Loop diuretic
0,662  0,040  Taurine dehydrogenase inhibitor
0,628  0,006  Glyoxylate oxidase inhibitor
0,636  0,015  Aspartate-phenylpyruvate transaminase inhibitor
0,628  0,009  (R)-Pantolactone dehydrogenase (flavin) inhibitor
0,626  0,009  Opheline kinase inhibitor
0,626  0,009  Taurocyamine kinase inhibitor
0,634  0,017  Kinase inhibitor
0,619  0,003  Glycogen synthase stimulant
0,629  0,015  Phenol O-methyltransferase inhibitor
0,636  0,022  Dimethylargininase inhibitor
0,631  0,021  Polyamine-transporting ATPase inhibitor
0,628  0,020  Cytoprotectant
0,624  0,018  Methylamine-glutamate N-methyltransferase inhibitor
0,631  0,026  Venombin AB inhibitor
0,630  0,029  Glucan endo-1,6-beta-glucosidase inhibitor
0,609  0,010  L-glucuronate reductase inhibitor
0,609  0,010  P-benzoquinone reductase (NADPH) inhibitor
0,613  0,014  Corticosteroid side-chain-isomerase inhibitor
0,612  0,015  Chenodeoxycholoyltaurine hydrolase inhibitor
0,612  0,019  Acetylcholine neuromuscular blocking agent
0,604  0,013  Peptide alpha-N-acetyltransferase inhibitor
0,615  0,027  2-Hydroxyquinoline 8-monooxygenase inhibitor
0,598  0,013  Prostaglandin-A1 DELTA-isomerase inhibitor
0,595  0,010  Cyclohexyl-isocyanide hydratase inhibitor
0,611  0,027  Fragilysin inhibitor
0,622  0,039  Omptin inhibitor
0,595  0,013  Platelet adhesion inhibitor
0,594  0,012  Long-chain-aldehyde dehydrogenase inhibitor
0,588  0,009  Sarcosine oxidase inhibitor
0,597  0,020  Creatininase inhibitor
0,592  0,017  Centromere associated protein inhibitor
0,595  0,023  L-glutamate oxidase inhibitor
0,582  0,011  Crotonoyl-[acyl-carrier-protein] hydratase inhibitor
0,579  0,008  2-Oxoaldehyde dehydrogenase (NADP+) inhibitor
0,580  0,009  Nitrite reductase [NAD(P)H] inhibitor
0,588  0,020  Complement factor 1s inhibitor
0,574  0,010  N-Acyl-D-aspartate deacylase inhibitor
0,587  0,024  Formaldehyde transketolase inhibitor
0,570  0,006  Plasmanylethanolamine desaturase inhibitor
0,587  0,024  Adenomatous polyposis treatment
0,575  0,012  (+)-borneol dehydrogenase inhibitor
0,599  0,039  Complement factor D inhibitor
0,570  0,011  Pyruvate decarboxylase inhibitor
0,572  0,016  NADPH-ferrihemoprotein reductase inhibitor
0,570  0,015  Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase inhibitor
0,571  0,017  Monodehydroascorbate reductase (NADH) inhibitor
0,577  0,024  Pullulanase inhibitor
0,575  0,022  NAD(P)+-arginine ADP-ribosyltransferase inhibitor
0,559  0,006  Aryl-alcohol dehydrogenase (NADP+) inhibitor
0,580  0,028  Peroxidase inhibitor
0,575  0,023  Cholesterol antagonist
0,561  0,010  Salicylate 1-monooxygenase inhibitor
0,569  0,019  Erythropoiesis stimulant
0,572  0,023  Glutamine-phenylpyruvate transaminase inhibitor
0,574  0,025  NACHT, LRR and PYD domains-containing protein 3 inhibitor
0,566  0,019  Gamma-guanidinobutyraldehyde dehydrogenase inhibitor
0,550  0,004  Quercetin 2,3-dioxygenase inhibitor
0,553  0,009  Mannitol-1-phosphatase inhibitor
0,557  0,018  Aspartate-ammonia ligase inhibitor
0,551  0,013  4-Methoxybenzoate monooxygenase (O-demethylating) inhibitor
0,537  0,004  NF-E2-related factor 2 stimulant
0,560  0,028  Hydrogen dehydrogenase inhibitor
0,553  0,023  Alkenylglycerophosphoethanolamine hydrolase inhibitor
0,562  0,034  Exoribonuclease II inhibitor
0,548  0,022  Female germline-specific tumor suppressor gld-1 inhibitor
0,546  0,020  Glyoxylate reductase inhibitor
0,564  0,040  Phospholipid-translocating ATPase inhibitor
0,539  0,016  Isopenicillin-N epimerase inhibitor
0,547  0,024  CC chemokine 6 receptor antagonist
0,528  0,006  HIV-2 integrase inhibitor
0,562  0,041  Glucose oxidase inhibitor
0,543  0,022  Malate dehydrogenase (acceptor) inhibitor
0,529  0,013  Gluconolactonase inhibitor
0,525  0,009  3-Hydroxy-4-oxoquinoline 2,4-dioxygenase inhibitor
0,587  0,074  Polyporopepsin inhibitor
0,552  0,039  Lysine 2,3-aminomutase inhibitor
0,517  0,005  Dihydroxy-acid dehydratase inhibitor
0,524  0,012  Arylesterase inhibitor
0,531  0,020  (-)-(4S)-limonene synthase inhibitor
0,567  0,057  Kidney function stimulant
0,542  0,033  Phosphatidylserine decarboxylase inhibitor
0,516  0,014  Chitosanase inhibitor
0,511  0,012  Quinoprotein glucose dehydrogenase inhibitor
0,519  0,021  S-alkylcysteine lyase inhibitor
0,529  0,032  MAP kinase stimulant
0,527  0,031  ADP-thymidine kinase inhibitor
0,511  0,016  Glutarate-semialdehyde dehydrogenase inhibitor
0,548  0,053  Lysase inhibitor
0,511  0,016  Hyponitrite reductase inhibitor
0,508  0,013  Glycolate dehydrogenase inhibitor
0,532  0,038  (R)-6-hydroxynicotine oxidase inhibitor
0,540  0,049  Carboxypeptidase Taq inhibitor
0,510  0,020  4-Hydroxyphenylacetate 3-monooxygenase inhibitor
0,499  0,009  Nitrate reductase inhibitor
0,527  0,037  Protein-tyrosine phosphatase alpha inhibitor
0,503  0,014  Beta-carotene 15,15'-monooxygenase inhibitor
0,500  0,011  Lactaldehyde reductase inhibitor
0,498  0,010  Glutathione dehydrogenase (ascorbate) inhibitor
0,501  0,014  Tryptophanamidase inhibitor
0,508  0,021  Dextranase inhibitor
0,508  0,022  Antiinfective
0,521  0,036  Pin1 inhibitor
0,501  0,019  Sulfite oxidase inhibitor
0,490  0,008  CYP2A6 inhibitor
0,493  0,012  4-Chlorophenylacetate 3,4-dioxygenase inhibitor
0,506  0,025  Cyclic AMP phosphodiesterase inhibitor
0,507  0,029  Lysostaphin inhibitor
0,488  0,011  Myosin ATPase inhibitor
0,493  0,016  Cyanoalanine nitrilase inhibitor
0,486  0,012  Benzaldehyde dehydrogenase (NADP+) inhibitor
0,505  0,032  Acetylesterase inhibitor
0,522  0,049  Glucan endo-1,3-beta-D-glucosidase inhibitor
0,509  0,038  Endopeptidase So inhibitor
0,486  0,015  Uroporphyrinogen-III synthase inhibitor
0,523  0,053  Pro-opiomelanocortin converting enzyme inhibitor
0,481  0,011  N-hydroxy-2-acetamidofluorene reductase inhibitor
0,514  0,045  Insulin growth factor agonist
0,514  0,045  Insulin like growth factor 1 agonist
0,505  0,037  Beta glucuronidase inhibitor
0,495  0,027  Urethanase inhibitor
0,494  0,026  Plastoquinol-plastocyanin reductase inhibitor
0,475  0,007  2-Enoate reductase inhibitor
0,478  0,011  6-Carboxyhexanoate-CoA ligase inhibitor
0,478  0,011  Biotin-CoA ligase inhibitor
0,478  0,011  Homoaconitate hydratase inhibitor
0,478  0,011  Triacetate-lactonase inhibitor
0,494  0,027  1-Alkylglycerophosphocholine O-acetyltransferase inhibitor
0,472  0,007  Trans-pentaprenyltranstransferase inhibitor
0,521  0,056  Glutamate-5-semialdehyde dehydrogenase inhibitor
0,477  0,013  Protein-Npi-phosphohistidine-sugar phosphotransferase inhibitor
0,478  0,015  Hydroxylamine reductase (NADH) inhibitor
0,486  0,023  Sulfite reductase inhibitor
0,481  0,021  N-acylmannosamine kinase inhibitor
0,518  0,059  Platelet aggregation stimulant
0,485  0,029  Cathepsin T inhibitor
0,478  0,022  Poly(beta-D-mannuronate) lyase inhibitor
0,462  0,007  Alcohol dehydrogenase [NAD(P)+] inhibitor
0,460  0,006  Fumarate reductase (NADH) inhibitor
0,500  0,046  Feruloyl esterase inhibitor
0,466  0,012  LGALS1 expression inhibitor
0,466  0,014  Ornithine cyclodeaminase inhibitor
0,537  0,085  Glycosylphosphatidylinositol phospholipase D inhibitor
0,472  0,020  Fructan beta-fructosidase inhibitor
0,468  0,020  Mannose isomerase inhibitor
0,472  0,025  Threonine aldolase inhibitor
0,468  0,022  4-Coumarate-CoA ligase inhibitor
0,506  0,062  Macrophage colony stimulating factor agonist
0,457  0,016  4-Hydroxyglutamate transaminase inhibitor
0,463  0,022  DNA-(apurinic or apyrimidinic site) lyase inhibitor
0,455  0,014  Aminomuconate-semialdehyde dehydrogenase inhibitor
0,446  0,006  Phloroglucinol reductase inhibitor
0,449  0,009  Pyruvate dehydrogenase (cytochrome) inhibitor
0,449  0,009  Trans-2-enoyl-CoA reductase (NAD+) inhibitor
0,459  0,021  Opine dehydrogenase inhibitor
0,463  0,025  Alanine-tRNA ligase inhibitor
0,446  0,009  Beta-lactamase TEM inhibitor
0,456  0,020  Bothrolysin inhibitor
0,458  0,022  Gingipain K inhibitor
0,469  0,034  S-formylglutathione hydrolase inhibitor
0,443  0,010  Glutaminase inhibitor
0,444  0,012  N-acetyl-gamma-glutamyl-phosphate reductase inhibitor
0,447  0,016  Aryldialkylphosphatase inhibitor
0,442  0,011  Creatinine deaminase inhibitor
0,452  0,024  H+-exporting ATPase inhibitor
0,498  0,070  NADPH peroxidase inhibitor
0,440  0,013  3-Carboxyethylcatechol 2,3-dioxygenase inhibitor
0,459  0,034  Vasodilator, coronary
0,451  0,025  Cytochrome-b5 reductase inhibitor
0,436  0,012  2,4-Diaminopentanoate dehydrogenase inhibitor
0,436  0,012  3-Hydroxybutyryl-CoA dehydrogenase inhibitor
0,436  0,012  Lysine 6-dehydrogenase inhibitor
0,446  0,022  Cyclomaltodextrinase inhibitor
0,437  0,015  6-Pyruvoyltetrahydropterin synthase inhibitor
0,489  0,067  Acylcarnitine hydrolase inhibitor
0,453  0,032  Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase inhibitor
0,466  0,046  HIV rev inhibitor
0,429  0,011  tRNA nucleotidyltransferase inhibitor
0,453  0,035  Mitochondrial processing peptidase inhibitor
0,451  0,032  N-hydroxyarylamine O-acetyltransferase inhibitor
0,460  0,042  Nucleotide metabolism regulator
0,441  0,023  Transitional endoplasmic reticulum ATPase inhibitor
0,442  0,024  Glycerol-3-phosphate dehydrogenase inhibitor
0,420  0,006  Glycerol dehydrogenase (NADP+) inhibitor
0,428  0,016  Styrene-oxide isomerase inhibitor
0,431  0,019  Dimethylmaleate hydratase inhibitor
0,430  0,020  D-alanine 2-hydroxymethyltransferase inhibitor
0,436  0,026  Prolyl aminopeptidase inhibitor
0,425  0,015  Malate dehydrogenase inhibitor
0,417  0,007  Aryl-alcohol dehydrogenase inhibitor
0,445  0,036  Membrane permeability enhancer
0,439  0,030  Nitrite reductase (NO-forming) inhibitor
0,425  0,016  Ubiquitin thiolesterase inhibitor
0,421  0,013  Eukaryotic translation initiation factor 4 gamma 1 inhibitor
0,421  0,013  Eukaryotic translation initiation factor 4E inhibitor
0,432  0,025  Carboxypeptidase D inhibitor
0,466  0,061  Lipid metabolism regulator
0,466  0,063  Oxygen scavenger
0,454  0,053  Biotinidase inhibitor
0,457  0,056  Thromboxane B2 antagonist
0,439  0,040  Cyclohexanone monooxygenase inhibitor
0,412  0,013  Alcohol dehydrogenase (NADP+) inhibitor
0,412  0,013  Aminocarboxymuconate-semialdehyde decarboxylase inhibitor
0,417  0,018  D-xylulose reductase inhibitor
0,407  0,009  Aldehyde dehydrogenase inhibitor
0,420  0,022  Transketolase inhibitor
0,400  0,003  Pim kinase inhibitor
0,405  0,009  Photosensitizer
0,411  0,014  Cyclopentanone monooxygenase inhibitor
0,429  0,034  Arylmalonate decarboxylase inhibitor
0,412  0,018  Camphor 1,2-monooxygenase inhibitor
0,425  0,031  Sulfite dehydrogenase inhibitor
0,411  0,018  2,6-Dihydroxypyridine 3-monooxygenase inhibitor
0,404  0,012  Lombricine kinase inhibitor
0,412  0,022  Anthranilate-CoA ligase inhibitor
0,402  0,013  N-acetylneuraminate synthase inhibitor
0,414  0,025  Xylan endo-1,3-beta-xylosidase inhibitor
0,461  0,073  Thioredoxin inhibitor
0,429  0,042  Reductant
0,425  0,038  Phosphoinositide 5-phosphatase inhibitor
0,415  0,028  Coccolysin inhibitor
0,404  0,017  Free radical scavenger
0,416  0,031  Nicotinate dehydrogenase inhibitor
0,403  0,018  3-Hydroxybenzoate 4-monooxygenase inhibitor
0,444  0,058  GABA C receptor rho-3 antagonist
0,403  0,018  CDP-4-dehydro-6-deoxyglucose reductase inhibitor
0,402  0,020  Acetylornithine deacetylase inhibitor
0,401  0,021  Glycerol 2-dehydrogenase (NADP+) inhibitor
0,413  0,035  N-methylhydantoinase (ATP-hydrolysing) inhibitor
0,450  0,071  Alkylacetylglycerophosphatase inhibitor
0,401  0,023  Catechol oxidase inhibitor
0,417  0,041  GABA aminotransferase inhibitor
0,415  0,042  N-formylmethionyl-peptidase inhibitor
0,411  0,039  Malate oxidase inhibitor
0,441  0,070  Benzoate-CoA ligase inhibitor
0,413  0,043  Steroid N-acetylglucosaminyltransferase inhibitor
0,491  0,123  NACHT, LRR and PYD domains-containing protein 1 inhibitor
0,403  0,040  D-lactaldehyde dehydrogenase inhibitor
0,402  0,043  4-Hydroxyproline epimerase inhibitor
0,408  0,049  Peptidoglycan glycosyltransferase inhibitor
0,406  0,049  RNA-directed RNA polymerase inhibitor
0,415  0,061  Superoxide dismutase inhibitor
0,405  0,054  Prostaglandin-E2 9-reductase inhibitor
0,471  0,138  Transferase inhibitor
0,403  0,091  Neurotransmitter antagonist
0,406  0,108  Glyceryl-ether monooxygenase inhibitor
0,420  0,130  Collagen inhibitor
0,426  0,186  Vasodilator, cerebral

>  <Metabolism>
0,825  0,030  CYP2C12 substrate
0,803  0,020  CYP2J substrate
0,604  0,017  CYP2B substrate
0,569  0,013  CYP1A1 substrate
0,571  0,022  CYP2B5 substrate
0,560  0,020  CYP1A substrate
0,557  0,020  CYP1 substrate
0,556  0,020  CYP2A4 substrate
0,513  0,028  CYP2F1 substrate
0,490  0,008  CYP2A6 inhibitor
0,481  0,008  CYP2B1 substrate
0,505  0,034  CYP2D16 substrate
0,504  0,044  CYP2B6 inhibitor
0,481  0,028  FMO1 substrate
0,434  0,021  CYP2A5 substrate
0,420  0,021  CYP1A inducer
0,401  0,013  CYP1A2 inducer
0,416  0,041  CYP2E1 inducer
0,435  0,062  CYP2 substrate
0,406  0,038  UGT1A9 substrate
0,407  0,051  CYP4A11 substrate
0,413  0,063  CYP2C8 substrate
0,439  0,113  CYP3A2 substrate

>  <Toxicity>
0,841  0,014  Neuritis
0,833  0,010  Cerebral hemorrhage
0,814  0,015  Eye pain
0,813  0,015  Lethargy
0,796  0,009  Nasal congestion
0,794  0,012  Photophobia
0,792  0,015  Hematemesis
0,770  0,004  Nephrotic syndrome
0,770  0,025  Ulcer, aphthous
0,761  0,018  Migraine
0,740  0,025  Malaise
0,725  0,010  Eosinophilia
0,704  0,006  Systemic lupus erythematosus
0,726  0,034  Chest pain
0,723  0,032  Hemorrhage
0,733  0,043  Stroke
0,712  0,025  Ulcer, esophageal
0,692  0,015  Fibrosis, interstitial
0,705  0,028  Stomatitis
0,699  0,023  Hypercholesterolemic
0,710  0,039  Dyspepsia
0,698  0,029  Vasculitis
0,700  0,036  Hemolysis
0,679  0,024  Withdrawal
0,692  0,040  Vertigo
0,693  0,047  Abdominal pain
0,681  0,038  Hypoxia
0,663  0,020  Pancytopenia
0,670  0,033  Gastrointestinal hemorrhage
0,677  0,041  Erythema
0,663  0,030  Drug eruption
0,634  0,003  Serum sickness
0,658  0,033  Anaphylaxis
0,665  0,044  Drowsiness
0,665  0,044  Allergic reaction
0,664  0,046  Hyponatremia
0,671  0,054  Rhinitis
0,644  0,037  Purpura
0,661  0,056  Arthralgia
0,656  0,051  Hematotoxic
0,627  0,024  Pseudoporphyria
0,641  0,044  Excitability
0,616  0,027  Neutropenia
0,628  0,040  Leukopenia
0,614  0,030  Cardiogenic shock
0,627  0,043  Nephrotoxic
0,623  0,045  Urticaria
0,618  0,052  Hepatotoxic
0,615  0,051  Tachycardiac
0,655  0,093  Shivering
0,595  0,036  Agranulocytosis
0,611  0,059  Dizziness
0,610  0,059  Myalgia
0,645  0,096  Lichenoid eruption
0,598  0,053  Ectropion
0,596  0,054  Toxic, vascular
0,574  0,039  Immunotoxin
0,569  0,050  Neurotoxic
0,598  0,081  Myocardial ischemia
0,587  0,070  Exanthema
0,566  0,053  Scleroderma
0,563  0,060  Convulsant
0,572  0,072  Dermatitis
0,569  0,070  Insomnia
0,559  0,072  Sensory disturbance
0,554  0,071  Sleep disturbance
0,558  0,076  Headache
0,502  0,021  Bullous pemphigoid
0,556  0,077  Toxic, respiration
0,550  0,071  Anxiety
0,548  0,079  Constipation
0,487  0,028  Ulcer, peptic
0,479  0,022  Ulcer, gastric
0,546  0,094  Renal insufficiency
0,522  0,078  Vision disturbance
0,506  0,065  Hematuria
0,492  0,051  Hallucinogen
0,529  0,089  Pain
0,482  0,047  Photoallergy dermatitis
0,518  0,085  Optic neuritis
0,496  0,063  Tremor
0,527  0,096  Anemia, hemolytic
0,507  0,078  Inflammation
0,466  0,041  Acidosis, lactic
0,489  0,069  Respiratory failure
0,511  0,091  Emetic
0,479  0,065  Allergic contact dermatitis
0,514  0,108  Lymphocytosis
0,444  0,040  Ulceration
0,464  0,060  Hypomagnesemia
0,458  0,054  Adrenal cortex hypoplasia
0,477  0,081  Desquamation
0,484  0,094  Diarrhea
0,478  0,091  Bronchoconstrictor
0,445  0,060  Hyperuricemia
0,484  0,105  Optic neuropathy
0,418  0,042  Urine discoloration
0,460  0,087  Weight loss
0,430  0,059  Fatty liver
0,442  0,074  Interstitial nephritis
0,400  0,033  Henoch-Schonlein purpura
0,455  0,099  Behavioral disturbance
0,450  0,099  Necrosis
0,413  0,063  ANCA-positive vasculitis
0,440  0,093  Enterocolitis
0,444  0,109  Nephritis
0,421  0,090  Glaucoma
0,443  0,118  Psychoses
0,409  0,086  Panic
0,428  0,108  Cardiotoxic
0,437  0,121  Nausea
0,446  0,132  Shock
0,411  0,099  Dyskinesia
0,448  0,143  Reproductive dysfunction
0,417  0,114  Edema
0,430  0,133  Hyperglycemic
0,401  0,105  Toxic
0,413  0,119  Respiratory impairment
0,415  0,130  Toxic, gastrointestinal
0,413  0,132  Hepatic necrosis
0,418  0,141  Thrombophlebitis
0,411  0,151  Syncope

>  <Murcko.CdId>
7325

>  <Murcko.Mol Weight>
146.1427

>  <Murcko.Formula>
C9H6O2

>  <Murcko.AKOS_NUMBER>
AKOS000296183

>  <Murcko.IntegerID>
7324

$$$$

  Mrv0541 04281317412D          

 12 13  0  0  0  0            999 V2000
    0.0288   -0.8455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6837   -0.4330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0288    0.8087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6837    0.3962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7413   -0.4330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7413    0.3962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2962   -0.9913    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1379   -1.6538    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9587   -1.7413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0246    1.6337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7413    2.0462    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4538    0.8170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  3  6  2  0  0  0  0
  4  2  2  0  0  0  0
  5  1  2  0  0  0  0
  6  5  1  0  0  0  0
  7  2  1  0  0  0  0
  8  1  1  0  0  0  0
  9  8  1  0  0  0  0
 10  3  1  0  0  0  0
 11 10  2  0  0  0  0
 12  6  1  0  0  0  0
  7  9  1  0  0  0  0
  3  4  1  0  0  0  0
M  END
>  <CdId>
7327

>  <Mol Weight>
164.158

>  <Formula>
C9H8O3

>  <AKOS_NUMBER>
AKOS000111504

>  <Lipinski's Rule of Five>
0

>  <XLogP (text field)>
1.22

>  <PASS_MNA_NEW_COUNT>
0

>  <PASS_RESULT_COUNT>
   34 of   464 Possible Pharmacological Effects at Pa > 0.400
  111 of  3850 Possible Mechanisms of Action at Pa > 0.400
  103 of   321 Possible Toxic and Adverse Effects at Pa > 0.400
    2 of   118 Possible Antitargets at Pa > 0.400
   26 of   195 Possible Metabolism-Related Actions at Pa > 0.400
  560 of  1610 Possible Gene Expression Regulation at Pa > 0.400
    0 of    68 Possible Transporters-Related Actions at Pa > 0.400

>  <Effects>
0,881  0,002  Carminative
0,820  0,007  Respiratory analeptic
0,735  0,030  Neuroprotector
0,698  0,017  Antidyskinetic
0,684  0,007  Anesthetic general
0,687  0,011  Analeptic
0,671  0,009  Leukopoiesis stimulant
0,652  0,003  Pediculicide
0,634  0,011  Ovulation inhibitor
0,611  0,003  Insecticide
0,628  0,039  Antineoplastic
0,587  0,045  Vasodilator, cerebral
0,547  0,006  Acaricide
0,565  0,030  Apoptosis agonist
0,551  0,066  Kidney function stimulant
0,496  0,016  Skin irritation, inactive
0,529  0,053  Antibacterial activity enhancer
0,484  0,022  Hepatoprotectant
0,481  0,022  Antiprotozoal (Trypanosoma)
0,471  0,018  Muscle relaxant
0,464  0,018  Antineoplastic (solid tumors)
0,442  0,018  Antineoplastic (lung cancer)
0,440  0,017  Hepatic disorders treatment
0,433  0,018  Antiviral (Adenovirus)
0,419  0,009  Antineoplastic (lymphoma)
0,419  0,013  Male reproductive disfunction treatment
0,417  0,026  Antiamyloidogenic
0,403  0,020  Antiparkinsonian, rigidity relieving
0,404  0,021  Antiseptic
0,402  0,025  Cardioprotectant
0,413  0,037  Antihypertensive
0,419  0,076  Erythropoiesis stimulant
0,403  0,104  Alopecia treatment
0,427  0,146  Antineurotic

>  <Antitargets>
0,835  0,003  GABA aminotransferase inhibitor
0,729  0,058  Ubiquinol-cytochrome-c reductase inhibitor

>  <Gene_Expression>
0,861  0,007  ID1 expression inhibitor
0,818  0,003  MMP9 expression inhibitor
0,817  0,012  APOM expression enhancer
0,819  0,018  SDC1 expression enhancer
0,801  0,004  MDK expression inhibitor
0,786  0,007  ERBB4 expression inhibitor
0,793  0,015  AGRN expression enhancer
0,778  0,006  MAOB expression enhancer
0,782  0,012  FGF2 expression inhibitor
0,780  0,019  CNN1 expression enhancer
0,770  0,009  IL6 expression inhibitor
0,767  0,023  CEACAM1 expression enhancer
0,755  0,019  VDR expression enhancer
0,788  0,052  HSPD1 expression inhibitor
0,753  0,020  GTF2F1 expression inhibitor
0,744  0,011  GSTM3 expression inhibitor
0,742  0,010  SESN2 expression enhancer
0,752  0,022  JAG1 expression inhibitor
0,741  0,011  NOC3L expression inhibitor
0,747  0,019  IGFBP6 expression inhibitor
0,737  0,009  MMP2 expression inhibitor
0,745  0,018  ABCB1 expression enhancer
0,738  0,012  EPM2AIP1 expression enhancer
0,756  0,031  SUZ12 expression inhibitor
0,739  0,015  WFDC2 expression enhancer
0,740  0,017  PDE9A expression inhibitor
0,765  0,043  NAA15 expression inhibitor
0,749  0,028  ILF3 expression inhibitor
0,733  0,013  CDKN1C expression inhibitor
0,734  0,014  IL1A expression inhibitor
0,739  0,020  ETV5 expression inhibitor
0,756  0,041  CXCR1 expression enhancer
0,747  0,038  STAT5B expression enhancer
0,730  0,021  IL1RN expression inhibitor
0,718  0,010  TM4SF1 expression enhancer
0,739  0,032  BST2 expression enhancer
0,723  0,016  IGF2 expression inhibitor
0,728  0,027  C10ORF116 expression enhancer
0,757  0,064  LPL expression enhancer
0,698  0,007  EGR3 expression inhibitor
0,700  0,010  FGFR3 expression inhibitor
0,707  0,018  GSTM2 expression inhibitor
0,704  0,017  EFEMP1 expression inhibitor
0,693  0,007  STAT3 expression inhibitor
0,728  0,045  PDXK expression inhibitor
0,726  0,043  STAR expression enhancer
0,721  0,039  FANCC expression inhibitor
0,711  0,028  NBN expression inhibitor
0,698  0,018  MAFB expression inhibitor
0,689  0,011  SP2 expression inhibitor
0,704  0,026  IL18 expression inhibitor
0,693  0,016  ALDH1A3 expression inhibitor
0,710  0,033  AHR expression inhibitor
0,696  0,020  NT5DC2 expression enhancer
0,696  0,020  RAI14 expression enhancer
0,696  0,020  RFTN1 expression enhancer
0,714  0,040  SERPINB5 expression inhibitor
0,692  0,018  TNFSF9 expression enhancer
0,687  0,016  RPS19 expression inhibitor
0,687  0,016  SIRT1 expression inhibitor
0,715  0,044  MYL6 expression enhancer
0,694  0,028  ID2 expression enhancer
0,696  0,031  PRKCA expression enhancer
0,707  0,042  OAS2 expression enhancer
0,672  0,012  RPS27L expression enhancer
0,674  0,017  MTHFD2 expression inhibitor
0,699  0,045  MAPT expression enhancer
0,679  0,025  MACF1 expression inhibitor
0,678  0,026  ITGB1 expression inhibitor
0,676  0,025  SLC16A4 expression enhancer
0,701  0,051  GPX1 expression inhibitor
0,679  0,036  CASP3 expression enhancer
0,656  0,016  IGFBP5 expression enhancer
0,643  0,005  LRP6 expression enhancer
0,653  0,016  DDX42 expression enhancer
0,654  0,018  CYB5R2 expression enhancer
0,659  0,026  NPM3 expression inhibitor
0,659  0,026  PTEN expression inhibitor
0,654  0,022  VAT1 expression enhancer
0,659  0,028  TNS3 expression enhancer
0,690  0,061  DUSP4 expression enhancer
0,656  0,027  CPE expression inhibitor
0,660  0,034  CDC25B expression enhancer
0,642  0,017  TGFA expression enhancer
0,640  0,015  CRABP2 expression inhibitor
0,656  0,032  DDX18 expression inhibitor
0,648  0,025  TP53TG1 expression enhancer
0,658  0,034  ACTA2 expression inhibitor
0,667  0,043  PLAUR expression enhancer
0,661  0,040  FILIP1L expression inhibitor
0,658  0,038  CDCA5 expression enhancer
0,665  0,046  SRPK1 expression inhibitor
0,641  0,021  CTTN expression inhibitor
0,665  0,046  SERPINB5 expression enhancer
0,675  0,058  ITGB1 expression enhancer
0,624  0,008  CDK2 expression enhancer
0,643  0,028  NEIL3 expression inhibitor
0,648  0,033  ALCAM expression inhibitor
0,640  0,027  HSPA1A expression inhibitor
0,657  0,044  GADD45A expression inhibitor
0,651  0,039  IFNGR1 expression enhancer
0,631  0,021  EZR expression inhibitor
0,631  0,021  GAK expression inhibitor
0,631  0,021  TERF1 expression inhibitor
0,628  0,019  POR expression enhancer
0,633  0,025  CDC16 expression inhibitor
0,629  0,021  ADD3 expression enhancer
0,621  0,015  PPP2CB expression enhancer
0,618  0,014  CSNK1D expression inhibitor
0,618  0,014  SPATA20 expression enhancer
0,625  0,024  ASXL1 expression inhibitor
0,625  0,024  C11ORF68 expression enhancer
0,625  0,024  CAPN7 expression inhibitor
0,625  0,024  FAM208A expression inhibitor
0,625  0,024  NKTR expression inhibitor
0,625  0,024  RABGAP1 expression inhibitor
0,625  0,024  SETD2 expression inhibitor
0,625  0,024  TIA1 expression inhibitor
0,625  0,024  TTC3 expression inhibitor
0,614  0,012  DPP4 expression enhancer
0,627  0,027  GNL3 expression inhibitor
0,623  0,023  GRPEL1 expression inhibitor
0,604  0,005  RHOC expression enhancer
0,617  0,019  EI24 expression enhancer
0,618  0,024  MMP2 expression enhancer
0,631  0,037  PKM2 expression enhancer
0,624  0,031  FKBP8 expression inhibitor
0,630  0,037  C3 expression enhancer
0,601  0,008  LRP8 expression inhibitor
0,600  0,008  F3 expression enhancer
0,612  0,021  PSAT1 expression inhibitor
0,620  0,028  WISP2 expression inhibitor
0,602  0,013  REL expression enhancer
0,639  0,049  PLIN2 expression enhancer
0,632  0,044  MCM6 expression enhancer
0,617  0,029  STRBP expression inhibitor
0,608  0,021  TRAM1 expression inhibitor
0,611  0,026  TRIM16 expression enhancer
0,613  0,029  SF1 expression inhibitor
0,627  0,042  MT1A expression enhancer
0,620  0,036  FUBP1 expression inhibitor
0,617  0,033  ASNS expression inhibitor
0,611  0,027  ATP2A2 expression enhancer
0,619  0,036  TNFRSF21 expression inhibitor
0,621  0,038  BIRC3 expression enhancer
0,622  0,039  SLC16A2 expression enhancer
0,598  0,016  PI4KA expression inhibitor
0,598  0,016  VCAN expression inhibitor
0,597  0,015  PLA2G16 expression enhancer
0,597  0,015  TCEB3 expression inhibitor
0,605  0,024  C1S expression enhancer
0,608  0,027  PLA2G4A expression enhancer
0,637  0,056  CD36 expression inhibitor
0,588  0,008  MAP3K8 expression enhancer
0,609  0,030  PRRX1 expression inhibitor
0,599  0,020  SLC17A2 expression inhibitor
0,603  0,026  CTSD expression inhibitor
0,597  0,024  PTN expression enhancer
0,605  0,033  CPNE1 expression enhancer
0,592  0,021  RECQL expression inhibitor
0,617  0,047  EIF2S1 expression enhancer
0,596  0,028  SESN1 expression inhibitor
0,595  0,027  NPTX2 expression enhancer
0,580  0,012  GARS expression inhibitor
0,596  0,030  ADAM17 expression inhibitor
0,596  0,030  CTBP1 expression inhibitor
0,602  0,037  TNFSF10 expression enhancer
0,576  0,011  CD47 expression inhibitor
0,599  0,034  CLMP expression inhibitor
0,582  0,018  HSBP1 expression inhibitor
0,587  0,023  CDK5 expression enhancer
0,592  0,030  EPHB4 expression inhibitor
0,592  0,030  NMT1 expression inhibitor
0,597  0,036  SOX9 expression enhancer
0,599  0,038  PSMC1 expression enhancer
0,612  0,052  ABCC5 expression enhancer
0,604  0,046  DHRS2 expression enhancer
0,581  0,024  POLE2 expression inhibitor
0,585  0,028  TUBA1A expression inhibitor
0,591  0,035  NAA15 expression enhancer
0,577  0,023  XRCC4 expression enhancer
0,573  0,018  PDK4 expression enhancer
0,583  0,031  ITGB7 expression enhancer
0,596  0,045  NAT1 expression enhancer
0,592  0,041  TNFRSF11A expression enhancer
0,611  0,064  CYR61 expression enhancer
0,588  0,042  SEPT2 expression inhibitor
0,572  0,026  UBE2C expression enhancer
0,560  0,017  SNAI1 expression enhancer
0,592  0,050  TMSB4X expression inhibitor
0,563  0,021  PLK3 expression enhancer
0,575  0,034  LAMC1 expression enhancer
0,565  0,024  ST3GAL1 expression enhancer
0,572  0,032  HLA-B expression enhancer
0,575  0,037  PRSS23 expression enhancer
0,553  0,017  ALDH4A1 expression inhibitor
0,586  0,049  EPRS expression inhibitor
0,577  0,043  ELL2 expression enhancer
0,580  0,047  TFDP2 expression inhibitor
0,561  0,028  PLA2G2A expression enhancer
0,553  0,020  CCNC expression inhibitor
0,558  0,026  MAP2K3 expression enhancer
0,552  0,020  KIAA0930 expression enhancer
0,563  0,034  MYB expression inhibitor
0,557  0,029  PELI1 expression inhibitor
0,563  0,034  TUBA4A expression enhancer
0,559  0,031  AREG expression enhancer
0,546  0,018  CLDN5 expression enhancer
0,554  0,027  TNNT1 expression inhibitor
0,558  0,031  ISG15 expression enhancer
0,579  0,052  CD44 expression inhibitor
0,551  0,026  ITGA6 expression inhibitor
0,559  0,034  PLD1 expression enhancer
0,556  0,032  MVP expression enhancer
0,544  0,021  GALNT1 expression inhibitor
0,559  0,036  SIDT2 expression enhancer
0,598  0,075  EZH2 expression inhibitor
0,532  0,010  CTH expression inhibitor
0,558  0,036  DAB2 expression enhancer
0,553  0,033  KLK6 expression enhancer
0,553  0,033  PADI3 expression enhancer
0,535  0,015  IFIT1 expression enhancer
0,557  0,038  DFFA expression inhibitor
0,557  0,039  PTGS2 expression enhancer
0,530  0,013  PPL expression inhibitor
0,534  0,017  SST expression inhibitor
0,531  0,015  PTPRK expression inhibitor
0,549  0,034  CASP2 expression enhancer
0,562  0,047  AHR expression enhancer
0,560  0,046  PCDH8 expression enhancer
0,556  0,042  MAPK8 expression inhibitor
0,546  0,034  KPNB1 expression enhancer
0,545  0,033  LYN expression inhibitor
0,555  0,044  NOL5A expression inhibitor
0,543  0,032  BMP1 expression inhibitor
0,538  0,027  TGFBI expression enhancer
0,534  0,024  FTL expression enhancer
0,541  0,032  EGR1 expression inhibitor
0,538  0,029  PGM2 expression enhancer
0,551  0,042  TIMP3 expression enhancer
0,546  0,038  DTYMK expression enhancer
0,549  0,042  JAK2 expression inhibitor
0,549  0,042  TBC1D1 expression inhibitor
0,564  0,056  THBD expression enhancer
0,536  0,028  DEK expression inhibitor
0,534  0,028  BAG5 expression inhibitor
0,535  0,029  PML expression inhibitor
0,575  0,071  UNG expression inhibitor
0,524  0,020  INPP4B expression inhibitor
0,557  0,053  HMBS expression inhibitor
0,554  0,051  PRTN3 expression enhancer
0,531  0,029  ANXA1 expression inhibitor
0,524  0,023  C5ORF32 expression enhancer
0,524  0,023  FAH expression enhancer
0,524  0,023  RRAS expression enhancer
0,524  0,023  SH3BGRL3 expression enhancer
0,528  0,027  ATR expression inhibitor
0,528  0,027  EFNA4 expression inhibitor
0,528  0,027  MARK3 expression inhibitor
0,528  0,027  SMAD1 expression inhibitor
0,569  0,068  MMP7 expression enhancer
0,529  0,029  NR5A2 expression enhancer
0,529  0,029  ZBTB10 expression inhibitor
0,529  0,030  NFKBIA expression enhancer
0,525  0,026  DFFB expression inhibitor
0,537  0,038  CREB1 expression inhibitor
0,509  0,011  FDXR expression enhancer
0,556  0,057  NCOA2 expression enhancer
0,570  0,072  STAT1 expression inhibitor
0,548  0,052  ORC4 expression enhancer
0,561  0,066  MYB expression enhancer
0,510  0,017  SH2D4A expression inhibitor
0,513  0,020  CSDA expression inhibitor
0,515  0,022  TPO expression enhancer
0,531  0,041  CEP57 expression inhibitor
0,528  0,038  PIK3R2 expression inhibitor
0,518  0,028  TNFAIP3 expression enhancer
0,505  0,017  CEBPG expression inhibitor
0,535  0,047  ZNF91 expression inhibitor
0,565  0,077  ITGB2 expression enhancer
0,535  0,048  CUTL1 expression inhibitor
0,510  0,024  MT1F expression inhibitor
0,534  0,048  HAPLN3 expression inhibitor
0,549  0,064  PRKAR2B expression enhancer
0,512  0,030  IL1A expression enhancer
0,506  0,025  HNRNPH2 expression inhibitor
0,507  0,026  AOX1 expression enhancer
0,507  0,028  ODZ3 expression inhibitor
0,507  0,028  TBC1D9 expression inhibitor
0,528  0,051  IL10 expression enhancer
0,496  0,019  DENND5A expression enhancer
0,517  0,041  HMGA1 expression inhibitor
0,511  0,035  YWHAH expression inhibitor
0,516  0,041  PA2G4 expression inhibitor
0,558  0,084  NFKB1 expression enhancer
0,513  0,039  BRD2 expression enhancer
0,513  0,039  NENF expression enhancer
0,513  0,039  SRRM2 expression inhibitor
0,513  0,039  ZCCHC2 expression inhibitor
0,516  0,042  COL4A1 expression inhibitor
0,548  0,075  SFPQ expression enhancer
0,495  0,023  BIRC5 expression enhancer
0,514  0,043  SLC1A1 expression enhancer
0,490  0,019  EPB41L2 expression inhibitor
0,530  0,060  TRAK2 expression enhancer
0,507  0,037  NR1H2 expression inhibitor
0,525  0,055  MEGF9 expression inhibitor
0,507  0,037  ALDOA expression enhancer
0,498  0,029  TP53I3 expression enhancer
0,493  0,023  NEK4 expression inhibitor
0,507  0,038  COL3A1 expression inhibitor
0,528  0,058  RNF4 expression inhibitor
0,509  0,040  PRNP expression enhancer
0,528  0,059  NASP expression inhibitor
0,485  0,017  TRIM24 expression inhibitor
0,488  0,020  PARP14 expression enhancer
0,489  0,021  CEBPD expression inhibitor
0,489  0,021  HADH expression enhancer
0,489  0,021  MELK expression enhancer
0,489  0,021  TFF3 expression enhancer
0,509  0,041  DDX24 expression inhibitor
0,476  0,009  NBL1 expression enhancer
0,528  0,062  MAF expression enhancer
0,534  0,068  UGCG expression enhancer
0,480  0,015  MND1 expression inhibitor
0,517  0,052  CLDN4 expression enhancer
0,516  0,052  HLA-G expression enhancer
0,504  0,041  KLF10 expression inhibitor
0,491  0,028  NCF1 expression enhancer
0,490  0,028  ADIPOR2 expression inhibitor
0,499  0,037  PARG expression enhancer
0,490  0,030  COL5A2 expression inhibitor
0,476  0,017  SHMT2 expression inhibitor
0,514  0,056  NAV1 expression inhibitor
0,481  0,024  TGOLN2 expression inhibitor
0,508  0,052  CDC25C expression inhibitor
0,481  0,025  CYB5A expression enhancer
0,512  0,056  SPP1 expression enhancer
0,498  0,044  SLC6A2 expression inhibitor
0,496  0,042  ETS2 expression inhibitor
0,512  0,059  CAV1 expression inhibitor
0,511  0,061  MGMT expression enhancer
0,530  0,080  ZFP36 expression enhancer
0,480  0,031  CCNK expression inhibitor
0,550  0,102  ITGB6 expression inhibitor
0,540  0,092  TXNRD1 expression inhibitor
0,486  0,038  SF3B5 expression enhancer
0,483  0,036  RRM2 expression enhancer
0,517  0,070  CCND2 expression enhancer
0,465  0,020  TRPV2 expression enhancer
0,533  0,088  TOP1 expression inhibitor
0,478  0,034  PAICS expression enhancer
0,485  0,041  PTGS2 expression inhibitor
0,474  0,030  LDOC1 expression inhibitor
0,474  0,030  RPRM expression inhibitor
0,504  0,061  SNAI2 expression inhibitor
0,521  0,078  MYBL1 expression enhancer
0,474  0,032  SULF2 expression enhancer
0,471  0,029  DHCR24 expression enhancer
0,484  0,042  AHRR expression enhancer
0,505  0,064  NOS2 expression enhancer
0,523  0,082  NOM1 expression inhibitor
0,494  0,053  CEACAM6 expression enhancer
0,484  0,043  DEPTOR expression enhancer
0,458  0,017  HERPUD1 expression inhibitor
0,500  0,059  DUSP5 expression enhancer
0,462  0,022  CBS expression inhibitor
0,486  0,047  PTPRE expression enhancer
0,493  0,053  AGPS expression inhibitor
0,549  0,110  PLAU expression inhibitor
0,470  0,031  BID expression inhibitor
0,498  0,059  TMPRSS2 expression inhibitor
0,482  0,043  CALM3 expression enhancer
0,478  0,040  HMGA1 expression enhancer
0,480  0,042  WAS expression enhancer
0,474  0,037  CLMN expression enhancer
0,451  0,014  PELI1 expression enhancer
0,474  0,038  HMGN2 expression inhibitor
0,496  0,061  CALR expression inhibitor
0,473  0,038  IMPDH2 expression enhancer
0,467  0,032  PTPRM expression enhancer
0,476  0,043  ANAPC1 expression enhancer
0,484  0,053  IER3 expression inhibitor
0,481  0,050  SERPINE2 expression enhancer
0,481  0,049  SCARB1 expression enhancer
0,474  0,043  ACPP expression enhancer
0,462  0,031  AP1S2 expression enhancer
0,506  0,075  KRCC1 expression enhancer
0,469  0,039  FEN1 expression inhibitor
0,446  0,018  ALDH1A1 expression enhancer
0,440  0,012  CXCR4 expression enhancer
0,479  0,052  FOSL1 expression enhancer
0,456  0,029  HLA-E expression enhancer
0,455  0,029  NEU4 expression enhancer
0,455  0,029  SH3GL2 expression inhibitor
0,455  0,030  PPP1R3C expression inhibitor
0,453  0,029  BFSP2 expression enhancer
0,453  0,029  EGLN3 expression enhancer
0,441  0,016  CAB39 expression inhibitor
0,462  0,038  TUBB3 expression enhancer
0,474  0,050  SAT expression enhancer
0,469  0,045  FOXD1 expression inhibitor
0,451  0,028  PHGDH expression inhibitor
0,476  0,053  FUS expression inhibitor
0,462  0,040  SMAD3 expression enhancer
0,459  0,037  ISYNA1 expression enhancer
0,488  0,068  PDCD4 expression inhibitor
0,465  0,045  PRDX6 expression enhancer
0,434  0,015  HOMER1 expression inhibitor
0,434  0,015  TNIK expression inhibitor
0,434  0,015  TRIB3 expression inhibitor
0,458  0,040  IGFBP2 expression inhibitor
0,467  0,051  PRDX2 expression enhancer
0,446  0,031  CLGN expression inhibitor
0,469  0,055  HS6ST2 expression inhibitor
0,429  0,015  ETS1 expression inhibitor
0,487  0,074  CP expression enhancer
0,456  0,043  ME1 expression enhancer
0,443  0,031  CYP1A1 expression enhancer
0,460  0,049  F2R expression enhancer
0,439  0,027  LYN expression enhancer
0,460  0,049  EGFR expression inhibitor
0,451  0,041  GPX2 expression enhancer
0,444  0,034  MDFI expression inhibitor
0,444  0,034  SYMPK expression inhibitor
0,487  0,077  TERT expression enhancer
0,466  0,057  IL2RA expression inhibitor
0,464  0,056  PMEPA1 expression inhibitor
0,439  0,031  IRF7 expression enhancer
0,453  0,045  SASH1 expression inhibitor
0,434  0,026  IGF1R expression enhancer
0,480  0,072  TNFSF10 expression inhibitor
0,441  0,034  RBMS1 expression inhibitor
0,423  0,016  AKR1B10 expression enhancer
0,439  0,033  MYLIP expression enhancer
0,503  0,097  BAD expression inhibitor
0,423  0,017  BCL2A1 expression enhancer
0,450  0,045  PSRC1 expression inhibitor
0,434  0,030  EIF4E expression inhibitor
0,415  0,013  MAP3K5 expression inhibitor
0,436  0,035  PDK1 expression inhibitor
0,485  0,084  NR4A2 expression enhancer
0,459  0,059  ADSL expression inhibitor
0,423  0,023  TULP3 expression inhibitor
0,420  0,020  MT1A expression inhibitor
0,428  0,028  ST7 expression inhibitor
0,415  0,016  ODC1 expression inhibitor
0,425  0,026  CAPN2 expression inhibitor
0,427  0,028  NOS1 expression inhibitor
0,416  0,019  IFIT2 expression enhancer
0,474  0,077  CCND1 expression inhibitor
0,420  0,024  PSPH expression inhibitor
0,412  0,016  BST2 expression inhibitor
0,465  0,069  PTGR1 expression enhancer
0,462  0,067  HSPA1A expression enhancer
0,479  0,083  BIK expression inhibitor
0,461  0,066  MLF1 expression enhancer
0,460  0,065  MAP1B expression enhancer
0,452  0,057  CYP11A1 expression inhibitor
0,492  0,099  HMGB1 expression inhibitor
0,439  0,046  EPAS1 expression enhancer
0,444  0,051  SUV420H1 expression inhibitor
0,405  0,011  HIVEP2 expression enhancer
0,418  0,026  ZBTB1 expression enhancer
0,435  0,043  CXCR7 expression inhibitor
0,429  0,037  DNMT1 expression inhibitor
0,447  0,057  BUB1B expression enhancer
0,429  0,039  PLAGL1 expression enhancer
0,403  0,013  PRUNE2 expression inhibitor
0,455  0,066  VAV3 expression inhibitor
0,419  0,032  RARB expression inhibitor
0,419  0,032  CCNB2 expression enhancer
0,449  0,064  DDIT3 expression enhancer
0,411  0,027  C6ORF108 expression inhibitor
0,411  0,027  CASK expression inhibitor
0,411  0,027  MAP2K5 expression inhibitor
0,411  0,027  PPP1CA expression inhibitor
0,411  0,027  TCF3 expression inhibitor
0,458  0,075  DDIT4 expression enhancer
0,432  0,049  MYBL2 expression inhibitor
0,455  0,072  SERPINE1 expression enhancer
0,415  0,032  SMG1 expression inhibitor
0,440  0,058  VIPR1 expression enhancer
0,416  0,033  APLP2 expression inhibitor
0,457  0,077  CCNE2 expression inhibitor
0,412  0,033  MCM2 expression enhancer
0,422  0,044  KIF15 expression inhibitor
0,422  0,047  SCML1 expression enhancer
0,422  0,047  SEPHS1 expression inhibitor
0,414  0,039  PLCB1 expression enhancer
0,408  0,034  TRAM2 expression inhibitor
0,428  0,054  SOX9 expression inhibitor
0,454  0,080  GSTA1 expression enhancer
0,418  0,044  MT1X expression inhibitor
0,412  0,039  SPARC expression inhibitor
0,458  0,086  SPATA13 expression enhancer
0,430  0,057  LMNA expression inhibitor
0,425  0,052  E2F1 expression inhibitor
0,445  0,073  ATM expression enhancer
0,419  0,048  SKP2 expression inhibitor
0,400  0,029  PKP4 expression inhibitor
0,400  0,029  TUBGCP3 expression inhibitor
0,407  0,036  SUMO1 expression inhibitor
0,429  0,060  PIM1 expression inhibitor
0,428  0,059  INCENP expression inhibitor
0,454  0,085  JUND expression inhibitor
0,410  0,041  BRF1 expression inhibitor
0,408  0,040  MT1H expression inhibitor
0,416  0,049  FOXC1 expression enhancer
0,422  0,055  G0S2 expression enhancer
0,428  0,061  AKR1C2 expression enhancer
0,409  0,045  STC2 expression enhancer
0,436  0,072  CBX3 expression inhibitor
0,440  0,075  TNFRSF21 expression enhancer
0,439  0,075  SLC3A2 expression enhancer
0,429  0,066  HLA-F expression enhancer
0,458  0,095  CCNA2 expression enhancer
0,441  0,080  CITED2 expression inhibitor
0,445  0,084  RASEF expression inhibitor
0,413  0,053  KLHL24 expression inhibitor
0,408  0,049  GFPT2 expression enhancer
0,438  0,079  AKT1 expression enhancer
0,405  0,047  APOBEC3B expression enhancer
0,447  0,090  COL2A1 expression enhancer
0,435  0,079  CBX1 expression inhibitor
0,402  0,048  TNFRSF25 expression inhibitor
0,414  0,062  CDK6 expression inhibitor
0,406  0,058  HSP27 expression enhancer
0,444  0,096  PDCD4 expression enhancer
0,419  0,071  MDK expression enhancer
0,404  0,057  BDNF expression inhibitor
0,421  0,074  MAP2K1 expression enhancer
0,452  0,105  EDN1 expression enhancer
0,415  0,070  TRAF3 expression enhancer
0,404  0,060  ALPL expression enhancer
0,405  0,062  BORA expression inhibitor
0,414  0,071  HIST1H4B expression inhibitor
0,413  0,073  TAOK3 expression inhibitor
0,424  0,084  SATB1 expression inhibitor
0,400  0,061  VEGF expression enhancer
0,412  0,072  UGT1A1 expression enhancer
0,400  0,061  DAPK1 expression inhibitor
0,421  0,082  GAS6 expression enhancer
0,407  0,069  PIK3CD expression inhibitor
0,413  0,076  AKR1C1 expression enhancer
0,459  0,122  JUN expression enhancer
0,408  0,073  CPM expression enhancer
0,402  0,071  PPARGC1A expression enhancer
0,404  0,074  ARL6IP5 expression enhancer
0,424  0,106  FAS expression inhibitor
0,413  0,096  RAD51AP1 expression enhancer
0,415  0,103  NR3C1 expression inhibitor
0,430  0,120  FGFR1 expression inhibitor
0,423  0,117  TIMP1 expression enhancer
0,412  0,109  VCAM1 expression enhancer
0,431  0,129  KPNA2 expression inhibitor
0,411  0,117  CDK2 expression inhibitor
0,409  0,120  BIRC2 expression inhibitor
0,401  0,145  MAPK8 expression enhancer
0,407  0,165  SLC2A4 expression enhancer

>  <Mechanisms>
0,934  0,010  Transferase stimulant
0,899  0,011  Membrane integrity agonist
0,868  0,003  Alpha tubulin antagonist
0,835  0,003  GABA aminotransferase inhibitor
0,762  0,005  Phosphatase inhibitor
0,731  0,003  CYP2A6 inhibitor
0,729  0,007  Aspartate-phenylpyruvate transaminase inhibitor
0,718  0,005  MAP kinase stimulant
0,711  0,000  Pyridoxamine-pyruvate transaminase inhibitor
0,684  0,007  Anesthetic general
0,729  0,058  Ubiquinol-cytochrome-c reductase inhibitor
0,675  0,008  Spermicide
0,669  0,011  Ecdysone 20-monooxygenase inhibitor
0,668  0,013  Caspase 3 stimulant
0,646  0,010  Acetylcholine neuromuscular blocking agent
0,650  0,027  Complement factor D inhibitor
0,617  0,007  Uroporphyrinogen-III synthase inhibitor
0,624  0,022  Fatty-acyl-CoA synthase inhibitor
0,600  0,008  Phosphopantothenoylcysteine decarboxylase inhibitor
0,593  0,005  Aminomuconate-semialdehyde dehydrogenase inhibitor
0,644  0,061  NACHT, LRR and PYD domains-containing protein 1 inhibitor
0,587  0,015  Cytochrome P450 stimulant
0,620  0,050  Sugar-phosphatase inhibitor
0,573  0,005  Tubulin antagonist
0,560  0,012  L-glucuronate reductase inhibitor
0,578  0,032  Alkane 1-monooxygenase inhibitor
0,587  0,045  Vasodilator, cerebral
0,548  0,011  Caspase 8 stimulant
0,604  0,067  Polyporopepsin inhibitor
0,556  0,027  3-Hydroxybenzoate 6-monooxygenase inhibitor
0,536  0,010  Epstein-Barr nuclear antigen 1 inhibitor
0,576  0,052  Omptin inhibitor
0,544  0,022  Malate dehydrogenase (acceptor) inhibitor
0,560  0,040  Venombin AB inhibitor
0,529  0,010  Perilipin-5 inhibitor
0,522  0,004  Beta tubulin antagonist
0,535  0,025  All-trans-retinyl-palmitate hydrolase inhibitor
0,551  0,041  Aldehyde oxidase inhibitor
0,513  0,008  Aspartyl aminopeptidase inhibitor
0,503  0,004  Aryl-alcohol dehydrogenase inhibitor
0,509  0,011  Perilipin-1 inhibitor
0,508  0,011  1-Acylglycerol-3-phosphate O-acyltransferase ABHD5 inhibitor
0,541  0,045  UDP-N-acetylglucosamine 4-epimerase inhibitor
0,535  0,040  Feruloyl esterase inhibitor
0,510  0,022  Monodehydroascorbate reductase (NADH) inhibitor
0,490  0,004  Neurotrophic factor enhancer
0,551  0,066  Kidney function stimulant
0,552  0,072  Chlordecone reductase inhibitor
0,506  0,028  Bisphosphoglycerate phosphatase inhibitor
0,494  0,017  Lipid peroxidase inhibitor
0,496  0,019  1-Acylglycerol-3-phosphate O-acyltransferase inhibitor
0,477  0,004  Pim-1 kinase inhibitor
0,474  0,011  Urease inhibitor
0,484  0,022  Hepatoprotectant
0,461  0,009  EphA4 antagonist
0,501  0,053  Dehydro-L-gulonate decarboxylase inhibitor
0,481  0,035  Mannan endo-1,4-beta-mannosidase inhibitor
0,460  0,017  Succinate-semialdehyde dehydrogenase [NAD(P)+] inhibitor
0,461  0,026  Isopenicillin-N epimerase inhibitor
0,485  0,052  Arginine 2-monooxygenase inhibitor
0,492  0,064  Phospholipid-translocating ATPase inhibitor
0,450  0,023  G-protein coupled receptor 55 antagonist
0,431  0,004  Nucleophosmin inhibitor
0,494  0,071  NADPH peroxidase inhibitor
0,477  0,053  Beta-adrenergic receptor kinase inhibitor
0,477  0,053  G-protein-coupled receptor kinase inhibitor
0,456  0,033  Sigma receptor agonist
0,447  0,029  2-Hydroxymuconate-semialdehyde hydrolase inhibitor
0,430  0,016  SMAD3 inhibitor
0,476  0,062  27-Hydroxycholesterol 7alpha-monooxygenase inhibitor
0,457  0,047  Gluconate 5-dehydrogenase inhibitor
0,478  0,070  Acylcarnitine hydrolase inhibitor
0,502  0,099  Glycosylphosphatidylinositol phospholipase D inhibitor
0,477  0,074  Macrophage colony stimulating factor agonist
0,440  0,037  tRNA-pseudouridine synthase I inhibitor
0,405  0,005  Lysyl oxidase inhibitor
0,412  0,014  Vomilenine glucosyltransferase inhibitor
0,445  0,048  Phenol O-methyltransferase inhibitor
0,463  0,070  Carboxypeptidase Taq inhibitor
0,455  0,062  Glutathione thiolesterase inhibitor
0,417  0,026  Antiamyloidogenic
0,462  0,072  Thioredoxin inhibitor
0,458  0,069  Alkylacetylglycerophosphatase inhibitor
0,450  0,063  Pterin deaminase inhibitor
0,426  0,039  (R)-Pantolactone dehydrogenase (flavin) inhibitor
0,457  0,070  Alkenylglycerophosphocholine hydrolase inhibitor
0,416  0,030  Mydriatic
0,409  0,025  Di-trans,poly-cis-decaprenylcistransferase inhibitor
0,423  0,042  Lysostaphin inhibitor
0,404  0,024  Cysteine protease ATG4B inhibitor
0,412  0,034  NADH kinase inhibitor
0,421  0,045  Glucan 1,4-alpha-maltotriohydrolase inhibitor
0,407  0,032  Carbon-monoxide dehydrogenase inhibitor
0,432  0,059  Polyamine-transporting ATPase inhibitor
0,414  0,046  Chenodeoxycholoyltaurine hydrolase inhibitor
0,415  0,050  Membrane permeability enhancer
0,423  0,058  Cl--transporting ATPase inhibitor
0,427  0,067  Dimethylargininase inhibitor
0,409  0,050  Plastoquinol-plastocyanin reductase inhibitor
0,407  0,059  L-glutamate oxidase inhibitor
0,432  0,084  Penicillin binding protein antagonist
0,432  0,084  Penicillin-binding protein ampH inhibitor
0,449  0,103  Platelet aggregation stimulant
0,419  0,076  Erythropoiesis stimulant
0,429  0,092  NACHT, LRR and PYD domains-containing protein 3 inhibitor
0,410  0,075  Glucan endo-1,6-beta-glucosidase inhibitor
0,444  0,112  Taurine dehydrogenase inhibitor
0,467  0,168  Membrane permeability inhibitor
0,404  0,109  Benzodiazepine omega receptor agonist
0,423  0,141  Platelet adhesion inhibitor
0,401  0,154  Cyclic AMP antagonist

>  <Metabolism>
0,845  0,008  CYP2 substrate
0,827  0,008  CYP2C substrate
0,765  0,009  CYP2B6 substrate
0,731  0,003  CYP2A6 inhibitor
0,716  0,045  CYP2J substrate
0,640  0,013  CYP1A2 substrate
0,630  0,015  CYP2B substrate
0,629  0,069  CYP2C12 substrate
0,554  0,020  CYP1A substrate
0,543  0,021  CYP1 substrate
0,524  0,003  Alcohol dehydrogenase substrate
0,565  0,049  CYP3A4 substrate
0,514  0,012  CYP1A inducer
0,518  0,036  CYP2C9 substrate
0,509  0,027  CYP2C19 substrate
0,510  0,031  CYP2B5 substrate
0,484  0,018  CYP1A1 substrate
0,492  0,032  CYP2F1 substrate
0,513  0,056  CYP3A substrate
0,498  0,046  CYP2B6 inhibitor
0,467  0,037  CYP2A4 substrate
0,406  0,016  CYP2C6 substrate
0,430  0,047  CYP2D6 substrate
0,435  0,057  CYP2D16 substrate
0,427  0,051  CYP2A8 substrate
0,418  0,048  CYP2D substrate

>  <Toxicity>
0,864  0,005  Non mutagenic, Salmonella
0,861  0,005  Urine discoloration
0,849  0,010  Muscle weakness
0,850  0,012  Weakness
0,839  0,006  Panic
0,839  0,007  Hyponatremia
0,827  0,004  Fatty liver
0,814  0,004  Carcinogenic, mouse, male
0,820  0,013  Cerebral hemorrhage
0,807  0,004  Carcinogenic, mouse, female
0,781  0,005  Carcinogenic, mouse
0,782  0,023  Euphoria
0,758  0,013  Status epilepticus
0,730  0,007  Sensitization
0,751  0,041  Ejaculation dysfunction
0,715  0,019  Lymphocytosis
0,711  0,031  Psychomotor impairment
0,688  0,015  Respiratory impairment
0,675  0,008  Spermicide
0,691  0,030  Respiratory failure
0,696  0,042  Psychosexual disorder
0,663  0,025  Psychoses
0,662  0,044  Reproductive dysfunction
0,635  0,021  Priapism
0,656  0,055  Renal insufficiency
0,629  0,028  Galactorrhea
0,606  0,055  Sexual dysfunction
0,589  0,042  Ataxia
0,607  0,060  Hyperglycemic
0,559  0,014  Carcinogenic, rat, male
0,598  0,053  Ectropion
0,561  0,026  Porphyria
0,553  0,029  Adrenal cortex hypoplasia
0,605  0,091  Dysesthesia
0,589  0,076  Hypoxia
0,562  0,050  Desquamation
0,546  0,043  Parkinsonism
0,508  0,008  Carcinogenic, group 2B
0,552  0,057  Hematemesis
0,545  0,050  Hepatic necrosis
0,557  0,064  Toxic, vascular
0,506  0,028  Palpitation
0,550  0,073  Drowsiness
0,532  0,058  Weight loss
0,549  0,076  Ulcer, esophageal
0,557  0,087  Hypercholesterolemic
0,486  0,019  Carcinogenic
0,510  0,044  Hirsutism
0,539  0,073  Optic neuritis
0,471  0,009  Skin irritation, moderate
0,529  0,067  Anorgasmia
0,553  0,092  Paranoia
0,517  0,067  Necrosis
0,467  0,020  Carcinogenic, rat
0,507  0,068  Nephritis
0,447  0,012  Eye irritation, moderate
0,498  0,066  Pseudoporphyria
0,482  0,052  Hyperuricemia
0,517  0,089  Photophobia
0,424  0,009  Mutagenic, Salmonella
0,428  0,018  Skin irritative effect
0,502  0,093  Optic neuropathy
0,475  0,069  Fibrosis, interstitial
0,422  0,016  Carcinogenic, group 1
0,415  0,010  Mutagenic
0,488  0,086  Delirium
0,472  0,071  Neurotoxic
0,496  0,095  Akinesia
0,500  0,100  Ulcer, aphthous
0,416  0,017  Carcinogenic, group 3
0,468  0,076  Choreoathetosis
0,405  0,014  Skin irritation, weak
0,488  0,098  Osteoporosis
0,416  0,030  Mydriatic
0,452  0,069  Interstitial nephritis
0,438  0,057  Spasmogenic
0,464  0,082  Convulsant
0,478  0,099  Hemolysis
0,455  0,079  Hyperthermic
0,451  0,078  Keratitis
0,453  0,085  Hypothermic
0,495  0,128  Neuritis
0,466  0,102  Sleep disturbance
0,477  0,120  Withdrawal
0,427  0,071  Hypomagnesemia
0,471  0,120  Hiccups
0,415  0,071  Torticollis
0,498  0,167  Lichenoid eruption
0,470  0,150  Shivering
0,443  0,125  Gastrointestinal hemorrhage
0,427  0,110  Myoclonus
0,443  0,129  Aggression
0,408  0,096  Pancytopenia
0,420  0,110  Acidosis
0,424  0,122  Inflammation
0,406  0,104  Yawning
0,423  0,128  Gait disturbance
0,403  0,112  Cataract
0,409  0,119  Behavioral disturbance
0,402  0,120  Colitis
0,437  0,156  Myocardial infarction
0,419  0,139  Scleroderma
0,402  0,189  Hyperreflexia

>  <Murcko.CdId>
7327

>  <Murcko.Mol Weight>
122.1213

>  <Murcko.Formula>
C7H6O2

>  <Murcko.AKOS_NUMBER>
AKOS000111504

>  <Murcko.IntegerID>
7326

$$$$

  Mrv0541 04281317412D          

 18 19  0  0  0  0            999 V2000
    2.3541   -0.0859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8799   -0.7595    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8696    0.5739    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0929   -0.5120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0860    0.3093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3746    0.7355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3746   -0.9210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3334    0.3093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0551    0.7252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3334   -0.5120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7665    0.3161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1858   -0.0825    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4744    0.7252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4744    1.5465    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1204    1.3609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1307   -1.5430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1892    0.3093    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0551   -0.9210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  3  1  1  0  0  0  0
  4  2  1  0  0  0  0
  5  3  1  0  0  0  0
  6  5  2  0  0  0  0
  7  4  2  0  0  0  0
  8  6  1  0  0  0  0
  9  8  1  0  0  0  0
 10  7  1  0  0  0  0
 11  9  2  0  0  0  0
 12  1  2  0  0  0  0
 13 11  1  0  0  0  0
 14 13  2  0  0  0  0
 15  3  1  0  0  0  0
 16  2  1  0  0  0  0
 17 13  1  0  0  0  0
 18 10  1  0  0  0  0
  5  4  1  0  0  0  0
  8 10  2  0  0  0  0
M  END
>  <CdId>
7572

>  <Mol Weight>
246.2619

>  <Formula>
C13H14N2O3

>  <AKOS_NUMBER>
AKOS005646626

>  <Lipinski's Rule of Five>
0

>  <XLogP (text field)>
0.38

>  <PASS_MNA_NEW_COUNT>
0

>  <PASS_RESULT_COUNT>
   29 of   464 Possible Pharmacological Effects at Pa > 0.400
   85 of  3850 Possible Mechanisms of Action at Pa > 0.400
  115 of   321 Possible Toxic and Adverse Effects at Pa > 0.400
    2 of   118 Possible Antitargets at Pa > 0.400
   21 of   195 Possible Metabolism-Related Actions at Pa > 0.400
  436 of  1610 Possible Gene Expression Regulation at Pa > 0.400
    1 of    68 Possible Transporters-Related Actions at Pa > 0.400

>  <Effects>
0,782  0,022  Antieczematic
0,723  0,007  Kidney function stimulant
0,712  0,008  Vasodilator, cerebral
0,555  0,011  Cell adhesion molecule inhibitor
0,556  0,028  Leukopoiesis stimulant
0,552  0,025  Antinephrotoxic
0,544  0,032  Lipid metabolism regulator
0,536  0,027  Antipruritic
0,526  0,019  Antipsoriatic
0,532  0,028  Erythropoiesis stimulant
0,537  0,036  Vasodilator, peripheral
0,526  0,030  Antipruritic, allergic
0,508  0,015  Antihelmintic (Nematodes)
0,508  0,016  Muscular dystrophy treatment
0,510  0,035  Antihypoxic
0,499  0,032  Dermatologic
0,481  0,015  Antipyretic
0,456  0,013  Loop diuretic
0,511  0,070  Antibacterial activity enhancer
0,493  0,055  Potassium sparing diuretic
0,434  0,020  Antimutagenic
0,403  0,008  Antinephritic
0,406  0,015  Intermittent claudication treatment
0,443  0,055  Immunosuppressant
0,441  0,059  Radiosensitizer
0,440  0,060  Vasoprotector
0,404  0,035  Eye irritation, inactive
0,409  0,093  Preneoplastic conditions treatment
0,405  0,093  Antiinflammatory

>  <Antitargets>
0,634  0,093  Ubiquinol-cytochrome-c reductase inhibitor
0,426  0,057  Superoxide dismutase inhibitor

>  <Gene_Expression>
0,910  0,004  C10ORF116 expression enhancer
0,869  0,007  PDXK expression inhibitor
0,869  0,010  ARL6IP5 expression enhancer
0,865  0,006  KPNA1 expression enhancer
0,852  0,004  SLC16A2 expression enhancer
0,859  0,014  PHB expression inhibitor
0,851  0,008  S100A8 expression inhibitor
0,848  0,007  ABCB10 expression inhibitor
0,843  0,005  PLIN2 expression enhancer
0,844  0,006  IGFBP6 expression inhibitor
0,842  0,004  RRBP1 expression enhancer
0,832  0,007  VIM expression inhibitor
0,845  0,023  NAA15 expression inhibitor
0,827  0,006  POLE2 expression inhibitor
0,856  0,035  LPL expression enhancer
0,831  0,014  OAS2 expression enhancer
0,824  0,009  TMSB4X expression inhibitor
0,825  0,010  TNFAIP2 expression enhancer
0,819  0,004  CTPS expression inhibitor
0,822  0,009  EIF3B expression inhibitor
0,830  0,019  MYL6 expression enhancer
0,832  0,023  XPO1 expression inhibitor
0,812  0,004  CCND2 expression enhancer
0,826  0,018  EIF2S1 expression inhibitor
0,813  0,007  PRTN3 expression enhancer
0,808  0,005  ADD3 expression enhancer
0,810  0,012  CCNE2 expression inhibitor
0,800  0,005  NOLC1 expression inhibitor
0,810  0,020  SRPK1 expression inhibitor
0,805  0,016  ILF3 expression inhibitor
0,793  0,005  VAT1 expression enhancer
0,790  0,006  PML expression inhibitor
0,798  0,018  MMP7 expression enhancer
0,796  0,016  CNN1 expression enhancer
0,788  0,011  DDX18 expression inhibitor
0,787  0,012  AHR expression enhancer
0,799  0,026  CXCR1 expression enhancer
0,780  0,009  CDK4 expression inhibitor
0,796  0,028  GPX1 expression inhibitor
0,774  0,008  HLA-F expression enhancer
0,771  0,010  SOX9 expression enhancer
0,764  0,009  FKBP8 expression inhibitor
0,763  0,010  CTNNA1 expression inhibitor
0,764  0,013  SDCBP expression enhancer
0,784  0,034  CD36 expression inhibitor
0,755  0,005  CRABP2 expression inhibitor
0,755  0,005  PLA2G2A expression enhancer
0,751  0,003  MGST1 expression inhibitor
0,758  0,010  IL12B expression inhibitor
0,764  0,016  ETV5 expression inhibitor
0,755  0,008  TK1 expression inhibitor
0,750  0,007  SIDT2 expression enhancer
0,768  0,028  SFPQ expression enhancer
0,747  0,009  MCM7 expression inhibitor
0,769  0,032  STAR expression enhancer
0,756  0,020  TFDP2 expression inhibitor
0,749  0,013  IGF2 expression inhibitor
0,742  0,007  FGFR3 expression inhibitor
0,741  0,007  TPM4 expression inhibitor
0,747  0,013  HSPE1 expression inhibitor
0,740  0,007  FTL expression enhancer
0,751  0,019  ID2 expression enhancer
0,747  0,015  MAF expression enhancer
0,785  0,053  HSPD1 expression inhibitor
0,740  0,008  ERMP1 expression enhancer
0,740  0,008  GAP43 expression enhancer
0,740  0,008  MSX2 expression enhancer
0,739  0,007  PDK4 expression enhancer
0,743  0,012  PRDX1 expression inhibitor
0,755  0,025  CEACAM1 expression enhancer
0,747  0,017  FUBP1 expression inhibitor
0,737  0,008  MYB expression inhibitor
0,738  0,014  DDIT4 expression enhancer
0,730  0,011  TNPO2 expression inhibitor
0,749  0,032  MAPT expression enhancer
0,732  0,016  PKM2 expression enhancer
0,721  0,006  POR expression enhancer
0,717  0,005  GINS2 expression inhibitor
0,729  0,017  GRN expression enhancer
0,726  0,018  PDCD4 expression enhancer
0,708  0,002  UQCRC2 expression inhibitor
0,730  0,024  CD38 expression enhancer
0,717  0,015  KPNA2 expression inhibitor
0,709  0,008  MYBL2 expression inhibitor
0,706  0,007  NPM1 expression inhibitor
0,724  0,024  ITGB2 expression enhancer
0,718  0,020  TNS3 expression enhancer
0,712  0,015  CDKN1C expression inhibitor
0,707  0,011  FEN1 expression inhibitor
0,718  0,031  CD44 expression inhibitor
0,700  0,013  CCL5 expression inhibitor
0,693  0,006  REL expression enhancer
0,711  0,024  MCM6 expression enhancer
0,690  0,008  TOB1 expression inhibitor
0,697  0,018  PRRX1 expression inhibitor
0,690  0,013  CYB5R2 expression enhancer
0,695  0,021  WFDC2 expression enhancer
0,693  0,019  MITF expression enhancer
0,696  0,022  ITGB1 expression inhibitor
0,686  0,012  TNFSF10 expression enhancer
0,676  0,005  IVL expression inhibitor
0,709  0,040  JUN expression enhancer
0,691  0,023  SLC16A4 expression enhancer
0,708  0,043  ITGA3 expression enhancer
0,693  0,028  IFNGR1 expression enhancer
0,665  0,007  PSAP expression enhancer
0,690  0,032  BIRC2 expression inhibitor
0,676  0,020  LAMC1 expression enhancer
0,666  0,014  YWHAE expression inhibitor
0,677  0,024  NOL5A expression inhibitor
0,678  0,029  BIRC3 expression enhancer
0,670  0,021  ITGB7 expression enhancer
0,659  0,012  EHD1 expression enhancer
0,654  0,010  ISYNA1 expression enhancer
0,680  0,041  GSTA1 expression enhancer
0,671  0,032  TRAK2 expression enhancer
0,659  0,021  HLA-B expression enhancer
0,648  0,014  CDK5 expression enhancer
0,648  0,014  SCARB1 expression enhancer
0,647  0,014  ISG15 expression enhancer
0,655  0,022  HLA-C expression enhancer
0,650  0,022  CAV1 expression inhibitor
0,652  0,026  CDK2 expression inhibitor
0,639  0,013  CSE1L expression inhibitor
0,642  0,017  PSAT1 expression inhibitor
0,658  0,033  THBD expression enhancer
0,646  0,021  PLD1 expression enhancer
0,642  0,018  TIMP1 expression enhancer
0,671  0,050  EZH2 expression inhibitor
0,630  0,010  BTG1 expression enhancer
0,640  0,022  TRIM16 expression enhancer
0,640  0,024  STRBP expression inhibitor
0,625  0,009  APOA1 expression enhancer
0,630  0,015  WAS expression enhancer
0,644  0,029  CLDN4 expression enhancer
0,632  0,018  EI24 expression enhancer
0,623  0,009  GARS expression inhibitor
0,617  0,005  TMSB4X expression enhancer
0,620  0,009  HMGB2 expression inhibitor
0,645  0,035  THBS1 expression enhancer
0,615  0,004  POLD3 expression inhibitor
0,634  0,024  KPNB1 expression inhibitor
0,625  0,016  TGFBI expression enhancer
0,613  0,008  TPO expression enhancer
0,622  0,018  CYP4A11 expression enhancer
0,625  0,023  GATA2 expression enhancer
0,652  0,050  PDIA3 expression enhancer
0,624  0,023  MMP2 expression enhancer
0,623  0,024  CLMN expression enhancer
0,625  0,026  NR3C1 expression inhibitor
0,622  0,024  DAB2 expression enhancer
0,604  0,007  BARD1 expression inhibitor
0,626  0,029  CASP9 expression enhancer
0,610  0,013  CBX3 expression inhibitor
0,609  0,013  BGLAP expression inhibitor
0,615  0,020  NFKBIA expression enhancer
0,602  0,008  MDK expression enhancer
0,614  0,020  STAT3 expression inhibitor
0,608  0,015  SKP2 expression inhibitor
0,611  0,019  FUS expression inhibitor
0,609  0,018  CD14 expression enhancer
0,633  0,042  FGF2 expression inhibitor
0,597  0,010  BTG2 expression enhancer
0,602  0,015  FASN expression inhibitor
0,619  0,035  IL10 expression enhancer
0,598  0,015  IMPDH2 expression enhancer
0,595  0,014  DNMT3A expression inhibitor
0,589  0,008  PPP1R3C expression inhibitor
0,599  0,019  DEK expression inhibitor
0,613  0,033  TP53TG1 expression enhancer
0,604  0,024  AREG expression enhancer
0,603  0,024  RB1 expression enhancer
0,604  0,025  FGFR2 expression enhancer
0,631  0,053  STAT1 expression inhibitor
0,591  0,013  TUBB3 expression enhancer
0,589  0,013  CDK1 expression inhibitor
0,605  0,029  ICAM1 expression enhancer
0,577  0,004  NBL1 expression enhancer
0,589  0,019  SMAD3 expression enhancer
0,597  0,028  CBX1 expression inhibitor
0,589  0,021  COL4A1 expression inhibitor
0,584  0,016  NCF1 expression enhancer
0,575  0,007  NARS expression inhibitor
0,579  0,012  SUMO1 expression inhibitor
0,596  0,029  CD86 expression enhancer
0,577  0,011  ITGA6 expression enhancer
0,617  0,052  NOM1 expression inhibitor
0,575  0,012  SLC7A1 expression inhibitor
0,566  0,004  EIF4G2 expression inhibitor
0,570  0,010  PTPRK expression inhibitor
0,565  0,006  CYP3A7 expression inhibitor
0,564  0,005  HDAC3 expression inhibitor
0,570  0,011  EPAS1 expression enhancer
0,561  0,005  SLC16A1 expression inhibitor
0,563  0,007  FABP4 expression enhancer
0,559  0,004  ENTPD5 expression inhibitor
0,578  0,024  PRNP expression enhancer
0,582  0,029  EGFR expression inhibitor
0,568  0,016  UGT1A1 expression enhancer
0,583  0,033  VAV3 expression inhibitor
0,563  0,014  S100P expression enhancer
0,579  0,032  TUBA4A expression enhancer
0,585  0,039  VEGFA expression enhancer
0,598  0,052  FOS expression enhancer
0,589  0,044  IL6 expression inhibitor
0,574  0,029  TOP2A expression inhibitor
0,596  0,053  CASP3 expression enhancer
0,562  0,020  FOXC1 expression enhancer
0,580  0,041  CCND1 expression inhibitor
0,542  0,004  RYBP expression inhibitor
0,578  0,042  PPARD expression enhancer
0,551  0,015  CYP11A1 expression enhancer
0,563  0,028  PA2G4 expression inhibitor
0,549  0,014  CEBPG expression inhibitor
0,544  0,009  DNMT1 expression inhibitor
0,555  0,022  IGFBP2 expression inhibitor
0,592  0,059  PNKD expression inhibitor
0,567  0,035  FAM49A expression enhancer
0,560  0,028  RRM2 expression inhibitor
0,539  0,010  IFIT3 expression enhancer
0,536  0,009  CDCA3 expression inhibitor
0,531  0,004  COL4A2 expression inhibitor
0,575  0,049  NASP expression inhibitor
0,572  0,046  GSTM2 expression inhibitor
0,545  0,020  ABCG1 expression enhancer
0,540  0,015  RCC2 expression inhibitor
0,530  0,005  ENO1 expression inhibitor
0,528  0,006  CDKN2B expression enhancer
0,537  0,015  LYN expression enhancer
0,554  0,034  PPARGC1A expression enhancer
0,526  0,006  CXCR4 expression enhancer
0,551  0,032  CDKN2A expression enhancer
0,564  0,046  FN1 expression inhibitor
0,523  0,005  EIF4EBP2 expression inhibitor
0,539  0,022  PTGS2 expression inhibitor
0,600  0,083  PLAU expression inhibitor
0,574  0,058  TP53 expression enhancer
0,554  0,042  AKT1 expression enhancer
0,563  0,053  ABHD3 expression enhancer
0,539  0,030  PIM1 expression enhancer
0,521  0,012  COL1A1 expression enhancer
0,564  0,056  COL2A1 expression enhancer
0,573  0,067  SERPINB5 expression enhancer
0,543  0,038  FAS expression inhibitor
0,538  0,033  THBS1 expression inhibitor
0,542  0,037  CDH1 expression enhancer
0,523  0,019  RAD51AP1 expression inhibitor
0,513  0,009  EIF4E expression inhibitor
0,539  0,037  MAFB expression inhibitor
0,531  0,029  CDKN1B expression inhibitor
0,515  0,013  NKX3-1 expression enhancer
0,579  0,080  SERPINB5 expression inhibitor
0,547  0,049  CDKN1A expression enhancer
0,520  0,023  TNFSF11 expression inhibitor
0,501  0,004  KIF2C expression inhibitor
0,504  0,007  ODC1 expression inhibitor
0,541  0,045  MGMT expression enhancer
0,512  0,016  NAT1 expression inhibitor
0,534  0,038  BRCA1 expression enhancer
0,523  0,030  PPARG expression enhancer
0,539  0,047  IL1B expression enhancer
0,564  0,074  SUZ12 expression inhibitor
0,502  0,013  KLK7 expression enhancer
0,544  0,056  EDN1 expression enhancer
0,519  0,031  G0S2 expression enhancer
0,496  0,008  BRAF expression inhibitor
0,499  0,013  MND1 expression inhibitor
0,499  0,015  PLAT expression enhancer
0,532  0,049  IL4 expression enhancer
0,504  0,022  APOD expression enhancer
0,504  0,022  BAK1 expression enhancer
0,561  0,079  TOP1 expression inhibitor
0,489  0,009  GSN expression enhancer
0,499  0,019  PIR expression enhancer
0,531  0,051  ID1 expression inhibitor
0,507  0,029  E2F1 expression inhibitor
0,488  0,010  IGFBP6 expression enhancer
0,517  0,039  TFDP1 expression inhibitor
0,492  0,015  IFNG expression inhibitor
0,529  0,051  BCL2 expression inhibitor
0,500  0,025  CYP17A1 expression enhancer
0,514  0,041  IL2RA expression inhibitor
0,552  0,079  FGFR1 expression inhibitor
0,541  0,068  PRKAR2B expression enhancer
0,527  0,054  PTGR1 expression enhancer
0,485  0,014  SOCS2 expression enhancer
0,549  0,078  HIF1A expression enhancer
0,492  0,022  TK1 expression enhancer
0,520  0,051  SLC3A2 expression enhancer
0,517  0,049  CTTN expression inhibitor
0,477  0,010  CRYAB expression enhancer
0,473  0,007  KRT10 expression inhibitor
0,486  0,020  RARB expression inhibitor
0,490  0,027  SPARC expression inhibitor
0,467  0,006  EIF4A1 expression inhibitor
0,505  0,046  DDIT3 expression enhancer
0,485  0,026  LAMC2 expression enhancer
0,462  0,005  RHOB expression inhibitor
0,536  0,079  BAD expression inhibitor
0,512  0,056  BCL2L1 expression inhibitor
0,511  0,059  APOA1 expression inhibitor
0,508  0,057  NEIL3 expression inhibitor
0,472  0,020  CCL4 expression enhancer
0,475  0,025  RXRA expression enhancer
0,524  0,075  BAX expression enhancer
0,459  0,013  BCL2A1 expression enhancer
0,525  0,080  VEGFA expression inhibitor
0,468  0,025  DENND5A expression enhancer
0,521  0,078  MYBL1 expression enhancer
0,446  0,004  SNRPB expression inhibitor
0,459  0,017  KRT17 expression inhibitor
0,473  0,032  ID3 expression enhancer
0,511  0,071  NBN expression inhibitor
0,503  0,065  TNFSF10 expression inhibitor
0,485  0,047  SAT expression enhancer
0,483  0,046  NR4A2 expression inhibitor
0,451  0,014  SLC30A5 expression inhibitor
0,499  0,063  SATB1 expression inhibitor
0,440  0,005  OCLN expression enhancer
0,493  0,058  SERPINE1 expression enhancer
0,454  0,022  SOX4 expression inhibitor
0,492  0,061  TMPRSS2 expression inhibitor
0,480  0,049  DDX24 expression inhibitor
0,486  0,056  CREB1 expression inhibitor
0,469  0,043  HSP27 expression enhancer
0,433  0,007  S100A9 expression enhancer
0,448  0,023  SLC5A5 expression enhancer
0,458  0,034  JUN expression inhibitor
0,491  0,068  ACTA2 expression inhibitor
0,439  0,016  SLA expression enhancer
0,468  0,049  ATF3 expression enhancer
0,522  0,104  MAPK8 expression enhancer
0,446  0,029  DUSP10 expression enhancer
0,442  0,024  EIF5A expression inhibitor
0,495  0,078  NSF expression inhibitor
0,465  0,049  BMP1 expression inhibitor
0,445  0,029  CALU expression inhibitor
0,420  0,004  MMP13 expression inhibitor
0,458  0,043  CCL2 expression enhancer
0,435  0,019  UGT2B15 expression enhancer
0,439  0,024  PPARG expression inhibitor
0,437  0,023  CYP24A1 expression enhancer
0,455  0,041  RPL7A expression inhibitor
0,430  0,018  ID1 expression enhancer
0,437  0,025  S100A8 expression enhancer
0,477  0,066  CUTL1 expression inhibitor
0,457  0,048  MTHFD2 expression inhibitor
0,445  0,037  BMP2 expression enhancer
0,415  0,008  NEDD9 expression enhancer
0,412  0,005  RARA expression enhancer
0,460  0,054  PRDX2 expression enhancer
0,414  0,008  YBX1 expression inhibitor
0,460  0,054  CDKN1A expression inhibitor
0,458  0,052  KLF10 expression inhibitor
0,418  0,013  ITGB4 expression inhibitor
0,435  0,031  TNFRSF11B expression enhancer
0,408  0,003  GSTM1 expression inhibitor
0,458  0,054  HMGA1 expression inhibitor
0,464  0,063  DDX42 expression enhancer
0,424  0,024  IL2 expression inhibitor
0,464  0,065  MLF1 expression enhancer
0,469  0,070  DUSP5 expression enhancer
0,442  0,044  TNF expression inhibitor
0,468  0,069  ESR1 expression inhibitor
0,411  0,013  CCL20 expression enhancer
0,485  0,089  GAS6 expression inhibitor
0,455  0,061  MAP2K1 expression enhancer
0,418  0,025  SOX11 expression inhibitor
0,454  0,060  ADSL expression inhibitor
0,420  0,027  CDKN2C expression enhancer
0,421  0,029  NOS1 expression inhibitor
0,412  0,021  CDKN1C expression enhancer
0,407  0,019  LGALS1 expression inhibitor
0,462  0,075  PPARD expression inhibitor
0,445  0,060  CYP11A1 expression inhibitor
0,453  0,071  NAT1 expression enhancer
0,425  0,044  CYFIP2 expression enhancer
0,411  0,032  BAD expression enhancer
0,461  0,082  SCARB1 expression inhibitor
0,414  0,036  COL1A1 expression inhibitor
0,417  0,042  PLAGL1 expression enhancer
0,404  0,030  IGF2 expression enhancer
0,427  0,054  TIMP1 expression inhibitor
0,442  0,069  DFFA expression inhibitor
0,426  0,054  CCNE1 expression inhibitor
0,451  0,080  ABCB1 expression enhancer
0,402  0,031  HSD17B1 expression enhancer
0,437  0,067  TP53I3 expression enhancer
0,420  0,051  HMGA1 expression enhancer
0,428  0,060  SP2 expression inhibitor
0,454  0,087  CD58 expression inhibitor
0,414  0,047  ALDH4A1 expression inhibitor
0,421  0,055  TGFBR2 expression enhancer
0,413  0,048  GPX2 expression enhancer
0,452  0,092  MMP2 expression inhibitor
0,402  0,043  HOXA10 expression enhancer
0,420  0,062  INCENP expression inhibitor
0,406  0,048  PLA2G16 expression enhancer
0,406  0,048  TCEB3 expression inhibitor
0,427  0,072  CDC25C expression inhibitor
0,411  0,057  SP1 expression inhibitor
0,404  0,050  MMP9 expression inhibitor
0,448  0,096  JAG1 expression inhibitor
0,444  0,092  JUND expression inhibitor
0,432  0,080  CPE expression inhibitor
0,440  0,089  ORC4 expression enhancer
0,467  0,116  TXNRD1 expression inhibitor
0,422  0,072  EDN1 expression inhibitor
0,435  0,085  ATP2A2 expression enhancer
0,485  0,136  DUSP4 expression enhancer
0,409  0,061  SERPINA3 expression enhancer
0,421  0,073  AKR1C1 expression enhancer
0,437  0,089  IL18 expression inhibitor
0,422  0,075  TGFB1 expression enhancer
0,467  0,121  MSH6 expression inhibitor
0,419  0,075  GNL3 expression inhibitor
0,435  0,097  ELL2 expression enhancer
0,404  0,067  SF3B5 expression enhancer
0,454  0,119  ITGB1 expression enhancer
0,401  0,066  PSRC1 expression inhibitor
0,419  0,084  FOLH1 expression inhibitor
0,413  0,082  FOXO1 expression enhancer
0,453  0,121  GTF2F1 expression inhibitor
0,418  0,092  NUMA1 expression inhibitor
0,440  0,115  FANCC expression inhibitor
0,411  0,086  CPNE1 expression enhancer
0,428  0,103  KRCC1 expression enhancer
0,406  0,083  HLA-G expression enhancer
0,431  0,111  IL1RN expression inhibitor
0,432  0,115  PLAUR expression enhancer
0,461  0,145  VDR expression enhancer
0,450  0,136  CYR61 expression enhancer
0,402  0,096  SESN2 expression enhancer
0,416  0,118  FILIP1L expression inhibitor
0,425  0,135  UNG expression inhibitor
0,403  0,144  APOM expression enhancer

>  <Mechanisms>
0,723  0,007  Kidney function stimulant
0,750  0,035  Mucomembranous protector
0,712  0,008  Vasodilator, cerebral
0,717  0,020  Feruloyl esterase inhibitor
0,679  0,048  Membrane permeability inhibitor
0,642  0,017  Insulysin inhibitor
0,629  0,011  4-Hydroxyphenylacetate 3-monooxygenase inhibitor
0,631  0,014  Gastrin inhibitor
0,610  0,022  Platelet aggregation stimulant
0,603  0,022  Oxygen scavenger
0,587  0,016  Insulin promoter
0,589  0,036  Aldose reductase-like protein inhibitor
0,558  0,006  Sulfur dioxygenase inhibitor
0,555  0,011  Cell adhesion molecule inhibitor
0,634  0,093  Ubiquinol-cytochrome-c reductase inhibitor
0,575  0,041  Carboxypeptidase Taq inhibitor
0,542  0,017  (R)-Pantolactone dehydrogenase (flavin) inhibitor
0,596  0,076  Membrane integrity agonist
0,544  0,032  Lipid metabolism regulator
0,581  0,070  Glycosylphosphatidylinositol phospholipase D inhibitor
0,521  0,011  4-Hydroxyglutamate transaminase inhibitor
0,536  0,027  Antipruritic
0,555  0,048  Proteasome ATPase inhibitor
0,532  0,028  Erythropoiesis stimulant
0,537  0,036  Vasodilator, peripheral
0,510  0,015  Pyruvate decarboxylase inhibitor
0,532  0,039  Dimethylargininase inhibitor
0,532  0,039  Fatty-acyl-CoA synthase inhibitor
0,493  0,004  Ferrochelatase inhibitor
0,544  0,057  NADPH peroxidase inhibitor
0,542  0,055  Penicillin binding protein antagonist
0,542  0,055  Penicillin-binding protein ampH inhibitor
0,491  0,010  Retinoic acid metabolism inhibitor
0,506  0,034  Methylamine-glutamate N-methyltransferase inhibitor
0,522  0,052  Phospholipid-translocating ATPase inhibitor
0,502  0,035  Aspartate-phenylpyruvate transaminase inhibitor
0,485  0,017  Prenyl-diphosphatase inhibitor
0,513  0,047  Beta-adrenergic receptor kinase inhibitor
0,513  0,047  G-protein-coupled receptor kinase inhibitor
0,481  0,024  N-methylhydantoinase (ATP-hydrolysing) inhibitor
0,464  0,020  Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase inhibitor
0,456  0,013  Loop diuretic
0,475  0,033  Lysostaphin inhibitor
0,473  0,034  All-trans-retinyl-palmitate hydrolase inhibitor
0,493  0,055  Potassium sparing diuretic
0,490  0,055  Cyclic AMP antagonist
0,480  0,048  Neurotransmitter antagonist
0,455  0,024  4-Coumarate-CoA ligase inhibitor
0,478  0,047  Histamine release inhibitor
0,495  0,065  Acylcarnitine hydrolase inhibitor
0,461  0,033  Reductant
0,457  0,036  Cyclohexanone monooxygenase inhibitor
0,462  0,041  Nucleotide metabolism regulator
0,437  0,019  Polyadenylate-binding protein 1 inhibitor
0,493  0,077  Oxidoreductase inhibitor
0,471  0,057  (R)-6-hydroxynicotine oxidase inhibitor
0,484  0,071  Macrophage colony stimulating factor agonist
0,429  0,020  Catechol oxidase inhibitor
0,417  0,015  Dolichyl-phosphatase inhibitor
0,437  0,037  Bilirubin oxidase inhibitor
0,450  0,050  Cholesterol antagonist
0,419  0,020  Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase inhibitor
0,443  0,048  Prostaglandin-E2 9-reductase inhibitor
0,461  0,068  Venombin AB inhibitor
0,400  0,011  Fumarate reductase (NADH) inhibitor
0,443  0,055  Immunosuppressant
0,407  0,019  LGALS1 expression inhibitor
0,418  0,034  NADH kinase inhibitor
0,458  0,076  Anorexiant
0,450  0,071  Alkylacetylglycerophosphatase inhibitor
0,464  0,094  Omptin inhibitor
0,426  0,057  Superoxide dismutase inhibitor
0,436  0,067  Pterin deaminase inhibitor
0,460  0,093  Chlordecone reductase inhibitor
0,400  0,039  Arylmalonate decarboxylase inhibitor
0,424  0,065  Lipoprotein lipase inhibitor
0,405  0,049  Glyoxylate reductase inhibitor
0,405  0,061  HIV rev inhibitor
0,446  0,104  Sugar-phosphatase inhibitor
0,451  0,112  Platelet adhesion inhibitor
0,409  0,082  Lysine 2,3-aminomutase inhibitor
0,403  0,076  Fibrolase inhibitor
0,415  0,090  UDP-N-acetylglucosamine 4-epimerase inhibitor
0,457  0,138  Polyporopepsin inhibitor
0,439  0,206  Transferase stimulant

>  <Metabolism>
0,773  0,028  CYP2J substrate
0,533  0,022  CYP1A2 substrate
0,496  0,011  CYP4A substrate
0,492  0,021  CYP2C18 substrate
0,506  0,043  CYP2B6 inhibitor
0,474  0,013  CYP2C10 substrate
0,498  0,039  CYP2C8 substrate
0,518  0,065  CYP3A2 substrate
0,501  0,048  CYP3A1 substrate
0,467  0,039  CYP2A6 substrate
0,455  0,032  CYP4A11 substrate
0,443  0,022  CYP2E1 substrate
0,453  0,035  CYP1 substrate
0,440  0,024  CYP2E substrate
0,420  0,007  CYP4A2 substrate
0,442  0,033  CYP2E1 inducer
0,440  0,039  CYP1A substrate
0,438  0,054  CYP2C9 substrate
0,400  0,040  CYP2C19 inducer
0,433  0,076  GST A substrate
0,423  0,106  CYP2C8 inhibitor

>  <Toxicity>
0,870  0,010  Hyperactivity
0,743  0,032  Ulcer, aphthous
0,718  0,025  Hematemesis
0,694  0,017  Psychoses
0,708  0,041  Pure red cell aplasia
0,661  0,044  Photophobia
0,657  0,046  Hypoxia
0,638  0,037  Withdrawal
0,633  0,031  Desquamation
0,642  0,043  Alopecia (hair loss)
0,659  0,061  Anemia, hemolytic
0,621  0,027  Aseptic meningitis
0,641  0,049  Hemolysis
0,623  0,050  Diarrhea
0,585  0,017  Sensitization
0,608  0,046  Acidosis
0,612  0,051  Gastrointestinal hemorrhage
0,629  0,069  Myocardial ischemia
0,617  0,069  Renal insufficiency
0,638  0,099  Shivering
0,566  0,035  Enterocolitis
0,586  0,072  Neuritis
0,585  0,072  Hypercholesterolemic
0,582  0,069  Hyperglycemic
0,567  0,056  Lethargy
0,561  0,053  Edema
0,545  0,041  Keratopathy
0,570  0,069  Ulcer, esophageal
0,555  0,066  Optic neuritis
0,561  0,076  Dry eye
0,515  0,031  Non mutagenic, Salmonella
0,495  0,012  Skin irritation, corrasive
0,533  0,053  Weight gain
0,525  0,046  Keratitis
0,547  0,070  Proteinuria
0,531  0,054  Apnea
0,544  0,069  Optic neuropathy
0,520  0,052  Pancytopenia
0,492  0,027  Ulcer, peptic
0,505  0,041  Systemic lupus erythematosus
0,528  0,066  Akathisia
0,505  0,047  Hirsutism
0,483  0,028  Ulceration
0,542  0,095  Nystagmus
0,542  0,098  Eye pain
0,542  0,102  Hemorrhage
0,465  0,029  Ophthalmoplegia
0,472  0,036  Urine discoloration
0,523  0,088  Hepatitis
0,499  0,067  Cataract
0,515  0,086  Drowsiness
0,453  0,026  Ulcer, gastric
0,489  0,064  Fibrosis, interstitial
0,504  0,086  Gait disturbance
0,485  0,069  Neurotoxic
0,516  0,106  Lymphocytosis
0,468  0,058  Serum sickness
0,494  0,090  Sleep disturbance
0,415  0,012  Zinc deficiency
0,423  0,024  Irritation
0,426  0,030  Bullous pemphigoid
0,477  0,082  Respiratory impairment
0,478  0,086  Nephritis
0,454  0,067  Panic
0,424  0,038  Cleft palate
0,458  0,076  Anorexiant
0,458  0,083  Hypothermic
0,441  0,068  Parkinsonism
0,467  0,098  Inflammation
0,477  0,110  Asthma
0,441  0,078  Allergic dermatitis
0,444  0,085  Neutropenia
0,466  0,108  Hyperbilirubinemia
0,474  0,116  Stomatitis
0,468  0,111  Cardiogenic shock
0,473  0,120  Hot flush
0,449  0,104  Ectropion
0,434  0,090  Respiratory failure
0,483  0,140  Cerebral hemorrhage
0,434  0,096  Colitis
0,427  0,092  Hyperthermic
0,466  0,133  Hyperreflexia
0,466  0,134  Pancreatitis
0,448  0,117  Scleroderma
0,441  0,112  Nasal congestion
0,437  0,111  Hepatic necrosis
0,425  0,102  Hyperkinesia
0,428  0,105  Pseudoporphyria
0,444  0,123  Anxiety
0,423  0,103  Agitation
0,439  0,119  Purpura
0,447  0,127  Aggression
0,438  0,123  Insomnia
0,442  0,128  Xerostomia
0,437  0,128  Chills
0,439  0,131  Vasculitis
0,415  0,108  Parotid gland enlargement
0,435  0,129  Stroke
0,455  0,150  Electrolyte imbalance
0,426  0,124  Drug eruption
0,429  0,127  Toxic epidermal necrolysis
0,433  0,132  Jaundice
0,417  0,116  Status epilepticus
0,429  0,129  Malaise
0,443  0,144  Muscle rigidity
0,401  0,103  Anemia
0,410  0,114  Euphoria
0,420  0,135  Bone marrow suppression
0,425  0,141  Constipation
0,446  0,162  Hyponatremia
0,435  0,170  Leukocytosis
0,440  0,182  Ejaculation dysfunction
0,421  0,170  Heart failure
0,417  0,178  Myocardial infarction
0,409  0,170  Chest pain

>  <Transporter>
0,544  0,034  Basolateral Na-K-Cl symporter inhibitor

>  <Murcko.CdId>
7572

>  <Murcko.Mol Weight>
134.1353

>  <Murcko.Formula>
C7H6N2O

>  <Murcko.AKOS_NUMBER>
AKOS005646626

>  <Murcko.IntegerID>
7571

$$$$

  Mrv0541 04281317412D          

 17 18  0  0  0  0            999 V2000
    1.2197   -0.1692    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7067    0.4967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7067   -0.8310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4933   -0.5813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4933    0.2428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3957   -0.1692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4886    0.5467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0766    1.2584    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0164    0.5467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0164   -0.8809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0766   -0.1692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2525   -0.1692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3127    0.5467    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8405   -0.8809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8405    0.5467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4528    1.2834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4528   -1.6176    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  3  1  1  0  0  0  0
  4  3  2  0  0  0  0
  5  2  2  0  0  0  0
  6  1  1  0  0  0  0
  7 11  1  0  0  0  0
  8  7  2  0  0  0  0
  9  6  1  0  0  0  0
 10  6  2  0  0  0  0
 11 12  1  0  0  0  0
 12 14  2  0  0  0  0
 13  7  1  0  0  0  0
 14 10  1  0  0  0  0
 15  9  2  0  0  0  0
 16  2  1  0  0  0  0
 17  3  1  0  0  0  0
  4  5  1  0  0  0  0
 15 12  1  0  0  0  0
M  END
>  <CdId>
7720

>  <Mol Weight>
229.2744

>  <Formula>
C14H15NO2

>  <AKOS_NUMBER>
AKOS000142329

>  <Lipinski's Rule of Five>
0

>  <XLogP (text field)>
1.66

>  <PASS_MNA_NEW_COUNT>
0

>  <PASS_RESULT_COUNT>
   31 of   464 Possible Pharmacological Effects at Pa > 0.400
  364 of  3850 Possible Mechanisms of Action at Pa > 0.400
  192 of   321 Possible Toxic and Adverse Effects at Pa > 0.400
    5 of   118 Possible Antitargets at Pa > 0.400
   29 of   195 Possible Metabolism-Related Actions at Pa > 0.400
  521 of  1610 Possible Gene Expression Regulation at Pa > 0.400
    1 of    68 Possible Transporters-Related Actions at Pa > 0.400

>  <Effects>
0,730  0,036  Antieczematic
0,653  0,022  Antiinflammatory
0,637  0,026  Kidney function stimulant
0,653  0,046  Antiseborrheic
0,613  0,006  Antipyretic
0,606  0,010  Antinephrotoxic
0,592  0,002  Antihyperammonemic
0,601  0,018  Leukopoiesis stimulant
0,584  0,024  Lipid metabolism regulator
0,565  0,020  Erythropoiesis stimulant
0,577  0,050  Vasodilator, cerebral
0,550  0,037  Preneoplastic conditions treatment
0,538  0,036  Alopecia treatment
0,582  0,083  Fibrinolytic
0,551  0,099  Neuroprotector
0,474  0,025  Rhinitis treatment
0,484  0,042  Antihypoxic
0,466  0,025  Leukopoiesis inhibitor
0,509  0,070  Mucositis treatment
0,474  0,051  Antipruritic, allergic
0,440  0,019  Immunomodulator
0,426  0,019  Non-steroidal antiinflammatory agent
0,475  0,068  Potassium sparing diuretic
0,415  0,008  Antiinflammatory, ophthalmic
0,485  0,100  Antibacterial activity enhancer
0,452  0,077  Cytoprotectant
0,403  0,039  Diabetic neuropathy treatment
0,407  0,050  Antithrombotic
0,401  0,044  Antiulcerative
0,435  0,082  Antinociceptive
0,417  0,094  Antidyskinetic

>  <Antitargets>
0,712  0,064  Ubiquinol-cytochrome-c reductase inhibitor
0,654  0,017  Superoxide dismutase inhibitor
0,489  0,012  Catalase inhibitor
0,422  0,040  GABA aminotransferase inhibitor
0,417  0,049  Peroxidase inhibitor

>  <Gene_Expression>
0,893  0,012  RAD23B expression inhibitor
0,881  0,004  TNFRSF21 expression inhibitor
0,858  0,006  SREBF2 expression inhibitor
0,859  0,008  ILF3 expression inhibitor
0,857  0,006  TMSB4X expression inhibitor
0,848  0,005  CDKN1B expression inhibitor
0,850  0,008  ID1 expression inhibitor
0,845  0,013  HSPA1A expression enhancer
0,836  0,006  VIM expression inhibitor
0,837  0,012  SERPINB5 expression inhibitor
0,824  0,004  CYP11A1 expression inhibitor
0,821  0,009  NOM1 expression inhibitor
0,795  0,008  LAMC1 expression enhancer
0,787  0,005  SUV420H1 expression inhibitor
0,793  0,014  THBS1 expression enhancer
0,822  0,045  LPL expression enhancer
0,785  0,009  HMGA1 expression inhibitor
0,799  0,026  CXCR1 expression enhancer
0,793  0,022  UNG expression inhibitor
0,779  0,009  SLC16A2 expression enhancer
0,780  0,010  PRRX1 expression inhibitor
0,803  0,033  NAA15 expression inhibitor
0,792  0,027  MYL6 expression enhancer
0,783  0,019  CD44 expression inhibitor
0,779  0,015  LYN expression inhibitor
0,783  0,020  MSMO1 expression enhancer
0,776  0,013  PPARD expression inhibitor
0,770  0,013  DDX18 expression inhibitor
0,766  0,016  ITGB2 expression enhancer
0,769  0,020  STAT1 expression inhibitor
0,755  0,007  PPARD expression enhancer
0,761  0,013  PRTN3 expression enhancer
0,767  0,020  C10ORF116 expression enhancer
0,767  0,021  PLAU expression inhibitor
0,753  0,010  HNRPC expression inhibitor
0,743  0,010  CDH1 expression enhancer
0,737  0,009  BAD expression inhibitor
0,752  0,026  CNN1 expression enhancer
0,757  0,030  SRPK1 expression inhibitor
0,747  0,021  NAT1 expression enhancer
0,749  0,024  GAS6 expression inhibitor
0,732  0,009  CARS expression inhibitor
0,725  0,006  TOB1 expression inhibitor
0,724  0,006  IL6ST expression inhibitor
0,739  0,022  ACTA2 expression inhibitor
0,753  0,037  PDXK expression inhibitor
0,736  0,020  FGF2 expression inhibitor
0,734  0,019  FUBP1 expression inhibitor
0,747  0,032  GSTA1 expression enhancer
0,742  0,032  JUN expression enhancer
0,722  0,013  CITED2 expression inhibitor
0,717  0,008  YWHAE expression inhibitor
0,717  0,010  JUNB expression inhibitor
0,713  0,009  CYP4A11 expression enhancer
0,720  0,018  PKM2 expression enhancer
0,723  0,024  MYBL1 expression enhancer
0,758  0,061  HSPD1 expression inhibitor
0,701  0,005  CSF2 expression enhancer
0,732  0,036  MAPT expression enhancer
0,705  0,015  CDK2 expression inhibitor
0,707  0,019  HIF1A expression inhibitor
0,715  0,027  TXNIP expression inhibitor
0,696  0,014  ADD3 expression enhancer
0,684  0,005  PPARA expression enhancer
0,715  0,038  EZH2 expression inhibitor
0,694  0,018  FKBP8 expression inhibitor
0,690  0,015  MTHFD2 expression inhibitor
0,724  0,050  DUSP4 expression enhancer
0,699  0,025  NASP expression inhibitor
0,718  0,047  GPX1 expression inhibitor
0,686  0,016  ATP2A2 expression enhancer
0,700  0,035  MMP7 expression enhancer
0,679  0,015  SIDT2 expression enhancer
0,675  0,018  CASP9 expression enhancer
0,666  0,008  PPARG expression enhancer
0,667  0,013  POR expression enhancer
0,667  0,014  NOLC1 expression inhibitor
0,676  0,024  CLMP expression inhibitor
0,654  0,004  TMSB4X expression enhancer
0,683  0,034  PLIN2 expression enhancer
0,681  0,033  IGFBP6 expression inhibitor
0,677  0,029  BIRC3 expression enhancer
0,666  0,020  VAT1 expression enhancer
0,659  0,013  CRABP2 expression inhibitor
0,661  0,017  TK1 expression inhibitor
0,659  0,018  ADSL expression inhibitor
0,693  0,052  STAR expression enhancer
0,666  0,026  WFDC2 expression enhancer
0,662  0,025  IGF2 expression inhibitor
0,669  0,032  ETV5 expression inhibitor
0,661  0,026  NEIL3 expression inhibitor
0,684  0,049  CD36 expression inhibitor
0,656  0,022  GNL3 expression inhibitor
0,680  0,050  OAS2 expression enhancer
0,634  0,005  PKP4 expression inhibitor
0,634  0,005  TUBGCP3 expression inhibitor
0,651  0,022  AKR1C1 expression enhancer
0,652  0,025  SERPINE1 expression enhancer
0,640  0,015  STAT3 expression inhibitor
0,653  0,028  SLC3A2 expression enhancer
0,659  0,034  TRAK2 expression enhancer
0,649  0,024  EDN1 expression enhancer
0,653  0,029  TNS3 expression enhancer
0,642  0,021  ICAM1 expression enhancer
0,672  0,051  TOP1 expression inhibitor
0,629  0,009  RPL7A expression inhibitor
0,648  0,029  NOL5A expression inhibitor
0,643  0,026  CPNE1 expression enhancer
0,644  0,029  HMBS expression inhibitor
0,655  0,042  FILIP1L expression inhibitor
0,638  0,024  AKT1 expression enhancer
0,625  0,014  PRDX2 expression enhancer
0,630  0,020  RRM2 expression inhibitor
0,642  0,032  PTGR1 expression enhancer
0,625  0,016  NPM1 expression inhibitor
0,621  0,014  SKP2 expression inhibitor
0,622  0,017  CALM3 expression enhancer
0,618  0,013  PLA2G16 expression enhancer
0,618  0,013  TCEB3 expression inhibitor
0,654  0,052  SFPQ expression enhancer
0,620  0,019  ACPP expression enhancer
0,642  0,042  IFNGR1 expression enhancer
0,641  0,041  MCM6 expression enhancer
0,640  0,042  JAG1 expression inhibitor
0,600  0,004  SLC16A1 expression inhibitor
0,601  0,005  POLD3 expression inhibitor
0,626  0,031  ELL2 expression enhancer
0,622  0,028  CDK4 expression inhibitor
0,631  0,038  TFDP2 expression inhibitor
0,635  0,042  NBN expression inhibitor
0,611  0,020  PLA2G2A expression enhancer
0,603  0,012  NOS1 expression inhibitor
0,600  0,011  HLA-E expression enhancer
0,638  0,050  HIF1A expression enhancer
0,601  0,013  REL expression enhancer
0,603  0,015  ISYNA1 expression enhancer
0,626  0,042  COL2A1 expression enhancer
0,604  0,020  CDK5 expression enhancer
0,618  0,035  CCND2 expression enhancer
0,618  0,035  ORC4 expression enhancer
0,605  0,024  RRBP1 expression enhancer
0,614  0,034  CLDN4 expression enhancer
0,625  0,045  PRKCA expression enhancer
0,601  0,022  SCARB1 expression enhancer
0,598  0,020  FEN1 expression inhibitor
0,606  0,028  ITGB7 expression enhancer
0,631  0,054  APOM expression enhancer
0,605  0,027  HLA-F expression enhancer
0,599  0,021  DDX24 expression inhibitor
0,599  0,022  HMGA1 expression enhancer
0,600  0,026  NPTX2 expression enhancer
0,591  0,018  FTL expression enhancer
0,599  0,026  CYB5R2 expression enhancer
0,589  0,017  SCML1 expression enhancer
0,589  0,017  SEPHS1 expression inhibitor
0,598  0,029  HLA-B expression enhancer
0,582  0,012  CYP17A1 expression inhibitor
0,584  0,015  HSPA2 expression enhancer
0,587  0,020  GFPT2 expression enhancer
0,610  0,043  VEGFA expression inhibitor
0,607  0,041  SLC16A4 expression enhancer
0,610  0,044  CCNE2 expression inhibitor
0,615  0,049  CASP3 expression enhancer
0,571  0,006  FABP4 expression enhancer
0,578  0,015  E2F1 expression inhibitor
0,594  0,033  PRSS23 expression enhancer
0,588  0,027  CDKN1C expression inhibitor
0,583  0,022  WAS expression enhancer
0,591  0,030  HLA-C expression enhancer
0,569  0,009  NKX3-1 expression enhancer
0,601  0,043  KPNA1 expression enhancer
0,602  0,045  PRKAR2B expression enhancer
0,617  0,061  SUZ12 expression inhibitor
0,563  0,006  POLR2A expression enhancer
0,593  0,038  CPE expression inhibitor
0,576  0,022  CDK6 expression inhibitor
0,557  0,005  CRYAB expression enhancer
0,587  0,036  ESR1 expression inhibitor
0,574  0,025  POLE2 expression inhibitor
0,571  0,022  VCAM1 expression enhancer
0,558  0,010  NGFR expression enhancer
0,574  0,027  PSAT1 expression inhibitor
0,581  0,035  TIMP1 expression enhancer
0,566  0,022  CBX3 expression inhibitor
0,586  0,042  TNFRSF11A expression enhancer
0,557  0,014  RCC2 expression inhibitor
0,572  0,032  MAFB expression inhibitor
0,575  0,035  PTGS2 expression enhancer
0,568  0,030  MCM7 expression inhibitor
0,557  0,019  STC2 expression enhancer
0,556  0,019  KIAA0930 expression enhancer
0,557  0,021  EHD1 expression enhancer
0,549  0,014  HMGB2 expression inhibitor
0,562  0,027  HSP27 expression enhancer
0,567  0,032  DDX42 expression enhancer
0,588  0,056  FOS expression enhancer
0,552  0,021  WDR4 expression inhibitor
0,555  0,025  TGFBI expression enhancer
0,571  0,042  SOX9 expression enhancer
0,547  0,018  CDK1 expression inhibitor
0,543  0,015  BTG1 expression enhancer
0,571  0,042  PDCD4 expression inhibitor
0,553  0,026  NR1H2 expression inhibitor
0,545  0,020  C5ORF32 expression enhancer
0,545  0,020  FAH expression enhancer
0,545  0,020  RRAS expression enhancer
0,545  0,020  SH3BGRL3 expression enhancer
0,546  0,021  SLC7A11 expression enhancer
0,555  0,030  SLC6A2 expression inhibitor
0,543  0,020  MT1F expression inhibitor
0,559  0,037  SLC1A1 expression enhancer
0,553  0,030  IL2RA expression inhibitor
0,587  0,066  GTF2F1 expression inhibitor
0,536  0,015  SMARCC1 expression inhibitor
0,551  0,030  SP2 expression inhibitor
0,553  0,032  MMP2 expression enhancer
0,548  0,028  FGFR3 expression inhibitor
0,554  0,035  TRIM16 expression enhancer
0,590  0,072  STAT5B expression enhancer
0,538  0,021  GCLM expression enhancer
0,523  0,006  MAP4K4 expression inhibitor
0,567  0,051  AGRN expression enhancer
0,538  0,023  MYBL2 expression inhibitor
0,552  0,039  DFFA expression inhibitor
0,528  0,015  ITPR1 expression inhibitor
0,547  0,035  TUBA1A expression inhibitor
0,538  0,028  DEK expression inhibitor
0,555  0,045  IL4 expression enhancer
0,537  0,026  SMAD3 expression enhancer
0,569  0,059  NR4A2 expression enhancer
0,526  0,017  SUMO1 expression inhibitor
0,542  0,033  MYC expression enhancer
0,552  0,043  MAPK8 expression inhibitor
0,545  0,037  MAP2K1 expression enhancer
0,511  0,004  NEDD9 expression enhancer
0,540  0,034  NR4A2 expression inhibitor
0,526  0,021  CALM1 expression enhancer
0,514  0,010  GSTA4 expression enhancer
0,527  0,023  PLAGL1 expression enhancer
0,545  0,041  CBX1 expression inhibitor
0,545  0,042  JUND expression inhibitor
0,546  0,044  SCARB1 expression inhibitor
0,543  0,041  MLF1 expression enhancer
0,541  0,039  MYB expression inhibitor
0,561  0,060  BAX expression enhancer
0,527  0,028  SASH1 expression inhibitor
0,548  0,049  AHR expression enhancer
0,522  0,023  SPARC expression inhibitor
0,528  0,030  PML expression inhibitor
0,549  0,051  NR3C1 expression inhibitor
0,536  0,039  DDIT3 expression enhancer
0,577  0,081  TXNRD1 expression inhibitor
0,543  0,048  HSPA1A expression inhibitor
0,528  0,034  PRNP expression enhancer
0,506  0,012  IFIT3 expression enhancer
0,534  0,042  FAS expression inhibitor
0,500  0,008  APOE expression enhancer
0,526  0,037  FUS expression inhibitor
0,507  0,018  GINS2 expression inhibitor
0,555  0,067  KPNA2 expression inhibitor
0,544  0,057  MAF expression enhancer
0,497  0,010  ASAH1 expression inhibitor
0,522  0,036  THBS1 expression inhibitor
0,530  0,045  CTTN expression inhibitor
0,537  0,052  CCNA2 expression enhancer
0,539  0,054  GSTM2 expression inhibitor
0,539  0,056  MACF1 expression inhibitor
0,539  0,056  BIRC2 expression inhibitor
0,502  0,021  ZFAND5 expression inhibitor
0,566  0,085  BST2 expression enhancer
0,525  0,044  DAB2 expression enhancer
0,529  0,050  CUTL1 expression inhibitor
0,539  0,060  ID2 expression enhancer
0,497  0,019  NAT1 expression inhibitor
0,506  0,028  MDK expression enhancer
0,497  0,019  PTPRK expression inhibitor
0,514  0,037  SELE expression enhancer
0,550  0,074  PLAUR expression enhancer
0,527  0,051  HAPLN3 expression inhibitor
0,505  0,029  FOXC1 expression enhancer
0,506  0,030  UGT1A1 expression enhancer
0,504  0,028  EGR3 expression inhibitor
0,501  0,025  CYFIP2 expression enhancer
0,527  0,054  CAV1 expression inhibitor
0,514  0,043  COL4A1 expression inhibitor
0,525  0,054  NAV1 expression inhibitor
0,498  0,027  NCF1 expression enhancer
0,502  0,033  IL1A expression enhancer
0,519  0,050  ASXL1 expression inhibitor
0,519  0,050  C11ORF68 expression enhancer
0,519  0,050  CAPN7 expression inhibitor
0,519  0,050  FAM208A expression inhibitor
0,519  0,050  NKTR expression inhibitor
0,519  0,050  RABGAP1 expression inhibitor
0,519  0,050  SETD2 expression inhibitor
0,519  0,050  TIA1 expression inhibitor
0,519  0,050  TTC3 expression inhibitor
0,534  0,067  THBD expression enhancer
0,497  0,029  ABCG1 expression enhancer
0,513  0,046  FOSL1 expression enhancer
0,550  0,085  HMGB1 expression inhibitor
0,530  0,066  C3 expression enhancer
0,514  0,051  ADAM17 expression inhibitor
0,514  0,051  CTBP1 expression inhibitor
0,488  0,025  S100P expression enhancer
0,530  0,068  IL1RN expression inhibitor
0,504  0,043  PTN expression enhancer
0,505  0,044  PLD1 expression enhancer
0,492  0,032  BDNF expression inhibitor
0,511  0,053  HLA-G expression enhancer
0,527  0,069  KRCC1 expression enhancer
0,502  0,045  PA2G4 expression inhibitor
0,499  0,043  EZR expression inhibitor
0,499  0,043  GAK expression inhibitor
0,499  0,043  TERF1 expression inhibitor
0,506  0,051  RPS19 expression inhibitor
0,506  0,051  SIRT1 expression inhibitor
0,513  0,058  PSMC1 expression enhancer
0,506  0,051  CDC16 expression inhibitor
0,502  0,048  FAM49A expression enhancer
0,484  0,029  TPO expression enhancer
0,478  0,025  PIR expression enhancer
0,500  0,047  CDKN2A expression enhancer
0,490  0,038  HMOX1 expression enhancer
0,469  0,018  INHBA expression enhancer
0,462  0,010  NBL1 expression enhancer
0,513  0,061  SEPT2 expression inhibitor
0,496  0,046  TM4SF1 expression enhancer
0,502  0,053  TGFB1 expression enhancer
0,471  0,022  LYN expression enhancer
0,500  0,052  VAV3 expression inhibitor
0,537  0,090  CREBBP expression inhibitor
0,498  0,051  CEP57 expression inhibitor
0,492  0,046  CD14 expression enhancer
0,545  0,099  VDR expression enhancer
0,520  0,074  TNFSF10 expression enhancer
0,486  0,040  PTGS2 expression inhibitor
0,476  0,031  CCNK expression inhibitor
0,514  0,069  CEACAM1 expression enhancer
0,531  0,087  AHR expression inhibitor
0,451  0,007  C3ORF26 expression inhibitor
0,451  0,007  NDE1 expression inhibitor
0,451  0,007  SLC22A18 expression enhancer
0,525  0,082  ZFP36 expression enhancer
0,490  0,047  PELI1 expression inhibitor
0,468  0,026  LGALS3 expression enhancer
0,507  0,066  ABHD3 expression enhancer
0,498  0,057  IL10 expression enhancer
0,495  0,055  NOC3L expression inhibitor
0,448  0,009  ABCG5 expression enhancer
0,448  0,009  CYP7A1 expression enhancer
0,520  0,081  TP53 expression enhancer
0,483  0,044  BMP1 expression inhibitor
0,474  0,037  CLMN expression enhancer
0,505  0,068  CP expression enhancer
0,475  0,038  CCNE1 expression inhibitor
0,492  0,056  SF1 expression inhibitor
0,486  0,050  TUBA4A expression enhancer
0,504  0,070  IL18 expression inhibitor
0,465  0,030  IVL expression inhibitor
0,448  0,014  BCL2A1 expression enhancer
0,483  0,051  HSD11B2 expression enhancer
0,494  0,062  CALR expression inhibitor
0,505  0,073  IL1A expression inhibitor
0,513  0,082  MT1A expression enhancer
0,456  0,025  IFI30 expression enhancer
0,446  0,015  SPAG6 expression enhancer
0,492  0,061  NAA15 expression enhancer
0,474  0,045  FGFR2 expression enhancer
0,487  0,058  ABCB10 expression inhibitor
0,454  0,026  MFAP4 expression inhibitor
0,450  0,024  GARS expression inhibitor
0,460  0,033  CYP17A1 expression enhancer
0,471  0,047  AREG expression enhancer
0,472  0,048  KLK3 expression inhibitor
0,455  0,031  CTPS expression inhibitor
0,448  0,024  EIF4E expression inhibitor
0,488  0,065  GSTM3 expression inhibitor
0,461  0,038  CYP11A1 expression enhancer
0,479  0,057  ISG15 expression enhancer
0,460  0,039  HS3ST3A1 expression enhancer
0,497  0,077  NSF expression inhibitor
0,435  0,019  CDCA3 expression inhibitor
0,476  0,060  CREB1 expression inhibitor
0,458  0,043  IMPDH2 expression enhancer
0,466  0,052  PPARGC1A expression enhancer
0,443  0,029  BNIP3 expression inhibitor
0,483  0,070  BCL2L1 expression inhibitor
0,427  0,014  GSN expression enhancer
0,444  0,032  RXRA expression enhancer
0,483  0,073  CCND1 expression inhibitor
0,465  0,056  EDN1 expression inhibitor
0,495  0,087  PPPDE1 expression inhibitor
0,459  0,051  ATF3 expression enhancer
0,504  0,097  GADD45A expression inhibitor
0,441  0,034  MT1H expression inhibitor
0,440  0,034  PPP1R3C expression inhibitor
0,445  0,039  KIF15 expression inhibitor
0,474  0,069  DDIT4 expression enhancer
0,462  0,057  MAOB expression enhancer
0,479  0,076  VEGFA expression enhancer
0,475  0,072  MEGF9 expression inhibitor
0,477  0,074  PCNA expression enhancer
0,463  0,061  BCL2 expression inhibitor
0,417  0,017  GADD45B expression enhancer
0,507  0,107  MSH6 expression inhibitor
0,405  0,005  RHOB expression enhancer
0,415  0,015  GCLC expression enhancer
0,421  0,022  KLK7 expression enhancer
0,455  0,056  CD86 expression enhancer
0,441  0,043  ATR expression inhibitor
0,441  0,043  EFNA4 expression inhibitor
0,441  0,043  MARK3 expression inhibitor
0,441  0,043  SMAD1 expression inhibitor
0,469  0,071  NT5DC2 expression enhancer
0,469  0,071  RAI14 expression enhancer
0,469  0,071  RFTN1 expression enhancer
0,443  0,046  BTG2 expression enhancer
0,434  0,041  MT1X expression inhibitor
0,408  0,016  CXCR4 expression enhancer
0,421  0,031  PHLDA1 expression enhancer
0,435  0,046  TUBB3 expression enhancer
0,405  0,017  LINC00467 expression enhancer
0,405  0,017  PHF17 expression inhibitor
0,413  0,025  PTP4A1 expression enhancer
0,421  0,033  CSDA expression inhibitor
0,465  0,077  CDC25B expression enhancer
0,425  0,038  DENND5A expression enhancer
0,438  0,051  AHSA1 expression enhancer
0,461  0,073  EFEMP1 expression inhibitor
0,426  0,040  JUN expression inhibitor
0,413  0,027  CYP19A1 expression inhibitor
0,443  0,057  RPS27L expression enhancer
0,439  0,053  YWHAH expression inhibitor
0,464  0,079  CDKN1A expression enhancer
0,417  0,032  CCL4 expression enhancer
0,433  0,048  EPAS1 expression enhancer
0,436  0,052  SOX9 expression inhibitor
0,471  0,088  EPRS expression inhibitor
0,408  0,027  MND1 expression inhibitor
0,433  0,052  GATA2 expression enhancer
0,474  0,094  EIF2S1 expression enhancer
0,451  0,071  FOXO1 expression enhancer
0,457  0,079  TNFSF10 expression inhibitor
0,480  0,101  FANCC expression inhibitor
0,445  0,067  EIF3B expression inhibitor
0,466  0,089  MGMT expression enhancer
0,490  0,113  CYR61 expression enhancer
0,478  0,101  IL6 expression inhibitor
0,461  0,085  APOA1 expression inhibitor
0,412  0,036  LGALS8 expression enhancer
0,465  0,089  ATP1B3 expression inhibitor
0,403  0,028  HERPUD1 expression inhibitor
0,413  0,039  DHCR24 expression enhancer
0,416  0,043  DNMT1 expression inhibitor
0,400  0,029  GATA1 expression enhancer
0,474  0,103  FGFR1 expression inhibitor
0,443  0,073  TNFRSF21 expression enhancer
0,411  0,042  S100A11 expression enhancer
0,407  0,039  PSAP expression enhancer
0,429  0,061  AKR1C2 expression enhancer
0,428  0,061  KPNB1 expression enhancer
0,423  0,057  F2R expression enhancer
0,401  0,035  KEAP1 expression enhancer
0,464  0,098  ABCC5 expression enhancer
0,471  0,106  MYB expression enhancer
0,424  0,059  SF3B5 expression enhancer
0,421  0,060  PARG expression enhancer
0,411  0,051  BMP2 expression enhancer
0,452  0,093  TNF expression enhancer
0,416  0,056  ALPL expression enhancer
0,421  0,063  PIM1 expression inhibitor
0,425  0,066  TRAF3 expression enhancer
0,421  0,063  ANAPC1 expression enhancer
0,418  0,060  PGM2 expression enhancer
0,446  0,089  NOS2 expression enhancer
0,440  0,084  CCL5 expression inhibitor
0,457  0,101  CEP350 expression inhibitor
0,457  0,101  PDE8A expression inhibitor
0,438  0,084  CDCA5 expression enhancer
0,442  0,089  SPATA13 expression enhancer
0,417  0,065  DLEU2 expression enhancer
0,406  0,055  IGFBP2 expression inhibitor
0,410  0,059  G0S2 expression enhancer
0,403  0,053  CD36 expression enhancer
0,438  0,088  PCDH8 expression enhancer
0,415  0,065  KLF10 expression inhibitor
0,430  0,080  CEACAM6 expression enhancer
0,411  0,061  FASN expression inhibitor
0,407  0,058  NEDD9 expression inhibitor
0,400  0,053  TRAM1 expression inhibitor
0,400  0,054  IFIT1 expression enhancer
0,433  0,088  STRBP expression inhibitor
0,419  0,075  TPM4 expression inhibitor
0,448  0,104  PNKD expression inhibitor
0,432  0,090  PLA2G4A expression enhancer
0,406  0,065  EI24 expression enhancer
0,405  0,064  TIMP1 expression inhibitor
0,414  0,074  IL1B expression enhancer
0,444  0,103  TERT expression enhancer
0,418  0,080  MAP1B expression enhancer
0,414  0,077  TIMP3 expression enhancer
0,401  0,066  CTSD expression inhibitor
0,443  0,109  SERPINB5 expression enhancer
0,434  0,103  PHB expression inhibitor
0,408  0,079  GRPEL1 expression inhibitor
0,430  0,103  MMP2 expression inhibitor
0,410  0,084  TMPRSS2 expression inhibitor
0,411  0,087  ATM expression enhancer
0,427  0,106  PDCD4 expression enhancer
0,416  0,098  RNF4 expression inhibitor
0,427  0,109  TNFAIP2 expression enhancer
0,422  0,111  TP53TG1 expression enhancer
0,435  0,128  NFKB1 expression enhancer
0,408  0,105  NCOA2 expression enhancer
0,418  0,132  ITGB1 expression enhancer
0,405  0,121  CD38 expression enhancer
0,404  0,120  ALCAM expression inhibitor
0,422  0,143  ITGA3 expression enhancer
0,423  0,157  SLC2A4 expression enhancer
0,409  0,167  ITGB6 expression inhibitor

>  <Mechanisms>
0,913  0,004  Chlordecone reductase inhibitor
0,872  0,005  Taurine dehydrogenase inhibitor
0,892  0,030  Transferase stimulant
0,827  0,004  Mitochondrial processing peptidase inhibitor
0,823  0,003  Protein-tyrosine phosphatase alpha inhibitor
0,831  0,029  Membrane integrity agonist
0,805  0,004  Corticosteroid side-chain-isomerase inhibitor
0,793  0,004  N-formylmethionyl-peptidase inhibitor
0,791  0,004  Insulin promoter
0,787  0,004  L-glucuronate reductase inhibitor
0,788  0,008  Carboxypeptidase Taq inhibitor
0,783  0,005  Aspartate-phenylpyruvate transaminase inhibitor
0,778  0,017  Glycosylphosphatidylinositol phospholipase D inhibitor
0,739  0,005  4-Hydroxyphenylacetate 3-monooxygenase inhibitor
0,738  0,004  Uroporphyrinogen-III synthase inhibitor
0,732  0,003  Penicillin amidase inhibitor
0,737  0,008  Methylamine-glutamate N-methyltransferase inhibitor
0,744  0,020  NADPH peroxidase inhibitor
0,734  0,011  Dimethylargininase inhibitor
0,732  0,013  Pullulanase inhibitor
0,721  0,004  Arylesterase inhibitor
0,717  0,004  Opine dehydrogenase inhibitor
0,723  0,011  Creatininase inhibitor
0,725  0,017  Omptin inhibitor
0,719  0,014  Prostaglandin-E2 9-reductase inhibitor
0,710  0,006  Endopeptidase So inhibitor
0,711  0,008  Lysostaphin inhibitor
0,700  0,007  NADH kinase inhibitor
0,729  0,044  Mucomembranous protector
0,693  0,008  Aspartate-ammonia ligase inhibitor
0,689  0,007  Allyl-alcohol dehydrogenase inhibitor
0,717  0,036  Polyporopepsin inhibitor
0,712  0,031  Sugar-phosphatase inhibitor
0,694  0,015  2-Hydroxyquinoline 8-monooxygenase inhibitor
0,707  0,030  Alkenylglycerophosphocholine hydrolase inhibitor
0,681  0,005  Glucan 1,4-alpha-maltotetraohydrolase inhibitor
0,678  0,004  N-Acyl-D-amino-acid deacylase inhibitor
0,671  0,007  Arylmalonate decarboxylase inhibitor
0,670  0,010  Poly(alpha-L-guluronate) lyase inhibitor
0,671  0,012  N-benzyloxycarbonylglycine hydrolase inhibitor
0,679  0,019  Fragilysin inhibitor
0,670  0,013  Linoleate diol synthase inhibitor
0,678  0,023  Alkylacetylglycerophosphatase inhibitor
0,662  0,007  Tryptophanamidase inhibitor
0,665  0,011  Adenomatous polyposis treatment
0,660  0,007  Glutarate-semialdehyde dehydrogenase inhibitor
0,670  0,020  Venombin AB inhibitor
0,663  0,015  Formaldehyde transketolase inhibitor
0,712  0,064  Ubiquinol-cytochrome-c reductase inhibitor
0,671  0,024  Aldose reductase-like protein inhibitor
0,651  0,004  Thromboxane B2 antagonist
0,653  0,008  Prostaglandin-A1 DELTA-isomerase inhibitor
0,652  0,009  Glyoxylate reductase inhibitor
0,670  0,031  Acylcarnitine hydrolase inhibitor
0,661  0,021  Exoribonuclease II inhibitor
0,651  0,013  Prolyl aminopeptidase inhibitor
0,654  0,017  Superoxide dismutase inhibitor
0,647  0,015  Glutamine-phenylpyruvate transaminase inhibitor
0,654  0,022  Proteasome ATPase inhibitor
0,637  0,006  Methanol dehydrogenase inhibitor
0,654  0,025  Arginine 2-monooxygenase inhibitor
0,651  0,022  Lysine 2,3-aminomutase inhibitor
0,635  0,009  DNA-(apurinic or apyrimidinic site) lyase inhibitor
0,630  0,006  4-Chlorophenylacetate 3,4-dioxygenase inhibitor
0,638  0,014  Phenol O-methyltransferase inhibitor
0,645  0,022  Macrophage colony stimulating factor agonist
0,632  0,009  Poly(beta-D-mannuronate) lyase inhibitor
0,626  0,005  4-Hydroxyglutamate transaminase inhibitor
0,638  0,018  Gluconate 5-dehydrogenase inhibitor
0,644  0,025  UDP-N-acetylglucosamine 4-epimerase inhibitor
0,630  0,012  4-Hydroxyproline epimerase inhibitor
0,621  0,006  Gluconolactonase inhibitor
0,615  0,003  15-Hydroxyprostaglandin-D dehydrogenase (NADP+) inhibitor
0,637  0,026  Kidney function stimulant
0,629  0,022  Phosphatidylserine decarboxylase inhibitor
0,635  0,028  Glutathione thiolesterase inhibitor
0,609  0,003  Hydroxymethylbilane synthase inhibitor
0,624  0,018  Platelet aggregation stimulant
0,620  0,017  Gastrin inhibitor
0,623  0,020  ADP-thymidine kinase inhibitor
0,624  0,022  Polyamine-transporting ATPase inhibitor
0,615  0,013  S-alkylcysteine lyase inhibitor
0,613  0,011  Mannan endo-1,4-beta-mannosidase inhibitor
0,623  0,023  Pterin deaminase inhibitor
0,607  0,009  Nitrite reductase (NO-forming) inhibitor
0,608  0,011  Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase inhibitor
0,614  0,022  Insulysin inhibitor
0,609  0,019  Biotinidase inhibitor
0,594  0,004  Phenylpyruvate decarboxylase inhibitor
0,603  0,016  X-methyl-His dipeptidase inhibitor
0,597  0,010  Alanine-tRNA ligase inhibitor
0,620  0,034  Dehydro-L-gulonate decarboxylase inhibitor
0,594  0,007  Mannitol-1-phosphatase inhibitor
0,600  0,015  Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase inhibitor
0,612  0,028  Alkane 1-monooxygenase inhibitor
0,587  0,006  6-Carboxyhexanoate-CoA ligase inhibitor
0,587  0,006  Biotin-CoA ligase inhibitor
0,587  0,006  Homoaconitate hydratase inhibitor
0,587  0,006  Triacetate-lactonase inhibitor
0,613  0,033  Oxidoreductase inhibitor
0,592  0,012  Xylan endo-1,3-beta-xylosidase inhibitor
0,590  0,015  Collagen inhibitor
0,586  0,013  3-Phytase inhibitor
0,586  0,014  Peptide alpha-N-acetyltransferase inhibitor
0,586  0,015  Sulfite reductase inhibitor
0,578  0,007  6-Pyruvoyltetrahydropterin synthase inhibitor
0,593  0,022  Hydrogen dehydrogenase inhibitor
0,597  0,028  Glucan endo-1,3-beta-D-glucosidase inhibitor
0,572  0,003  Ferrochelatase inhibitor
0,575  0,008  Horrilysin inhibitor
0,593  0,027  Fatty-acyl-CoA synthase inhibitor
0,594  0,029  Lipoprotein lipase inhibitor
0,582  0,019  Urethanase inhibitor
0,580  0,018  Histidine kinase inhibitor
0,579  0,018  Ferredoxin-NAD+ reductase inhibitor
0,579  0,018  Naphthalene 1,2-dioxygenase inhibitor
0,582  0,021  Fibrolase inhibitor
0,571  0,010  Bothrolysin inhibitor
0,571  0,010  Di-trans,poly-cis-decaprenylcistransferase inhibitor
0,584  0,024  Lipid metabolism regulator
0,567  0,007  N-acetylneuraminate synthase inhibitor
0,567  0,007  Dimethylmaleate hydratase inhibitor
0,583  0,025  L-glutamate oxidase inhibitor
0,581  0,027  Cl--transporting ATPase inhibitor
0,576  0,023  Insulin growth factor agonist
0,576  0,023  Insulin like growth factor 1 agonist
0,558  0,008  2-Hydroxy-3-oxoadipate synthase inhibitor
0,569  0,019  Pitrilysin inhibitor
0,577  0,028  Peptidyl-dipeptidase Dcp inhibitor
0,556  0,009  Acetylornithine deacetylase inhibitor
0,563  0,017  Carnitinamidase inhibitor
0,565  0,020  Erythropoiesis stimulant
0,549  0,006  Creatinine deaminase inhibitor
0,559  0,018  Cyclohexanone monooxygenase inhibitor
0,553  0,013  Peptidoglycan glycosyltransferase inhibitor
0,568  0,029  Manganese peroxidase inhibitor
0,562  0,025  Arylsulfate sulfotransferase inhibitor
0,541  0,005  tRNA nucleotidyltransferase inhibitor
0,580  0,045  Pro-opiomelanocortin converting enzyme inhibitor
0,546  0,012  Leucolysin inhibitor
0,538  0,005  2-Enoate reductase inhibitor
0,568  0,036  Feruloyl esterase inhibitor
0,570  0,038  Phospholipid-translocating ATPase inhibitor
0,552  0,022  Chenodeoxycholoyltaurine hydrolase inhibitor
0,551  0,021  Amine dehydrogenase inhibitor
0,539  0,009  Snapalysin inhibitor
0,577  0,050  Vasodilator, cerebral
0,530  0,007  Mannan endo-1,6-alpha-mannosidase inhibitor
0,527  0,005  Benzoylformate decarboxylase inhibitor
0,531  0,008  3-Carboxyethylcatechol 2,3-dioxygenase inhibitor
0,554  0,032  (R)-6-hydroxynicotine oxidase inhibitor
0,530  0,011  Meprin B inhibitor
0,532  0,013  Aldehyde dehydrogenase (pyrroloquinoline-quinone) inhibitor
0,547  0,029  Fibrinogen receptor antagonist
0,535  0,017  Laccase inhibitor
0,538  0,022  2-Hydroxymuconate-semialdehyde hydrolase inhibitor
0,520  0,007  Leukotriene-C4 synthase inhibitor
0,533  0,020  1-Alkylglycerophosphocholine O-acetyltransferase inhibitor
0,528  0,015  Cyclohexyl-isocyanide hydratase inhibitor
0,537  0,025  Bisphosphoglycerate phosphatase inhibitor
0,519  0,008  Aspartyl aminopeptidase inhibitor
0,518  0,009  Gamma-D-Glutamyl-meso-diaminopimelate peptidase inhibitor
0,521  0,012  Glycolate dehydrogenase inhibitor
0,521  0,015  Fructan beta-fructosidase inhibitor
0,514  0,010  Inulinase inhibitor
0,506  0,005  N-Carbamoyl-D-amino acid hydrolase inhibitor
0,505  0,005  (R,R)-butanediol dehydrogenase inhibitor
0,582  0,084  NACHT, LRR and PYD domains-containing protein 1 inhibitor
0,521  0,023  Hydroxylamine oxidase inhibitor
0,508  0,009  Indanol dehydrogenase inhibitor
0,504  0,006  Gallate decarboxylase inhibitor
0,522  0,025  tRNA-pseudouridine synthase I inhibitor
0,502  0,005  Prephenate dehydrogenase inhibitor
0,525  0,028  Alkenylglycerophosphoethanolamine hydrolase inhibitor
0,550  0,053  Lysase inhibitor
0,500  0,004  Bromodomain-containing protein 2 inhibitor
0,500  0,004  Runt-related transcription factor 1 inhibitor
0,530  0,034  HIV rev inhibitor
0,500  0,006  Tryptophan transaminase inhibitor
0,533  0,041  Platelet adhesion inhibitor
0,519  0,029  Sulfur reductase inhibitor
0,505  0,015  Sulfite dehydrogenase inhibitor
0,533  0,044  Glucose oxidase inhibitor
0,522  0,033  Fucosterol-epoxide lyase inhibitor
0,504  0,015  Crotonoyl-[acyl-carrier-protein] hydratase inhibitor
0,503  0,015  Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase inhibitor
0,502  0,015  N-Acyl-D-aspartate deacylase inhibitor
0,491  0,004  Orotate reductase (NADH) inhibitor
0,531  0,046  Glucan endo-1,6-beta-glucosidase inhibitor
0,500  0,016  Pyruvate decarboxylase inhibitor
0,502  0,019  Opheline kinase inhibitor
0,502  0,019  Taurocyamine kinase inhibitor
0,495  0,013  Quinoprotein glucose dehydrogenase inhibitor
0,483  0,002  Imidazoleacetate 4-monooxygenase inhibitor
0,490  0,011  Sarcosine oxidase inhibitor
0,491  0,013  Sphinganine-1-phosphate aldolase inhibitor
0,488  0,010  Serine-pyruvate transaminase inhibitor
0,491  0,013  Aryldialkylphosphatase inhibitor
0,489  0,012  Catalase inhibitor
0,498  0,021  Dolichyl-diphosphooligosaccharide-protein glycotransferase inhibitor
0,493  0,018  Histidinol-phosphatase inhibitor
0,487  0,014  Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase inhibitor
0,499  0,026  S-formylglutathione hydrolase inhibitor
0,484  0,011  Ubiquitin thiolesterase inhibitor
0,492  0,021  Long-chain-aldehyde dehydrogenase inhibitor
0,488  0,017  Cyanoalanine nitrilase inhibitor
0,510  0,039  Muramoyltetrapeptide carboxypeptidase inhibitor
0,482  0,012  Phenylalanine(histidine) transaminase inhibitor
0,483  0,014  D-xylulose reductase inhibitor
0,490  0,022  Phosphopantothenoylcysteine decarboxylase inhibitor
0,480  0,013  2-Oxoglutarate decarboxylase inhibitor
0,499  0,032  Nucleotide metabolism regulator
0,472  0,006  Hyaluronic acid agonist
0,559  0,093  Transferase inhibitor
0,491  0,025  D-lactaldehyde dehydrogenase inhibitor
0,503  0,039  Neurotransmitter antagonist
0,482  0,018  Mannose isomerase inhibitor
0,473  0,010  Thiosulfate dehydrogenase inhibitor
0,486  0,024  Thiol oxidase inhibitor
0,475  0,014  2,3,4,5-Tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase inhibitor
0,471  0,009  Gly-X carboxypeptidase inhibitor
0,475  0,015  Glucuronate isomerase inhibitor
0,470  0,010  Bontoxilysin inhibitor
0,470  0,012  Camphor 1,2-monooxygenase inhibitor
0,489  0,032  All-trans-retinyl-palmitate hydrolase inhibitor
0,494  0,037  3-Hydroxybenzoate 6-monooxygenase inhibitor
0,486  0,029  Leukotriene-B4 20-monooxygenase inhibitor
0,467  0,011  Aminocarboxymuconate-semialdehyde decarboxylase inhibitor
0,482  0,026  Phosphoinositide 5-phosphatase inhibitor
0,474  0,019  Gingipain K inhibitor
0,496  0,042  Ecdysone 20-monooxygenase inhibitor
0,465  0,011  2-Haloacid dehalogenase (configuration-inverting) inhibitor
0,477  0,023  IgA-specific metalloendopeptidase inhibitor
0,468  0,017  Transketolase inhibitor
0,521  0,070  Nicotinic alpha2beta2 receptor antagonist
0,475  0,025  Dextranase inhibitor
0,466  0,016  D-alanine 2-hydroxymethyltransferase inhibitor
0,481  0,032  Gamma-guanidinobutyraldehyde dehydrogenase inhibitor
0,478  0,030  Cathepsin T inhibitor
0,465  0,016  Succinate-semialdehyde dehydrogenase [NAD(P)+] inhibitor
0,486  0,038  Cyclic AMP agonist
0,456  0,009  3-Oxoadipate enol-lactonase inhibitor
0,458  0,011  Phosphoenolpyruvate mutase inhibitor
0,481  0,035  Malate dehydrogenase (acceptor) inhibitor
0,466  0,021  Coccolysin inhibitor
0,467  0,022  Carbon-monoxide dehydrogenase inhibitor
0,451  0,007  Thyroxine 5-deiodinase inhibitor
0,462  0,018  Venom exonuclease inhibitor
0,468  0,026  Monodehydroascorbate reductase (NADH) inhibitor
0,459  0,017  2-Oxoaldehyde dehydrogenase (NADP+) inhibitor
0,477  0,036  5 Hydroxytryptamine release inhibitor
0,452  0,011  Aminoacylase inhibitor
0,471  0,030  Reductant
0,466  0,026  Membrane permeability enhancer
0,451  0,012  Peptide-tryptophan 2,3-dioxygenase inhibitor
0,462  0,025  4-Methoxybenzoate monooxygenase (O-demethylating) inhibitor
0,469  0,032  Plastoquinol-plastocyanin reductase inhibitor
0,464  0,028  Interleukin 2 agonist
0,438  0,003  Phosphotyrosine-protein phosphatase PTPB inhibitor
0,464  0,030  (R)-Pantolactone dehydrogenase (flavin) inhibitor
0,460  0,026  Threonine aldolase inhibitor
0,480  0,046  Histamine release inhibitor
0,438  0,005  Glucan endo-1,3-alpha-glucosidase inhibitor
0,448  0,015  Benzaldehyde dehydrogenase (NADP+) inhibitor
0,464  0,031  Methylumbelliferyl-acetate deacetylase inhibitor
0,454  0,024  Chitosanase inhibitor
0,442  0,013  Flavin-containing monooxygenase inhibitor
0,433  0,005  Porphobilinogen synthase inhibitor
0,443  0,015  Plasmanylethanolamine desaturase inhibitor
0,448  0,021  Shikimate O-hydroxycinnamoyltransferase inhibitor
0,442  0,015  N-hydroxy-2-acetamidofluorene reductase inhibitor
0,442  0,016  Ornithine cyclodeaminase inhibitor
0,441  0,016  Licheninase inhibitor
0,436  0,013  Nardilysin inhibitor
0,451  0,028  (-)-(4S)-limonene synthase inhibitor
0,436  0,013  Dolichyl-phosphatase inhibitor
0,444  0,022  Phosphatidylglycerophosphatase inhibitor
0,429  0,007  Glycerol-1-phosphatase inhibitor
0,450  0,028  Alcohol dehydrogenase (acceptor) inhibitor
0,440  0,019  Immunomodulator
0,428  0,009  Cyclamate sulfohydrolase inhibitor
0,428  0,009  Pappalysin-1 inhibitor
0,451  0,033  Arylacetonitrilase inhibitor
0,477  0,059  Oxygen scavenger
0,479  0,062  Benzoate-CoA ligase inhibitor
0,441  0,025  Glyoxylate oxidase inhibitor
0,431  0,016  N-carbamoyl-L-amino-acid hydrolase inhibitor
0,462  0,047  Cholesterol antagonist
0,447  0,033  Aspergillopepsin I inhibitor
0,427  0,014  3-Demethylubiquinone-9 3-O-methyltransferase inhibitor
0,465  0,053  Nitrate reductase (cytochrome) inhibitor
0,478  0,066  Thioredoxin inhibitor
0,432  0,019  Phenylacetate-CoA ligase inhibitor
0,434  0,022  Pyroglutamyl-peptidase II inhibitor
0,432  0,021  Procollagen N-endopeptidase inhibitor
0,429  0,017  Glycine dehydrogenase (decarboxylating) inhibitor
0,432  0,020  N-(long-chain-acyl)ethanolamine deacylase inhibitor
0,419  0,011  Xaa-Pro dipeptidyl-peptidase inhibitor
0,510  0,102  Phosphatase inhibitor
0,416  0,008  Aureolysin inhibitor
0,422  0,014  N-acetyl-gamma-glutamyl-phosphate reductase inhibitor
0,432  0,024  Cyclomaltodextrinase inhibitor
0,458  0,051  Methylenetetrahydrofolate reductase (NADPH) inhibitor
0,426  0,019  Non-steroidal antiinflammatory agent
0,475  0,068  Potassium sparing diuretic
0,425  0,019  Succinyl-diaminopimelate desuccinylase inhibitor
0,419  0,014  Indoleacetaldoxime dehydratase inhibitor
0,412  0,008  Phospholipase A-2-activating protein inhibitor
0,433  0,028  N-acylmannosamine kinase inhibitor
0,417  0,014  Cyclopentanone monooxygenase inhibitor
0,414  0,014  2,4-Diaminopentanoate dehydrogenase inhibitor
0,414  0,014  3-Hydroxybutyryl-CoA dehydrogenase inhibitor
0,414  0,014  Lysine 6-dehydrogenase inhibitor
0,415  0,015  L-threonine 3-dehydrogenase inhibitor
0,467  0,066  27-Hydroxycholesterol 7alpha-monooxygenase inhibitor
0,414  0,015  Bisphosphoglycerate mutase inhibitor
0,404  0,004  Anthrax lethal factor inhibitor
0,410  0,011  Phosphoenolpyruvate-protein phosphotransferase inhibitor
0,443  0,044  Centromere associated protein inhibitor
0,412  0,013  Alcohol dehydrogenase (NADP+) inhibitor
0,410  0,012  Aryl sulfotransferase inhibitor
0,403  0,005  Acyl-lysine deacylase inhibitor
0,404  0,009  Peptidylamidoglycolate lyase inhibitor
0,426  0,030  Mediator release inhibitor
0,405  0,010  Glycine C-acetyltransferase inhibitor
0,414  0,019  GABA C receptor agonist
0,434  0,040  Aryl-acylamidase inhibitor
0,526  0,132  Membrane permeability inhibitor
0,468  0,074  Cyclic AMP antagonist
0,424  0,030  Adenylyl-sulfate reductase inhibitor
0,428  0,035  RNA-directed RNA polymerase inhibitor
0,411  0,018  Rhamnulose-1-phosphate aldolase inhibitor
0,420  0,027  Carboxypeptidase D inhibitor
0,409  0,016  Glycine amidinotransferase inhibitor
0,431  0,039  Steroid N-acetylglucosaminyltransferase inhibitor
0,425  0,033  (+)-borneol dehydrogenase inhibitor
0,410  0,020  Mandelate 4-monooxygenase inhibitor
0,417  0,027  Hyponitrite reductase inhibitor
0,433  0,044  Acetylesterase inhibitor
0,463  0,074  Penicillin binding protein antagonist
0,463  0,074  Penicillin-binding protein ampH inhibitor
0,409  0,023  DNA-3-methyladenine glycosylase I inhibitor
0,400  0,015  D-amino-acid dehydrogenase inhibitor
0,444  0,060  Beta-adrenergic receptor kinase inhibitor
0,444  0,060  G-protein-coupled receptor kinase inhibitor
0,422  0,040  GABA aminotransferase inhibitor
0,416  0,034  Aspergillus nuclease S1 inhibitor
0,402  0,024  Glutathione dehydrogenase (ascorbate) inhibitor
0,409  0,031  Levanase inhibitor
0,452  0,077  Cytoprotectant
0,461  0,089  Complement factor D inhibitor
0,417  0,049  Peroxidase inhibitor
0,400  0,033  Formate-dihydrofolate ligase inhibitor
0,464  0,098  Acetylcholine neuromuscular blocking agent
0,444  0,078  Glutamate-5-semialdehyde dehydrogenase inhibitor
0,405  0,042  Malate oxidase inhibitor
0,401  0,038  NADPH-ferrihemoprotein reductase inhibitor
0,409  0,048  Glucan 1,4-alpha-maltotriohydrolase inhibitor
0,470  0,116  DNA ligase 1 inhibitor
0,439  0,087  Anorexiant
0,406  0,062  Fibroblast growth factor agonist
0,433  0,092  Glyceryl-ether monooxygenase inhibitor
0,413  0,086  MAP kinase stimulant
0,409  0,099  Galanin receptor antagonist

>  <Metabolism>
0,879  0,007  CYP2J substrate
0,678  0,003  CYP4A1 inhibitor
0,590  0,009  CYP17 inhibitor
0,584  0,009  CYP4A11 substrate
0,580  0,007  FMO1 substrate
0,593  0,040  GST A substrate
0,544  0,025  CYP2D16 substrate
0,526  0,013  CYP2C18 substrate
0,491  0,009  Flavin-containing monooxygenase substrate
0,481  0,013  CYP4A substrate
0,475  0,027  CYP2C11 substrate
0,479  0,038  CYP2A8 substrate
0,507  0,071  CYP3A2 substrate
0,493  0,066  CYP2C8 inhibitor
0,470  0,045  CYP2C8 substrate
0,463  0,048  CYP2C9 substrate
0,453  0,042  CYP2A6 substrate
0,423  0,023  CYP7 inhibitor
0,462  0,063  CYP3A1 substrate
0,405  0,008  CYP4A2 substrate
0,408  0,017  FMO3 substrate
0,477  0,093  CYP2C12 substrate
0,409  0,026  UGT2B4 substrate
0,415  0,036  UGT1A9 substrate
0,421  0,050  CYP2B5 substrate
0,429  0,065  CYP2A1 substrate
0,401  0,053  CYP2A substrate
0,408  0,067  CYP3A5 substrate
0,407  0,071  CYP2C substrate

>  <Toxicity>
0,912  0,003  Gastrointestinal hemorrhage
0,908  0,005  Hyperactivity
0,902  0,004  Aseptic meningitis
0,870  0,005  Hematemesis
0,860  0,005  Hyponatremia
0,809  0,009  Ulcer, esophageal
0,813  0,014  Cerebral hemorrhage
0,809  0,015  Renal insufficiency
0,807  0,020  Anemia, hemolytic
0,816  0,041  Bone marrow suppression
0,792  0,041  Shivering
0,774  0,028  Toxic, respiration
0,769  0,025  Ulcer, aphthous
0,767  0,036  Lichenoid eruption
0,717  0,004  Ulcer, peptic
0,739  0,029  Fibrillation, atrial
0,723  0,024  Alopecia (hair loss)
0,730  0,033  Dysesthesia
0,730  0,034  Neuritis
0,699  0,005  Ulcer, gastric
0,698  0,004  Ulceration
0,729  0,037  Pure red cell aplasia
0,710  0,022  Weight gain
0,720  0,035  Myocardial ischemia
0,721  0,040  Paranoia
0,725  0,045  Stroke
0,690  0,019  Urine discoloration
0,694  0,024  Hypercholesterolemic
0,698  0,039  Hyperreflexia
0,674  0,018  Fibrosis, interstitial
0,670  0,024  Anorgasmia
0,695  0,050  Leukocytosis
0,678  0,037  Euphoria
0,656  0,020  Hematuria
0,663  0,028  Allergic contact dermatitis
0,657  0,026  Splenomegaly
0,641  0,011  Nephrotic syndrome
0,647  0,020  Pseudoporphyria
0,661  0,038  Erythema multiforme
0,655  0,036  Diplopia
0,636  0,020  Enterocolitis
0,649  0,038  Enuresis
0,642  0,039  Acidosis
0,635  0,032  Proteinuria
0,619  0,022  Nephritis
0,638  0,042  Lymphocytosis
0,604  0,013  Photoallergy dermatitis
0,640  0,051  Gait disturbance
0,635  0,052  Photophobia
0,611  0,029  Hypomagnesemia
0,614  0,036  Acidosis, metabolic
0,621  0,044  Withdrawal
0,608  0,033  Cardiogenic shock
0,588  0,016  Interstitial nephritis
0,614  0,044  Aphasia
0,623  0,055  Heart failure
0,568  0,004  Renal papillary necrosis
0,614  0,051  Psychomotor impairment
0,615  0,054  Pancreatitis
0,598  0,040  Desquamation
0,593  0,036  Immunotoxin
0,592  0,039  Ototoxicity
0,607  0,055  Hepatitis
0,608  0,061  Muscle rigidity
0,561  0,015  Bullous pemphigoid
0,588  0,044  Scleroderma
0,580  0,037  Hepatic necrosis
0,599  0,059  Hemolysis
0,589  0,055  Psychoses
0,581  0,047  Edema
0,607  0,075  Eye pain
0,581  0,049  Toxic epidermal necrolysis
0,567  0,035  Keratitis
0,569  0,040  Allergic dermatitis
0,553  0,026  Systemic lupus erythematosus
0,564  0,040  Glycosuria
0,561  0,036  Panic
0,582  0,058  Stomatitis
0,560  0,038  Keratopathy
0,575  0,056  Optic neuritis
0,537  0,018  Serum sickness
0,570  0,052  Drug eruption
0,615  0,097  Ejaculation dysfunction
0,522  0,005  Henoch-Schonlein purpura
0,566  0,057  Asthma
0,548  0,040  Colitis
0,575  0,068  Dry eye
0,561  0,058  Jaundice
0,534  0,031  ANCA-positive vasculitis
0,556  0,058  Hyperbilirubinemia
0,563  0,065  Dysarthria
0,569  0,071  Erectile dysfunction
0,542  0,047  Hyperkinesia
0,520  0,024  Palpitation
0,571  0,077  Mania
0,578  0,085  Electrolyte imbalance
0,555  0,063  Optic neuropathy
0,569  0,081  Migraine
0,557  0,069  Purpura
0,523  0,037  Eosinophilia
0,550  0,067  Ectropion
0,482  0,007  Zinc deficiency
0,529  0,054  Apnea
0,511  0,036  Parotid gland enlargement
0,485  0,011  Pemphigus
0,564  0,089  Hemorrhage
0,532  0,058  Respiratory impairment
0,534  0,060  Necrosis
0,518  0,045  Hyperuricemia
0,547  0,075  Vasculitis
0,530  0,059  Anemia
0,556  0,086  Hiccups
0,488  0,019  Cleft palate
0,514  0,054  Pancytopenia
0,528  0,074  Nightmare
0,538  0,084  Myocardial infarction
0,478  0,028  Anemia, sideroblastic
0,539  0,090  Vertigo
0,483  0,034  Acidosis, lactic
0,533  0,086  Aggression
0,494  0,048  Chorea
0,510  0,071  Lethargy
0,493  0,054  Hirsutism
0,485  0,046  Dysphoria
0,514  0,084  Osteoporosis
0,481  0,052  Glaucoma
0,518  0,092  Thrombocytopenia
0,467  0,042  Acneiform eruption
0,525  0,101  Reproductive dysfunction
0,522  0,103  Chest pain
0,482  0,068  Choreoathetosis
0,490  0,079  Anaphylaxis
0,508  0,098  Hyperglycemic
0,462  0,054  Gastrointestinal disturbance
0,499  0,091  Erythema
0,474  0,073  Hypothermic
0,490  0,091  Thrombophlebitis
0,495  0,097  Chills
0,507  0,113  Nystagmus
0,487  0,093  Memory impairment
0,502  0,108  Dyspepsia
0,469  0,075  Coma
0,507  0,118  Hypoxia
0,463  0,075  Hyperthermic
0,447  0,060  Cholestasis
0,488  0,102  Malaise
0,494  0,111  Rhinitis
0,445  0,063  Laryngospasm
0,477  0,096  Diarrhea
0,474  0,093  Bronchoconstrictor
0,487  0,108  Shock
0,469  0,091  Myoclonus
0,473  0,098  Bradycardic
0,436  0,064  Hypersexuality
0,443  0,071  Speech disturbance
0,413  0,042  Myasthenia Gravis
0,487  0,117  Myalgia
0,470  0,101  Vision disturbance
0,457  0,091  Galactorrhea
0,471  0,106  Excitability
0,434  0,071  Endocrine disruptor
0,487  0,127  Arthralgia
0,440  0,081  Agranulocytosis
0,470  0,111  Constipation
0,451  0,097  Paralysis
0,437  0,083  Postural (orthostatic) hypotension
0,439  0,087  Anorexiant
0,461  0,112  Syncope
0,465  0,116  Xerostomia
0,462  0,122  Sexual dysfunction
0,454  0,114  Insomnia
0,452  0,114  Tachycardiac
0,445  0,110  Urticaria
0,445  0,114  Pruritus
0,463  0,135  Abdominal pain
0,448  0,121  Anxiety
0,434  0,106  Leukopenia
0,422  0,096  Respiratory failure
0,448  0,123  Exanthema
0,424  0,100  Neutropenia
0,422  0,107  Weight loss
0,419  0,104  Cataract
0,425  0,119  Toxic, vascular
0,422  0,129  Weakness
0,405  0,113  Akathisia
0,415  0,128  Inflammation
0,409  0,125  Urinary retention
0,419  0,138  Hypotonia
0,414  0,133  Allergic reaction
0,403  0,144  Headache
0,418  0,164  Akinesia
0,401  0,158  Psychosexual disorder

>  <Transporter>
0,406  0,005  Excitatory amino acid transporter EAAC1 inhibitor

>  <Murcko.CdId>
7720

>  <Murcko.Mol Weight>
143.1852

>  <Murcko.Formula>
C10H9N

>  <Murcko.AKOS_NUMBER>
AKOS000142329

>  <Murcko.IntegerID>
7719

$$$$

  Mrv0541 04281317412D          

 13 13  0  0  0  0            999 V2000
   -0.6558    0.0596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4817    1.3013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0609   -0.3529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7734    0.0638    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3683   -0.3529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7567    1.7138    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0609   -1.1779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4859    0.4846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3683   -1.1779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1817    1.7346    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6558   -1.5904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6641    0.8846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0891   -1.5904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  8  1  0  0  0  0
  3  1  2  0  0  0  0
  4  3  1  0  0  0  0
  5  1  1  0  0  0  0
  6  2  2  0  0  0  0
  7  3  1  0  0  0  0
  8  4  1  0  0  0  0
  9  5  2  0  0  0  0
 10  2  1  0  0  0  0
 11  9  1  0  0  0  0
 12  1  1  0  0  0  0
 13  9  1  0  0  0  0
  7 11  2  0  0  0  0
M  END
>  <CdId>
7870

>  <Mol Weight>
180.2005

>  <Formula>
C10H12O3

>  <AKOS_NUMBER>
AKOS000104794

>  <Lipinski's Rule of Five>
0

>  <XLogP (text field)>
1.22

>  <PASS_MNA_NEW_COUNT>
0

>  <PASS_RESULT_COUNT>
   63 of   464 Possible Pharmacological Effects at Pa > 0.400
  412 of  3850 Possible Mechanisms of Action at Pa > 0.400
  240 of   321 Possible Toxic and Adverse Effects at Pa > 0.400
    4 of   118 Possible Antitargets at Pa > 0.400
   34 of   195 Possible Metabolism-Related Actions at Pa > 0.400
  789 of  1610 Possible Gene Expression Regulation at Pa > 0.400
    0 of    68 Possible Transporters-Related Actions at Pa > 0.400

>  <Effects>
0,876  0,006  Antiseborrheic
0,783  0,005  Fibrinolytic
0,727  0,005  Antidiabetic
0,713  0,010  Vasoprotector
0,697  0,005  Antipyretic
0,691  0,012  Lipid metabolism regulator
0,712  0,036  Neuroprotector
0,702  0,045  Antieczematic
0,657  0,004  Lipoprotein disorders treatment
0,656  0,013  Cytoprotectant
0,652  0,012  Antihypoxic
0,654  0,026  Antidyskinetic
0,629  0,011  Eye irritation, inactive
0,621  0,005  Antihelmintic (Nematodes)
0,618  0,008  Atherosclerosis treatment
0,614  0,016  Leukopoiesis stimulant
0,600  0,004  Antiuremic
0,626  0,030  Kidney function stimulant
0,608  0,013  Antihypercholesterolemic
0,602  0,008  Antiseptic
0,590  0,014  Antipruritic, allergic
0,592  0,023  Vasodilator, peripheral
0,587  0,025  Hypolipemic
0,566  0,014  Carminative
0,565  0,021  Antinephrotoxic
0,563  0,025  Radiosensitizer
0,559  0,022  Antipruritic
0,555  0,022  Erythropoiesis stimulant
0,542  0,013  Skin irritation, inactive
0,556  0,035  Preneoplastic conditions treatment
0,536  0,024  Antithrombotic
0,522  0,015  Rhinitis treatment
0,531  0,034  Potassium sparing diuretic
0,530  0,039  Alopecia treatment
0,510  0,021  Antiulcerative
0,527  0,042  Spasmolytic, urinary
0,489  0,004  Uric acid excretion stimulant
0,486  0,005  Expectorant
0,490  0,009  Choleretic
0,492  0,023  Antiinfective
0,464  0,010  Diuretic inhibitor
0,460  0,013  Antidiabetic (type 2)
0,456  0,013  Loop diuretic
0,451  0,012  Sclerosant
0,510  0,077  Acute neurologic disorders treatment
0,446  0,013  Antiinflammatory, intestinal
0,436  0,004  Saluretic
0,524  0,100  Antineurotic
0,418  0,005  Antihyperlipoproteinemic
0,437  0,034  Dementia treatment
0,407  0,008  Antianorexic
0,466  0,067  Antiinflammatory
0,429  0,037  Antipsoriatic
0,473  0,082  Mucositis treatment
0,401  0,018  Intermittent claudication treatment
0,421  0,041  Menopausal disorders treatment
0,412  0,034  Cardiovascular analeptic
0,418  0,042  Antimyopathies
0,481  0,124  Vasodilator, cerebral
0,400  0,053  Dermatologic
0,406  0,066  Respiratory analeptic
0,409  0,102  Antinociceptive
0,442  0,157  Antibacterial activity enhancer

>  <Antitargets>
0,844  0,019  Ubiquinol-cytochrome-c reductase inhibitor
0,687  0,014  Superoxide dismutase inhibitor
0,589  0,026  Peroxidase inhibitor
0,496  0,022  GABA aminotransferase inhibitor

>  <Gene_Expression>
0,941  0,001  FTL expression enhancer
0,938  0,004  TNF expression enhancer
0,902  0,004  MAPK8 expression inhibitor
0,903  0,008  TXNRD1 expression inhibitor
0,905  0,016  HSPD1 expression inhibitor
0,893  0,005  MAPT expression enhancer
0,891  0,005  AKR1C1 expression enhancer
0,904  0,019  LPL expression enhancer
0,894  0,014  CD36 expression inhibitor
0,888  0,009  UNG expression inhibitor
0,874  0,004  DDX18 expression inhibitor
0,873  0,010  SFPQ expression enhancer
0,871  0,010  DUSP4 expression enhancer
0,861  0,003  CYP11A1 expression inhibitor
0,871  0,016  NAA15 expression inhibitor
0,857  0,008  CALR expression inhibitor
0,850  0,006  MYBL1 expression enhancer
0,848  0,006  TNS3 expression enhancer
0,846  0,009  ACTA2 expression inhibitor
0,847  0,016  MYL6 expression enhancer
0,839  0,007  CCL2 expression enhancer
0,838  0,011  ILF3 expression inhibitor
0,831  0,009  CCNE2 expression inhibitor
0,823  0,001  ABCG5 expression enhancer
0,823  0,001  CYP7A1 expression enhancer
0,833  0,013  EZH2 expression inhibitor
0,826  0,006  IFNGR1 expression enhancer
0,835  0,016  CASP3 expression enhancer
0,819  0,004  MAP2K1 expression enhancer
0,822  0,007  MCM6 expression enhancer
0,832  0,018  TOP1 expression inhibitor
0,830  0,017  CYR61 expression enhancer
0,823  0,011  STAT1 expression inhibitor
0,823  0,014  ABCC5 expression enhancer
0,819  0,011  PLAU expression inhibitor
0,821  0,019  STAR expression enhancer
0,816  0,013  CD44 expression inhibitor
0,821  0,020  CXCR1 expression enhancer
0,810  0,011  TMSB4X expression inhibitor
0,822  0,023  GPX1 expression inhibitor
0,805  0,008  PRRX1 expression inhibitor
0,809  0,013  C10ORF116 expression enhancer
0,812  0,017  SERPINB5 expression inhibitor
0,806  0,010  ETV5 expression inhibitor
0,809  0,014  CNN1 expression enhancer
0,809  0,016  MMP7 expression enhancer
0,808  0,015  IL4 expression enhancer
0,815  0,024  ITGB1 expression enhancer
0,797  0,006  CPNE1 expression enhancer
0,788  0,008  PKM2 expression enhancer
0,794  0,016  BIRC3 expression enhancer
0,786  0,009  POLE2 expression inhibitor
0,799  0,022  PDXK expression inhibitor
0,800  0,024  HMGB1 expression inhibitor
0,798  0,023  SRPK1 expression inhibitor
0,796  0,022  ARL6IP5 expression enhancer
0,783  0,010  WFDC2 expression enhancer
0,790  0,019  BST2 expression enhancer
0,792  0,026  GSTA1 expression enhancer
0,776  0,010  LAMC1 expression enhancer
0,778  0,013  NASP expression inhibitor
0,782  0,017  APOM expression enhancer
0,779  0,017  JAG1 expression inhibitor
0,786  0,025  SUZ12 expression inhibitor
0,773  0,012  CLMP expression inhibitor
0,775  0,014  IGFBP6 expression inhibitor
0,773  0,014  FUBP1 expression inhibitor
0,764  0,008  DAB2 expression enhancer
0,776  0,021  SPATA13 expression enhancer
0,780  0,024  OAS2 expression enhancer
0,758  0,005  CRABP2 expression inhibitor
0,758  0,005  CALM3 expression enhancer
0,764  0,012  IGF2 expression inhibitor
0,766  0,016  IL10 expression enhancer
0,761  0,012  ITGB7 expression enhancer
0,761  0,015  FGF2 expression inhibitor
0,758  0,012  MAFB expression inhibitor
0,762  0,017  TRAK2 expression enhancer
0,755  0,011  PCNA expression enhancer
0,757  0,014  NOL5A expression inhibitor
0,758  0,018  COL2A1 expression enhancer
0,749  0,009  ADD3 expression enhancer
0,747  0,009  FEN1 expression inhibitor
0,751  0,013  PPARGC1A expression enhancer
0,748  0,011  HMBS expression inhibitor
0,750  0,014  PRTN3 expression enhancer
0,747  0,011  EDN1 expression enhancer
0,750  0,014  ORC4 expression enhancer
0,744  0,009  PML expression inhibitor
0,755  0,021  FILIP1L expression inhibitor
0,751  0,017  PLIN2 expression enhancer
0,759  0,025  BIRC2 expression inhibitor
0,751  0,018  NR4A2 expression enhancer
0,740  0,008  PSAT1 expression inhibitor
0,740  0,009  TUBA1A expression inhibitor
0,746  0,017  TNFRSF11A expression enhancer
0,768  0,039  XPO1 expression inhibitor
0,748  0,023  PRKCA expression enhancer
0,726  0,004  SUMO1 expression inhibitor
0,742  0,021  ITGB2 expression enhancer
0,744  0,023  HSPA1A expression enhancer
0,741  0,020  THBS1 expression enhancer
0,742  0,022  NOM1 expression inhibitor
0,752  0,033  EIF2S1 expression inhibitor
0,725  0,007  DEK expression inhibitor
0,734  0,017  CLDN4 expression enhancer
0,724  0,007  CDK5 expression enhancer
0,732  0,016  SLC16A4 expression enhancer
0,747  0,031  JUN expression enhancer
0,728  0,013  FKBP8 expression inhibitor
0,738  0,023  CDC25B expression enhancer
0,726  0,012  MMP2 expression enhancer
0,723  0,011  VAT1 expression enhancer
0,718  0,007  SCARB1 expression enhancer
0,733  0,023  NAT1 expression enhancer
0,723  0,013  DDIT3 expression enhancer
0,718  0,009  CBX1 expression inhibitor
0,729  0,020  TNFRSF21 expression inhibitor
0,719  0,010  CARS expression inhibitor
0,715  0,006  FUS expression inhibitor
0,722  0,013  TRIM16 expression enhancer
0,732  0,025  NBN expression inhibitor
0,721  0,015  FOSL1 expression enhancer
0,719  0,014  CDKN1C expression inhibitor
0,715  0,010  SIDT2 expression enhancer
0,721  0,016  NEIL3 expression inhibitor
0,716  0,015  GNL3 expression inhibitor
0,712  0,011  TK1 expression inhibitor
0,715  0,015  GSTM3 expression inhibitor
0,704  0,006  REL expression enhancer
0,703  0,004  IFIT3 expression enhancer
0,703  0,004  UGT1A1 expression enhancer
0,725  0,028  RASEF expression inhibitor
0,710  0,014  HLA-F expression enhancer
0,711  0,015  HLA-B expression enhancer
0,704  0,010  CYP4A11 expression enhancer
0,707  0,013  MTHFD2 expression inhibitor
0,711  0,020  SLC16A2 expression enhancer
0,699  0,008  TNFSF11 expression inhibitor
0,710  0,020  MAF expression enhancer
0,706  0,017  KPNA2 expression inhibitor
0,702  0,015  TUBA4A expression enhancer
0,713  0,026  KIF23 expression enhancer
0,693  0,007  NOS1 expression inhibitor
0,706  0,021  PTGR1 expression enhancer
0,698  0,015  GPX2 expression enhancer
0,700  0,017  ELL2 expression enhancer
0,695  0,013  CYB5R2 expression enhancer
0,691  0,009  HMOX1 expression enhancer
0,687  0,008  PLA2G16 expression enhancer
0,687  0,008  TCEB3 expression inhibitor
0,691  0,014  SUV420H1 expression inhibitor
0,695  0,018  IL6 expression inhibitor
0,688  0,012  DDX42 expression enhancer
0,689  0,014  ADSL expression inhibitor
0,718  0,045  STAT5B expression enhancer
0,692  0,018  PRSS23 expression enhancer
0,678  0,005  CBX3 expression inhibitor
0,678  0,005  SPAG6 expression enhancer
0,683  0,011  PLA2G2A expression enhancer
0,685  0,013  CCNA2 expression enhancer
0,706  0,034  AHR expression inhibitor
0,679  0,010  WAS expression enhancer
0,686  0,018  HLA-C expression enhancer
0,689  0,021  SPP1 expression enhancer
0,705  0,038  SERPINB5 expression enhancer
0,686  0,019  EFEMP1 expression inhibitor
0,683  0,016  HNRPC expression inhibitor
0,689  0,023  GRN expression enhancer
0,684  0,019  CLMN expression enhancer
0,685  0,020  SOX9 expression enhancer
0,669  0,006  HMGB2 expression inhibitor
0,671  0,008  NCF1 expression enhancer
0,685  0,026  NCOA2 expression enhancer
0,681  0,022  SLC1A1 expression enhancer
0,673  0,014  NR3C1 expression inhibitor
0,683  0,025  MACF1 expression inhibitor
0,679  0,021  VEGFA expression inhibitor
0,669  0,012  TGFBI expression enhancer
0,671  0,015  MYB expression inhibitor
0,679  0,023  IL1B expression enhancer
0,691  0,035  HIF1A expression enhancer
0,728  0,072  RAD23B expression inhibitor
0,680  0,024  F2R expression enhancer
0,666  0,011  PARG expression enhancer
0,665  0,011  IL2RA expression inhibitor
0,667  0,013  FGFR3 expression inhibitor
0,682  0,029  GAS6 expression enhancer
0,673  0,021  MEGF9 expression inhibitor
0,667  0,014  ACPP expression enhancer
0,674  0,023  SESN1 expression inhibitor
0,686  0,036  GTF2F1 expression inhibitor
0,659  0,009  PPARG expression enhancer
0,677  0,028  PPARA expression inhibitor
0,668  0,019  CASP9 expression enhancer
0,676  0,028  C3 expression enhancer
0,670  0,021  PDCD4 expression inhibitor
0,663  0,014  HSP27 expression enhancer
0,666  0,020  HMGA1 expression inhibitor
0,658  0,012  KIAA0930 expression enhancer
0,661  0,016  NFKBIA expression enhancer
0,652  0,007  CD36 expression enhancer
0,656  0,012  STAT3 expression inhibitor
0,663  0,020  AKT1 expression enhancer
0,661  0,019  NPTX2 expression enhancer
0,657  0,015  HMGA1 expression enhancer
0,656  0,014  POR expression enhancer
0,682  0,041  POLE2 expression enhancer
0,661  0,021  ATM expression enhancer
0,648  0,011  PRDX2 expression enhancer
0,662  0,025  TGFB1 expression enhancer
0,647  0,010  BGLAP expression inhibitor
0,659  0,023  CUTL1 expression inhibitor
0,651  0,015  JUNB expression inhibitor
0,664  0,030  ID1 expression inhibitor
0,658  0,025  CDK2 expression inhibitor
0,645  0,012  IFI30 expression enhancer
0,660  0,027  CPE expression inhibitor
0,649  0,017  PIM1 expression enhancer
0,639  0,008  APOA1 expression enhancer
0,640  0,010  MFAP4 expression inhibitor
0,660  0,032  THBD expression enhancer
0,644  0,016  SP2 expression inhibitor
0,651  0,024  CPM expression enhancer
0,660  0,033  TFDP2 expression inhibitor
0,670  0,044  VDR expression enhancer
0,638  0,012  EGR3 expression inhibitor
0,640  0,014  SLC7A11 expression enhancer
0,659  0,034  ID2 expression enhancer
0,659  0,034  IL1RN expression inhibitor
0,646  0,021  ATP2A2 expression enhancer
0,631  0,007  CYP17A1 expression inhibitor
0,652  0,029  IL1A expression inhibitor
0,643  0,021  GATA2 expression enhancer
0,625  0,004  ASTN2 expression enhancer
0,674  0,056  MSH6 expression inhibitor
0,626  0,008  BTG2 expression enhancer
0,641  0,024  NOC3L expression inhibitor
0,621  0,005  POLR2A expression enhancer
0,642  0,026  ESR1 expression inhibitor
0,628  0,013  ISYNA1 expression enhancer
0,641  0,026  PCDH8 expression enhancer
0,622  0,008  LYN expression enhancer
0,643  0,030  PPARD expression inhibitor
0,636  0,023  MLF1 expression enhancer
0,657  0,045  GAS6 expression inhibitor
0,631  0,019  YWHAE expression inhibitor
0,631  0,018  NOLC1 expression inhibitor
0,630  0,018  AKR1C2 expression enhancer
0,645  0,034  AHR expression enhancer
0,641  0,029  HLA-G expression enhancer
0,646  0,035  ZFP36 expression enhancer
0,640  0,029  DDIT4 expression enhancer
0,630  0,019  TM4SF1 expression enhancer
0,647  0,036  FOS expression enhancer
0,629  0,019  SOX9 expression inhibitor
0,666  0,057  NFKB1 expression enhancer
0,625  0,017  DDX24 expression inhibitor
0,638  0,030  ASNS expression inhibitor
0,616  0,009  ZFAND5 expression inhibitor
0,618  0,012  TNF expression inhibitor
0,630  0,024  CDH1 expression enhancer
0,631  0,025  CD86 expression enhancer
0,629  0,023  ADAM17 expression inhibitor
0,629  0,023  CTBP1 expression inhibitor
0,668  0,064  IQGAP1 expression inhibitor
0,621  0,016  ME1 expression enhancer
0,634  0,031  SLC3A2 expression enhancer
0,610  0,007  PICALM expression inhibitor
0,616  0,014  FOXC1 expression enhancer
0,625  0,026  DFFA expression inhibitor
0,638  0,039  MT1A expression enhancer
0,613  0,014  SASH1 expression inhibitor
0,608  0,009  IVL expression inhibitor
0,612  0,013  C5ORF32 expression enhancer
0,612  0,013  FAH expression enhancer
0,612  0,013  RRAS expression enhancer
0,612  0,013  SH3BGRL3 expression enhancer
0,630  0,032  FOXO1 expression enhancer
0,620  0,022  FOXD1 expression inhibitor
0,611  0,013  MT1F expression inhibitor
0,621  0,024  PLD1 expression enhancer
0,623  0,026  MYC expression enhancer
0,619  0,023  MCM7 expression inhibitor
0,615  0,019  BAG5 expression inhibitor
0,610  0,015  TOB1 expression inhibitor
0,611  0,017  CD14 expression enhancer
0,604  0,011  E2F1 expression inhibitor
0,661  0,069  SLC2A4 expression enhancer
0,616  0,024  TIMP1 expression enhancer
0,618  0,027  RPS19 expression inhibitor
0,618  0,027  SIRT1 expression inhibitor
0,633  0,042  IL6 expression enhancer
0,618  0,027  CDC16 expression inhibitor
0,601  0,011  CEBPG expression inhibitor
0,624  0,034  GSTM2 expression inhibitor
0,619  0,029  CDK4 expression inhibitor
0,627  0,037  KPNA1 expression enhancer
0,604  0,015  PLAGL1 expression enhancer
0,612  0,023  CEP57 expression inhibitor
0,603  0,015  TNFAIP3 expression enhancer
0,598  0,011  PPARA expression enhancer
0,638  0,050  PLAUR expression enhancer
0,603  0,016  SPARC expression inhibitor
0,624  0,037  BAD expression inhibitor
0,610  0,026  ALDH1A3 expression inhibitor
0,610  0,025  CTSD expression inhibitor
0,612  0,028  VAV3 expression inhibitor
0,597  0,013  CSF2 expression enhancer
0,599  0,015  CCNK expression inhibitor
0,606  0,022  NR4A2 expression inhibitor
0,592  0,008  PTPRK expression inhibitor
0,611  0,028  ICAM1 expression enhancer
0,602  0,020  PA2G4 expression inhibitor
0,593  0,011  GARS expression inhibitor
0,590  0,008  RXRA expression enhancer
0,621  0,039  PRKAR2B expression enhancer
0,621  0,040  EPRS expression inhibitor
0,592  0,012  HLA-E expression enhancer
0,584  0,004  NBL1 expression enhancer
0,621  0,042  IL18 expression inhibitor
0,608  0,030  CAV1 expression inhibitor
0,612  0,035  CCND1 expression inhibitor
0,596  0,019  FAS expression inhibitor
0,605  0,030  HAPLN3 expression inhibitor
0,611  0,037  CCND2 expression enhancer
0,590  0,016  IMPDH2 expression enhancer
0,589  0,017  MMP9 expression inhibitor
0,589  0,017  SCML1 expression enhancer
0,589  0,017  SEPHS1 expression inhibitor
0,611  0,040  FN1 expression inhibitor
0,593  0,023  EDN1 expression inhibitor
0,589  0,019  ALPL expression enhancer
0,603  0,034  TERT expression enhancer
0,598  0,029  RND3 expression inhibitor
0,591  0,022  IGFBP5 expression enhancer
0,592  0,023  ISG15 expression enhancer
0,591  0,022  PELI1 expression inhibitor
0,591  0,022  RPS27L expression enhancer
0,585  0,016  STC2 expression enhancer
0,622  0,054  GADD45A expression inhibitor
0,636  0,070  ITGB6 expression inhibitor
0,609  0,045  DHRS2 expression enhancer
0,597  0,033  SERPINE1 expression enhancer
0,601  0,038  NT5DC2 expression enhancer
0,601  0,038  RAI14 expression enhancer
0,601  0,038  RFTN1 expression enhancer
0,595  0,033  SF1 expression inhibitor
0,600  0,038  TNFSF10 expression enhancer
0,566  0,005  SLC16A1 expression inhibitor
0,568  0,009  DENND5A expression enhancer
0,607  0,048  MYB expression enhancer
0,576  0,019  MT1X expression inhibitor
0,618  0,061  CREBBP expression inhibitor
0,588  0,030  SCARB1 expression inhibitor
0,573  0,017  IL1A expression enhancer
0,585  0,029  ELOVL5 expression inhibitor
0,591  0,036  PMEPA1 expression inhibitor
0,566  0,012  SMARCC1 expression inhibitor
0,586  0,032  CCL5 expression inhibitor
0,578  0,024  PRNP expression enhancer
0,573  0,020  RSAD2 expression enhancer
0,565  0,012  GATA1 expression enhancer
0,563  0,012  IFIT1 expression enhancer
0,566  0,014  CYP17A1 expression enhancer
0,573  0,021  GFPT2 expression enhancer
0,587  0,036  DUSP5 expression enhancer
0,576  0,025  TRAM1 expression inhibitor
0,559  0,010  NGFR expression enhancer
0,570  0,022  SMAD3 expression enhancer
0,573  0,025  COL4A1 expression inhibitor
0,576  0,029  FGFR2 expression enhancer
0,576  0,029  RRBP1 expression enhancer
0,576  0,029  ATF3 expression enhancer
0,556  0,010  IGF1R expression enhancer
0,565  0,020  EHD1 expression enhancer
0,570  0,027  SLC6A2 expression inhibitor
0,560  0,017  MT1H expression inhibitor
0,571  0,029  AREG expression enhancer
0,553  0,013  ITPR1 expression inhibitor
0,562  0,022  PPP2CB expression enhancer
0,564  0,024  PGM2 expression enhancer
0,580  0,041  NOS2 expression enhancer
0,557  0,019  GCLM expression enhancer
0,579  0,041  PPARD expression enhancer
0,604  0,066  FANCC expression inhibitor
0,572  0,035  ASXL1 expression inhibitor
0,572  0,035  C11ORF68 expression enhancer
0,572  0,035  CAPN7 expression inhibitor
0,572  0,035  FAM208A expression inhibitor
0,572  0,035  NKTR expression inhibitor
0,572  0,035  RABGAP1 expression inhibitor
0,572  0,035  SETD2 expression inhibitor
0,572  0,035  TIA1 expression inhibitor
0,572  0,035  TTC3 expression inhibitor
0,579  0,042  TMPRSS2 expression inhibitor
0,569  0,032  MGMT expression enhancer
0,548  0,012  RARB expression inhibitor
0,572  0,037  RAD51C expression enhancer
0,572  0,037  SMC4 expression enhancer
0,572  0,037  ZWINT expression enhancer
0,561  0,026  IL8 expression enhancer
0,550  0,018  CYB5A expression enhancer
0,556  0,024  MT1G expression enhancer
0,549  0,018  LAMC2 expression enhancer
0,579  0,048  RAD51AP1 expression enhancer
0,570  0,042  HSPA1A expression inhibitor
0,543  0,015  BAD expression enhancer
0,548  0,020  CA2 expression enhancer
0,540  0,013  TGFB3 expression enhancer
0,545  0,019  HSPA2 expression enhancer
0,606  0,082  MAPK8 expression enhancer
0,548  0,024  PRDX6 expression enhancer
0,537  0,013  TMSB4X expression enhancer
0,544  0,022  HOXA10 expression enhancer
0,539  0,017  TPO expression enhancer
0,553  0,032  NPM1 expression inhibitor
0,555  0,035  MITF expression enhancer
0,548  0,028  MT2A expression enhancer
0,524  0,005  ELF3 expression enhancer
0,551  0,032  LYN expression inhibitor
0,576  0,058  SREBF2 expression inhibitor
0,567  0,048  RNF4 expression inhibitor
0,557  0,038  CTTN expression inhibitor
0,551  0,032  PTN expression enhancer
0,563  0,045  VEGFA expression enhancer
0,548  0,030  VCAM1 expression enhancer
0,545  0,029  EI24 expression enhancer
0,547  0,033  CDKN2A expression enhancer
0,546  0,033  EZR expression inhibitor
0,546  0,033  GAK expression inhibitor
0,546  0,033  TERF1 expression inhibitor
0,530  0,018  IL4 expression inhibitor
0,518  0,007  CXCR4 expression enhancer
0,570  0,059  EIF2S1 expression enhancer
0,528  0,019  EPAS1 expression enhancer
0,536  0,028  CDK6 expression inhibitor
0,577  0,070  FYTTD1 expression inhibitor
0,577  0,070  MST4 expression inhibitor
0,577  0,070  TRAK2 expression inhibitor
0,577  0,070  USP32 expression inhibitor
0,532  0,025  IGFBP2 expression inhibitor
0,518  0,011  TNFRSF1B expression enhancer
0,558  0,051  PRKDC expression inhibitor
0,539  0,032  RRM2 expression inhibitor
0,534  0,028  ANAPC1 expression enhancer
0,520  0,014  ACAN expression enhancer
0,530  0,024  WDR4 expression inhibitor
0,539  0,034  KLF10 expression inhibitor
0,530  0,025  ID3 expression inhibitor
0,524  0,019  CSDA expression inhibitor
0,535  0,030  DEPTOR expression enhancer
0,526  0,021  CALM1 expression enhancer
0,512  0,007  APOE expression enhancer
0,526  0,022  MDK expression enhancer
0,531  0,028  IL6ST expression inhibitor
0,555  0,053  TNFSF10 expression inhibitor
0,511  0,010  GSTA4 expression enhancer
0,512  0,012  MND1 expression inhibitor
0,514  0,013  IL2 expression inhibitor
0,543  0,043  WISP2 expression inhibitor
0,577  0,077  ITGA3 expression enhancer
0,548  0,048  NAV1 expression inhibitor
0,516  0,017  IGF2 expression enhancer
0,529  0,031  ST3GAL1 expression enhancer
0,525  0,028  RECQL expression inhibitor
0,522  0,025  DLEU2 expression enhancer
0,551  0,055  AGRN expression enhancer
0,525  0,030  CDKN1B expression inhibitor
0,515  0,020  BNIP3 expression inhibitor
0,525  0,031  MAD1L1 expression enhancer
0,514  0,019  TK1 expression enhancer
0,569  0,075  FGFR1 expression inhibitor
0,552  0,059  CDCA5 expression enhancer
0,530  0,038  SESN2 expression enhancer
0,505  0,013  KLK7 expression enhancer
0,518  0,027  KIF15 expression inhibitor
0,521  0,031  G0S2 expression enhancer
0,505  0,015  DNMT1 expression inhibitor
0,508  0,018  PPP1R3C expression inhibitor
0,538  0,050  BCL2 expression inhibitor
0,497  0,008  GSN expression enhancer
0,504  0,016  CCL4 expression enhancer
0,519  0,030  BUB1B expression enhancer
0,516  0,028  PTGS2 expression inhibitor
0,517  0,029  TXNRD1 expression enhancer
0,522  0,035  SELE expression enhancer
0,541  0,053  SNAI2 expression inhibitor
0,529  0,041  TAOK3 expression inhibitor
0,501  0,015  S100A8 expression enhancer
0,550  0,065  BAX expression enhancer
0,505  0,020  DUSP10 expression enhancer
0,511  0,026  S100A11 expression enhancer
0,547  0,063  KRCC1 expression enhancer
0,494  0,010  ASAH1 expression inhibitor
0,533  0,049  NAA15 expression enhancer
0,522  0,039  KPNB1 expression enhancer
0,507  0,024  CEBPD expression enhancer
0,491  0,008  IL24 expression inhibitor
0,501  0,019  GINS2 expression inhibitor
0,509  0,027  TUBB3 expression enhancer
0,524  0,043  GRPEL1 expression inhibitor
0,513  0,034  TCEB2 expression inhibitor
0,525  0,045  PTGS2 expression enhancer
0,549  0,070  CEP350 expression inhibitor
0,549  0,070  PDE8A expression inhibitor
0,510  0,032  SF3B5 expression enhancer
0,506  0,027  SKP2 expression inhibitor
0,503  0,024  CYP11A1 expression enhancer
0,490  0,012  CDCA3 expression inhibitor
0,539  0,061  NCOA1 expression enhancer
0,490  0,013  SOCS2 expression enhancer
0,513  0,036  SERPINA3 expression enhancer
0,487  0,010  BCL2A1 expression enhancer
0,505  0,029  PI4KA expression inhibitor
0,505  0,029  VCAN expression inhibitor
0,501  0,025  CYFIP2 expression enhancer
0,508  0,033  NR5A2 expression enhancer
0,508  0,033  ZBTB10 expression inhibitor
0,501  0,026  CTPS expression inhibitor
0,503  0,029  MYBL2 expression inhibitor
0,508  0,033  SLC17A2 expression inhibitor
0,509  0,036  NR1H2 expression inhibitor
0,496  0,024  S100P expression enhancer
0,499  0,028  CDK1 expression inhibitor
0,535  0,064  CEACAM1 expression enhancer
0,490  0,019  TNFRSF11B expression enhancer
0,511  0,042  VIM expression inhibitor
0,538  0,069  CD38 expression enhancer
0,506  0,037  TNNT1 expression inhibitor
0,534  0,065  ALCAM expression inhibitor
0,514  0,046  DTYMK expression enhancer
0,531  0,063  MMP15 expression inhibitor
0,517  0,050  CDC25C expression inhibitor
0,502  0,035  SDCBP expression enhancer
0,514  0,047  EZH1 expression enhancer
0,496  0,031  BDNF expression inhibitor
0,491  0,027  BID expression inhibitor
0,490  0,025  BRF1 expression inhibitor
0,519  0,055  APOA1 expression inhibitor
0,478  0,014  FABP4 expression enhancer
0,478  0,016  EIF4E expression inhibitor
0,511  0,050  EIF3B expression inhibitor
0,485  0,024  PLCB1 expression enhancer
0,517  0,056  IL1R1 expression inhibitor
0,504  0,044  EPHB4 expression inhibitor
0,504  0,044  NMT1 expression inhibitor
0,510  0,050  KPNB1 expression inhibitor
0,489  0,029  LAMB3 expression enhancer
0,472  0,012  LRP6 expression enhancer
0,484  0,025  ESR1 expression enhancer
0,470  0,012  SLC30A5 expression inhibitor
0,514  0,056  BCL2L1 expression inhibitor
0,468  0,009  CPT1A expression enhancer
0,497  0,039  AHRR expression enhancer
0,480  0,023  LAMA3 expression enhancer
0,491  0,035  SLC26A2 expression inhibitor
0,480  0,024  SST expression inhibitor
0,464  0,009  GCLC expression enhancer
0,481  0,027  BMP2 expression enhancer
0,499  0,044  TRAF3 expression enhancer
0,486  0,032  PDK4 expression enhancer
0,468  0,016  ABCG2 expression inhibitor
0,463  0,012  CRYAB expression enhancer
0,488  0,037  NEDD9 expression inhibitor
0,470  0,020  NKX3-1 expression enhancer
0,481  0,030  JUN expression inhibitor
0,473  0,024  BTG1 expression enhancer
0,489  0,041  COL3A1 expression inhibitor
0,519  0,071  PDE9A expression inhibitor
0,507  0,059  STRBP expression inhibitor
0,478  0,030  CLSTN1 expression inhibitor
0,487  0,040  ERBB4 expression inhibitor
0,490  0,043  BRD2 expression enhancer
0,490  0,043  NENF expression enhancer
0,490  0,043  SRRM2 expression inhibitor
0,490  0,043  ZCCHC2 expression inhibitor
0,477  0,031  SHBG expression enhancer
0,525  0,079  TP53 expression enhancer
0,472  0,027  BIRC5 expression enhancer
0,480  0,035  CSNK1D expression inhibitor
0,480  0,035  SPATA20 expression enhancer
0,474  0,030  CDK2 expression enhancer
0,470  0,026  CCNB2 expression enhancer
0,482  0,038  ANXA1 expression inhibitor
0,458  0,015  MET expression enhancer
0,458  0,015  TCF12 expression enhancer
0,448  0,006  ICAM1 expression inhibitor
0,505  0,063  SEPT2 expression inhibitor
0,489  0,047  KLK6 expression enhancer
0,489  0,047  PADI3 expression enhancer
0,478  0,037  HMGN2 expression inhibitor
0,521  0,081  TNPO1 expression inhibitor
0,467  0,029  MDFI expression inhibitor
0,467  0,029  SYMPK expression inhibitor
0,485  0,047  C1S expression enhancer
0,463  0,026  IGFBP2 expression enhancer
0,480  0,043  TFF1 expression inhibitor
0,481  0,045  PIK3R2 expression inhibitor
0,507  0,071  NPM3 expression inhibitor
0,507  0,071  PTEN expression inhibitor
0,468  0,032  CSF3 expression enhancer
0,457  0,021  CYP2E1 expression enhancer
0,474  0,039  CCNE1 expression inhibitor
0,467  0,032  PTPRM expression enhancer
0,453  0,019  PKP4 expression inhibitor
0,453  0,019  TUBGCP3 expression inhibitor
0,449  0,015  PELI1 expression enhancer
0,470  0,036  ITGA6 expression inhibitor
0,484  0,051  MAOB expression enhancer
0,450  0,017  CITED2 expression enhancer
0,464  0,031  TNFRSF25 expression inhibitor
0,460  0,027  LGALS3 expression enhancer
0,465  0,034  ID3 expression enhancer
0,450  0,018  HERPUD1 expression inhibitor
0,453  0,023  RCC2 expression inhibitor
0,449  0,020  TULP3 expression inhibitor
0,449  0,020  IFNG expression inhibitor
0,470  0,041  KLHL24 expression inhibitor
0,492  0,064  PSMC1 expression enhancer
0,461  0,033  BAK1 expression enhancer
0,442  0,015  LGALS1 expression inhibitor
0,466  0,039  EFNB2 expression inhibitor
0,470  0,043  ALDOA expression enhancer
0,460  0,035  NKD1 expression inhibitor
0,466  0,041  TIMP1 expression inhibitor
0,436  0,011  CORO1C expression enhancer
0,443  0,019  CTH expression inhibitor
0,444  0,021  CDKN2C expression enhancer
0,471  0,048  KLK3 expression inhibitor
0,444  0,022  BCAT1 expression inhibitor
0,454  0,033  PIR expression enhancer
0,443  0,022  ATP5B expression enhancer
0,456  0,036  AURKA expression enhancer
0,477  0,058  TNFRSF21 expression enhancer
0,433  0,016  NDC80 expression inhibitor
0,441  0,024  MGST1 expression inhibitor
0,500  0,083  PHB expression inhibitor
0,476  0,060  JAK2 expression inhibitor
0,476  0,060  TBC1D1 expression inhibitor
0,458  0,041  SERPINB9 expression enhancer
0,431  0,016  IVNS1ABP expression inhibitor
0,451  0,037  GALNT1 expression inhibitor
0,464  0,050  NKX3-1 expression inhibitor
0,487  0,074  CP expression enhancer
0,489  0,075  PDCD4 expression enhancer
0,451  0,038  HNRNPH2 expression inhibitor
0,443  0,030  COL1A1 expression inhibitor
0,466  0,054  TPM4 expression inhibitor
0,461  0,049  TP53I3 expression enhancer
0,434  0,023  NRIP1 expression enhancer
0,483  0,072  MSMO1 expression enhancer
0,431  0,021  KRT17 expression inhibitor
0,429  0,019  MYO10 expression enhancer
0,431  0,022  SOX11 expression inhibitor
0,434  0,026  RGS2 expression enhancer
0,462  0,053  CDKN1A expression inhibitor
0,441  0,033  NARS expression inhibitor
0,431  0,023  BTG1 expression inhibitor
0,434  0,028  PHLDA1 expression enhancer
0,446  0,042  ATR expression inhibitor
0,446  0,042  EFNA4 expression inhibitor
0,446  0,042  MARK3 expression inhibitor
0,446  0,042  SMAD1 expression inhibitor
0,433  0,030  SLC31A1 expression enhancer
0,431  0,029  GPR142 expression enhancer
0,419  0,017  PRKCA expression inhibitor
0,434  0,033  NEU4 expression enhancer
0,434  0,033  SH3GL2 expression inhibitor
0,469  0,068  CITED2 expression inhibitor
0,437  0,036  CDKN2C expression inhibitor
0,451  0,051  TOP2A expression inhibitor
0,430  0,030  MCM2 expression enhancer
0,412  0,013  SERPINB2 expression inhibitor
0,418  0,020  SOD2 expression inhibitor
0,456  0,058  HSD11B2 expression enhancer
0,417  0,019  ADARB1 expression inhibitor
0,441  0,044  DLX4 expression inhibitor
0,444  0,047  TARS expression inhibitor
0,419  0,023  GPR56 expression enhancer
0,487  0,091  PPPDE1 expression inhibitor
0,404  0,009  NEDD9 expression enhancer
0,463  0,068  CSE1L expression inhibitor
0,448  0,053  PIM1 expression inhibitor
0,421  0,027  PECAM1 expression inhibitor
0,432  0,039  SNAI1 expression enhancer
0,433  0,041  DPP4 expression enhancer
0,441  0,049  ASCL1 expression enhancer
0,426  0,033  VWF expression enhancer
0,415  0,023  EID1 expression enhancer
0,431  0,039  APOD expression enhancer
0,446  0,054  BMP1 expression inhibitor
0,414  0,023  PPM1D expression enhancer
0,469  0,078  ABHD3 expression enhancer
0,416  0,026  PTGER4 expression enhancer
0,468  0,077  IFRD1 expression inhibitor
0,424  0,034  RORA expression enhancer
0,412  0,022  MT1X expression enhancer
0,430  0,040  APOBEC3B expression enhancer
0,405  0,017  LINC00467 expression enhancer
0,405  0,017  PHF17 expression inhibitor
0,429  0,041  MAFF expression enhancer
0,452  0,064  TIMP3 expression enhancer
0,409  0,022  DHRS3 expression enhancer
0,470  0,083  TP53TG1 expression enhancer
0,434  0,047  SP1 expression inhibitor
0,409  0,023  INHBA expression enhancer
0,432  0,046  VEGF expression enhancer
0,416  0,030  TACC1 expression inhibitor
0,422  0,037  MDK expression inhibitor
0,422  0,037  DHCR24 expression enhancer
0,422  0,037  TGOLN2 expression inhibitor
0,412  0,027  PLAT expression enhancer
0,464  0,079  CDKN1A expression enhancer
0,422  0,039  RBMS1 expression inhibitor
0,412  0,029  CBS expression inhibitor
0,400  0,017  CD74 expression inhibitor
0,446  0,063  EPHA4 expression enhancer
0,418  0,035  CYP1A1 expression inhibitor
0,432  0,049  RPL7A expression inhibitor
0,452  0,070  ABCB10 expression inhibitor
0,411  0,029  TRPV2 expression enhancer
0,417  0,036  BFSP2 expression enhancer
0,417  0,036  EGLN3 expression enhancer
0,411  0,032  ESR2 expression inhibitor
0,423  0,044  ALDH4A1 expression inhibitor
0,401  0,023  IFIT2 expression enhancer
0,406  0,028  CD47 expression inhibitor
0,410  0,033  ESRRA expression enhancer
0,430  0,054  AHSA1 expression enhancer
0,410  0,034  ERMP1 expression enhancer
0,410  0,034  GAP43 expression enhancer
0,410  0,034  MSX2 expression enhancer
0,409  0,034  PRKX expression enhancer
0,423  0,048  NCAPG expression enhancer
0,423  0,048  PBK expression enhancer
0,421  0,048  HS3ST3A1 expression enhancer
0,410  0,039  NAT1 expression inhibitor
0,400  0,029  HIVEP1 expression enhancer
0,415  0,046  ITGA6 expression enhancer
0,443  0,074  CEACAM6 expression enhancer
0,418  0,049  UBE2C expression enhancer
0,402  0,035  KEAP1 expression enhancer
0,419  0,052  ABCG1 expression enhancer
0,417  0,052  CTNNA1 expression inhibitor
0,433  0,067  HS6ST2 expression inhibitor
0,401  0,039  C22ORF29 expression enhancer
0,401  0,039  ETNK2 expression enhancer
0,474  0,111  TMEM158 expression enhancer
0,439  0,076  CREB1 expression inhibitor
0,421  0,060  DNMT3A expression inhibitor
0,432  0,071  WIPI1 expression enhancer
0,402  0,041  MT1L expression enhancer
0,434  0,075  MVP expression enhancer
0,458  0,100  UGCG expression enhancer
0,450  0,093  MMP2 expression inhibitor
0,405  0,048  ODZ3 expression inhibitor
0,405  0,048  TBC1D9 expression inhibitor
0,415  0,059  FASN expression inhibitor
0,421  0,067  IER3 expression inhibitor
0,421  0,068  HIST1H4B expression inhibitor
0,408  0,058  BAX expression inhibitor
0,435  0,085  ABCB1 expression enhancer
0,411  0,061  YWHAH expression inhibitor
0,445  0,095  ATP1B3 expression inhibitor
0,409  0,061  BORA expression inhibitor
0,414  0,066  PIK3CD expression inhibitor
0,406  0,060  ARF3 expression enhancer
0,412  0,067  VIPR1 expression enhancer
0,420  0,077  SDC2 expression enhancer
0,405  0,062  FADD expression enhancer
0,427  0,086  OS9 expression enhancer
0,402  0,063  TGFBR2 expression enhancer
0,418  0,080  MAP1B expression enhancer
0,407  0,069  NCL expression inhibitor
0,416  0,078  ZNF91 expression inhibitor
0,402  0,068  THBS1 expression inhibitor
0,415  0,083  IL4R expression enhancer
0,415  0,087  CASP9 expression inhibitor
0,403  0,079  FAM49A expression enhancer
0,406  0,085  NR2F1 expression enhancer
0,419  0,098  PLA2G4A expression enhancer
0,429  0,112  NSF expression inhibitor
0,448  0,133  PDIA3 expression enhancer
0,401  0,089  DCC expression enhancer
0,418  0,111  JUND expression inhibitor
0,405  0,106  AGPS expression inhibitor
0,410  0,119  TNFAIP2 expression enhancer
0,402  0,142  INHBE expression enhancer

>  <Mechanisms>
0,935  0,003  Chlordecone reductase inhibitor
0,932  0,003  Prolyl aminopeptidase inhibitor
0,910  0,004  Monodehydroascorbate reductase (NADH) inhibitor
0,911  0,006  Methylenetetrahydrofolate reductase (NADPH) inhibitor
0,906  0,005  Mucomembranous protector
0,908  0,009  Membrane integrity agonist
0,914  0,019  Transferase stimulant
0,884  0,007  Alkenylglycerophosphocholine hydrolase inhibitor
0,865  0,002  Penicillin amidase inhibitor
0,863  0,002  Polygalacturonase inhibitor
0,865  0,004  Arylsulfate sulfotransferase inhibitor
0,856  0,004  Cl--transporting ATPase inhibitor
0,839  0,004  Venombin AB inhibitor
0,844  0,019  Ubiquinol-cytochrome-c reductase inhibitor
0,838  0,014  Polyporopepsin inhibitor
0,823  0,007  Arginine 2-monooxygenase inhibitor
0,810  0,004  Centromere associated protein inhibitor
0,815  0,010  Feruloyl esterase inhibitor
0,810  0,008  Membrane permeability inhibitor
0,794  0,007  2-Hydroxymuconate-semialdehyde hydrolase inhibitor
0,784  0,003  Di-trans,poly-cis-decaprenylcistransferase inhibitor
0,798  0,017  Sugar-phosphatase inhibitor
0,785  0,006  Dextranase inhibitor
0,778  0,003  Glutaminase inhibitor
0,777  0,004  Lysostaphin inhibitor
0,772  0,003  Nitrite reductase (NO-forming) inhibitor
0,780  0,015  NADPH peroxidase inhibitor
0,769  0,004  NADPH-ferrihemoprotein reductase inhibitor
0,774  0,010  Carboxypeptidase Taq inhibitor
0,772  0,009  Alkane 1-monooxygenase inhibitor
0,763  0,004  Pyruvate decarboxylase inhibitor
0,767  0,008  Linoleate diol synthase inhibitor
0,775  0,020  NACHT, LRR and PYD domains-containing protein 1 inhibitor
0,762  0,008  Creatininase inhibitor
0,751  0,003  Cyanoalanine nitrilase inhibitor
0,757  0,010  Fucosterol-epoxide lyase inhibitor
0,756  0,011  Pullulanase inhibitor
0,765  0,020  Glycosylphosphatidylinositol phospholipase D inhibitor
0,765  0,027  Transferase inhibitor
0,745  0,013  Fragilysin inhibitor
0,744  0,018  Beta-adrenergic receptor kinase inhibitor
0,744  0,018  G-protein-coupled receptor kinase inhibitor
0,729  0,003  Ferredoxin hydrogenase inhibitor
0,730  0,009  N-benzyloxycarbonylglycine hydrolase inhibitor
0,733  0,016  Omptin inhibitor
0,724  0,007  Sulfite reductase inhibitor
0,720  0,004  Mannitol-1-phosphatase inhibitor
0,719  0,004  Aryldialkylphosphatase inhibitor
0,718  0,005  Long-chain-aldehyde dehydrogenase inhibitor
0,709  0,004  Arylesterase inhibitor
0,710  0,006  L-glucuronate reductase inhibitor
0,710  0,008  Aspartate-phenylpyruvate transaminase inhibitor
0,703  0,002  Glutathione dehydrogenase (ascorbate) inhibitor
0,704  0,007  Alkenylglycerophosphoethanolamine hydrolase inhibitor
0,710  0,016  Exoribonuclease II inhibitor
0,706  0,013  Macrophage colony stimulating factor agonist
0,695  0,007  NADH kinase inhibitor
0,687  0,004  Benzoylformate decarboxylase inhibitor
0,691  0,012  Lipid metabolism regulator
0,699  0,020  Alkylacetylglycerophosphatase inhibitor
0,685  0,008  Peptide alpha-N-acetyltransferase inhibitor
0,685  0,009  Phenol O-methyltransferase inhibitor
0,687  0,014  Superoxide dismutase inhibitor
0,675  0,005  Aminocarboxymuconate-semialdehyde decarboxylase inhibitor
0,675  0,006  Sarcosine oxidase inhibitor
0,675  0,009  tRNA-pseudouridine synthase I inhibitor
0,690  0,024  Dehydro-L-gulonate decarboxylase inhibitor
0,671  0,007  Shikimate O-hydroxycinnamoyltransferase inhibitor
0,667  0,004  Peptidoglycan glycosyltransferase inhibitor
0,678  0,015  Phosphatidylserine decarboxylase inhibitor
0,680  0,018  Oxidoreductase inhibitor
0,681  0,019  UDP-N-acetylglucosamine 4-epimerase inhibitor
0,670  0,010  Adenomatous polyposis treatment
0,664  0,005  Perilipin-5 inhibitor
0,669  0,010  Oxygen scavenger
0,673  0,016  ADP-thymidine kinase inhibitor
0,661  0,005  3-Carboxyethylcatechol 2,3-dioxygenase inhibitor
0,667  0,014  3-Hydroxybenzoate 6-monooxygenase inhibitor
0,672  0,019  Lysine 2,3-aminomutase inhibitor
0,665  0,013  Hydrogen dehydrogenase inhibitor
0,668  0,018  Nitrate reductase (cytochrome) inhibitor
0,665  0,015  Gluconate 5-dehydrogenase inhibitor
0,654  0,003  2-Enoate reductase inhibitor
0,677  0,027  Glucose oxidase inhibitor
0,652  0,003  3-Demethylubiquinone-9 3-O-methyltransferase inhibitor
0,664  0,016  Fatty-acyl-CoA synthase inhibitor
0,651  0,004  Quinoprotein glucose dehydrogenase inhibitor
0,649  0,003  Ferredoxin-nitrite reductase inhibitor
0,656  0,012  Urethanase inhibitor
0,656  0,013  Cytoprotectant
0,654  0,012  Corticosteroid side-chain-isomerase inhibitor
0,654  0,012  Platelet aggregation stimulant
0,660  0,019  Dimethylargininase inhibitor
0,650  0,009  Insulin promoter
0,644  0,004  Thromboxane B2 antagonist
0,655  0,015  Methylamine-glutamate N-methyltransferase inhibitor
0,652  0,013  Cholesterol antagonist
0,642  0,004  Dolichyl-phosphatase inhibitor
0,645  0,007  Fructan beta-fructosidase inhibitor
0,650  0,013  All-trans-retinyl-palmitate hydrolase inhibitor
0,645  0,009  Reductant
0,667  0,031  Acylcarnitine hydrolase inhibitor
0,643  0,009  Poly(beta-D-mannuronate) lyase inhibitor
0,638  0,005  1-Acylglycerol-3-phosphate O-acyltransferase inhibitor
0,642  0,012  Poly(alpha-L-guluronate) lyase inhibitor
0,648  0,018  Manganese peroxidase inhibitor
0,631  0,005  1-Acylglycerol-3-phosphate O-acyltransferase ABHD5 inhibitor
0,630  0,005  Perilipin-1 inhibitor
0,635  0,012  Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase inhibitor
0,639  0,017  Formaldehyde transketolase inhibitor
0,624  0,003  Shikimate 5-dehydrogenase inhibitor
0,647  0,026  Glutathione thiolesterase inhibitor
0,627  0,007  D-xylulose reductase inhibitor
0,628  0,011  Glyoxylate reductase inhibitor
0,617  0,002  Thiamine pyridinylase inhibitor
0,643  0,029  Phosphatase inhibitor
0,625  0,010  Phosphoinositide 5-phosphatase inhibitor
0,637  0,023  2-Hydroxyquinoline 8-monooxygenase inhibitor
0,634  0,022  Lipoprotein lipase inhibitor
0,621  0,011  Arylmalonate decarboxylase inhibitor
0,631  0,021  Glucan endo-1,3-beta-D-glucosidase inhibitor
0,618  0,011  Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase inhibitor
0,609  0,003  Dihydroxy-acid dehydratase inhibitor
0,614  0,009  Phosphatidylglycerophosphatase inhibitor
0,611  0,006  2-Oxoaldehyde dehydrogenase (NADP+) inhibitor
0,620  0,016  Endopeptidase So inhibitor
0,617  0,015  Threonine aldolase inhibitor
0,608  0,007  Uroporphyrinogen-III synthase inhibitor
0,608  0,007  D-alanine 2-hydroxymethyltransferase inhibitor
0,609  0,011  Xylan endo-1,3-beta-xylosidase inhibitor
0,611  0,014  N-formylmethionyl-peptidase inhibitor
0,626  0,030  Kidney function stimulant
0,608  0,015  Fibrinogen receptor antagonist
0,606  0,019  Glutamine-phenylpyruvate transaminase inhibitor
0,599  0,013  Laccase inhibitor
0,592  0,007  Phenylacetate-CoA ligase inhibitor
0,589  0,006  Glycerol-3-phosphate dehydrogenase inhibitor
0,596  0,013  4-Hydroxyphenylacetate 3-monooxygenase inhibitor
0,615  0,032  Aldose reductase-like protein inhibitor
0,612  0,030  Aldehyde oxidase inhibitor
0,596  0,015  Aspartate-ammonia ligase inhibitor
0,591  0,010  DNA-(apurinic or apyrimidinic site) lyase inhibitor
0,587  0,006  Chloride channel blocker
0,590  0,011  Aspergillopepsin I inhibitor
0,608  0,032  Proteasome ATPase inhibitor
0,582  0,008  Chitosanase inhibitor
0,585  0,014  Prostaglandin-A1 DELTA-isomerase inhibitor
0,576  0,006  Aspartyl aminopeptidase inhibitor
0,592  0,023  Vasodilator, peripheral
0,591  0,022  Arylacetonitrilase inhibitor
0,577  0,009  Transketolase inhibitor
0,593  0,025  Gastrin inhibitor
0,577  0,012  Glucan 1,4-alpha-maltotetraohydrolase inhibitor
0,589  0,026  Peroxidase inhibitor
0,588  0,026  Membrane integrity antagonist
0,568  0,009  N-(long-chain-acyl)ethanolamine deacylase inhibitor
0,566  0,007  2-Haloacid dehalogenase (configuration-inverting) inhibitor
0,573  0,016  (-)-(4S)-limonene synthase inhibitor
0,565  0,010  Gluconolactonase inhibitor
0,562  0,008  Glycine dehydrogenase (decarboxylating) inhibitor
0,588  0,036  Glucan endo-1,6-beta-glucosidase inhibitor
0,576  0,024  Ecdysone 20-monooxygenase inhibitor
0,557  0,005  Inorganic diphosphatase inhibitor
0,558  0,008  Protein-Npi-phosphohistidine-sugar phosphotransferase inhibitor
0,556  0,009  Mannose isomerase inhibitor
0,562  0,016  Hydroxylamine oxidase inhibitor
0,562  0,017  IgA-specific metalloendopeptidase inhibitor
0,561  0,016  5 Hydroxytryptamine release inhibitor
0,554  0,013  Glutarate-semialdehyde dehydrogenase inhibitor
0,552  0,011  Sulfite dehydrogenase inhibitor
0,574  0,033  Acetylcholine neuromuscular blocking agent
0,553  0,014  H+-exporting ATPase inhibitor
0,557  0,019  Mannan endo-1,4-beta-mannosidase inhibitor
0,562  0,023  NAD(P)+-arginine ADP-ribosyltransferase inhibitor
0,556  0,018  S-alkylcysteine lyase inhibitor
0,559  0,022  Antipruritic
0,561  0,025  Platelet adhesion inhibitor
0,571  0,036  Glyceryl-ether monooxygenase inhibitor
0,544  0,009  Lactaldehyde reductase inhibitor
0,543  0,008  CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase inhibitor
0,564  0,030  Prostaglandin-E2 9-reductase inhibitor
0,555  0,022  Erythropoiesis stimulant
0,577  0,044  Complement factor D inhibitor
0,538  0,008  Formate-dihydrofolate ligase inhibitor
0,538  0,008  Levansucrase inhibitor
0,576  0,047  Lysase inhibitor
0,541  0,012  Carboxypeptidase D inhibitor
0,543  0,015  Dolichyl-diphosphooligosaccharide-protein glycotransferase inhibitor
0,544  0,017  Levanase inhibitor
0,534  0,009  Pectate lyase inhibitor
0,531  0,010  Clavaminate synthase inhibitor
0,524  0,004  Peptidylamidoglycolate lyase inhibitor
0,536  0,016  N-hydroxyarylamine O-acetyltransferase inhibitor
0,525  0,007  Poly(3-hydroxybutyrate) depolymerase inhibitor
0,529  0,014  Glyoxylate oxidase inhibitor
0,526  0,014  Hypocalcaemic
0,559  0,048  Pro-opiomelanocortin converting enzyme inhibitor
0,527  0,018  3-Phytase inhibitor
0,529  0,021  D-lactaldehyde dehydrogenase inhibitor
0,528  0,020  S-formylglutathione hydrolase inhibitor
0,525  0,022  Leukotriene-B4 20-monooxygenase inhibitor
0,523  0,020  Plastoquinol-plastocyanin reductase inhibitor
0,515  0,012  4-Hydroxyglutamate transaminase inhibitor
0,517  0,014  Cyclomaltodextrinase inhibitor
0,504  0,005  Aldehyde dehydrogenase inhibitor
0,522  0,022  Steroid N-acetylglucosaminyltransferase inhibitor
0,549  0,050  Benzoate-CoA ligase inhibitor
0,506  0,008  Vomilenine glucosyltransferase inhibitor
0,522  0,023  Cyclohexanone monooxygenase inhibitor
0,552  0,053  Penicillin binding protein antagonist
0,552  0,053  Penicillin-binding protein ampH inhibitor
0,534  0,036  Insulin growth factor agonist
0,534  0,036  Insulin like growth factor 1 agonist
0,518  0,021  (R)-Pantolactone dehydrogenase (flavin) inhibitor
0,531  0,034  Potassium sparing diuretic
0,508  0,012  Rhamnulose-1-phosphate aldolase inhibitor
0,535  0,039  Insulysin inhibitor
0,506  0,010  Plasmanylethanolamine desaturase inhibitor
0,500  0,005  Glycine C-acetyltransferase inhibitor
0,498  0,004  Peroxisome proliferator-activated receptor agonist
0,506  0,012  Sphinganine-1-phosphate aldolase inhibitor
0,502  0,008  Retinoic acid metabolism inhibitor
0,503  0,010  Myosin ATPase inhibitor
0,502  0,010  Thiopurine S-methyltransferase inhibitor
0,495  0,005  Phloroglucinol reductase inhibitor
0,518  0,027  Spermicide
0,508  0,018  Aspergillus nuclease S1 inhibitor
0,518  0,028  Glucan 1,4-alpha-maltotriohydrolase inhibitor
0,507  0,018  Sulfite oxidase inhibitor
0,512  0,024  1-Alkylglycerophosphocholine O-acetyltransferase inhibitor
0,529  0,041  Pterin deaminase inhibitor
0,527  0,039  Collagen inhibitor
0,491  0,005  Fumarate reductase (NADH) inhibitor
0,492  0,006  Allantoate deiminase inhibitor
0,497  0,012  3-Hydroxy-4-oxoquinoline 2,4-dioxygenase inhibitor
0,497  0,013  Licheninase inhibitor
0,489  0,004  Uric acid excretion stimulant
0,504  0,020  Alanine-tRNA ligase inhibitor
0,503  0,019  Opheline kinase inhibitor
0,503  0,019  Taurocyamine kinase inhibitor
0,520  0,038  Protein-tyrosine phosphatase alpha inhibitor
0,486  0,005  Alkylglycerophosphoethanolamine phosphodiesterase inhibitor
0,486  0,005  Expectorant
0,492  0,011  6-Pyruvoyltetrahydropterin synthase inhibitor
0,490  0,012  2-Hydroxy-3-oxoadipate synthase inhibitor
0,485  0,008  Glucan 1,4-beta-glucosidase inhibitor
0,516  0,039  Polyamine-transporting ATPase inhibitor
0,492  0,016  Methanol dehydrogenase inhibitor
0,493  0,018  4-Coumarate-CoA ligase inhibitor
0,496  0,022  GABA aminotransferase inhibitor
0,491  0,018  Coccolysin inhibitor
0,483  0,011  Ubiquitin thiolesterase inhibitor
0,483  0,011  Aminomuconate-semialdehyde dehydrogenase inhibitor
0,484  0,013  2,3-Dihydroxyindole 2,3-dioxygenase inhibitor
0,510  0,040  Galanin receptor antagonist
0,492  0,023  Antiinfective
0,473  0,005  Diisopropyl-fluorophosphatase inhibitor
0,499  0,032  Acetylesterase inhibitor
0,501  0,036  Histamine release inhibitor
0,475  0,010  N-acetylneuraminate synthase inhibitor
0,471  0,008  tRNA nucleotidyltransferase inhibitor
0,479  0,016  Tryptophanamidase inhibitor
0,501  0,039  HIV rev inhibitor
0,492  0,030  Chenodeoxycholoyltaurine hydrolase inhibitor
0,481  0,020  Carbon-monoxide dehydrogenase inhibitor
0,478  0,019  Opine dehydrogenase inhibitor
0,477  0,018  Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase inhibitor
0,475  0,016  Beta-carotene 15,15'-monooxygenase inhibitor
0,478  0,019  Histidinol-phosphatase inhibitor
0,482  0,023  Phosphopantothenoylcysteine decarboxylase inhibitor
0,476  0,019  Gingipain K inhibitor
0,470  0,014  4-Chlorophenylacetate 3,4-dioxygenase inhibitor
0,460  0,005  Glycerol dehydratase inhibitor
0,497  0,042  Biotinidase inhibitor
0,470  0,015  Dimethylmaleate hydratase inhibitor
0,464  0,010  Diuretic inhibitor
0,461  0,008  Glucan 1,6-alpha-glucosidase inhibitor
0,466  0,013  Glycopeptide alpha-N-acetylgalactosaminidase inhibitor
0,507  0,054  Anorexiant
0,457  0,005  Aureolysin inhibitor
0,462  0,010  Aminoacylase inhibitor
0,465  0,015  Sorbitol-6-phosphate 2-dehydrogenase inhibitor
0,478  0,030  Bisphosphoglycerate phosphatase inhibitor
0,465  0,016  Succinate-semialdehyde dehydrogenase [NAD(P)+] inhibitor
0,455  0,008  Phenylpyruvate decarboxylase inhibitor
0,455  0,007  NAD+ synthase (glutamine-hydrolysing) inhibitor
0,478  0,030  Mitochondrial processing peptidase inhibitor
0,478  0,031  Renal tissue kallikrein inhibitor
0,457  0,011  Nardilysin inhibitor
0,453  0,007  Calcium-sensing receptor agonist
0,461  0,015  Aldehyde dehydrogenase (NADP+) inhibitor
0,486  0,040  L-glutamate oxidase inhibitor
0,452  0,007  Pappalysin-1 inhibitor
0,458  0,013  Styrene-oxide isomerase inhibitor
0,487  0,043  Fibrolase inhibitor
0,454  0,011  Acyl-CoA hydrolase inhibitor
0,454  0,011  Palmitoyl-CoA hydrolase inhibitor
0,478  0,036  Malate dehydrogenase (acceptor) inhibitor
0,456  0,013  Loop diuretic
0,455  0,013  6-Carboxyhexanoate-CoA ligase inhibitor
0,455  0,013  Biotin-CoA ligase inhibitor
0,455  0,013  Homoaconitate hydratase inhibitor
0,455  0,013  Triacetate-lactonase inhibitor
0,473  0,031  Cathepsin T inhibitor
0,453  0,013  Serine-pyruvate transaminase inhibitor
0,444  0,006  Sterol 3-beta-glucosyltransferase inhibitor
0,460  0,022  Cyclohexyl-isocyanide hydratase inhibitor
0,483  0,045  Muramoyltetrapeptide carboxypeptidase inhibitor
0,465  0,027  Gonadotropin antagonist
0,445  0,008  Alcohol dehydrogenase [NAD(P)+] inhibitor
0,444  0,007  Aldehyde dehydrogenase (NAD+) inhibitor
0,455  0,018  Procollagen N-endopeptidase inhibitor
0,443  0,007  Aspartate-tRNA ligase inhibitor
0,447  0,010  Mannan endo-1,6-alpha-mannosidase inhibitor
0,440  0,003  Branched-chain-amino-acid transaminase inhibitor
0,517  0,083  Taurine dehydrogenase inhibitor
0,436  0,004  Saluretic
0,442  0,010  Sulfur dioxygenase inhibitor
0,441  0,010  Farnesyltranstransferase inhibitor
0,470  0,039  Nucleotide metabolism regulator
0,449  0,019  Hydroxylamine reductase (NADH) inhibitor
0,440  0,011  Alpha-amylase inhibitor
0,440  0,011  Amylase inhibitor
0,446  0,018  Horrilysin inhibitor
0,441  0,012  Acetate kinase inhibitor
0,432  0,004  Gingipain R inhibitor
0,442  0,015  LGALS1 expression inhibitor
0,445  0,017  Protein-tyrosine sulfotransferase inhibitor
0,437  0,012  Bisphosphoglycerate mutase inhibitor
0,459  0,035  Ferredoxin-NAD+ reductase inhibitor
0,459  0,035  Naphthalene 1,2-dioxygenase inhibitor
0,445  0,022  DELTA14-sterol reductase inhibitor
0,444  0,021  Phosphatidylinositol diacylglycerol-lyase inhibitor
0,438  0,017  Galactolipase inhibitor
0,445  0,026  Phosphatidylcholine-sterol O-acyltransferase inhibitor
0,429  0,011  Arylformamidase inhibitor
0,431  0,012  Arylsulfatase inhibitor
0,433  0,016  Glycerol 2-dehydrogenase (NADP+) inhibitor
0,484  0,067  Phospholipid-translocating ATPase inhibitor
0,465  0,048  Cyclic AMP agonist
0,436  0,020  Anthranilate-CoA ligase inhibitor
0,439  0,022  Bothrolysin inhibitor
0,436  0,022  Ethanolamine-phosphate cytidylyltransferase inhibitor
0,432  0,020  N-Acyl-D-aspartate deacylase inhibitor
0,417  0,007  Ferrochelatase inhibitor
0,425  0,016  Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase inhibitor
0,425  0,016  N-acetyllactosamine synthase inhibitor
0,434  0,025  Salicylate 1-monooxygenase inhibitor
0,414  0,006  Phosphoglycerate mutase inhibitor
0,418  0,011  3-Oxoadipate enol-lactonase inhibitor
0,425  0,018  Oryzin inhibitor
0,429  0,022  Meprin B inhibitor
0,424  0,017  2-Oxoglutarate decarboxylase inhibitor
0,463  0,056  Neurotransmitter antagonist
0,419  0,014  Nitrate reductase inhibitor
0,432  0,026  Cutinase inhibitor
0,426  0,020  2,3,4,5-Tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase inhibitor
0,418  0,013  Creatinine deaminase inhibitor
0,427  0,022  Crotonoyl-[acyl-carrier-protein] hydratase inhibitor
0,423  0,018  GABA C receptor agonist
0,416  0,012  Hyaluronic acid agonist
0,414  0,010  Hydroxymethylbilane synthase inhibitor
0,429  0,025  4-Hydroxymandelate oxidase inhibitor
0,421  0,018  Allyl-alcohol dehydrogenase inhibitor
0,416  0,013  Alcohol dehydrogenase (NADP+) inhibitor
0,412  0,010  Acylphosphatase inhibitor
0,409  0,008  Aryl-alcohol dehydrogenase inhibitor
0,410  0,009  L-iduronidase inhibitor
0,414  0,015  N-Acyl-D-amino-acid deacylase inhibitor
0,429  0,029  Mediator release inhibitor
0,410  0,011  Phosphoenolpyruvate-protein phosphotransferase inhibitor
0,438  0,042  Gamma-guanidinobutyraldehyde dehydrogenase inhibitor
0,448  0,053  Transforming growth factor agonist
0,403  0,009  Gamma-butyrobetaine dioxygenase inhibitor
0,467  0,075  Cyclic AMP antagonist
0,464  0,071  NACHT, LRR and PYD domains-containing protein 3 inhibitor
0,412  0,020  Endothelial growth factor antagonist
0,401  0,009  Isopenicillin-N synthase inhibitor
0,404  0,012  Lombricine kinase inhibitor
0,402  0,013  Prunasin beta-glucosidase inhibitor
0,418  0,030  Lipid peroxidase inhibitor
0,410  0,022  Catechol oxidase inhibitor
0,408  0,020  4-Hydroxybenzoate nonaprenyltransferase inhibitor
0,430  0,042  Membrane permeability enhancer
0,415  0,027  Glycolate dehydrogenase inhibitor
0,404  0,016  Phosphoenolpyruvate mutase inhibitor
0,403  0,017  Snapalysin inhibitor
0,404  0,019  Gamma-glutamyltransferase inhibitor
0,403  0,020  Methane monooxygenase inhibitor
0,410  0,027  Venom exonuclease inhibitor
0,408  0,026  Aldehyde dehydrogenase (pyrroloquinoline-quinone) inhibitor
0,411  0,029  Phosphatidate phosphatase inhibitor
0,411  0,030  Carbonyl reductase [NADPH] inhibitor
0,411  0,034  Adenylyl-sulfate reductase inhibitor
0,487  0,109  DNA ligase 1 inhibitor
0,409  0,033  N-acylmannosamine kinase inhibitor
0,418  0,043  Aryl-acylamidase inhibitor
0,407  0,034  Leukotriene-C4 synthase inhibitor
0,437  0,067  Pin1 inhibitor
0,433  0,063  Sulfur reductase inhibitor
0,423  0,060  Alcohol O-acetyltransferase inhibitor
0,421  0,059  Galanin receptor 2 antagonist
0,481  0,124  Vasodilator, cerebral
0,449  0,096  Nicotinic alpha2beta2 receptor antagonist
0,401  0,052  Nav1.6 sodium channel blocker
0,424  0,079  MAP kinase stimulant
0,428  0,087  27-Hydroxycholesterol 7alpha-monooxygenase inhibitor
0,428  0,088  Thioredoxin inhibitor
0,419  0,087  Glutamate-5-semialdehyde dehydrogenase inhibitor
0,408  0,079  Histamine release stimulant
0,416  0,101  Mannotetraose 2-alpha-N-acetylglucosaminyltransferase inhibitor
0,424  0,112  Guanyl-specific ribonuclease T1 inhibitor

>  <Metabolism>
0,851  0,024  CYP2C12 substrate
0,808  0,019  CYP2J substrate
0,797  0,010  GST A substrate
0,681  0,010  CYP2B5 substrate
0,646  0,004  CYP2C18 substrate
0,619  0,012  CYP2F1 substrate
0,610  0,005  FMO1 substrate
0,616  0,012  CYP2A4 substrate
0,602  0,004  CYP2C10 substrate
0,614  0,019  CYP2C9 substrate
0,601  0,020  CYP2C8 substrate
0,568  0,010  CYP2E1 inducer
0,562  0,020  CYP2A2 substrate
0,569  0,032  CYP2C substrate
0,541  0,009  CYP4A1 inhibitor
0,554  0,047  CYP3A2 substrate
0,510  0,010  CYP2A5 substrate
0,517  0,017  CYP4A11 substrate
0,523  0,031  CYP2A1 substrate
0,518  0,042  CYP3A1 substrate
0,468  0,015  CYP4A substrate
0,490  0,048  CYP2 substrate
0,443  0,018  UGT2B4 substrate
0,452  0,030  UGT1A9 substrate
0,440  0,019  UGT1A6 substrate
0,424  0,006  UGT2B9 substrate
0,432  0,023  GST P substrate
0,417  0,012  CYP1A2 inducer
0,401  0,017  CYP2C6 substrate
0,439  0,073  CYP2B6 inhibitor
0,426  0,061  CYP2D16 substrate
0,400  0,041  CYP2C9 inducer
0,416  0,064  CYP3A5 substrate
0,428  0,102  CYP2C8 inhibitor

>  <Toxicity>
0,942  0,012  Toxic, respiration
0,897  0,003  Hypomagnesemia
0,890  0,004  Hematemesis
0,877  0,004  Ulcer, esophageal
0,869  0,008  Anemia, hemolytic
0,856  0,009  Muscle weakness
0,850  0,012  Weakness
0,840  0,004  Fibrosis, interstitial
0,834  0,011  Ulcer, aphthous
0,813  0,006  Gastrointestinal hemorrhage
0,802  0,012  Hyponatremia
0,803  0,016  Cerebral hemorrhage
0,792  0,014  Enuresis
0,775  0,007  Hypercholesterolemic
0,791  0,026  Lichenoid eruption
0,780  0,017  Nystagmus
0,773  0,013  Hyperglycemic
0,782  0,028  Diarrhea
0,771  0,033  Stroke
0,759  0,025  Toxic, vascular
0,748  0,014  Coma
0,762  0,035  Hyperactivity
0,730  0,016  Urine discoloration
0,723  0,015  Non mutagenic, Salmonella
0,732  0,030  Hemolysis
0,725  0,028  Hot flush
0,724  0,042  Eye pain
0,699  0,021  Allergic contact dermatitis
0,695  0,018  Panic
0,712  0,038  Myocardial ischemia
0,713  0,038  Neuritis
0,685  0,017  Ototoxicity
0,682  0,016  Scleroderma
0,695  0,035  Heart failure
0,673  0,014  Gastrointestinal disturbance
0,678  0,020  Aseptic meningitis
0,692  0,034  Hypoxia
0,725  0,068  Shivering
0,687  0,031  Consciousness alteration
0,684  0,029  Anemia
0,700  0,046  Hiccups
0,667  0,016  Cardiogenic shock
0,685  0,035  Pancreatitis
0,694  0,047  Rhinitis
0,686  0,042  Vertigo
0,676  0,035  Hepatitis
0,657  0,018  Pseudoporphyria
0,653  0,015  Nephritis
0,679  0,046  Dyspepsia
0,680  0,047  Renal insufficiency
0,677  0,052  Electrolyte imbalance
0,655  0,036  Memory impairment
0,686  0,070  Bone marrow suppression
0,654  0,039  Alopecia (hair loss)
0,665  0,050  Chest pain
0,641  0,031  Edema
0,679  0,069  Ejaculation dysfunction
0,642  0,036  Withdrawal
0,619  0,020  Pulmonary edema
0,623  0,025  Allergic dermatitis
0,606  0,008  Ulceration
0,643  0,047  Hepatotoxic
0,654  0,059  Arthralgia
0,641  0,046  Ocular toxicity
0,628  0,034  Amnesia
0,638  0,043  Ectropion
0,615  0,023  Cataract
0,600  0,008  Vasopressor
0,619  0,027  Hepatic necrosis
0,609  0,019  Dysphoria
0,624  0,036  Optic neuritis
0,598  0,019  Porphyria
0,611  0,033  Immunotoxin
0,637  0,059  Fibrillation, atrial
0,624  0,046  Vasculitis
0,616  0,039  Postural (orthostatic) hypotension
0,621  0,050  Erythema multiforme
0,624  0,053  Malaise
0,608  0,039  Weight loss
0,630  0,060  Hemorrhage
0,615  0,049  Aggression
0,636  0,071  Dysesthesia
0,624  0,060  Migraine
0,572  0,011  Ulcer, gastric
0,563  0,003  Henoch-Schonlein purpura
0,578  0,018  Interstitial nephritis
0,579  0,020  Nephrotic syndrome
0,625  0,066  Abdominal pain
0,614  0,056  Drowsiness
0,600  0,045  Optic neuropathy
0,595  0,041  Bronchoconstrictor
0,567  0,014  Ulcer, peptic
0,571  0,020  Photoallergy dermatitis
0,570  0,021  Glaucoma
0,613  0,064  Nausea
0,579  0,030  Endocrine disruptor
0,569  0,022  Raynaud's phenomenon
0,604  0,057  Myocardial infarction
0,576  0,032  Colitis
0,604  0,062  Myalgia
0,593  0,054  Shock
0,588  0,049  Syncope
0,546  0,008  Skin irritation, weak
0,586  0,048  Jaundice
0,548  0,012  Eye irritation, high
0,558  0,025  Systemic lupus erythematosus
0,565  0,032  Peripheral neuropathy
0,581  0,048  Hyperbilirubinemia
0,599  0,070  Toxic, gastrointestinal
0,578  0,050  Toxic epidermal necrolysis
0,576  0,048  Bradycardic
0,581  0,054  Nightmare
0,561  0,037  Hyperuricemia
0,583  0,059  Thrombocytopenia
0,585  0,061  Erectile dysfunction
0,534  0,011  Carcinogenic, group 3
0,573  0,052  Thrombophlebitis
0,582  0,061  Anxiety
0,543  0,023  Miotic
0,571  0,052  Drug eruption
0,578  0,061  Behavioral disturbance
0,584  0,067  Dermatitis
0,526  0,014  Hypocalcaemic
0,559  0,047  Hematuria
0,573  0,062  Purpura
0,582  0,071  Hematotoxic
0,559  0,048  Respiratory impairment
0,558  0,049  Acidosis, metabolic
0,581  0,073  Reproductive dysfunction
0,572  0,067  Sleep disturbance
0,534  0,031  ANCA-positive vasculitis
0,565  0,065  Status epilepticus
0,574  0,074  Exanthema
0,565  0,065  Stomatitis
0,571  0,072  Chills
0,550  0,052  Respiratory failure
0,564  0,066  Erythema
0,513  0,016  Carcinogenic, mouse, male
0,561  0,065  Hypertensive
0,520  0,025  Serum sickness
0,556  0,063  Asthma
0,553  0,060  Nephrotoxic
0,518  0,027  Spermicide
0,511  0,020  Bullous pemphigoid
0,556  0,066  Tachycardiac
0,557  0,068  Osteoporosis
0,533  0,045  Enterocolitis
0,499  0,014  Skin irritative effect
0,508  0,026  Acidosis, lactic
0,489  0,007  Renal papillary necrosis
0,544  0,068  Pure red cell aplasia
0,499  0,023  Fasciculation
0,530  0,056  Ataxia
0,551  0,078  Headache
0,519  0,048  Neutropenia
0,489  0,020  Carcinogenic, mouse
0,540  0,073  Proteinuria
0,505  0,039  Spasmogenic
0,546  0,079  Photophobia
0,512  0,048  Dyspnea
0,540  0,076  Pruritus
0,491  0,028  Sensitization
0,540  0,078  Xerostomia
0,493  0,032  Palpitation
0,535  0,074  Urticaria
0,485  0,027  Anemia, sideroblastic
0,513  0,057  Tremor
0,503  0,049  Teratogen
0,507  0,054  Anorexiant
0,513  0,061  Galactorrhea
0,521  0,070  Urinary retention
0,504  0,056  Glycosuria
0,496  0,048  Embryotoxic
0,515  0,068  Injection site pain
0,532  0,088  Pain
0,453  0,010  Skin irritation, moderate
0,454  0,012  Eye irritation, moderate
0,464  0,024  Myasthenia Gravis
0,534  0,095  Psychosexual disorder
0,522  0,083  Sensory disturbance
0,520  0,082  Excitability
0,513  0,075  Inflammation
0,523  0,086  Insomnia
0,515  0,081  Vision disturbance
0,505  0,073  Lethargy
0,491  0,060  Splenomegaly
0,512  0,081  Extrapyramidal effect
0,504  0,074  Anaphylaxis
0,490  0,062  Pancytopenia
0,514  0,087  Dizziness
0,512  0,086  Psychoses
0,494  0,069  Depression
0,447  0,023  Carcinogenic, mouse, female
0,502  0,079  Cardiotoxic
0,503  0,080  Leukopenia
0,496  0,073  Desquamation
0,522  0,102  Lymphocytosis
0,503  0,086  Diplopia
0,466  0,052  Cholestasis
0,506  0,093  Emetic
0,423  0,012  Hypoglycemic
0,504  0,094  Allergic reaction
0,474  0,065  Agranulocytosis
0,426  0,017  Ectopic pregnancy
0,503  0,096  Constipation
0,481  0,077  Convulsant
0,441  0,038  Demyelination
0,430  0,031  Pemphigus
0,512  0,115  Leukocytosis
0,479  0,083  Necrosis
0,443  0,048  Acneiform eruption
0,469  0,074  Hirsutism
0,475  0,085  Toxic
0,479  0,089  Confusion
0,443  0,054  Fatty liver
0,475  0,086  Arrhythmogenic
0,448  0,062  Laryngospasm
0,423  0,039  Cleft palate
0,451  0,067  Eosinophilia
0,468  0,087  Paralysis
0,451  0,075  Apnea
0,458  0,091  Anorgasmia
0,486  0,120  Muscle rigidity
0,429  0,065  Adrenal cortex hypoplasia
0,454  0,097  Euphoria
0,470  0,114  Mania
0,439  0,084  Keratitis
0,425  0,071  Hallucinogen
0,473  0,121  Dry eye
0,443  0,091  Hypothermic
0,451  0,100  Hypotension
0,470  0,118  Sexual dysfunction
0,436  0,090  Dyskinesia
0,425  0,107  Acidosis
0,408  0,092  Keratopathy
0,438  0,129  Paranoia
0,412  0,109  Hyperkinesia
0,407  0,131  Nasal congestion
0,409  0,138  Gait disturbance
0,411  0,180  Hyperreflexia

>  <Murcko.CdId>
7870

>  <Murcko.Mol Weight>
78.1118

>  <Murcko.Formula>
C6H6

>  <Murcko.AKOS_NUMBER>
AKOS000104794

>  <Murcko.IntegerID>
7869

$$$$

  Mrv0541 04281317412D          

 13 14  0  0  0  0            999 V2000
    0.9230    0.1948    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1022    0.1205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2496   -0.6298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0704   -0.7040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3491    0.9024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4662   -0.4292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5453   -0.0288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3727    0.7957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2269   -0.1031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1527    0.7178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1978    0.7185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4180   -1.4514    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.3661   -0.1031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  3  2  2  0  0  0  0
  4  3  1  0  0  0  0
  5  1  1  0  0  0  0
  6  1  1  0  0  0  0
  7 11  1  0  0  0  0
  8  2  1  0  0  0  0
  9  6  2  0  0  0  0
 10  5  2  0  0  0  0
 11  8  2  0  0  0  0
 12  4  1  0  0  0  0
 13  7  1  0  0  0  0
  9 10  1  0  0  0  0
  4  7  2  0  0  0  0
M  END
>  <CdId>
8451

>  <Mol Weight>
191.657

>  <Formula>
C11H10ClN

>  <AKOS_NUMBER>
AKOS001476546

>  <Lipinski's Rule of Five>
0

>  <XLogP (text field)>
2.56

>  <PASS_MNA_NEW_COUNT>
0

>  <PASS_RESULT_COUNT>
   29 of   464 Possible Pharmacological Effects at Pa > 0.400
  182 of  3850 Possible Mechanisms of Action at Pa > 0.400
  145 of   321 Possible Toxic and Adverse Effects at Pa > 0.400
    3 of   118 Possible Antitargets at Pa > 0.400
   24 of   195 Possible Metabolism-Related Actions at Pa > 0.400
  431 of  1610 Possible Gene Expression Regulation at Pa > 0.400
    2 of    68 Possible Transporters-Related Actions at Pa > 0.400

>  <Effects>
0,720  0,034  Antiseborrheic
0,507  0,005  Antiprotozoal (Coccidial)
0,496  0,005  Diabetic neuropathy treatment
0,575  0,087  Fibrinolytic
0,538  0,073  Kidney function stimulant
0,485  0,024  Antiinfective
0,463  0,018  Antiamyloidogenic
0,460  0,015  Antiprotozoal (Amoeba)
0,456  0,013  Loop diuretic
0,446  0,011  Antialcoholic
0,483  0,057  Antinephrotoxic
0,484  0,061  Potassium sparing diuretic
0,473  0,053  Antinociceptive
0,476  0,070  Cytoprotectant
0,424  0,018  Stroke treatment
0,460  0,054  Erythropoiesis stimulant
0,492  0,091  Antibacterial activity enhancer
0,446  0,049  Anticonvulsant
0,458  0,065  Lipid metabolism regulator
0,480  0,094  Acute neurologic disorders treatment
0,425  0,045  Analgesic, non-opioid
0,491  0,114  Antineurotic
0,505  0,129  Neuroprotector
0,403  0,050  Dementia treatment
0,477  0,128  Vasodilator, cerebral
0,413  0,066  Analgesic
0,400  0,077  Vasoprotector
0,409  0,093  Preneoplastic conditions treatment
0,437  0,154  Antiischemic, cerebral

>  <Antitargets>
0,720  0,061  Ubiquinol-cytochrome-c reductase inhibitor
0,525  0,005  5 Hydroxytryptamine 2B agonist
0,447  0,051  Superoxide dismutase inhibitor

>  <Gene_Expression>
0,858  0,012  SERPINB5 expression enhancer
0,835  0,005  ITGB1 expression inhibitor
0,814  0,011  TIMP3 expression enhancer
0,806  0,005  MTHFD2 expression inhibitor
0,785  0,006  MAOB expression enhancer
0,761  0,012  SAT expression enhancer
0,763  0,016  IGFBP6 expression inhibitor
0,758  0,022  APOM expression enhancer
0,762  0,028  OAS2 expression enhancer
0,739  0,005  PAICS expression enhancer
0,745  0,014  PKM2 expression enhancer
0,757  0,027  BST2 expression enhancer
0,755  0,025  ABCC5 expression enhancer
0,755  0,030  CYR61 expression enhancer
0,745  0,027  CNN1 expression enhancer
0,753  0,041  SLC2A4 expression enhancer
0,722  0,014  GSTM3 expression inhibitor
0,717  0,017  IL1A expression inhibitor
0,715  0,015  EFEMP1 expression inhibitor
0,700  0,008  PELI1 expression inhibitor
0,706  0,014  CTSD expression inhibitor
0,712  0,022  FUBP1 expression inhibitor
0,702  0,021  SLC16A2 expression enhancer
0,693  0,019  NPM3 expression inhibitor
0,693  0,019  PTEN expression inhibitor
0,693  0,023  PSMC1 expression enhancer
0,735  0,068  HSPD1 expression inhibitor
0,676  0,017  PLA2G4A expression enhancer
0,683  0,024  F2R expression enhancer
0,702  0,044  MAPT expression enhancer
0,685  0,029  ETV5 expression inhibitor
0,668  0,012  POR expression enhancer
0,681  0,025  PRKAR2B expression enhancer
0,681  0,026  ALCAM expression inhibitor
0,683  0,033  CDCA5 expression enhancer
0,668  0,019  VAT1 expression enhancer
0,665  0,019  HAPLN3 expression inhibitor
0,671  0,024  NT5DC2 expression enhancer
0,671  0,024  RAI14 expression enhancer
0,671  0,024  RFTN1 expression enhancer
0,681  0,035  PLIN2 expression enhancer
0,660  0,015  DDX42 expression enhancer
0,653  0,011  ASAH1 expression enhancer
0,666  0,024  IGF2 expression inhibitor
0,664  0,026  WFDC2 expression enhancer
0,692  0,058  PDXK expression inhibitor
0,651  0,018  WIPI1 expression enhancer
0,646  0,014  PDAP1 expression inhibitor
0,665  0,033  ID2 expression enhancer
0,671  0,040  C10ORF116 expression enhancer
0,646  0,016  MVP expression enhancer
0,642  0,012  ANAPC1 expression enhancer
0,641  0,012  AHRR expression enhancer
0,684  0,056  ITGB1 expression enhancer
0,645  0,017  TM4SF1 expression enhancer
0,655  0,032  AHR expression enhancer
0,657  0,035  NAT1 expression enhancer
0,658  0,037  IFNGR1 expression enhancer
0,631  0,014  NR1H2 expression inhibitor
0,633  0,017  SCARB1 expression enhancer
0,626  0,011  CCNC expression inhibitor
0,616  0,007  IFIT1 expression enhancer
0,623  0,014  DFFB expression inhibitor
0,632  0,026  STRBP expression inhibitor
0,639  0,033  SLC16A4 expression enhancer
0,618  0,012  EIF2B4 expression enhancer
0,628  0,023  VIM expression inhibitor
0,623  0,020  SLC2A3 expression inhibitor
0,630  0,027  TNFSF10 expression enhancer
0,669  0,067  DUSP4 expression enhancer
0,627  0,026  INHBE expression enhancer
0,619  0,023  CYB5R2 expression enhancer
0,610  0,015  HSBP1 expression inhibitor
0,621  0,027  NOC3L expression inhibitor
0,607  0,016  SERPINA3 expression enhancer
0,629  0,040  IL1RN expression inhibitor
0,623  0,034  TNS3 expression enhancer
0,596  0,011  HPN expression enhancer
0,626  0,041  IL18 expression inhibitor
0,598  0,015  EGR3 expression inhibitor
0,602  0,020  CYP11A1 expression inhibitor
0,600  0,023  PSAT1 expression inhibitor
0,611  0,034  ELL2 expression enhancer
0,582  0,010  LRP8 expression inhibitor
0,590  0,018  PPP2CB expression enhancer
0,625  0,053  PLAUR expression enhancer
0,606  0,034  NOS2 expression enhancer
0,589  0,017  CSNK1D expression inhibitor
0,589  0,017  SPATA20 expression enhancer
0,599  0,029  ATP2A2 expression enhancer
0,607  0,039  PRTN3 expression enhancer
0,596  0,029  ITGB7 expression enhancer
0,609  0,042  C3 expression enhancer
0,621  0,055  GTF2F1 expression inhibitor
0,597  0,032  AKT1 expression enhancer
0,575  0,010  CIRBP expression inhibitor
0,628  0,064  EZH2 expression inhibitor
0,571  0,007  RHOC expression enhancer
0,611  0,048  JAG1 expression inhibitor
0,589  0,027  C10ORF10 expression enhancer
0,586  0,027  CDKN1C expression inhibitor
0,574  0,018  PSRC1 expression inhibitor
0,577  0,022  ST3GAL1 expression enhancer
0,575  0,023  IGFBP5 expression enhancer
0,556  0,008  LRP6 expression enhancer
0,575  0,027  ISG15 expression enhancer
0,576  0,029  C1S expression enhancer
0,608  0,061  CD36 expression inhibitor
0,564  0,017  DPP4 expression enhancer
0,566  0,019  IMPDH2 expression enhancer
0,576  0,031  TRIM16 expression enhancer
0,584  0,040  NEIL3 expression inhibitor
0,633  0,089  CXCR1 expression enhancer
0,587  0,044  CCND2 expression enhancer
0,581  0,040  SOX9 expression enhancer
0,580  0,041  TNFRSF21 expression inhibitor
0,559  0,021  TNFAIP3 expression enhancer
0,569  0,033  MYB expression inhibitor
0,591  0,057  FILIP1L expression inhibitor
0,564  0,033  ALDH1A3 expression inhibitor
0,572  0,042  PCDH8 expression enhancer
0,547  0,019  SC5DL expression enhancer
0,567  0,041  CUTL1 expression inhibitor
0,577  0,052  EPRS expression inhibitor
0,536  0,011  AMHR2 expression inhibitor
0,560  0,035  GRPEL1 expression inhibitor
0,545  0,020  NCF1 expression enhancer
0,545  0,022  PI4KA expression inhibitor
0,545  0,022  VCAN expression inhibitor
0,561  0,039  GNL3 expression inhibitor
0,536  0,014  PARP14 expression enhancer
0,555  0,034  CREB1 expression inhibitor
0,547  0,027  FNDC4 expression enhancer
0,547  0,027  CBX3 expression inhibitor
0,555  0,036  CEACAM6 expression enhancer
0,545  0,027  RRM2 expression enhancer
0,536  0,019  LGALS3 expression enhancer
0,536  0,020  REL expression enhancer
0,531  0,014  TMSB4X expression enhancer
0,567  0,054  NCOA2 expression enhancer
0,544  0,032  LMNA expression inhibitor
0,571  0,060  BAD expression inhibitor
0,561  0,052  CDC25B expression enhancer
0,532  0,023  PLA2G16 expression enhancer
0,532  0,023  TCEB3 expression inhibitor
0,558  0,050  GSTM2 expression inhibitor
0,577  0,070  STAT1 expression inhibitor
0,544  0,039  DAB2 expression enhancer
0,541  0,037  PLD1 expression enhancer
0,525  0,022  CYP17A1 expression inhibitor
0,544  0,041  CTTN expression inhibitor
0,587  0,085  STAR expression enhancer
0,554  0,053  THBS1 expression enhancer
0,527  0,028  SF3B5 expression enhancer
0,538  0,040  LAMC1 expression enhancer
0,557  0,059  NBN expression inhibitor
0,587  0,090  NAA15 expression inhibitor
0,561  0,065  ZFP36 expression enhancer
0,522  0,027  HMGN2 expression inhibitor
0,514  0,020  NEK4 expression inhibitor
0,531  0,037  KLK6 expression enhancer
0,531  0,037  PADI3 expression enhancer
0,567  0,073  AHR expression inhibitor
0,544  0,051  VEGFA expression enhancer
0,518  0,026  FTL expression enhancer
0,557  0,067  MYB expression enhancer
0,563  0,074  GADD45A expression inhibitor
0,566  0,076  FANCC expression inhibitor
0,548  0,061  IL6 expression inhibitor
0,517  0,030  S100A10 expression enhancer
0,525  0,039  NPTX2 expression enhancer
0,532  0,045  WISP2 expression inhibitor
0,512  0,026  FABP1 expression enhancer
0,522  0,038  BORA expression inhibitor
0,549  0,065  EIF2S1 expression enhancer
0,499  0,015  PPL expression inhibitor
0,520  0,037  SP2 expression inhibitor
0,533  0,050  HSPA1A expression inhibitor
0,505  0,023  BIK expression enhancer
0,529  0,047  ASXL1 expression inhibitor
0,529  0,047  C11ORF68 expression enhancer
0,529  0,047  CAPN7 expression inhibitor
0,529  0,047  FAM208A expression inhibitor
0,529  0,047  NKTR expression inhibitor
0,529  0,047  RABGAP1 expression inhibitor
0,529  0,047  SETD2 expression inhibitor
0,529  0,047  TIA1 expression inhibitor
0,529  0,047  TTC3 expression inhibitor
0,520  0,039  PTN expression enhancer
0,552  0,071  NOM1 expression inhibitor
0,545  0,064  KRCC1 expression enhancer
0,516  0,036  PLA2G2A expression enhancer
0,525  0,047  JAK2 expression inhibitor
0,525  0,047  TBC1D1 expression inhibitor
0,498  0,021  CLGN expression inhibitor
0,502  0,027  IL9 expression inhibitor
0,529  0,055  FKBP8 expression inhibitor
0,554  0,080  STAT5B expression enhancer
0,514  0,040  MAFB expression inhibitor
0,523  0,050  HLA-G expression enhancer
0,553  0,083  ITGB2 expression enhancer
0,520  0,050  ADAM17 expression inhibitor
0,520  0,050  CTBP1 expression inhibitor
0,522  0,052  SPP1 expression enhancer
0,516  0,049  PRSS23 expression enhancer
0,492  0,025  VEGF expression enhancer
0,512  0,045  TUBA4A expression enhancer
0,509  0,043  HIST1H4B expression inhibitor
0,532  0,066  PRKCA expression enhancer
0,521  0,056  CAV1 expression inhibitor
0,483  0,020  SH2D4A expression inhibitor
0,477  0,014  LSS expression enhancer
0,495  0,032  CSF2 expression enhancer
0,523  0,060  MACF1 expression inhibitor
0,517  0,054  HSPA1A expression enhancer
0,519  0,058  PDCD4 expression inhibitor
0,545  0,084  MYL6 expression enhancer
0,524  0,063  MAF expression enhancer
0,520  0,059  SEPT2 expression inhibitor
0,504  0,044  IL2RA expression inhibitor
0,512  0,052  IL4 expression enhancer
0,524  0,065  DDX18 expression inhibitor
0,486  0,027  DHCR24 expression enhancer
0,520  0,061  TERT expression enhancer
0,514  0,056  ID1 expression inhibitor
0,519  0,061  RNF4 expression inhibitor
0,477  0,020  GPR142 expression enhancer
0,512  0,056  CPE expression inhibitor
0,532  0,075  ILF3 expression inhibitor
0,493  0,036  G0S2 expression enhancer
0,490  0,035  POLE2 expression inhibitor
0,485  0,031  PPARA expression enhancer
0,475  0,021  EPB41L2 expression inhibitor
0,502  0,049  TXNIP expression inhibitor
0,483  0,030  AOX1 expression enhancer
0,479  0,028  HMGCS1 expression enhancer
0,490  0,041  DEPTOR expression enhancer
0,541  0,094  SERPINB5 expression inhibitor
0,477  0,029  LDOC1 expression inhibitor
0,477  0,029  RPRM expression inhibitor
0,474  0,027  OLFM1 expression enhancer
0,467  0,021  CCL4 expression enhancer
0,509  0,064  CCNE2 expression inhibitor
0,472  0,028  TNFSF11 expression inhibitor
0,477  0,033  ODZ3 expression inhibitor
0,477  0,033  TBC1D9 expression inhibitor
0,476  0,033  GDPD3 expression enhancer
0,517  0,073  THBD expression enhancer
0,469  0,026  BFSP2 expression enhancer
0,469  0,026  EGLN3 expression enhancer
0,465  0,022  GARS expression inhibitor
0,496  0,053  VAV3 expression inhibitor
0,471  0,028  KIAA0930 expression enhancer
0,479  0,038  NR5A2 expression enhancer
0,479  0,038  ZBTB10 expression inhibitor
0,458  0,017  CTH expression inhibitor
0,512  0,073  PDE9A expression inhibitor
0,500  0,062  TNFRSF11A expression enhancer
0,476  0,038  FEN1 expression inhibitor
0,492  0,056  SF1 expression inhibitor
0,485  0,049  TUBA1A expression inhibitor
0,465  0,030  CTPS expression inhibitor
0,476  0,041  EPHA3 expression inhibitor
0,470  0,037  CRH expression inhibitor
0,465  0,032  C5ORF32 expression enhancer
0,465  0,032  FAH expression enhancer
0,465  0,032  RRAS expression enhancer
0,465  0,032  SH3BGRL3 expression enhancer
0,488  0,055  RPS19 expression inhibitor
0,488  0,055  SIRT1 expression inhibitor
0,478  0,045  HLA-B expression enhancer
0,488  0,056  CDC16 expression inhibitor
0,462  0,031  IVL expression inhibitor
0,486  0,056  DFFA expression inhibitor
0,495  0,066  STAT3 expression inhibitor
0,452  0,023  EIF4E expression inhibitor
0,523  0,094  NFKB1 expression enhancer
0,464  0,036  CYP11A1 expression enhancer
0,467  0,040  TGFBI expression enhancer
0,462  0,035  HNRNPH2 expression inhibitor
0,503  0,076  TMSB4X expression inhibitor
0,446  0,020  PKP4 expression inhibitor
0,446  0,020  TUBGCP3 expression inhibitor
0,469  0,043  EGR1 expression inhibitor
0,447  0,022  CD47 expression inhibitor
0,449  0,024  CBS expression inhibitor
0,483  0,059  YWHAE expression inhibitor
0,465  0,042  SLC17A2 expression inhibitor
0,450  0,028  CYB5A expression enhancer
0,442  0,021  MND1 expression inhibitor
0,482  0,062  BIRC3 expression enhancer
0,445  0,025  DNASE2 expression inhibitor
0,451  0,033  ADIPOR2 expression inhibitor
0,460  0,043  PPARG expression enhancer
0,438  0,021  IFNG expression inhibitor
0,449  0,032  SPARC expression inhibitor
0,483  0,067  DHRS2 expression enhancer
0,465  0,050  ADD3 expression enhancer
0,449  0,035  PIR expression enhancer
0,505  0,090  SUZ12 expression inhibitor
0,439  0,025  CYP2E1 expression enhancer
0,455  0,041  RPL7A expression inhibitor
0,450  0,036  ALDH4A1 expression inhibitor
0,436  0,023  HIVEP1 expression enhancer
0,436  0,023  HSD17B1 expression enhancer
0,476  0,064  CPNE1 expression enhancer
0,442  0,030  PHGDH expression inhibitor
0,444  0,031  PHYH expression enhancer
0,445  0,033  MT1F expression inhibitor
0,432  0,021  ALDH1A1 expression enhancer
0,427  0,015  ARHGAP18 expression inhibitor
0,427  0,015  RHBDD2 expression enhancer
0,452  0,043  PML expression inhibitor
0,430  0,021  SLC16A1 expression inhibitor
0,524  0,116  LPL expression enhancer
0,465  0,057  ADSL expression inhibitor
0,432  0,025  ASRGL1 expression enhancer
0,430  0,024  SHMT2 expression inhibitor
0,477  0,072  MEGF9 expression inhibitor
0,424  0,019  MT1A expression inhibitor
0,454  0,049  IL1A expression enhancer
0,497  0,092  TP53 expression enhancer
0,423  0,019  PELI1 expression enhancer
0,438  0,034  LAMA3 expression enhancer
0,427  0,024  ZBTB1 expression enhancer
0,437  0,035  PPP1R3C expression inhibitor
0,444  0,042  IL4 expression inhibitor
0,454  0,053  RPS27L expression enhancer
0,446  0,046  LYN expression inhibitor
0,468  0,069  NAA15 expression enhancer
0,424  0,026  MFN2 expression enhancer
0,424  0,026  NEIL2 expression enhancer
0,438  0,040  MT1X expression inhibitor
0,413  0,016  CXCR4 expression enhancer
0,411  0,015  NBL1 expression enhancer
0,431  0,034  NEU4 expression enhancer
0,431  0,034  SH3GL2 expression inhibitor
0,461  0,065  CEP57 expression inhibitor
0,430  0,035  MDK expression inhibitor
0,448  0,055  TFF1 expression inhibitor
0,486  0,093  MCM6 expression enhancer
0,420  0,027  TRPV2 expression enhancer
0,444  0,051  CRABP2 expression inhibitor
0,459  0,066  TNFRSF21 expression enhancer
0,440  0,048  MMP2 expression enhancer
0,410  0,019  HOMER1 expression inhibitor
0,410  0,019  TNIK expression inhibitor
0,410  0,019  TRIB3 expression inhibitor
0,473  0,082  FGF2 expression inhibitor
0,454  0,063  DTYMK expression enhancer
0,489  0,099  KPNA2 expression inhibitor
0,474  0,084  CCNA2 expression enhancer
0,452  0,062  MAP2K1 expression enhancer
0,432  0,043  ITGA6 expression inhibitor
0,486  0,097  HIF1A expression enhancer
0,409  0,021  SOD2 expression inhibitor
0,421  0,033  SLC31A1 expression enhancer
0,507  0,119  VDR expression enhancer
0,443  0,056  SLC1A1 expression enhancer
0,433  0,046  UBE2C expression enhancer
0,467  0,080  ICAM1 expression enhancer
0,411  0,025  GALNT4 expression enhancer
0,432  0,046  TUBB3 expression enhancer
0,410  0,024  PDZK1 expression inhibitor
0,453  0,069  IL10 expression enhancer
0,419  0,036  HLA-E expression enhancer
0,441  0,058  CDH1 expression enhancer
0,414  0,032  LYN expression enhancer
0,464  0,082  CP expression enhancer
0,404  0,022  IFIT2 expression enhancer
0,455  0,074  ESR1 expression inhibitor
0,440  0,060  SERPINE2 expression enhancer
0,438  0,058  UGT1A1 expression enhancer
0,447  0,068  SIDT2 expression enhancer
0,440  0,062  SLC6A2 expression inhibitor
0,428  0,050  FGFR3 expression inhibitor
0,421  0,046  CXCR7 expression inhibitor
0,459  0,084  SRPK1 expression inhibitor
0,485  0,110  TXNRD1 expression inhibitor
0,412  0,040  RXRA expression enhancer
0,418  0,045  GALNT1 expression inhibitor
0,414  0,042  PTPRM expression enhancer
0,451  0,079  ACTA2 expression inhibitor
0,409  0,037  C22ORF29 expression enhancer
0,409  0,037  ETNK2 expression enhancer
0,436  0,065  MAPK8 expression inhibitor
0,425  0,055  SOX9 expression inhibitor
0,430  0,060  KPNB1 expression enhancer
0,430  0,062  CDK5 expression enhancer
0,433  0,067  HS6ST2 expression inhibitor
0,431  0,066  DDX24 expression inhibitor
0,429  0,066  HLA-F expression enhancer
0,421  0,058  YWHAH expression inhibitor
0,474  0,111  UNG expression inhibitor
0,422  0,060  WAS expression enhancer
0,400  0,039  SST expression inhibitor
0,466  0,105  MMP7 expression enhancer
0,407  0,052  COL5A2 expression inhibitor
0,401  0,048  S100P expression enhancer
0,415  0,062  EZR expression inhibitor
0,415  0,062  GAK expression inhibitor
0,415  0,062  TERF1 expression inhibitor
0,415  0,063  TNNT1 expression inhibitor
0,403  0,053  SKP2 expression inhibitor
0,424  0,076  FN1 expression inhibitor
0,423  0,076  ASNS expression inhibitor
0,403  0,056  IGFBP2 expression inhibitor
0,433  0,092  TFDP2 expression inhibitor
0,412  0,071  TRAF3 expression enhancer
0,430  0,093  ORC4 expression enhancer
0,417  0,083  PTGR1 expression enhancer
0,401  0,070  PIM1 expression inhibitor
0,410  0,081  FUS expression inhibitor
0,402  0,073  CD86 expression enhancer
0,460  0,133  GPX1 expression inhibitor
0,448  0,126  JUN expression enhancer
0,412  0,090  TP53I3 expression enhancer
0,437  0,115  EDN1 expression enhancer
0,427  0,107  CDK2 expression inhibitor
0,422  0,107  JUND expression inhibitor
0,429  0,116  MGMT expression enhancer
0,407  0,098  TNFSF10 expression inhibitor
0,424  0,114  HMBS expression inhibitor
0,424  0,115  MYBL1 expression enhancer
0,406  0,098  ABCB1 expression enhancer
0,401  0,094  NASP expression inhibitor
0,464  0,159  PLAU expression inhibitor
0,428  0,123  VEGFA expression inhibitor
0,430  0,127  TOP1 expression inhibitor
0,414  0,115  SFPQ expression enhancer
0,406  0,125  APOA1 expression inhibitor

>  <Mechanisms>
0,944  0,002  NACHT, LRR and PYD domains-containing protein 1 inhibitor
0,870  0,005  Glycosylphosphatidylinositol phospholipase D inhibitor
0,808  0,005  Creatininase inhibitor
0,806  0,004  Centromere associated protein inhibitor
0,808  0,012  Taurine dehydrogenase inhibitor
0,791  0,005  Nitrate reductase (cytochrome) inhibitor
0,839  0,060  Transferase stimulant
0,766  0,008  2-Hydroxyquinoline 8-monooxygenase inhibitor
0,732  0,012  Alkane 1-monooxygenase inhibitor
0,728  0,023  NADPH peroxidase inhibitor
0,743  0,047  Membrane integrity agonist
0,690  0,015  Phospholipid-translocating ATPase inhibitor
0,694  0,020  Carboxypeptidase Taq inhibitor
0,679  0,009  Endopeptidase So inhibitor
0,681  0,016  Cl--transporting ATPase inhibitor
0,702  0,039  Chlordecone reductase inhibitor
0,691  0,028  Nicotinic alpha2beta2 receptor antagonist
0,667  0,005  Nicotinate dehydrogenase inhibitor
0,686  0,024  Dehydro-L-gulonate decarboxylase inhibitor
0,681  0,021  Glutathione thiolesterase inhibitor
0,720  0,061  Ubiquinol-cytochrome-c reductase inhibitor
0,664  0,009  Ferredoxin-NAD+ reductase inhibitor
0,664  0,009  Naphthalene 1,2-dioxygenase inhibitor
0,650  0,007  Hydroxylamine oxidase inhibitor
0,652  0,011  Amine dehydrogenase inhibitor
0,662  0,025  Complement factor D inhibitor
0,650  0,018  27-Hydroxycholesterol 7alpha-monooxygenase inhibitor
0,643  0,012  Chenodeoxycholoyltaurine hydrolase inhibitor
0,625  0,014  (S)-6-hydroxynicotine oxidase inhibitor
0,622  0,014  N-benzyloxycarbonylglycine hydrolase inhibitor
0,620  0,013  IgA-specific metalloendopeptidase inhibitor
0,611  0,005  Benzodiazepine omega receptor agonist
0,621  0,016  Lysostaphin inhibitor
0,622  0,017  2-Hydroxymuconate-semialdehyde hydrolase inhibitor
0,671  0,070  Mucomembranous protector
0,614  0,014  tRNA-pseudouridine synthase I inhibitor
0,611  0,014  4-Hydroxyproline epimerase inhibitor
0,605  0,015  Calmodulin antagonist
0,648  0,061  Transferase inhibitor
0,608  0,021  (R)-6-hydroxynicotine oxidase inhibitor
0,596  0,017  Urethanase inhibitor
0,597  0,023  L-glutamate oxidase inhibitor
0,569  0,005  Thiosulfate dehydrogenase inhibitor
0,570  0,019  Gamma-guanidinobutyraldehyde dehydrogenase inhibitor
0,569  0,018  Insulin promoter
0,569  0,020  X-methyl-His dipeptidase inhibitor
0,547  0,012  Tetrahydroxynaphthalene reductase inhibitor
0,555  0,020  Sulfur reductase inhibitor
0,534  0,004  Aryl-alcohol dehydrogenase inhibitor
0,542  0,013  Carbon-monoxide dehydrogenase inhibitor
0,554  0,026  IgA-specific serine endopeptidase inhibitor
0,549  0,021  Cyclic AMP antagonist
0,546  0,019  Cyclohexanone monooxygenase inhibitor
0,525  0,005  5 Hydroxytryptamine 2B agonist
0,572  0,053  Omptin inhibitor
0,559  0,040  Venombin AB inhibitor
0,529  0,013  Methanol dehydrogenase inhibitor
0,526  0,011  Polyneuridine-aldehyde esterase inhibitor
0,529  0,020  Corticosteroid side-chain-isomerase inhibitor
0,553  0,044  Acetylcholine neuromuscular blocking agent
0,597  0,089  Membrane permeability inhibitor
0,507  0,004  Retinal dehydrogenase inhibitor
0,538  0,039  Insulysin inhibitor
0,500  0,003  Quinoline-4-carboxylate 2-oxidoreductase inhibitor
0,526  0,030  Aspartate-phenylpyruvate transaminase inhibitor
0,537  0,045  Thioredoxin inhibitor
0,552  0,068  Sugar-phosphatase inhibitor
0,516  0,035  Formaldehyde transketolase inhibitor
0,522  0,041  Fragilysin inhibitor
0,516  0,043  Fatty-acyl-CoA synthase inhibitor
0,516  0,044  Pterin deaminase inhibitor
0,486  0,014  Myeloblastin inhibitor
0,507  0,037  Fibrolase inhibitor
0,500  0,031  Malate dehydrogenase (acceptor) inhibitor
0,484  0,015  Tryptophanamidase inhibitor
0,523  0,055  Gastrin inhibitor
0,490  0,023  (+)-borneol dehydrogenase inhibitor
0,538  0,073  Kidney function stimulant
0,475  0,012  Aminomuconate-semialdehyde dehydrogenase inhibitor
0,487  0,026  (R)-Pantolactone dehydrogenase (flavin) inhibitor
0,485  0,024  Antiinfective
0,509  0,049  NACHT, LRR and PYD domains-containing protein 3 inhibitor
0,492  0,035  Thromboxane B2 antagonist
0,469  0,014  4-Chlorophenylacetate 3,4-dioxygenase inhibitor
0,461  0,007  Indolepyruvate C-methyltransferase inhibitor
0,491  0,039  GABA C receptor rho-3 antagonist
0,514  0,062  Lysase inhibitor
0,506  0,055  UDP-N-acetylglucosamine 4-epimerase inhibitor
0,482  0,033  All-trans-retinyl-palmitate hydrolase inhibitor
0,457  0,009  Eukaryotic translation initiation factor 4 gamma 1 inhibitor
0,457  0,009  Eukaryotic translation initiation factor 4E inhibitor
0,463  0,018  Antiamyloidogenic
0,476  0,031  Na+-transporting two-sector ATPase inhibitor
0,460  0,016  Allyl-alcohol dehydrogenase inhibitor
0,475  0,031  Mitochondrial processing peptidase inhibitor
0,470  0,027  Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase inhibitor
0,456  0,013  Loop diuretic
0,463  0,022  Cyanoalanine nitrilase inhibitor
0,462  0,021  Nitrite reductase [NAD(P)H] inhibitor
0,459  0,020  DELTA14-sterol reductase inhibitor
0,475  0,035  Arylsulfate sulfotransferase inhibitor
0,451  0,017  Horrilysin inhibitor
0,447  0,014  2,4-Dichlorophenol 6-monooxygenase inhibitor
0,455  0,022  Coccolysin inhibitor
0,493  0,060  Collagen inhibitor
0,446  0,014  6-Carboxyhexanoate-CoA ligase inhibitor
0,446  0,014  Biotin-CoA ligase inhibitor
0,446  0,014  Homoaconitate hydratase inhibitor
0,446  0,014  Triacetate-lactonase inhibitor
0,466  0,034  Pullulanase inhibitor
0,451  0,025  Albendazole monooxygenase inhibitor
0,445  0,021  Bothrolysin inhibitor
0,436  0,013  Botulin neurotoxin A light chain inhibitor
0,484  0,061  Potassium sparing diuretic
0,451  0,029  Phosphopantothenoylcysteine decarboxylase inhibitor
0,431  0,012  Eukaryotic translation initiation factor inhibitor
0,520  0,103  Polyporopepsin inhibitor
0,461  0,046  Gluconate 5-dehydrogenase inhibitor
0,452  0,038  Cytochrome P450 stimulant
0,431  0,024  Gluconolactonase inhibitor
0,436  0,029  Sulfite oxidase inhibitor
0,476  0,070  Cytoprotectant
0,460  0,054  Erythropoiesis stimulant
0,409  0,004  K(Ca) 3.1 channel activator
0,409  0,004  Potassium channel intermediate-conductance Ca-activated activator
0,428  0,025  Retinoic acid metabolism inhibitor
0,428  0,028  Opheline kinase inhibitor
0,428  0,028  Taurocyamine kinase inhibitor
0,432  0,032  Thiol oxidase inhibitor
0,415  0,017  CDP-4-dehydro-6-deoxyglucose reductase inhibitor
0,428  0,030  Sulfite dehydrogenase inhibitor
0,412  0,016  Snapalysin inhibitor
0,461  0,065  Oxygen scavenger
0,447  0,051  Superoxide dismutase inhibitor
0,445  0,050  HIV rev inhibitor
0,418  0,023  Meprin B inhibitor
0,407  0,014  Creatinine deaminase inhibitor
0,458  0,065  Lipid metabolism regulator
0,421  0,028  H+-exporting ATPase inhibitor
0,458  0,066  Galanin receptor antagonist
0,403  0,015  Nucleoside-diphosphatase inhibitor
0,403  0,015  Gallate decarboxylase inhibitor
0,403  0,015  D-amino-acid dehydrogenase inhibitor
0,448  0,065  Glucan endo-1,6-beta-glucosidase inhibitor
0,457  0,076  Penicillin binding protein antagonist
0,457  0,076  Penicillin-binding protein ampH inhibitor
0,402  0,022  Indanol dehydrogenase inhibitor
0,437  0,057  Polyamine-transporting ATPase inhibitor
0,465  0,086  Oxidoreductase inhibitor
0,412  0,034  4-Methoxybenzoate monooxygenase (O-demethylating) inhibitor
0,411  0,034  G-protein coupled receptor 55 antagonist
0,429  0,053  Nucleotide metabolism regulator
0,409  0,036  Transitional endoplasmic reticulum ATPase inhibitor
0,404  0,034  4-Hydroxyphenylacetate 3-monooxygenase inhibitor
0,423  0,054  Phenol O-methyltransferase inhibitor
0,429  0,063  Ecdysone 20-monooxygenase inhibitor
0,410  0,044  Aryl-acylamidase inhibitor
0,417  0,051  Cyclic AMP phosphodiesterase inhibitor
0,433  0,067  Pro-opiomelanocortin converting enzyme inhibitor
0,423  0,060  Linoleate diol synthase inhibitor
0,426  0,067  Dimethylargininase inhibitor
0,418  0,060  Manganese peroxidase inhibitor
0,400  0,043  Cathepsin T inhibitor
0,418  0,065  Membrane integrity antagonist
0,406  0,057  Mannan endo-1,4-beta-mannosidase inhibitor
0,401  0,052  RNA-directed RNA polymerase inhibitor
0,477  0,128  Vasodilator, cerebral
0,413  0,066  Analgesic
0,418  0,072  Protein-tyrosine phosphatase alpha inhibitor
0,424  0,081  Alkylacetylglycerophosphatase inhibitor
0,408  0,067  Glucose oxidase inhibitor
0,403  0,063  3-Hydroxybenzoate 6-monooxygenase inhibitor
0,406  0,067  Feruloyl esterase inhibitor
0,418  0,081  Histamine release inhibitor
0,405  0,069  Galanin receptor 2 antagonist
0,405  0,069  Biotinidase inhibitor
0,409  0,073  Arginine 2-monooxygenase inhibitor
0,411  0,087  MAP kinase stimulant
0,437  0,121  Nicotinic alpha4beta4 receptor agonist
0,413  0,097  Glucan endo-1,3-beta-D-glucosidase inhibitor
0,426  0,137  Platelet adhesion inhibitor
0,402  0,118  Macrophage colony stimulating factor agonist

>  <Metabolism>
0,810  0,004  CYP2A8 substrate
0,708  0,048  CYP2J substrate
0,548  0,024  CYP2A6 substrate
0,524  0,026  CYP2F1 substrate
0,537  0,046  CYP2C8 inhibitor
0,505  0,026  CYP1A2 substrate
0,475  0,005  CYP2C3 substrate
0,501  0,032  CYP2A substrate
0,484  0,016  CYP4A1 inhibitor
0,477  0,012  CYP2E1 inhibitor
0,464  0,042  CYP2B6 substrate
0,446  0,037  CYP1A substrate
0,444  0,038  CYP1 substrate
0,428  0,044  FMO1 substrate
0,410  0,026  CYP7 inhibitor
0,430  0,048  CYP2B5 substrate
0,401  0,019  CYP2C19 inhibitor
0,443  0,071  CYP2B6 inhibitor
0,425  0,062  CYP2D16 substrate
0,408  0,047  CYP2C18 substrate
0,429  0,080  CYP3A4 substrate
0,415  0,081  CYP3A substrate
0,414  0,082  GST A substrate
0,433  0,117  CYP3A2 substrate

>  <Toxicity>
0,873  0,009  Hyperactivity
0,869  0,008  Ejaculation dysfunction
0,849  0,007  Hematemesis
0,834  0,009  Fibrillation, atrial
0,825  0,005  Gastrointestinal hemorrhage
0,777  0,023  Ulcer, aphthous
0,777  0,032  Lichenoid eruption
0,737  0,026  Hyponatremia
0,707  0,017  Withdrawal
0,715  0,030  Psychomotor impairment
0,737  0,060  Bone marrow suppression
0,692  0,020  Desquamation
0,692  0,025  Lymphocytosis
0,677  0,022  Anorgasmia
0,704  0,051  Stroke
0,683  0,030  Enuresis
0,645  0,014  Adrenal cortex hypoplasia
0,683  0,054  Anemia, hemolytic
0,629  0,012  Hypomania
0,642  0,024  Aseptic meningitis
0,655  0,045  Mania
0,645  0,041  Extrapyramidal effect
0,637  0,071  Dysesthesia
0,604  0,041  Weight gain
0,619  0,056  Pure red cell aplasia
0,623  0,065  Nystagmus
0,598  0,045  Anemia
0,573  0,023  Visual acuity impairment
0,601  0,063  Photophobia
0,587  0,051  Delirium
0,591  0,055  Diplopia
0,597  0,063  Gait disturbance
0,596  0,066  Hypercholesterolemic
0,571  0,044  Allergic contact dermatitis
0,557  0,039  Delusion
0,602  0,085  Cerebral hemorrhage
0,569  0,063  Dysarthria
0,546  0,041  Hypomagnesemia
0,580  0,075  Neuritis
0,559  0,057  Akathisia
0,584  0,083  Paranoia
0,562  0,063  Hypotonia
0,550  0,052  Dystonia
0,558  0,062  Aphasia
0,522  0,031  Parotid gland enlargement
0,541  0,052  Hepatic necrosis
0,531  0,043  Panic
0,539  0,055  Respiratory impairment
0,558  0,078  Hyperglycemic
0,550  0,071  Psychoses
0,540  0,062  Akinesia
0,542  0,070  Ectropion
0,520  0,049  Choreoathetosis
0,494  0,024  Fasciculation
0,563  0,093  Myocardial ischemia
0,557  0,090  Renal insufficiency
0,549  0,088  Hyperreflexia
0,517  0,057  Apnea
0,550  0,096  Leukocytosis
0,505  0,052  Priapism
0,526  0,075  Nightmare
0,504  0,056  Enterocolitis
0,523  0,080  Proteinuria
0,484  0,047  Photoallergy dermatitis
0,522  0,092  Sexual dysfunction
0,527  0,108  Electrolyte imbalance
0,482  0,064  Glycosuria
0,491  0,075  Edema
0,471  0,056  Serum sickness
0,449  0,035  Sialorrhea
0,449  0,036  Demyelination
0,478  0,066  Hirsutism
0,513  0,104  Psychosexual disorder
0,497  0,088  Scleroderma
0,538  0,129  Shivering
0,510  0,105  Muscle rigidity
0,451  0,046  Acneiform eruption
0,473  0,070  Fibrosis, interstitial
0,492  0,094  Cardiogenic shock
0,453  0,058  Hyperuricemia
0,496  0,103  Aggression
0,465  0,073  Postural (orthostatic) hypotension
0,456  0,066  Interstitial nephritis
0,449  0,059  Gastrointestinal disturbance
0,466  0,077  Hypothermic
0,459  0,071  Allergic dermatitis
0,469  0,082  Weight loss
0,509  0,123  Hemorrhage
0,498  0,112  Alopecia (hair loss)
0,413  0,028  Henoch-Schonlein purpura
0,457  0,074  Yawning
0,437  0,055  Torticollis
0,424  0,047  Ulcer, peptic
0,469  0,093  Urinary retention
0,461  0,087  Lethargy
0,450  0,076  Ototoxicity
0,474  0,101  Hemolysis
0,430  0,057  ANCA-positive vasculitis
0,480  0,109  Optic neuritis
0,425  0,062  Fatty liver
0,425  0,064  Porphyria
0,407  0,047  Methemoglobinemia
0,464  0,108  Erythema multiforme
0,422  0,069  Hypersexuality
0,454  0,102  Nephritis
0,464  0,113  Toxic, respiration
0,411  0,061  Peripheral neuropathy
0,466  0,118  Optic neuropathy
0,424  0,076  Torsades de pointes
0,475  0,128  Reproductive dysfunction
0,443  0,097  Acidosis
0,453  0,108  Memory impairment
0,428  0,084  Keratopathy
0,432  0,088  Keratitis
0,413  0,071  Chorea
0,414  0,072  Palpitation
0,449  0,107  Amnesia
0,433  0,092  Acidosis, metabolic
0,418  0,078  Systemic lupus erythematosus
0,431  0,091  Nephrotic syndrome
0,454  0,116  Erythema
0,425  0,087  Glaucoma
0,454  0,117  Jaundice
0,434  0,097  Hyperkinesia
0,416  0,082  Speech disturbance
0,466  0,134  Pancreatitis
0,451  0,118  Hyperbilirubinemia
0,463  0,135  Eye pain
0,432  0,107  Myoclonus
0,462  0,138  Erectile dysfunction
0,426  0,101  Colitis
0,446  0,123  Hepatitis
0,402  0,086  Cholestasis
0,458  0,146  Heart failure
0,420  0,108  Cyanosis
0,444  0,138  Migraine
0,419  0,116  Galactorrhea
0,438  0,138  Hiccups
0,414  0,117  Status epilepticus
0,405  0,121  Pseudoporphyria
0,415  0,133  Weakness
0,411  0,132  Necrosis
0,404  0,140  Drug eruption
0,415  0,165  Hypoxia
0,407  0,191  Myocardial infarction

>  <Transporter>
0,492  0,010  Monoamine uptake inhibitor
0,462  0,057  Basolateral Na-K-Cl symporter inhibitor

>  <Murcko.CdId>
8451

>  <Murcko.Mol Weight>
143.1852

>  <Murcko.Formula>
C10H9N

>  <Murcko.AKOS_NUMBER>
AKOS001476546

>  <Murcko.IntegerID>
8450

$$$$

  Mrv0541 04281317412D          

 23 25  0  0  0  0            999 V2000
    2.7035    0.8491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4160    0.4366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9910    0.4366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2743    0.8450    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5840   -0.8134    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5618    0.4283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8674   -0.4009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4118   -0.3884    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.2965   -0.4009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1549    0.8408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1549   -0.8134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5618   -0.4009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8674    0.4283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0132   -0.8134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6951    1.6700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1285    0.8533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0090   -1.6342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7257   -0.3967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4035    2.0866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1285    1.6783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4382   -0.8092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7215   -2.0467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4424   -1.6342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  2  0  0  0  0
  3  1  1  0  0  0  0
  4  3  1  0  0  0  0
  5  7  1  0  0  0  0
  6  4  1  0  0  0  0
  7 11  1  0  0  0  0
  8  2  1  0  0  0  0
  9  5  1  0  0  0  0
 10  6  2  0  0  0  0
 11 12  2  0  0  0  0
 12  6  1  0  0  0  0
 13 10  1  0  0  0  0
 14  9  1  0  0  0  0
 15  1  1  0  0  0  0
 16  2  1  0  0  0  0
 17 14  1  0  0  0  0
 18 14  2  0  0  0  0
 19 15  2  0  0  0  0
 20 19  1  0  0  0  0
 21 18  1  0  0  0  0
 22 17  2  0  0  0  0
 23 22  1  0  0  0  0
 20 16  2  0  0  0  0
  7 13  2  0  0  0  0
 23 21  2  0  0  0  0
M  END
>  <CdId>
9140

>  <Mol Weight>
324.801

>  <Formula>
C20H17ClO2

>  <AKOS_NUMBER>
AKOS000444898

>  <Lipinski's Rule of Five>
0

>  <XLogP (text field)>
3.63

>  <PASS_MNA_NEW_COUNT>
0

>  <PASS_RESULT_COUNT>
   36 of   464 Possible Pharmacological Effects at Pa > 0.400
  183 of  3850 Possible Mechanisms of Action at Pa > 0.400
  146 of   321 Possible Toxic and Adverse Effects at Pa > 0.400
    4 of   118 Possible Antitargets at Pa > 0.400
   31 of   195 Possible Metabolism-Related Actions at Pa > 0.400
  766 of  1610 Possible Gene Expression Regulation at Pa > 0.400
    2 of    68 Possible Transporters-Related Actions at Pa > 0.400

>  <Effects>
0,804  0,018  Antiseborrheic
0,738  0,022  Antiischemic, cerebral
0,702  0,022  Fibrinolytic
0,641  0,004  Pediculicide
0,617  0,024  Cytoprotectant
0,621  0,064  Antineurotic
0,545  0,003  Antifungal (Candida)
0,525  0,024  Antiallergic
0,524  0,044  Preneoplastic conditions treatment
0,488  0,014  Antiseptic
0,478  0,009  Acaricide
0,558  0,095  Neuroprotector
0,495  0,041  Vasoprotector
0,501  0,047  Antinephrotoxic
0,462  0,011  Antiinflammatory, intestinal
0,454  0,004  Sickle-cell anemia treatment
0,444  0,023  Carminative
0,412  0,004  Antiviral (CMV)
0,486  0,078  Mucositis treatment
0,439  0,034  Antidiabetic
0,418  0,020  Loop diuretic
0,468  0,073  Antidyskinetic
0,404  0,017  Sclerosant
0,427  0,040  Antiasthmatic
0,463  0,078  Potassium sparing diuretic
0,423  0,039  Antimyopathies
0,403  0,037  Atherosclerosis treatment
0,426  0,070  Antiarthritic
0,404  0,050  Dementia treatment
0,428  0,076  Leukopoiesis stimulant
0,418  0,085  Lipid metabolism regulator
0,420  0,093  Alopecia treatment
0,406  0,116  Ovulation inhibitor
0,417  0,131  Acute neurologic disorders treatment
0,441  0,168  Vasodilator, cerebral
0,415  0,195  Antibacterial activity enhancer

>  <Antitargets>
0,824  0,025  Ubiquinol-cytochrome-c reductase inhibitor
0,666  0,003  5 Hydroxytryptamine 2B agonist
0,400  0,004  MAO inhibitor
0,409  0,018  CYP2C9 inhibitor

>  <Gene_Expression>
0,874  0,003  HMGCS2 expression enhancer
0,866  0,006  APOM expression enhancer
0,858  0,008  BST2 expression enhancer
0,852  0,009  AHR expression inhibitor
0,865  0,028  HSPD1 expression inhibitor
0,851  0,016  ITGB1 expression enhancer
0,843  0,012  ABCC5 expression enhancer
0,846  0,016  DUSP4 expression enhancer
0,824  0,004  EIF2B4 expression enhancer
0,818  0,005  PKM2 expression enhancer
0,828  0,015  MAPT expression enhancer
0,814  0,006  IL1A expression inhibitor
0,807  0,004  HAPLN3 expression inhibitor
0,811  0,010  IL18 expression inhibitor
0,822  0,023  SLC2A4 expression enhancer
0,803  0,003  PELI1 expression inhibitor
0,808  0,011  TIMP3 expression enhancer
0,802  0,008  IFNGR1 expression enhancer
0,803  0,011  TNFRSF21 expression inhibitor
0,794  0,006  NOC3L expression inhibitor
0,791  0,004  MANSC1 expression inhibitor
0,799  0,013  F2R expression enhancer
0,792  0,006  GSTM3 expression inhibitor
0,794  0,012  ETV5 expression inhibitor
0,803  0,021  SERPINB5 expression enhancer
0,784  0,004  ANAPC1 expression enhancer
0,798  0,019  EZH2 expression inhibitor
0,798  0,023  CYR61 expression enhancer
0,775  0,004  NEU4 expression enhancer
0,775  0,004  SH3GL2 expression inhibitor
0,780  0,010  SAT expression enhancer
0,776  0,008  PCDH8 expression enhancer
0,784  0,019  CNN1 expression enhancer
0,772  0,008  NPM3 expression inhibitor
0,772  0,008  PTEN expression inhibitor
0,770  0,007  SLC17A2 expression inhibitor
0,765  0,003  CIRBP expression inhibitor
0,770  0,013  NCOA2 expression enhancer
0,768  0,014  PLIN2 expression enhancer
0,772  0,018  CDC25B expression enhancer
0,776  0,027  SUZ12 expression inhibitor
0,753  0,004  CCNC expression inhibitor
0,770  0,022  SPATA13 expression enhancer
0,752  0,011  EFEMP1 expression inhibitor
0,750  0,010  CDH1 expression enhancer
0,748  0,009  MAOB expression enhancer
0,747  0,008  TM4SF1 expression enhancer
0,753  0,016  TNFRSF11A expression enhancer
0,751  0,015  ALCAM expression inhibitor
0,735  0,005  PI4KA expression inhibitor
0,735  0,005  VCAN expression inhibitor
0,750  0,022  DHRS2 expression enhancer
0,757  0,030  OAS2 expression enhancer
0,749  0,022  CDCA5 expression enhancer
0,740  0,014  NEIL3 expression inhibitor
0,740  0,015  WFDC2 expression enhancer
0,751  0,026  PLAUR expression enhancer
0,726  0,003  MT1A expression inhibitor
0,733  0,013  WISP2 expression inhibitor
0,732  0,013  HSPA1A expression inhibitor
0,727  0,008  FTL expression enhancer
0,730  0,012  CTSD expression inhibitor
0,740  0,023  EIF2S1 expression enhancer
0,731  0,015  NT5DC2 expression enhancer
0,731  0,015  RAI14 expression enhancer
0,731  0,015  RFTN1 expression enhancer
0,733  0,018  TNS3 expression enhancer
0,728  0,014  JAK2 expression inhibitor
0,728  0,014  TBC1D1 expression inhibitor
0,729  0,017  SLC16A4 expression enhancer
0,726  0,013  GNL3 expression inhibitor
0,725  0,013  TRIM16 expression enhancer
0,750  0,039  CD36 expression inhibitor
0,721  0,012  STRBP expression inhibitor
0,719  0,009  WIPI1 expression enhancer
0,722  0,014  CEACAM6 expression enhancer
0,719  0,012  AP1S2 expression enhancer
0,729  0,024  NAT1 expression enhancer
0,726  0,022  IL1RN expression inhibitor
0,707  0,003  ZBTB1 expression enhancer
0,710  0,007  CYB5A expression enhancer
0,718  0,015  HMBS expression inhibitor
0,710  0,008  SLC2A3 expression inhibitor
0,719  0,016  ITGB7 expression enhancer
0,711  0,009  MVP expression enhancer
0,727  0,026  FILIP1L expression inhibitor
0,727  0,026  TXNIP expression inhibitor
0,709  0,010  PSAT1 expression inhibitor
0,702  0,005  PDZK1 expression inhibitor
0,701  0,005  EPB41L2 expression inhibitor
0,715  0,019  SPP1 expression enhancer
0,699  0,005  SLC31A1 expression enhancer
0,717  0,023  THBS1 expression enhancer
0,723  0,029  STAT1 expression inhibitor
0,715  0,030  RASEF expression inhibitor
0,688  0,004  CLGN expression inhibitor
0,700  0,016  MEGF9 expression inhibitor
0,687  0,005  WDR67 expression inhibitor
0,695  0,013  PIM1 expression enhancer
0,708  0,026  IGFBP6 expression inhibitor
0,694  0,013  C1S expression enhancer
0,701  0,021  ITGB1 expression inhibitor
0,687  0,007  HSBP1 expression inhibitor
0,683  0,005  RNF144A expression inhibitor
0,683  0,005  SPRY1 expression inhibitor
0,699  0,022  ZFP36 expression enhancer
0,685  0,009  INPP4B expression inhibitor
0,691  0,015  PLA2G4A expression enhancer
0,685  0,009  IFI30 expression enhancer
0,694  0,018  PRSS23 expression enhancer
0,679  0,005  ASRGL1 expression enhancer
0,677  0,004  AKR1B10 expression enhancer
0,688  0,015  GRPEL1 expression inhibitor
0,683  0,009  PARG expression enhancer
0,703  0,030  PRKCA expression enhancer
0,684  0,011  DLX4 expression inhibitor
0,687  0,015  DAB2 expression enhancer
0,696  0,024  C3 expression enhancer
0,676  0,005  CD36 expression enhancer
0,695  0,025  MAPK8 expression inhibitor
0,681  0,013  SLC26A2 expression inhibitor
0,689  0,021  IGF2 expression inhibitor
0,678  0,010  FNDC4 expression enhancer
0,678  0,011  DEPTOR expression enhancer
0,685  0,019  ELL2 expression enhancer
0,671  0,005  HIVEP1 expression enhancer
0,674  0,008  MT1H expression inhibitor
0,676  0,011  SCARB1 expression enhancer
0,679  0,014  IGFBP5 expression enhancer
0,668  0,005  HPN expression enhancer
0,677  0,014  MAP2K1 expression enhancer
0,667  0,005  BST2 expression inhibitor
0,671  0,009  PAICS expression enhancer
0,673  0,011  ODZ3 expression inhibitor
0,673  0,011  TBC1D9 expression inhibitor
0,665  0,004  ALDH1A1 expression enhancer
0,680  0,020  ESR1 expression inhibitor
0,673  0,013  ADIPOR2 expression inhibitor
0,692  0,032  JAG1 expression inhibitor
0,668  0,009  PHGDH expression inhibitor
0,669  0,011  AOX1 expression enhancer
0,670  0,014  PTN expression enhancer
0,670  0,014  INHBE expression enhancer
0,665  0,010  AHRR expression enhancer
0,677  0,022  LYN expression inhibitor
0,661  0,007  SH2D4A expression inhibitor
0,683  0,029  ID2 expression enhancer
0,659  0,006  PARP14 expression enhancer
0,663  0,010  DHCR24 expression enhancer
0,684  0,031  FN1 expression inhibitor
0,657  0,005  MFN2 expression enhancer
0,657  0,005  NEIL2 expression enhancer
0,723  0,072  LPL expression enhancer
0,668  0,018  NPTX2 expression enhancer
0,656  0,007  CSF2 expression enhancer
0,658  0,009  SERPINA3 expression enhancer
0,675  0,026  PMEPA1 expression inhibitor
0,676  0,028  EPRS expression inhibitor
0,658  0,010  SF3B5 expression enhancer
0,652  0,005  GPR142 expression enhancer
0,651  0,004  RHOC expression enhancer
0,654  0,009  HMGN2 expression inhibitor
0,654  0,010  C5ORF32 expression enhancer
0,654  0,010  FAH expression enhancer
0,654  0,010  RRAS expression enhancer
0,654  0,010  SH3BGRL3 expression enhancer
0,656  0,011  CSNK1D expression inhibitor
0,656  0,011  SPATA20 expression enhancer
0,666  0,022  PDCD4 expression inhibitor
0,665  0,022  CPM expression enhancer
0,665  0,022  TERT expression enhancer
0,648  0,005  SHMT2 expression inhibitor
0,693  0,051  HMGB1 expression inhibitor
0,645  0,004  SLCO2A1 expression enhancer
0,653  0,013  STAT3 expression inhibitor
0,674  0,033  KRCC1 expression enhancer
0,652  0,012  GALNT1 expression inhibitor
0,663  0,023  SOX9 expression enhancer
0,664  0,027  RNF4 expression inhibitor
0,665  0,029  PRKAR2B expression enhancer
0,644  0,007  NEK4 expression inhibitor
0,655  0,019  MTHFD2 expression inhibitor
0,656  0,020  CDKN1C expression inhibitor
0,656  0,020  ATP2A2 expression enhancer
0,642  0,006  DST expression enhancer
0,648  0,012  IL6ST expression inhibitor
0,640  0,006  IFIT1 expression enhancer
0,644  0,010  MT1F expression inhibitor
0,647  0,014  CYP11A1 expression inhibitor
0,661  0,028  ASNS expression inhibitor
0,694  0,061  NAA15 expression inhibitor
0,648  0,015  TRAM2 expression inhibitor
0,643  0,011  EGR3 expression inhibitor
0,652  0,021  TUBA4A expression enhancer
0,649  0,018  KLK6 expression enhancer
0,649  0,018  PADI3 expression enhancer
0,636  0,005  PKP4 expression inhibitor
0,636  0,005  TUBGCP3 expression inhibitor
0,671  0,040  GTF2F1 expression inhibitor
0,643  0,012  RSAD2 expression enhancer
0,647  0,019  FOXD1 expression inhibitor
0,638  0,010  DPP4 expression enhancer
0,645  0,017  TRAM1 expression inhibitor
0,636  0,009  HNRNPH2 expression inhibitor
0,638  0,012  LGALS3 expression enhancer
0,633  0,006  TGFB2 expression inhibitor
0,637  0,011  IMPDH2 expression enhancer
0,649  0,023  MAFB expression inhibitor
0,638  0,014  NR1H2 expression inhibitor
0,628  0,006  XPA expression enhancer
0,638  0,017  POR expression enhancer
0,634  0,013  ASAH1 expression enhancer
0,635  0,014  ST3GAL1 expression enhancer
0,639  0,021  APOA1 expression inhibitor
0,622  0,005  LRP6 expression enhancer
0,622  0,005  ADAMTS9 expression enhancer
0,626  0,010  BIK expression enhancer
0,628  0,012  S100A10 expression enhancer
0,653  0,038  NR4A2 expression enhancer
0,621  0,006  TSKU expression enhancer
0,626  0,012  NCF1 expression enhancer
0,648  0,034  THBD expression enhancer
0,635  0,022  EGR1 expression inhibitor
0,663  0,050  SFPQ expression enhancer
0,619  0,007  IL4 expression inhibitor
0,645  0,033  AHR expression enhancer
0,641  0,032  CALR expression inhibitor
0,638  0,030  CPE expression inhibitor
0,622  0,014  MT1X expression inhibitor
0,629  0,022  CYB5R2 expression enhancer
0,641  0,035  GAS6 expression enhancer
0,610  0,005  PRUNE2 expression inhibitor
0,634  0,029  CLMP expression inhibitor
0,659  0,055  JUN expression enhancer
0,613  0,010  BFSP2 expression enhancer
0,613  0,010  EGLN3 expression enhancer
0,615  0,012  OLFM1 expression enhancer
0,649  0,046  GADD45A expression inhibitor
0,610  0,008  TACC1 expression inhibitor
0,608  0,006  CCL4 expression enhancer
0,640  0,043  MYBL1 expression enhancer
0,618  0,020  GPX2 expression enhancer
0,614  0,018  NR5A2 expression enhancer
0,614  0,018  ZBTB10 expression inhibitor
0,634  0,037  NASP expression inhibitor
0,601  0,005  MLPH expression enhancer
0,623  0,027  CAV1 expression inhibitor
0,632  0,036  PDE9A expression inhibitor
0,602  0,008  PSPH expression inhibitor
0,601  0,007  TRPV2 expression enhancer
0,657  0,063  STAR expression enhancer
0,608  0,015  TNFAIP3 expression enhancer
0,622  0,030  FOSL1 expression enhancer
0,635  0,043  MCM6 expression enhancer
0,602  0,011  CBS expression inhibitor
0,600  0,008  LRP8 expression inhibitor
0,599  0,009  PPL expression inhibitor
0,614  0,025  PLD1 expression enhancer
0,615  0,026  ADAM17 expression inhibitor
0,615  0,026  CTBP1 expression inhibitor
0,597  0,012  IRF7 expression enhancer
0,608  0,023  UBE2C expression enhancer
0,606  0,020  PLA2G2A expression enhancer
0,602  0,016  PPARG expression enhancer
0,592  0,007  LRP6 expression inhibitor
0,622  0,040  UGCG expression enhancer
0,619  0,036  IL4 expression enhancer
0,597  0,015  PSRC1 expression inhibitor
0,603  0,021  ISG15 expression enhancer
0,614  0,032  EDN1 expression enhancer
0,610  0,031  CUTL1 expression inhibitor
0,640  0,062  STAT5B expression enhancer
0,587  0,009  C6ORF48 expression inhibitor
0,621  0,043  COL2A1 expression enhancer
0,603  0,025  CEP57 expression inhibitor
0,640  0,063  NFKB1 expression enhancer
0,587  0,010  C22ORF29 expression enhancer
0,587  0,010  ETNK2 expression enhancer
0,610  0,034  HLA-G expression enhancer
0,656  0,080  CXCR1 expression enhancer
0,590  0,014  GDPD3 expression enhancer
0,601  0,025  C10ORF10 expression enhancer
0,591  0,016  KIAA0930 expression enhancer
0,608  0,034  TNFSF10 expression enhancer
0,638  0,064  TXNRD1 expression inhibitor
0,617  0,045  MYB expression enhancer
0,603  0,031  PRRX1 expression inhibitor
0,581  0,009  VEGF expression enhancer
0,589  0,018  DFFB expression inhibitor
0,588  0,017  TFF1 expression inhibitor
0,603  0,032  VAT1 expression enhancer
0,576  0,006  KCTD20 expression enhancer
0,576  0,006  LPPR2 expression enhancer
0,576  0,006  MAPK13 expression inhibitor
0,576  0,006  METTL21D expression inhibitor
0,576  0,006  PDCD7 expression enhancer
0,576  0,006  PRKAR2A expression enhancer
0,576  0,006  TSC22D1 expression inhibitor
0,576  0,006  ZKSCAN2 expression enhancer
0,576  0,006  ZMYM3 expression enhancer
0,602  0,031  AKT1 expression enhancer
0,619  0,051  NOM1 expression inhibitor
0,636  0,068  GPX1 expression inhibitor
0,605  0,038  PCNA expression enhancer
0,610  0,044  CCNE2 expression inhibitor
0,609  0,042  DDX18 expression inhibitor
0,573  0,007  ERCC3 expression enhancer
0,588  0,021  RRM2 expression enhancer
0,596  0,031  LAMC1 expression enhancer
0,596  0,032  SERPINE2 expression enhancer
0,573  0,011  CD47 expression inhibitor
0,568  0,006  CABLES1 expression enhancer
0,568  0,006  CHAC2 expression enhancer
0,568  0,006  GALR2 expression inhibitor
0,568  0,006  HES2 expression enhancer
0,568  0,006  MEOX1 expression inhibitor
0,568  0,006  MFGE8 expression inhibitor
0,570  0,008  FOXN3 expression inhibitor
0,594  0,032  SLC1A1 expression enhancer
0,581  0,021  NKD1 expression inhibitor
0,619  0,058  UNG expression inhibitor
0,569  0,010  HIST1H2BD expression enhancer
0,624  0,066  SERPINB5 expression inhibitor
0,580  0,022  G0S2 expression enhancer
0,562  0,005  LAMP3 expression inhibitor
0,592  0,035  CPNE1 expression enhancer
0,587  0,032  VAV3 expression inhibitor
0,569  0,014  CEBPD expression inhibitor
0,569  0,014  HADH expression enhancer
0,569  0,014  MELK expression enhancer
0,569  0,014  TFF3 expression enhancer
0,564  0,010  ACSL3 expression inhibitor
0,593  0,039  IL10 expression enhancer
0,591  0,038  NOS2 expression enhancer
0,579  0,029  VIPR1 expression enhancer
0,572  0,022  ANXA1 expression inhibitor
0,590  0,041  SEPT2 expression inhibitor
0,583  0,035  CCNA2 expression enhancer
0,573  0,025  RPS27L expression enhancer
0,565  0,018  MDK expression inhibitor
0,551  0,005  APOE expression enhancer
0,565  0,019  PLA2G16 expression enhancer
0,565  0,019  TCEB3 expression inhibitor
0,552  0,008  GALNT4 expression enhancer
0,549  0,005  LSS expression enhancer
0,550  0,008  MGST1 expression enhancer
0,646  0,104  RAD23B expression inhibitor
0,559  0,017  REL expression enhancer
0,556  0,014  CYP11A1 expression enhancer
0,561  0,020  SPARC expression inhibitor
0,568  0,027  FUS expression inhibitor
0,616  0,075  PLAU expression inhibitor
0,572  0,032  ALDH1A3 expression inhibitor
0,553  0,013  GGH expression enhancer
0,553  0,013  STMN1 expression enhancer
0,542  0,004  ABCG5 expression enhancer
0,542  0,004  CYP7A1 expression enhancer
0,557  0,019  LDOC1 expression inhibitor
0,557  0,019  RPRM expression inhibitor
0,544  0,008  TFAM expression inhibitor
0,551  0,015  GARS expression inhibitor
0,545  0,009  CTH expression inhibitor
0,553  0,017  MCM2 expression enhancer
0,554  0,020  PTPRM expression enhancer
0,580  0,049  TNF expression enhancer
0,578  0,046  SNAI2 expression inhibitor
0,542  0,011  PTGER4 expression enhancer
0,585  0,054  BAD expression inhibitor
0,601  0,071  VDR expression enhancer
0,540  0,010  AMHR2 expression inhibitor
0,542  0,012  TRIM24 expression inhibitor
0,554  0,026  PGM2 expression enhancer
0,538  0,011  EID1 expression enhancer
0,542  0,014  CEBPG expression inhibitor
0,557  0,031  COL3A1 expression inhibitor
0,553  0,028  HSP27 expression enhancer
0,578  0,054  NBN expression inhibitor
0,547  0,023  KIF15 expression inhibitor
0,557  0,033  HIST1H4B expression inhibitor
0,549  0,026  DEK expression inhibitor
0,592  0,069  FANCC expression inhibitor
0,558  0,035  MYB expression inhibitor
0,555  0,033  PTPRE expression enhancer
0,542  0,019  FABP1 expression enhancer
0,527  0,007  NOTCH1 expression inhibitor
0,539  0,018  BRF1 expression inhibitor
0,559  0,039  ASXL1 expression inhibitor
0,559  0,039  C11ORF68 expression enhancer
0,559  0,039  CAPN7 expression inhibitor
0,559  0,039  FAM208A expression inhibitor
0,559  0,039  NKTR expression inhibitor
0,559  0,039  RABGAP1 expression inhibitor
0,559  0,039  SETD2 expression inhibitor
0,559  0,039  TIA1 expression inhibitor
0,559  0,039  TTC3 expression inhibitor
0,530  0,010  DOK4 expression enhancer
0,606  0,088  PDXK expression inhibitor
0,528  0,010  MND1 expression inhibitor
0,530  0,013  BCAT1 expression inhibitor
0,524  0,007  PELI1 expression enhancer
0,549  0,034  HS6ST2 expression inhibitor
0,533  0,019  MDFI expression inhibitor
0,533  0,019  SYMPK expression inhibitor
0,522  0,009  GSTM1 expression enhancer
0,533  0,020  ALDH4A1 expression inhibitor
0,561  0,049  ORC4 expression enhancer
0,543  0,032  ERBB4 expression inhibitor
0,519  0,008  ARHGAP18 expression inhibitor
0,519  0,008  RHBDD2 expression enhancer
0,554  0,043  CDC25C expression inhibitor
0,539  0,029  PIM1 expression inhibitor
0,559  0,051  MACF1 expression inhibitor
0,543  0,036  HLA-B expression enhancer
0,548  0,042  SF1 expression inhibitor
0,536  0,031  CARS expression inhibitor
0,512  0,007  FOXD1 expression enhancer
0,532  0,028  CXCR7 expression inhibitor
0,544  0,041  DFFA expression inhibitor
0,545  0,041  RPS19 expression inhibitor
0,545  0,041  SIRT1 expression inhibitor
0,515  0,012  LPL expression inhibitor
0,545  0,042  CDC16 expression inhibitor
0,536  0,033  SP2 expression inhibitor
0,564  0,063  MT1A expression enhancer
0,532  0,031  KLHL24 expression inhibitor
0,526  0,025  ID3 expression inhibitor
0,549  0,049  HSPA1A expression enhancer
0,555  0,056  BIK expression inhibitor
0,511  0,012  DMXL1 expression inhibitor
0,511  0,012  TMEM59L expression inhibitor
0,522  0,023  SC5DL expression enhancer
0,523  0,024  TGFA expression enhancer
0,509  0,010  MET expression enhancer
0,544  0,046  NAA15 expression enhancer
0,519  0,021  CCNB2 expression enhancer
0,561  0,064  KPNA2 expression inhibitor
0,557  0,059  SLC16A2 expression enhancer
0,573  0,077  MYL6 expression enhancer
0,530  0,033  SOX9 expression inhibitor
0,505  0,009  CYP19A1 expression inhibitor
0,564  0,068  ILF3 expression inhibitor
0,519  0,024  CYP17A1 expression inhibitor
0,503  0,009  HOMER1 expression inhibitor
0,503  0,009  TNIK expression inhibitor
0,503  0,009  TRIB3 expression inhibitor
0,534  0,040  DDX42 expression enhancer
0,523  0,031  POLE2 expression inhibitor
0,510  0,019  TMSB4X expression enhancer
0,564  0,073  HIF1A expression enhancer
0,505  0,014  IL2 expression inhibitor
0,495  0,005  NPC1 expression inhibitor
0,512  0,023  CEBPD expression enhancer
0,513  0,023  TNFSF11 expression inhibitor
0,525  0,036  SLC6A2 expression inhibitor
0,502  0,013  CSTA expression inhibitor
0,506  0,017  KEAP1 expression enhancer
0,535  0,047  IL1B expression enhancer
0,548  0,061  IL6 expression inhibitor
0,507  0,021  HLA-E expression enhancer
0,515  0,030  RECQL expression inhibitor
0,539  0,054  GSTM2 expression inhibitor
0,527  0,044  YWHAE expression inhibitor
0,534  0,051  ID1 expression inhibitor
0,495  0,012  EIF4E expression inhibitor
0,514  0,031  TGFBI expression enhancer
0,561  0,079  ITGB2 expression enhancer
0,508  0,025  PPARA expression enhancer
0,518  0,037  MMP2 expression enhancer
0,522  0,040  TUBA1A expression inhibitor
0,487  0,007  CAPN9 expression enhancer
0,487  0,007  FAM107A expression inhibitor
0,487  0,007  GDPD5 expression enhancer
0,533  0,052  PTGR1 expression enhancer
0,533  0,052  BIRC3 expression enhancer
0,494  0,014  HEY2 expression enhancer
0,537  0,057  CDK2 expression inhibitor
0,486  0,007  UGT1A10 expression enhancer
0,514  0,036  PRDX2 expression enhancer
0,507  0,030  UGT1A1 expression enhancer
0,529  0,053  ICAM1 expression enhancer
0,489  0,014  BMP6 expression inhibitor
0,524  0,049  SERPINE1 expression enhancer
0,507  0,031  ITGA6 expression inhibitor
0,518  0,043  VCAM1 expression enhancer
0,494  0,022  PDK1 expression inhibitor
0,491  0,020  ST7 expression inhibitor
0,482  0,011  IVNS1ABP expression inhibitor
0,523  0,052  BCL2L1 expression inhibitor
0,510  0,040  BORA expression inhibitor
0,490  0,022  RXRA expression enhancer
0,485  0,016  NFE2L2 expression enhancer
0,494  0,026  TNFRSF25 expression inhibitor
0,500  0,033  IL1A expression enhancer
0,500  0,035  NFKBIA expression enhancer
0,487  0,023  CDCA8 expression inhibitor
0,475  0,013  GPR56 expression enhancer
0,537  0,076  C10ORF116 expression enhancer
0,503  0,043  CBX3 expression inhibitor
0,474  0,013  TIPARP expression enhancer
0,474  0,014  TCF12 expression enhancer
0,493  0,034  CDKN1B expression inhibitor
0,535  0,076  VEGFA expression inhibitor
0,519  0,060  TIMP1 expression enhancer
0,473  0,015  KRT23 expression inhibitor
0,481  0,023  LAMA3 expression enhancer
0,487  0,030  ID3 expression enhancer
0,496  0,040  SUV420H1 expression inhibitor
0,482  0,025  ESR1 expression enhancer
0,510  0,054  FUBP1 expression inhibitor
0,472  0,018  PPAP2B expression inhibitor
0,483  0,030  APOBEC3B expression enhancer
0,507  0,054  SLC3A2 expression enhancer
0,515  0,062  TNFSF10 expression inhibitor
0,485  0,032  TUBB3 expression enhancer
0,466  0,013  CYP2B6 expression enhancer
0,463  0,011  MAP4K4 expression inhibitor
0,538  0,086  TOP1 expression inhibitor
0,473  0,022  LYN expression enhancer
0,492  0,043  ETS2 expression inhibitor
0,503  0,054  CBX1 expression inhibitor
0,482  0,035  E2F1 expression inhibitor
0,487  0,040  YWHAH expression inhibitor
0,510  0,063  ACTA2 expression inhibitor
0,451  0,005  GSTA2 expression inhibitor
0,451  0,005  NUDT3 expression inhibitor
0,451  0,005  OAT expression inhibitor
0,451  0,005  ZKSCAN4 expression enhancer
0,488  0,043  KLK3 expression inhibitor
0,487  0,042  INCENP expression inhibitor
0,498  0,053  CSE1L expression inhibitor
0,484  0,041  XRCC4 expression enhancer
0,486  0,044  CDK5 expression enhancer
0,477  0,035  IGFBP2 expression inhibitor
0,512  0,073  TMSB4X expression inhibitor
0,476  0,038  FEN1 expression inhibitor
0,455  0,017  DHRS3 expression enhancer
0,487  0,049  IL2RA expression inhibitor
0,476  0,038  PML expression inhibitor
0,474  0,037  BAG5 expression inhibitor
0,452  0,015  SRSF2 expression enhancer
0,489  0,052  DTYMK expression enhancer
0,448  0,012  PRKCA expression inhibitor
0,485  0,049  VIM expression inhibitor
0,467  0,032  CYP17A1 expression enhancer
0,475  0,040  TP53I3 expression enhancer
0,474  0,040  ME1 expression enhancer
0,456  0,022  IGF1R expression enhancer
0,454  0,021  MGST1 expression inhibitor
0,517  0,085  MMP7 expression enhancer
0,465  0,035  MAFF expression enhancer
0,478  0,049  TRAF3 expression enhancer
0,448  0,020  RGS10 expression enhancer
0,434  0,008  PAPSS2 expression inhibitor
0,449  0,023  GATA1 expression enhancer
0,444  0,019  ATG5 expression inhibitor
0,443  0,019  SLC16A1 expression inhibitor
0,448  0,023  S100A8 expression enhancer
0,441  0,016  FAM105A expression enhancer
0,441  0,016  KRT6A expression enhancer
0,472  0,047  BRD2 expression enhancer
0,472  0,047  NENF expression enhancer
0,472  0,047  SRRM2 expression inhibitor
0,472  0,047  ZCCHC2 expression inhibitor
0,465  0,042  CCL2 expression enhancer
0,479  0,057  TNFRSF21 expression enhancer
0,443  0,022  ENC1 expression inhibitor
0,468  0,047  BUB1B expression enhancer
0,431  0,011  PNN expression inhibitor
0,465  0,045  EPHA3 expression inhibitor
0,486  0,065  PSMC1 expression enhancer
0,470  0,050  EPHB4 expression inhibitor
0,470  0,050  NMT1 expression inhibitor
0,432  0,013  NBL1 expression enhancer
0,464  0,045  CDK6 expression inhibitor
0,446  0,027  MFAP4 expression inhibitor
0,473  0,055  ADSL expression inhibitor
0,489  0,071  CCND1 expression inhibitor
0,456  0,039  CLMN expression enhancer
0,451  0,035  CLDN5 expression enhancer
0,455  0,038  COL5A2 expression inhibitor
0,421  0,005  AKIRIN1 expression inhibitor
0,421  0,005  ATAD2B expression inhibitor
0,421  0,005  BTBD11 expression inhibitor
0,421  0,005  CCDC88C expression inhibitor
0,421  0,005  COBLL1 expression inhibitor
0,421  0,005  DAB2 expression inhibitor
0,421  0,005  DDEF2 expression inhibitor
0,421  0,005  DIP2B expression inhibitor
0,421  0,005  FKBP14 expression inhibitor
0,421  0,005  GALNAC4S-6ST expression inhibitor
0,421  0,005  GNG11 expression enhancer
0,421  0,005  HIST1H2BI expression enhancer
0,421  0,005  MAML2 expression inhibitor
0,421  0,005  PLCB1 expression inhibitor
0,421  0,005  PLXNA2 expression inhibitor
0,421  0,005  PNPT1 expression inhibitor
0,421  0,005  RPGRIP1L expression inhibitor
0,421  0,005  SDPR expression enhancer
0,421  0,005  SH3D19 expression inhibitor
0,421  0,005  SHCBP1 expression inhibitor
0,421  0,005  SYNGR3 expression enhancer
0,421  0,005  TAF5 expression inhibitor
0,421  0,005  TANC1 expression inhibitor
0,421  0,005  UTRN expression inhibitor
0,421  0,005  VLDLR expression inhibitor
0,421  0,005  VWCE expression enhancer
0,421  0,005  ZNF652 expression inhibitor
0,451  0,035  CSF3 expression enhancer
0,441  0,025  GTF3C4 expression enhancer
0,475  0,060  AGPS expression inhibitor
0,446  0,032  PPP1R3C expression inhibitor
0,443  0,030  NHLRC2 expression inhibitor
0,456  0,042  TNFRSF10B expression inhibitor
0,462  0,049  LMNA expression inhibitor
0,459  0,046  DLEU2 expression enhancer
0,444  0,031  PHYH expression enhancer
0,444  0,031  TGOLN2 expression inhibitor
0,460  0,047  CRABP2 expression inhibitor
0,465  0,053  CD86 expression enhancer
0,477  0,066  PRKDC expression inhibitor
0,453  0,042  PPP2CB expression enhancer
0,431  0,020  B4GALT5 expression inhibitor
0,431  0,020  TLE3 expression inhibitor
0,473  0,062  CLDN4 expression enhancer
0,428  0,018  SOD2 expression inhibitor
0,420  0,011  SLC20A1 expression enhancer
0,479  0,070  ABCB1 expression enhancer
0,484  0,075  BIRC2 expression inhibitor
0,457  0,049  CALM3 expression enhancer
0,464  0,056  HSD11B2 expression enhancer
0,440  0,033  PLCB1 expression enhancer
0,426  0,018  PGR expression enhancer
0,421  0,014  CPT1A expression enhancer
0,430  0,023  PICALM expression inhibitor
0,444  0,038  SULF2 expression enhancer
0,413  0,007  SCAMP1 expression inhibitor
0,484  0,079  SRPK1 expression inhibitor
0,466  0,061  NOL5A expression inhibitor
0,496  0,092  TP53 expression enhancer
0,423  0,019  RPS6KA3 expression enhancer
0,468  0,063  MLF1 expression enhancer
0,457  0,053  KPNB1 expression enhancer
0,406  0,005  HSD17B1 expression inhibitor
0,480  0,078  MMP2 expression inhibitor
0,470  0,069  NAV1 expression inhibitor
0,446  0,046  HMGA1 expression enhancer
0,417  0,017  GADD45B expression enhancer
0,414  0,014  NOTCH1 expression enhancer
0,420  0,020  PLAU expression enhancer
0,439  0,040  SHBG expression enhancer
0,479  0,081  FGF2 expression inhibitor
0,446  0,048  ALDOA expression enhancer
0,449  0,052  TNNT1 expression inhibitor
0,433  0,036  RBMS1 expression inhibitor
0,440  0,043  ATR expression inhibitor
0,440  0,043  EFNA4 expression inhibitor
0,440  0,043  MARK3 expression inhibitor
0,440  0,043  SMAD1 expression inhibitor
0,470  0,073  IL1R1 expression inhibitor
0,469  0,073  FKBP8 expression inhibitor
0,433  0,037  S100A11 expression enhancer
0,438  0,042  WDR4 expression inhibitor
0,447  0,051  PRDX6 expression enhancer
0,473  0,079  CP expression enhancer
0,465  0,071  DUSP5 expression enhancer
0,405  0,012  STK39 expression inhibitor
0,447  0,054  EZR expression inhibitor
0,447  0,054  GAK expression inhibitor
0,447  0,054  TERF1 expression inhibitor
0,447  0,054  ADD3 expression enhancer
0,417  0,024  SOCS2 expression enhancer
0,479  0,088  CCND2 expression enhancer
0,418  0,027  HSD17B1 expression enhancer
0,429  0,040  SNAI1 expression enhancer
0,406  0,017  CXCR4 expression enhancer
0,440  0,051  CRH expression inhibitor
0,427  0,038  HSPA2 expression enhancer
0,443  0,055  NR4A2 expression inhibitor
0,473  0,085  MGMT expression enhancer
0,428  0,040  CLSTN1 expression inhibitor
0,411  0,023  KRT17 expression inhibitor
0,442  0,055  BMP1 expression inhibitor
0,401  0,014  APTX expression inhibitor
0,401  0,014  FGF5 expression inhibitor
0,401  0,014  RSBN1 expression inhibitor
0,415  0,029  ACAN expression enhancer
0,470  0,084  MAF expression enhancer
0,427  0,041  OLFML3 expression enhancer
0,467  0,081  NR3C1 expression inhibitor
0,420  0,035  PTPRK expression inhibitor
0,430  0,045  JUNB expression inhibitor
0,454  0,071  CD44 expression inhibitor
0,428  0,046  TCEB2 expression inhibitor
0,442  0,059  CDKN1A expression inhibitor
0,405  0,025  SLC6A6 expression enhancer
0,413  0,032  ESRRA expression enhancer
0,435  0,055  WAS expression enhancer
0,431  0,051  ALPL expression enhancer
0,453  0,074  CITED2 expression inhibitor
0,415  0,037  CTPS expression inhibitor
0,458  0,081  TFDP2 expression inhibitor
0,475  0,099  CASP3 expression enhancer
0,435  0,060  PPARGC1A expression enhancer
0,419  0,044  IVL expression inhibitor
0,406  0,032  GPR30 expression inhibitor
0,421  0,048  PIR expression enhancer
0,424  0,050  LAMB3 expression enhancer
0,412  0,038  LAMC2 expression enhancer
0,442  0,069  SIDT2 expression enhancer
0,415  0,043  PLAGL1 expression enhancer
0,425  0,053  SASH1 expression inhibitor
0,442  0,071  MAP1B expression enhancer
0,453  0,081  PRTN3 expression enhancer
0,405  0,034  NKX3-1 expression enhancer
0,422  0,052  FGFR3 expression inhibitor
0,418  0,048  FOXC1 expression enhancer
0,439  0,070  PA2G4 expression inhibitor
0,422  0,054  HMOX1 expression enhancer
0,412  0,044  STC2 expression enhancer
0,408  0,040  MYLIP expression enhancer
0,438  0,070  PTGS2 expression inhibitor
0,406  0,039  TNFRSF11B expression enhancer
0,401  0,035  PHLDA1 expression enhancer
0,417  0,053  ZNF114 expression enhancer
0,410  0,046  MYC expression enhancer
0,414  0,050  TXNRD1 expression enhancer
0,449  0,086  CDKN1A expression enhancer
0,422  0,059  HNRPC expression inhibitor
0,446  0,085  TRAK2 expression enhancer
0,409  0,048  PTEN expression enhancer
0,408  0,047  CCNK expression inhibitor
0,437  0,076  ATM expression enhancer
0,422  0,064  PTGS2 expression enhancer
0,414  0,056  EPAS1 expression enhancer
0,430  0,072  TGFB1 expression enhancer
0,404  0,048  DNMT1 expression inhibitor
0,432  0,078  CTTN expression inhibitor
0,423  0,069  DDX24 expression inhibitor
0,406  0,052  SKP2 expression inhibitor
0,412  0,059  CDK1 expression inhibitor
0,433  0,082  HMGCS1 expression inhibitor
0,402  0,052  SCML1 expression enhancer
0,402  0,052  SEPHS1 expression inhibitor
0,458  0,110  FOS expression enhancer
0,422  0,076  PPARA expression inhibitor
0,407  0,063  TIMP1 expression inhibitor
0,405  0,063  CCNE1 expression inhibitor
0,407  0,067  NKX3-1 expression inhibitor
0,423  0,083  PCAF expression enhancer
0,408  0,069  HMGA1 expression inhibitor
0,422  0,085  CREB1 expression inhibitor
0,413  0,079  CD14 expression enhancer
0,434  0,101  VEGFA expression enhancer
0,446  0,113  KIF23 expression enhancer
0,429  0,097  TNFSF9 expression enhancer
0,409  0,079  CDKN2A expression enhancer
0,426  0,111  CDK4 expression inhibitor
0,421  0,108  JUND expression inhibitor
0,404  0,100  DDIT4 expression enhancer
0,429  0,135  FYTTD1 expression inhibitor
0,429  0,135  MST4 expression inhibitor
0,429  0,135  TRAK2 expression inhibitor
0,429  0,135  USP32 expression inhibitor
0,401  0,115  RND3 expression inhibitor
0,404  0,121  FAS expression inhibitor
0,406  0,124  CASP9 expression enhancer

>  <Mechanisms>
0,913  0,019  Transferase stimulant
0,883  0,004  NACHT, LRR and PYD domains-containing protein 1 inhibitor
0,853  0,011  Chlordecone reductase inhibitor
0,844  0,004  Complement factor D inhibitor
0,847  0,025  Membrane integrity agonist
0,824  0,025  Ubiquinol-cytochrome-c reductase inhibitor
0,803  0,009  Nicotinic alpha2beta2 receptor antagonist
0,795  0,014  Glycosylphosphatidylinositol phospholipase D inhibitor
0,778  0,007  27-Hydroxycholesterol 7alpha-monooxygenase inhibitor
0,769  0,025  Polyporopepsin inhibitor
0,749  0,010  2-Hydroxymuconate-semialdehyde hydrolase inhibitor
0,761  0,023  Alkenylglycerophosphocholine hydrolase inhibitor
0,734  0,011  IgA-specific serine endopeptidase inhibitor
0,732  0,028  Sugar-phosphatase inhibitor
0,703  0,001  (R)-limonene 6-monooxygenase inhibitor
0,700  0,003  Aminomuconate-semialdehyde dehydrogenase inhibitor
0,720  0,024  NADPH peroxidase inhibitor
0,692  0,012  L-glutamate oxidase inhibitor
0,683  0,005  Tetrahydroxynaphthalene reductase inhibitor
0,691  0,015  Cl--transporting ATPase inhibitor
0,704  0,030  Taurine dehydrogenase inhibitor
0,666  0,003  5 Hydroxytryptamine 2B agonist
0,661  0,007  H+-exporting ATPase inhibitor
0,679  0,027  Lysase inhibitor
0,655  0,011  Centromere associated protein inhibitor
0,664  0,023  Arginine 2-monooxygenase inhibitor
0,642  0,003  Glycogen synthase stimulant
0,642  0,005  Galanin receptor antagonist
0,650  0,018  Arylsulfate sulfotransferase inhibitor
0,634  0,005  Myeloblastin inhibitor
0,632  0,011  Cytochrome P450 stimulant
0,637  0,022  Nitrate reductase (cytochrome) inhibitor
0,638  0,026  UDP-N-acetylglucosamine 4-epimerase inhibitor
0,666  0,054  Membrane permeability inhibitor
0,621  0,014  Cutinase inhibitor
0,623  0,018  3-Hydroxybenzoate 6-monooxygenase inhibitor
0,612  0,013  Insulin promoter
0,626  0,027  Venombin AB inhibitor
0,630  0,032  Dehydro-L-gulonate decarboxylase inhibitor
0,617  0,024  Cytoprotectant
0,603  0,015  Spermicide
0,592  0,005  Galanin receptor 2 antagonist
0,614  0,030  Feruloyl esterase inhibitor
0,609  0,028  2-Hydroxyquinoline 8-monooxygenase inhibitor
0,587  0,021  Cholesterol antagonist
0,632  0,066  Transferase inhibitor
0,579  0,016  IgA-specific metalloendopeptidase inhibitor
0,589  0,027  Phosphatidylserine decarboxylase inhibitor
0,588  0,027  Gastrin inhibitor
0,595  0,035  Glucan endo-1,6-beta-glucosidase inhibitor
0,568  0,009  DELTA14-sterol reductase inhibitor
0,592  0,034  Macrophage colony stimulating factor agonist
0,551  0,009  Neuropeptide Y2 antagonist
0,565  0,028  NACHT, LRR and PYD domains-containing protein 3 inhibitor
0,572  0,038  Phospholipid-translocating ATPase inhibitor
0,578  0,051  Omptin inhibitor
0,551  0,024  Alkenylglycerophosphoethanolamine hydrolase inhibitor
0,573  0,046  Oxidoreductase inhibitor
0,536  0,010  Polyneuridine-aldehyde esterase inhibitor
0,563  0,040  Glutathione thiolesterase inhibitor
0,551  0,028  Collagen inhibitor
0,525  0,011  Imidazoline receptor agonist
0,531  0,017  Long-chain-aldehyde dehydrogenase inhibitor
0,538  0,029  Linoleate diol synthase inhibitor
0,525  0,017  Opheline kinase inhibitor
0,525  0,017  Taurocyamine kinase inhibitor
0,536  0,029  Aspartate-phenylpyruvate transaminase inhibitor
0,518  0,014  Di-trans,poly-cis-decaprenylcistransferase inhibitor
0,511  0,012  Calpain 2 inhibitor
0,515  0,017  Sulfite oxidase inhibitor
0,540  0,043  Glucose oxidase inhibitor
0,543  0,049  Acetylcholine neuromuscular blocking agent
0,517  0,024  Benzodiazepine omega receptor agonist
0,518  0,026  Creatininase inhibitor
0,511  0,019  N-hydroxyarylamine O-acetyltransferase inhibitor
0,526  0,035  Calmodulin antagonist
0,508  0,019  Nitrite reductase (NO-forming) inhibitor
0,509  0,021  Aspergillopepsin I inhibitor
0,511  0,028  All-trans-retinyl-palmitate hydrolase inhibitor
0,510  0,028  Malate dehydrogenase (acceptor) inhibitor
0,505  0,023  (R)-Pantolactone dehydrogenase (flavin) inhibitor
0,521  0,041  Alkane 1-monooxygenase inhibitor
0,502  0,024  Na+-transporting two-sector ATPase inhibitor
0,510  0,033  GABA C receptor rho-3 antagonist
0,509  0,033  Phenol O-methyltransferase inhibitor
0,513  0,038  Pin1 inhibitor
0,482  0,013  RNA-directed RNA polymerase inhibitor
0,498  0,031  Glucan 1,4-alpha-maltotriohydrolase inhibitor
0,493  0,029  Hydroxylamine oxidase inhibitor
0,509  0,046  Lipoprotein lipase inhibitor
0,512  0,053  Thioredoxin inhibitor
0,508  0,049  Aldehyde oxidase inhibitor
0,488  0,029  tRNA-pseudouridine synthase I inhibitor
0,495  0,037  Fucosterol-epoxide lyase inhibitor
0,463  0,005  Aspergillopepsin II inhibitor
0,471  0,013  CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase inhibitor
0,517  0,060  Platelet aggregation stimulant
0,470  0,016  Transketolase inhibitor
0,481  0,030  Cyclohexanone monooxygenase inhibitor
0,464  0,014  Oryzin inhibitor
0,468  0,020  Nicotinate dehydrogenase inhibitor
0,488  0,041  Gluconate 5-dehydrogenase inhibitor
0,472  0,026  (-)-(4S)-limonene synthase inhibitor
0,454  0,009  Benzodiazepine agonist partial
0,450  0,005  Aryl-alcohol dehydrogenase inhibitor
0,465  0,021  Glyoxylate oxidase inhibitor
0,492  0,049  Fatty-acyl-CoA synthase inhibitor
0,466  0,023  Cytochrome-b5 reductase inhibitor
0,445  0,003  Dual specificity phosphatase 1 inhibitor
0,453  0,014  2,4-Dichlorophenol 6-monooxygenase inhibitor
0,447  0,008  Hyaluronic acid agonist
0,464  0,026  3-Phytase inhibitor
0,551  0,118  Mucomembranous protector
0,466  0,034  Glyoxylate reductase inhibitor
0,460  0,028  NADPH-ferrihemoprotein reductase inhibitor
0,489  0,057  Insulin growth factor agonist
0,489  0,057  Insulin like growth factor 1 agonist
0,442  0,015  CDP-4-dehydro-6-deoxyglucose reductase inhibitor
0,492  0,066  Penicillin binding protein antagonist
0,492  0,066  Penicillin-binding protein ampH inhibitor
0,450  0,023  Pyruvate decarboxylase inhibitor
0,475  0,048  Exoribonuclease II inhibitor
0,435  0,013  G-protein coupled receptor 35 antagonist
0,470  0,050  Hydrogen dehydrogenase inhibitor
0,440  0,021  Retinoic acid metabolism inhibitor
0,424  0,005  Glucagon-like peptide 1 agonist
0,442  0,029  Dextranase inhibitor
0,467  0,056  MAP kinase stimulant
0,447  0,037  Pullulanase inhibitor
0,448  0,038  Chenodeoxycholoyltaurine hydrolase inhibitor
0,417  0,007  Benzoate 4-monooxygenase inhibitor
0,445  0,040  Histidine kinase inhibitor
0,446  0,040  Amine dehydrogenase inhibitor
0,431  0,028  DNA-(apurinic or apyrimidinic site) lyase inhibitor
0,453  0,051  Manganese peroxidase inhibitor
0,434  0,033  Phosphopantothenoylcysteine decarboxylase inhibitor
0,420  0,018  Kruppel-like factor 5 inhibitor
0,469  0,068  Carboxypeptidase Taq inhibitor
0,434  0,034  Bisphosphoglycerate phosphatase inhibitor
0,403  0,004  Renilla-luciferin 2-monooxygenase inhibitor
0,416  0,018  Botulin neurotoxin A light chain inhibitor
0,418  0,020  Loop diuretic
0,400  0,004  MAO inhibitor
0,424  0,031  Albendazole monooxygenase inhibitor
0,432  0,038  N-formylmethionyl-peptidase inhibitor
0,447  0,056  Sulfur reductase inhibitor
0,447  0,059  Beta-adrenergic receptor kinase inhibitor
0,447  0,059  G-protein-coupled receptor kinase inhibitor
0,415  0,028  Fructan beta-fructosidase inhibitor
0,402  0,017  Eukaryotic translation initiation factor inhibitor
0,463  0,079  Cyclic AMP antagonist
0,463  0,078  Potassium sparing diuretic
0,419  0,035  Arylmalonate decarboxylase inhibitor
0,432  0,049  Mannan endo-1,4-beta-mannosidase inhibitor
0,403  0,020  2,3-Dihydroxyindole 2,3-dioxygenase inhibitor
0,426  0,045  Plastoquinol-plastocyanin reductase inhibitor
0,406  0,025  Vanilloid 1 agonist
0,417  0,037  Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase inhibitor
0,412  0,032  Leukotriene-C4 synthase inhibitor
0,407  0,028  Cyclohexyl-isocyanide hydratase inhibitor
0,418  0,039  Choline-phosphate cytidylyltransferase inhibitor
0,410  0,031  Phosphatidylcholine-sterol O-acyltransferase inhibitor
0,406  0,029  Cyclomaltodextrinase inhibitor
0,421  0,044  Peptidoglycan glycosyltransferase inhibitor
0,411  0,044  Lysostaphin inhibitor
0,405  0,038  Transitional endoplasmic reticulum ATPase inhibitor
0,416  0,052  NAD(P)+-arginine ADP-ribosyltransferase inhibitor
0,412  0,053  Prostaglandin-E2 9-reductase inhibitor
0,442  0,083  Glucan endo-1,3-beta-D-glucosidase inhibitor
0,480  0,124  Phosphatase inhibitor
0,408  0,053  Gonadotropin antagonist
0,423  0,070  Histamine release stimulant
0,411  0,065  Polyamine-transporting ATPase inhibitor
0,406  0,071  5 Hydroxytryptamine release stimulant
0,406  0,072  Fragilysin inhibitor
0,418  0,085  Lipid metabolism regulator
0,403  0,070  Biotinidase inhibitor
0,417  0,086  Thromboxane B2 antagonist
0,405  0,075  Dimethylargininase inhibitor
0,412  0,086  Alkylacetylglycerophosphatase inhibitor
0,407  0,083  Lysine 2,3-aminomutase inhibitor
0,405  0,106  Anorexiant
0,441  0,168  Vasodilator, cerebral

>  <Metabolism>
0,868  0,003  CYP2B5 substrate
0,810  0,034  CYP2C12 substrate
0,742  0,037  CYP2J substrate
0,654  0,003  CYP2B11 substrate
0,676  0,026  GST A substrate
0,646  0,012  CYP2A8 substrate
0,614  0,017  CYP3A1 substrate
0,603  0,028  CYP3A2 substrate
0,576  0,005  CYP2A5 substrate
0,564  0,017  CYP3A3 substrate
0,542  0,022  CYP2A4 substrate
0,516  0,011  CYP2G1 substrate
0,544  0,043  CYP2C8 inhibitor
0,524  0,025  CYP2F1 substrate
0,519  0,032  CYP2A1 substrate
0,518  0,031  CYP2D16 substrate
0,517  0,039  CYP2B6 inhibitor
0,450  0,006  CYP2C3 substrate
0,456  0,013  CYP2E1 inhibitor
0,469  0,039  CYP2A6 substrate
0,428  0,003  CYP51 inhibitor
0,451  0,032  CYP2C18 substrate
0,421  0,024  CYP2C10 substrate
0,410  0,015  CYP2C6 substrate
0,415  0,020  GST M substrate
0,409  0,018  CYP2C9 inhibitor
0,428  0,041  CYP4A11 substrate
0,410  0,026  CYP7 inhibitor
0,428  0,046  CYP2A substrate
0,402  0,070  CYP3A5 substrate
0,409  0,086  CYP3A4 substrate

>  <Toxicity>
0,878  0,007  Ejaculation dysfunction
0,854  0,005  Galactorrhea
0,839  0,016  Hyperactivity
0,821  0,009  Hyponatremia
0,818  0,018  Lichenoid eruption
0,800  0,005  Hypomagnesemia
0,794  0,026  Stroke
0,761  0,004  Adrenal cortex hypoplasia
0,732  0,011  Anorgasmia
0,745  0,031  Ulcer, aphthous
0,728  0,032  Fibrillation, atrial
0,721  0,024  Hematemesis
0,695  0,011  Demyelination
0,697  0,024  Hypercholesterolemic
0,692  0,020  Withdrawal
0,696  0,028  Enuresis
0,672  0,032  Gastrointestinal hemorrhage
0,688  0,053  Anemia, hemolytic
0,696  0,079  Shivering
0,634  0,020  Akinesia
0,651  0,040  Extrapyramidal effect
0,659  0,053  Hyperreflexia
0,645  0,040  Lymphocytosis
0,603  0,015  Spermicide
0,657  0,075  Bone marrow suppression
0,578  0,017  Fatty liver
0,592  0,032  Aseptic meningitis
0,609  0,052  Psychomotor impairment
0,596  0,041  Weight loss
0,596  0,041  Scleroderma
0,623  0,076  Cerebral hemorrhage
0,618  0,073  Myocardial ischemia
0,602  0,062  Hyperglycemic
0,606  0,070  Nystagmus
0,561  0,025  Hypomania
0,567  0,035  Panic
0,561  0,032  Choreoathetosis
0,571  0,044  Respiratory impairment
0,571  0,045  Acidosis, metabolic
0,549  0,027  Visual acuity impairment
0,561  0,041  Immunotoxin
0,581  0,068  Alopecia (hair loss)
0,548  0,037  Yawning
0,602  0,092  Dysesthesia
0,587  0,079  Renal insufficiency
0,552  0,053  Desquamation
0,561  0,063  Optic neuritis
0,573  0,077  Mania
0,529  0,034  Porphyria
0,511  0,020  Torticollis
0,509  0,020  Fasciculation
0,537  0,049  Allergic dermatitis
0,495  0,007  Henoch-Schonlein purpura
0,537  0,049  Fibrosis, interstitial
0,534  0,054  Apnea
0,508  0,032  Serum sickness
0,532  0,056  Hepatic necrosis
0,518  0,048  Priapism
0,539  0,070  Nightmare
0,538  0,072  Optic neuropathy
0,521  0,056  Muscle weakness
0,530  0,074  Ectropion
0,547  0,091  Neuritis
0,512  0,056  Allergic contact dermatitis
0,507  0,052  Parkinsonism
0,527  0,078  Weakness
0,496  0,049  Hyperuricemia
0,540  0,093  Reproductive dysfunction
0,515  0,073  Pure red cell aplasia
0,521  0,082  Osteoporosis
0,488  0,051  Parotid gland enlargement
0,505  0,069  Nephritis
0,490  0,057  Raynaud's phenomenon
0,479  0,048  Laryngospasm
0,480  0,053  Endocrine disruptor
0,438  0,011  Renal papillary necrosis
0,495  0,073  Dystonia
0,500  0,081  Delirium
0,512  0,096  Sexual dysfunction
0,452  0,037  Ulcer, peptic
0,498  0,084  Aphasia
0,442  0,028  Ulcer, gastric
0,450  0,038  Urine discoloration
0,467  0,055  Hypersexuality
0,489  0,078  Akathisia
0,468  0,063  Nephrotic syndrome
0,495  0,093  Erythema
0,477  0,077  Pseudoporphyria
0,462  0,064  Colic
0,470  0,074  Enterocolitis
0,447  0,052  Palpitation
0,485  0,093  Gait disturbance
0,486  0,096  Hemolysis
0,418  0,030  Catatonia
0,440  0,053  Acidosis, lactic
0,419  0,033  Oculogyric crisis
0,444  0,061  Chorea
0,443  0,065  Photoallergy dermatitis
0,459  0,083  Hirsutism
0,447  0,073  Glaucoma
0,466  0,092  Myoclonus
0,444  0,073  Interstitial nephritis
0,408  0,038  Lacrimal secretion stimulant
0,458  0,090  Edema
0,444  0,081  Glycosuria
0,439  0,079  Keratopathy
0,467  0,110  Photophobia
0,452  0,096  Dysarthria
0,436  0,080  Ototoxicity
0,439  0,084  Keratitis
0,448  0,094  Acidosis
0,462  0,110  Proteinuria
0,436  0,085  Delusion
0,464  0,113  Toxic, respiration
0,403  0,055  Ulceration
0,441  0,093  Cataract
0,464  0,118  Aggression
0,446  0,100  Euphoria
0,430  0,087  Hematuria
0,456  0,114  Diplopia
0,404  0,061  Sialorrhea
0,468  0,130  Muscle rigidity
0,416  0,079  Systemic lupus erythematosus
0,402  0,068  Renal colic
0,472  0,140  Leukocytosis
0,442  0,119  Psychoses
0,446  0,126  Paranoia
0,405  0,086  Weight gain
0,441  0,123  Hypotonia
0,444  0,136  Psychosexual disorder
0,433  0,129  Erythema multiforme
0,451  0,147  Erectile dysfunction
0,404  0,102  Anemia
0,422  0,120  Diarrhea
0,405  0,106  Anorexiant
0,450  0,154  Electrolyte imbalance
0,404  0,111  Coma
0,428  0,144  Cardiogenic shock
0,406  0,125  Paralysis
0,409  0,132  Amnesia
0,424  0,160  Eye pain
0,426  0,168  Myocardial infarction
0,420  0,170  Heart failure
0,405  0,166  Hot flush
0,403  0,178  Abdominal pain
0,402  0,185  Pancreatitis

>  <Transporter>
0,499  0,045  Basolateral Na-K-Cl symporter inhibitor
0,402  0,040  Neuronal K-Cl cotransporter inhibitor

>  <Murcko.CdId>
9140

>  <Murcko.Mol Weight>
290.3557

>  <Murcko.Formula>
C20H18O2

>  <Murcko.AKOS_NUMBER>
AKOS000444898

>  <Murcko.IntegerID>
9139

$$$$

  Mrv0541 04281317412D          

 13 14  0  0  0  0            999 V2000
   -0.6593   -0.2538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -0.6663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6593    0.5712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    0.9837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7699   -0.2538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7699    0.5712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9157   -0.6663    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3718   -0.6663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1949   -0.2538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3718    0.9837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4824   -0.6663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0926   -0.2538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0926    0.5712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  3  1  2  0  0  0  0
  4  3  1  0  0  0  0
  5  2  2  0  0  0  0
  6  4  2  0  0  0  0
  7  9  1  0  0  0  0
  8  1  1  0  0  0  0
  9 11  1  0  0  0  0
 10  3  1  0  0  0  0
 11  5  1  0  0  0  0
 12  8  2  0  0  0  0
 13 12  1  0  0  0  0
 10 13  2  0  0  0  0
  5  6  1  0  0  0  0
M  END
>  <CdId>
9412

>  <Mol Weight>
171.2383

>  <Formula>
C12H13N

>  <AKOS_NUMBER>
AKOS000151504

>  <Lipinski's Rule of Five>
0

>  <XLogP (text field)>
2.24

>  <PASS_MNA_NEW_COUNT>
0

>  <PASS_RESULT_COUNT>
   39 of   464 Possible Pharmacological Effects at Pa > 0.400
  357 of  3850 Possible Mechanisms of Action at Pa > 0.400
  254 of   321 Possible Toxic and Adverse Effects at Pa > 0.400
    8 of   118 Possible Antitargets at Pa > 0.400
   40 of   195 Possible Metabolism-Related Actions at Pa > 0.400
  675 of  1610 Possible Gene Expression Regulation at Pa > 0.400
    1 of    68 Possible Transporters-Related Actions at Pa > 0.400

>  <Effects>
0,832  0,013  Antiseborrheic
0,760  0,017  Mucositis treatment
0,729  0,033  Antineurotic
0,703  0,008  Preneoplastic conditions treatment
0,689  0,009  Antihypoxic
0,682  0,020  Antidyskinetic
0,663  0,004  Antibacterial activity enhancer
0,671  0,034  Fibrinolytic
0,647  0,012  Alopecia treatment
0,625  0,022  Cytoprotectant
0,601  0,040  Kidney function stimulant
0,546  0,016  Psychostimulant
0,564  0,057  Vasodilator, cerebral
0,551  0,056  Acute neurologic disorders treatment
0,532  0,041  Ovulation inhibitor
0,526  0,036  Leukopoiesis stimulant
0,488  0,005  Antianorexic
0,515  0,036  Vasoprotector
0,486  0,010  Acidifying agent non gastric
0,475  0,005  Antimigraine
0,493  0,026  Radioprotector
0,474  0,016  Hematopoietic inhibitor
0,492  0,041  Antinociceptive
0,480  0,040  Anticonvulsant
0,493  0,055  Potassium sparing diuretic
0,471  0,049  Erythropoiesis stimulant
0,528  0,115  Neuroprotector
0,441  0,031  Leukopoiesis inhibitor
0,413  0,010  Cancer associated disorders treatment
0,466  0,067  Antinephrotoxic
0,419  0,026  Carminative
0,416  0,043  Antimyopathies
0,424  0,059  Respiratory analeptic
0,410  0,054  Analeptic
0,427  0,071  Spasmolytic, urinary
0,405  0,049  Dementia treatment
0,404  0,056  Antisecretoric
0,412  0,190  Antieczematic
0,410  0,206  Nootropic

>  <Antitargets>
0,754  0,009  Superoxide dismutase inhibitor
0,629  0,003  Phenylalanine 4-hydroxylase inhibitor
0,687  0,073  Ubiquinol-cytochrome-c reductase inhibitor
0,566  0,030  Peroxidase inhibitor
0,458  0,010  5 Hydroxytryptamine 2B agonist
0,446  0,007  Aryl hydrocarbon receptor agonist
0,425  0,010  Tyrosine 3 hydroxylase inhibitor
0,413  0,043  GABA aminotransferase inhibitor

>  <Gene_Expression>
0,901  0,003  PLA2G4A expression enhancer
0,900  0,005  PDE4B expression enhancer
0,855  0,005  IL12B expression inhibitor
0,847  0,003  SLC6A2 expression inhibitor
0,847  0,006  NOM1 expression inhibitor
0,808  0,003  CSF2 expression enhancer
0,807  0,005  NOS2 expression enhancer
0,806  0,008  PTGR1 expression enhancer
0,799  0,007  SLC16A2 expression enhancer
0,770  0,006  TM4SF1 expression enhancer
0,779  0,015  KRCC1 expression enhancer
0,789  0,026  GSTA1 expression enhancer
0,773  0,019  C10ORF116 expression enhancer
0,761  0,007  SUV420H1 expression inhibitor
0,754  0,004  RPL7A expression inhibitor
0,756  0,006  ITGA6 expression inhibitor
0,752  0,008  BAD expression inhibitor
0,774  0,030  HMGB1 expression inhibitor
0,755  0,013  MYB expression enhancer
0,747  0,007  JUND expression inhibitor
0,757  0,019  GTF2F1 expression inhibitor
0,763  0,027  EZH2 expression inhibitor
0,735  0,004  ST7 expression inhibitor
0,735  0,007  HS6ST2 expression inhibitor
0,767  0,042  NAA15 expression inhibitor
0,730  0,009  JUNB expression inhibitor
0,730  0,013  PDCD4 expression inhibitor
0,729  0,012  HNRPC expression inhibitor
0,738  0,022  NAT1 expression enhancer
0,739  0,024  DHRS2 expression enhancer
0,735  0,019  IFNGR1 expression enhancer
0,722  0,009  YWHAH expression inhibitor
0,731  0,019  TNFRSF11A expression enhancer
0,744  0,033  OAS2 expression enhancer
0,721  0,011  MAOB expression enhancer
0,721  0,015  HMBS expression inhibitor
0,745  0,039  NFKB1 expression enhancer
0,745  0,040  GPX1 expression inhibitor
0,716  0,014  MEGF9 expression inhibitor
0,734  0,035  SUZ12 expression inhibitor
0,714  0,015  TFDP1 expression inhibitor
0,738  0,039  TXNRD1 expression inhibitor
0,717  0,019  MACF1 expression inhibitor
0,727  0,032  CNN1 expression enhancer
0,729  0,034  BST2 expression enhancer
0,736  0,042  PDXK expression inhibitor
0,722  0,029  RASEF expression inhibitor
0,703  0,011  CARS expression inhibitor
0,697  0,011  CREB1 expression inhibitor
0,711  0,025  NR4A2 expression enhancer
0,707  0,022  EPRS expression inhibitor
0,709  0,026  TFDP2 expression inhibitor
0,698  0,016  VIM expression inhibitor
0,706  0,025  ID1 expression inhibitor
0,693  0,022  RNF4 expression inhibitor
0,689  0,021  SEPT2 expression inhibitor
0,709  0,041  SERPINB5 expression inhibitor
0,684  0,021  NPM3 expression inhibitor
0,684  0,021  PTEN expression inhibitor
0,687  0,026  C3 expression enhancer
0,685  0,024  PRTN3 expression enhancer
0,682  0,025  PRKAR2B expression enhancer
0,664  0,009  HSPA2 expression enhancer
0,695  0,041  SRPK1 expression inhibitor
0,689  0,035  HIF1A expression enhancer
0,659  0,006  EPB41L2 expression inhibitor
0,672  0,021  CPM expression enhancer
0,695  0,045  FANCC expression inhibitor
0,661  0,010  RSAD2 expression enhancer
0,658  0,009  EPHA3 expression inhibitor
0,664  0,017  ADD3 expression enhancer
0,697  0,051  STAR expression enhancer
0,662  0,017  ASXL1 expression inhibitor
0,662  0,017  C11ORF68 expression enhancer
0,662  0,017  CAPN7 expression inhibitor
0,662  0,017  FAM208A expression inhibitor
0,662  0,017  NKTR expression inhibitor
0,662  0,017  RABGAP1 expression inhibitor
0,662  0,017  SETD2 expression inhibitor
0,662  0,017  TIA1 expression inhibitor
0,662  0,017  TTC3 expression inhibitor
0,654  0,010  IL9 expression inhibitor
0,682  0,040  APOM expression enhancer
0,660  0,017  TUBA1A expression inhibitor
0,659  0,018  ADAM17 expression inhibitor
0,659  0,018  CTBP1 expression inhibitor
0,652  0,012  PIM1 expression inhibitor
0,650  0,010  SASH1 expression inhibitor
0,644  0,004  AKR1B10 expression enhancer
0,654  0,015  MVP expression enhancer
0,680  0,043  ILF3 expression inhibitor
0,671  0,035  CDCA5 expression enhancer
0,674  0,038  CD44 expression inhibitor
0,667  0,032  ETV5 expression inhibitor
0,670  0,036  IL6 expression enhancer
0,664  0,032  NASP expression inhibitor
0,645  0,012  DFFB expression inhibitor
0,637  0,005  SHMT2 expression inhibitor
0,657  0,024  FOSL1 expression enhancer
0,658  0,027  IL1A expression inhibitor
0,695  0,064  CXCR1 expression enhancer
0,652  0,022  CAV1 expression inhibitor
0,662  0,034  PRKDC expression inhibitor
0,658  0,030  TNFRSF21 expression inhibitor
0,647  0,019  HIST1H4B expression inhibitor
0,638  0,011  WDR4 expression inhibitor
0,648  0,021  IL1R1 expression inhibitor
0,674  0,048  SFPQ expression enhancer
0,636  0,013  AHRR expression enhancer
0,639  0,020  MTHFD2 expression inhibitor
0,659  0,041  ITGB2 expression enhancer
0,654  0,036  TMSB4X expression inhibitor
0,643  0,026  CPNE1 expression enhancer
0,654  0,037  FGF2 expression inhibitor
0,623  0,007  IFIT1 expression enhancer
0,664  0,049  CYR61 expression enhancer
0,667  0,056  STAT5B expression enhancer
0,656  0,046  AHR expression inhibitor
0,643  0,035  TNF expression enhancer
0,638  0,031  PSMC1 expression enhancer
0,651  0,045  PLIN2 expression enhancer
0,627  0,021  CEP57 expression inhibitor
0,626  0,020  POR expression enhancer
0,635  0,030  NEIL3 expression inhibitor
0,612  0,006  DNASE2 expression inhibitor
0,631  0,027  NAA15 expression enhancer
0,636  0,032  PCNA expression enhancer
0,636  0,033  BCL2 expression inhibitor
0,669  0,067  DUSP4 expression enhancer
0,685  0,085  HSPD1 expression inhibitor
0,636  0,036  ALCAM expression inhibitor
0,645  0,047  GADD45A expression inhibitor
0,617  0,020  HSP27 expression enhancer
0,621  0,025  BORA expression inhibitor
0,663  0,068  SLC2A4 expression enhancer
0,605  0,010  PPARA expression enhancer
0,620  0,027  HAPLN3 expression inhibitor
0,611  0,019  FUS expression inhibitor
0,616  0,025  HSD11B2 expression enhancer
0,644  0,054  VDR expression enhancer
0,617  0,027  NOC3L expression inhibitor
0,648  0,059  JUN expression enhancer
0,620  0,031  HSPA1A expression inhibitor
0,625  0,036  SLC16A4 expression enhancer
0,652  0,064  ITGB1 expression enhancer
0,613  0,025  ALDH1A3 expression inhibitor
0,606  0,019  DEPTOR expression enhancer
0,631  0,044  MCM6 expression enhancer
0,615  0,029  GNL3 expression inhibitor
0,629  0,044  PRKCA expression enhancer
0,594  0,009  BMP6 expression inhibitor
0,670  0,085  LPL expression enhancer
0,616  0,031  PCDH8 expression enhancer
0,597  0,016  TNFAIP3 expression enhancer
0,628  0,049  SPATA13 expression enhancer
0,618  0,039  SNAI2 expression inhibitor
0,605  0,026  CTSD expression inhibitor
0,637  0,059  TOP1 expression inhibitor
0,620  0,042  IL1RN expression inhibitor
0,602  0,024  C1S expression enhancer
0,620  0,043  COL2A1 expression enhancer
0,596  0,019  FNDC4 expression enhancer
0,599  0,022  BMP1 expression inhibitor
0,606  0,030  ATM expression enhancer
0,582  0,005  AATK expression enhancer
0,582  0,005  C5AR1 expression inhibitor
0,582  0,005  CBL expression enhancer
0,582  0,005  CCL16 expression inhibitor
0,582  0,005  CCR5 expression enhancer
0,582  0,005  CKS1 expression inhibitor
0,582  0,005  GDF1 expression enhancer
0,582  0,005  GRO2 expression inhibitor
0,582  0,005  IFNAR1 expression inhibitor
0,582  0,005  IGHM expression inhibitor
0,582  0,005  IL3RA expression inhibitor
0,582  0,005  MST1 expression inhibitor
0,582  0,005  NFKBIE expression inhibitor
0,582  0,005  PLD expression inhibitor
0,582  0,005  PLD2 expression enhancer
0,582  0,005  POU2F1 expression enhancer
0,582  0,005  PSMB6 expression inhibitor
0,582  0,005  PTAFR expression inhibitor
0,582  0,005  RPS25 expression enhancer
0,582  0,005  SLC9A3R2 expression inhibitor
0,582  0,005  SMAD9 expression enhancer
0,582  0,005  STAT2 expression inhibitor
0,582  0,005  STK25 expression enhancer
0,582  0,005  UGP2 expression enhancer
0,606  0,030  WISP2 expression inhibitor
0,616  0,042  KPNA2 expression inhibitor
0,613  0,039  HSPA1A expression enhancer
0,620  0,046  EIF2S1 expression enhancer
0,589  0,016  COL5A2 expression inhibitor
0,580  0,008  AMHR2 expression inhibitor
0,596  0,025  FOXD1 expression inhibitor
0,597  0,025  DDX42 expression enhancer
0,601  0,030  RPS19 expression inhibitor
0,601  0,030  SIRT1 expression inhibitor
0,588  0,017  S100A10 expression enhancer
0,593  0,022  INCENP expression inhibitor
0,627  0,056  UNG expression inhibitor
0,574  0,005  B4GALT5 expression inhibitor
0,574  0,005  TLE3 expression inhibitor
0,615  0,046  MT1A expression enhancer
0,606  0,037  NAV1 expression inhibitor
0,594  0,026  EZR expression inhibitor
0,594  0,026  GAK expression inhibitor
0,594  0,026  TERF1 expression inhibitor
0,592  0,025  PTN expression enhancer
0,609  0,042  PKM2 expression enhancer
0,595  0,029  CDH1 expression enhancer
0,580  0,014  CLDN5 expression enhancer
0,588  0,022  CRABP2 expression inhibitor
0,606  0,041  ITGB1 expression inhibitor
0,628  0,064  MYL6 expression enhancer
0,601  0,039  FUBP1 expression inhibitor
0,613  0,051  IGFBP6 expression inhibitor
0,591  0,029  HMGA1 expression inhibitor
0,611  0,050  MYBL1 expression enhancer
0,595  0,035  CLMP expression inhibitor
0,624  0,067  MAPT expression enhancer
0,573  0,017  MDK expression inhibitor
0,576  0,021  ATR expression inhibitor
0,576  0,021  EFNA4 expression inhibitor
0,576  0,021  MARK3 expression inhibitor
0,576  0,021  SMAD1 expression inhibitor
0,596  0,041  CCND2 expression enhancer
0,610  0,056  MMP7 expression enhancer
0,587  0,034  JAK2 expression inhibitor
0,587  0,034  TBC1D1 expression inhibitor
0,571  0,019  PRDX6 expression enhancer
0,559  0,008  MGST1 expression enhancer
0,558  0,008  ZBTB1 expression enhancer
0,581  0,030  TRIM16 expression enhancer
0,562  0,012  PARP14 expression enhancer
0,577  0,029  BRD2 expression enhancer
0,577  0,029  NENF expression enhancer
0,577  0,029  SRRM2 expression inhibitor
0,577  0,029  ZCCHC2 expression inhibitor
0,586  0,039  GSTM3 expression inhibitor
0,588  0,042  INHBE expression enhancer
0,577  0,032  ITGB7 expression enhancer
0,576  0,032  SIDT2 expression enhancer
0,581  0,037  CUTL1 expression inhibitor
0,573  0,030  NPTX2 expression enhancer
0,566  0,024  DLX4 expression inhibitor
0,558  0,016  ALDH4A1 expression inhibitor
0,565  0,023  ASAH1 expression enhancer
0,551  0,010  S100A8 expression enhancer
0,557  0,016  CYP17A1 expression inhibitor
0,567  0,026  TRAM1 expression inhibitor
0,564  0,023  ANXA1 expression inhibitor
0,567  0,027  SP2 expression inhibitor
0,561  0,021  CSNK1D expression inhibitor
0,561  0,021  SPATA20 expression enhancer
0,547  0,007  CD59 expression enhancer
0,569  0,030  COL3A1 expression inhibitor
0,568  0,029  ALDOA expression enhancer
0,579  0,040  CLDN4 expression enhancer
0,571  0,033  CEACAM6 expression enhancer
0,572  0,034  F2R expression enhancer
0,563  0,025  PRDX2 expression enhancer
0,567  0,029  SLC2A3 expression inhibitor
0,585  0,047  DDX18 expression inhibitor
0,556  0,019  C5ORF32 expression enhancer
0,556  0,019  FAH expression enhancer
0,556  0,019  RRAS expression enhancer
0,556  0,019  SH3BGRL3 expression enhancer
0,564  0,028  DDX24 expression inhibitor
0,557  0,020  IL1A expression enhancer
0,571  0,035  ATP2A2 expression enhancer
0,563  0,028  PELI1 expression inhibitor
0,556  0,020  PSRC1 expression inhibitor
0,542  0,007  POLR2A expression enhancer
0,582  0,049  ID2 expression enhancer
0,545  0,014  TGOLN2 expression inhibitor
0,537  0,007  BCL2A1 expression enhancer
0,568  0,038  SF1 expression inhibitor
0,567  0,038  PRSS23 expression enhancer
0,536  0,008  HERPUD1 expression inhibitor
0,577  0,050  CCNE2 expression inhibitor
0,539  0,013  C6ORF108 expression inhibitor
0,539  0,013  CASK expression inhibitor
0,539  0,013  MAP2K5 expression inhibitor
0,539  0,013  PPP1CA expression inhibitor
0,539  0,013  TCF3 expression inhibitor
0,545  0,019  SC5DL expression enhancer
0,542  0,018  CYFIP2 expression enhancer
0,570  0,046  GSTM2 expression inhibitor
0,559  0,036  AKR1C1 expression enhancer
0,570  0,047  CDK2 expression inhibitor
0,545  0,022  PI4KA expression inhibitor
0,545  0,022  VCAN expression inhibitor
0,534  0,012  TRPV2 expression enhancer
0,541  0,020  MT1F expression inhibitor
0,567  0,046  WFDC2 expression enhancer
0,561  0,041  ASNS expression inhibitor
0,556  0,037  SERPINE2 expression enhancer
0,563  0,044  MMP2 expression inhibitor
0,526  0,009  ALDH1A1 expression enhancer
0,565  0,049  GAS6 expression enhancer
0,540  0,025  PPP2CB expression enhancer
0,561  0,047  NT5DC2 expression enhancer
0,561  0,047  RAI14 expression enhancer
0,561  0,047  RFTN1 expression enhancer
0,574  0,060  ZFP36 expression enhancer
0,561  0,048  BIRC3 expression enhancer
0,544  0,031  AKR1C2 expression enhancer
0,562  0,050  CASP9 expression enhancer
0,551  0,041  PRRX1 expression inhibitor
0,575  0,066  PLAUR expression enhancer
0,540  0,032  CYP11A1 expression inhibitor
0,565  0,056  THBD expression enhancer
0,549  0,041  CDC16 expression inhibitor
0,537  0,030  KLHL24 expression inhibitor
0,530  0,025  SCML1 expression enhancer
0,530  0,025  SEPHS1 expression inhibitor
0,517  0,011  IFIT3 expression enhancer
0,557  0,052  CP expression enhancer
0,537  0,033  PSAT1 expression inhibitor
0,521  0,017  GARS expression inhibitor
0,538  0,034  SCARB1 expression enhancer
0,510  0,007  IFIT2 expression enhancer
0,528  0,027  GFPT2 expression enhancer
0,524  0,022  DHCR24 expression enhancer
0,550  0,048  TMPRSS2 expression inhibitor
0,544  0,043  TIMP3 expression enhancer
0,511  0,011  MT1A expression inhibitor
0,526  0,025  ISYNA1 expression enhancer
0,509  0,009  GPR56 expression enhancer
0,530  0,031  ME1 expression enhancer
0,541  0,042  PTGS2 expression enhancer
0,503  0,005  C3ORF26 expression inhibitor
0,503  0,005  NDE1 expression inhibitor
0,503  0,005  SLC22A18 expression enhancer
0,544  0,045  CDC25C expression inhibitor
0,510  0,012  CTH expression inhibitor
0,512  0,014  PPL expression inhibitor
0,535  0,038  ISG15 expression enhancer
0,539  0,042  WIPI1 expression enhancer
0,555  0,058  NCOA2 expression enhancer
0,518  0,023  KIAA0930 expression enhancer
0,528  0,034  EGR1 expression inhibitor
0,500  0,006  CCL5 expression enhancer
0,529  0,034  LMNA expression inhibitor
0,516  0,022  LAMB3 expression enhancer
0,534  0,041  DTYMK expression enhancer
0,516  0,022  EZR expression enhancer
0,529  0,036  NR4A2 expression inhibitor
0,558  0,065  ABCC5 expression enhancer
0,522  0,029  ZNF114 expression enhancer
0,525  0,033  CALM3 expression enhancer
0,539  0,048  EFEMP1 expression inhibitor
0,541  0,051  FKBP8 expression inhibitor
0,511  0,021  NEU4 expression enhancer
0,511  0,021  SH3GL2 expression inhibitor
0,505  0,015  GTF3C4 expression enhancer
0,526  0,037  MCM7 expression inhibitor
0,582  0,093  PLAU expression inhibitor
0,506  0,017  LRP8 expression inhibitor
0,520  0,031  ANAPC1 expression enhancer
0,508  0,020  CDCA8 expression inhibitor
0,509  0,021  HLA-E expression enhancer
0,555  0,067  FOS expression enhancer
0,505  0,018  PTPRK expression inhibitor
0,543  0,057  TRAK2 expression enhancer
0,538  0,052  CCNA2 expression enhancer
0,545  0,060  IL18 expression inhibitor
0,508  0,024  SNAI1 expression enhancer
0,516  0,032  PDAP1 expression inhibitor
0,510  0,026  AOX1 expression enhancer
0,512  0,029  HMGN2 expression inhibitor
0,531  0,048  AKT1 expression enhancer
0,510  0,028  NKD1 expression inhibitor
0,519  0,037  CBX3 expression inhibitor
0,516  0,035  TNNT1 expression inhibitor
0,522  0,041  VCAM1 expression enhancer
0,514  0,032  SLC17A2 expression inhibitor
0,504  0,027  JUN expression inhibitor
0,524  0,047  CTTN expression inhibitor
0,529  0,053  AHR expression enhancer
0,498  0,022  RBMS1 expression inhibitor
0,522  0,047  MAP1B expression enhancer
0,498  0,024  BRF1 expression inhibitor
0,511  0,038  CDK5 expression enhancer
0,483  0,011  APOBEC3C expression enhancer
0,483  0,011  CEP55 expression inhibitor
0,483  0,011  FARS2 expression inhibitor
0,483  0,011  FNDC3B expression inhibitor
0,483  0,011  MPP7 expression inhibitor
0,483  0,011  SERTAD1 expression enhancer
0,492  0,020  FTH1 expression inhibitor
0,509  0,038  CDKN1C expression inhibitor
0,506  0,035  PARG expression enhancer
0,502  0,031  HSBP1 expression inhibitor
0,524  0,055  ICAM1 expression enhancer
0,488  0,019  SH2D4A expression inhibitor
0,491  0,022  PDK1 expression inhibitor
0,502  0,034  TNFRSF10B expression inhibitor
0,499  0,032  RECQL expression inhibitor
0,485  0,019  CAPN2 expression inhibitor
0,474  0,009  LAMA5 expression inhibitor
0,496  0,031  FOXC1 expression enhancer
0,497  0,034  SLC26A2 expression inhibitor
0,519  0,055  CALR expression inhibitor
0,473  0,010  MED13L expression inhibitor
0,473  0,010  SLCO3A1 expression inhibitor
0,493  0,030  ODZ3 expression inhibitor
0,493  0,030  TBC1D9 expression inhibitor
0,490  0,029  SULF2 expression enhancer
0,474  0,013  TRIAP1 expression enhancer
0,480  0,020  SMARCC1 expression inhibitor
0,542  0,082  STAT1 expression inhibitor
0,490  0,030  HPN expression enhancer
0,512  0,052  FAS expression inhibitor
0,504  0,044  EPHB4 expression inhibitor
0,504  0,044  NMT1 expression inhibitor
0,480  0,020  KEAP1 expression enhancer
0,505  0,046  SESN2 expression enhancer
0,483  0,023  PIR expression enhancer
0,482  0,023  COL1A1 expression inhibitor
0,488  0,029  APOBEC3B expression enhancer
0,483  0,025  NHLRC2 expression inhibitor
0,471  0,013  F3 expression enhancer
0,494  0,036  SF3B5 expression enhancer
0,492  0,034  GPX2 expression enhancer
0,525  0,068  NBN expression inhibitor
0,482  0,024  LGALS3 expression enhancer
0,534  0,078  SERPINB5 expression enhancer
0,512  0,056  SPP1 expression enhancer
0,529  0,073  BAX expression enhancer
0,481  0,028  VEGF expression enhancer
0,488  0,035  DLEU2 expression enhancer
0,463  0,011  MET expression inhibitor
0,502  0,051  DFFA expression inhibitor
0,514  0,064  NR3C1 expression inhibitor
0,500  0,049  IER3 expression inhibitor
0,504  0,054  IL4 expression enhancer
0,471  0,022  ITPR1 expression inhibitor
0,474  0,025  PHGDH expression inhibitor
0,497  0,049  MAP2K1 expression enhancer
0,482  0,034  MYBL2 expression inhibitor
0,469  0,021  TACC1 expression inhibitor
0,493  0,045  KPNB1 expression enhancer
0,496  0,048  TUBA4A expression enhancer
0,510  0,063  THBS1 expression enhancer
0,478  0,031  GALNT1 expression inhibitor
0,482  0,035  IL8 expression enhancer
0,482  0,036  CDKN1B expression inhibitor
0,478  0,033  EHD1 expression enhancer
0,469  0,024  SUMO1 expression inhibitor
0,477  0,033  EGR3 expression inhibitor
0,476  0,033  MT1X expression inhibitor
0,521  0,078  CASP3 expression enhancer
0,469  0,027  CALM1 expression enhancer
0,472  0,030  BIK expression enhancer
0,467  0,025  CDK1 expression enhancer
0,489  0,048  PLD1 expression enhancer
0,510  0,069  SDC1 expression enhancer
0,506  0,066  ELL2 expression enhancer
0,480  0,040  HMGA1 expression enhancer
0,464  0,024  GINS2 expression inhibitor
0,460  0,020  ACSL3 expression inhibitor
0,497  0,058  FN1 expression inhibitor
0,510  0,071  EDN1 expression enhancer
0,459  0,020  XPA expression enhancer
0,463  0,025  PRKX expression enhancer
0,516  0,079  FILIP1L expression inhibitor
0,490  0,053  TNFRSF21 expression enhancer
0,468  0,031  PTEN expression enhancer
0,469  0,032  CD36 expression enhancer
0,502  0,066  ORC4 expression enhancer
0,483  0,049  CD14 expression enhancer
0,492  0,058  CBX1 expression inhibitor
0,479  0,045  RPS27L expression enhancer
0,454  0,020  TNFRSF1A expression inhibitor
0,499  0,066  ACTA2 expression inhibitor
0,447  0,014  HOMER1 expression inhibitor
0,447  0,014  TNIK expression inhibitor
0,447  0,014  TRIB3 expression inhibitor
0,449  0,016  WDR67 expression inhibitor
0,468  0,036  PAICS expression enhancer
0,465  0,033  NCF1 expression enhancer
0,467  0,035  KIF15 expression inhibitor
0,469  0,038  BAG5 expression inhibitor
0,463  0,034  CDK2 expression enhancer
0,460  0,030  MT1H expression inhibitor
0,468  0,039  FEN1 expression inhibitor
0,454  0,025  IFI30 expression enhancer
0,474  0,045  SERPINA3 expression enhancer
0,446  0,017  CDCA3 expression inhibitor
0,447  0,019  CYP1A2 expression enhancer
0,499  0,072  MAF expression enhancer
0,462  0,035  MMP9 expression inhibitor
0,456  0,030  NEK4 expression inhibitor
0,452  0,027  TNFRSF11B expression enhancer
0,434  0,009  FILIP1L expression enhancer
0,479  0,055  GRPEL1 expression inhibitor
0,444  0,020  MND1 expression inhibitor
0,438  0,014  ARHGAP18 expression inhibitor
0,438  0,014  RHBDD2 expression enhancer
0,470  0,047  BUB1B expression enhancer
0,462  0,039  BDNF expression inhibitor
0,510  0,087  VEGFA expression inhibitor
0,441  0,019  ATG5 expression inhibitor
0,450  0,028  CYB5A expression enhancer
0,442  0,020  PKP4 expression inhibitor
0,442  0,020  TUBGCP3 expression inhibitor
0,434  0,013  GTF2IRD1 expression inhibitor
0,434  0,013  PAFAH1B1 expression inhibitor
0,434  0,013  SRPK2 expression inhibitor
0,474  0,054  PMEPA1 expression inhibitor
0,435  0,016  RNF144A expression inhibitor
0,435  0,016  SPRY1 expression inhibitor
0,500  0,081  SREBF2 expression inhibitor
0,430  0,012  PRUNE2 expression inhibitor
0,438  0,020  EID1 expression enhancer
0,477  0,059  VAV3 expression inhibitor
0,437  0,020  MADD expression inhibitor
0,458  0,041  IGFBP5 expression inhibitor
0,472  0,055  ADSL expression inhibitor
0,448  0,031  MYLIP expression enhancer
0,458  0,041  POLE2 expression inhibitor
0,442  0,027  INPP4B expression inhibitor
0,482  0,067  TNS3 expression enhancer
0,425  0,011  PFN1 expression inhibitor
0,445  0,031  PHYH expression enhancer
0,475  0,062  HLA-G expression enhancer
0,485  0,071  CDC25B expression enhancer
0,460  0,047  CDK6 expression inhibitor
0,487  0,074  CDK4 expression inhibitor
0,470  0,057  PA2G4 expression inhibitor
0,443  0,030  SST expression inhibitor
0,450  0,038  GCLM expression enhancer
0,461  0,050  NR1H2 expression inhibitor
0,434  0,023  CEBPG expression inhibitor
0,464  0,053  TRAF3 expression enhancer
0,442  0,032  CLGN expression inhibitor
0,428  0,018  PELI1 expression enhancer
0,446  0,037  CYP17A1 expression enhancer
0,442  0,033  TCF7 expression enhancer
0,432  0,024  TRIM24 expression inhibitor
0,483  0,074  VEGFA expression enhancer
0,472  0,063  YWHAE expression inhibitor
0,450  0,042  NFKBIA expression enhancer
0,439  0,031  IRF7 expression enhancer
0,449  0,042  EPAS1 expression enhancer
0,429  0,023  PSPH expression inhibitor
0,439  0,033  PLCB1 expression enhancer
0,448  0,042  TUBB3 expression enhancer
0,469  0,063  MLF1 expression enhancer
0,433  0,027  NOS1 expression inhibitor
0,439  0,034  ADIPOR2 expression inhibitor
0,420  0,018  ZFHX3 expression inhibitor
0,448  0,046  IMPDH2 expression enhancer
0,460  0,060  IL2RA expression inhibitor
0,420  0,020  SLC30A5 expression inhibitor
0,413  0,013  PDSS2 expression inhibitor
0,413  0,013  SRGAP2 expression inhibitor
0,430  0,030  CXCL2 expression inhibitor
0,463  0,063  DAB2 expression enhancer
0,408  0,009  BTF3 expression inhibitor
0,402  0,002  IL16 expression enhancer
0,441  0,042  SLC7A11 expression enhancer
0,441  0,042  CCNC expression inhibitor
0,426  0,028  SEC16A expression inhibitor
0,422  0,024  PTP4A1 expression enhancer
0,463  0,067  VAT1 expression enhancer
0,478  0,082  MGMT expression enhancer
0,437  0,041  SHBG expression enhancer
0,451  0,056  SAT expression enhancer
0,441  0,047  PPARG expression enhancer
0,443  0,049  CRH expression inhibitor
0,436  0,043  SKP2 expression inhibitor
0,442  0,049  DAPK1 expression inhibitor
0,464  0,071  DUSP5 expression enhancer
0,415  0,023  PDZK1 expression inhibitor
0,408  0,016  LINC00467 expression enhancer
0,408  0,016  PHF17 expression inhibitor
0,416  0,025  HIST1H2BD expression enhancer
0,411  0,020  ADARB1 expression inhibitor
0,408  0,016  CXCR4 expression enhancer
0,425  0,034  ZFAND5 expression inhibitor
0,477  0,086  JAG1 expression inhibitor
0,457  0,067  IGF2 expression inhibitor
0,483  0,093  TNFSF10 expression enhancer
0,423  0,032  SLC31A1 expression enhancer
0,420  0,030  EIF2B4 expression enhancer
0,447  0,058  CDKN1A expression inhibitor
0,439  0,050  G0S2 expression enhancer
0,423  0,034  EIF4E expression inhibitor
0,419  0,031  GPR142 expression enhancer
0,470  0,082  BIRC2 expression inhibitor
0,440  0,052  TK1 expression inhibitor
0,449  0,062  PRNP expression enhancer
0,459  0,072  ESR1 expression inhibitor
0,423  0,037  AP1S2 expression enhancer
0,412  0,026  BCAT1 expression inhibitor
0,411  0,025  GALNT4 expression enhancer
0,483  0,098  IL6 expression inhibitor
0,438  0,053  MAFB expression inhibitor
0,405  0,021  FOXN3 expression inhibitor
0,421  0,036  CTPS expression inhibitor
0,427  0,044  HNRNPH2 expression inhibitor
0,433  0,050  BTG2 expression enhancer
0,432  0,050  NEDD9 expression inhibitor
0,459  0,077  SOX9 expression enhancer
0,406  0,024  MAP3K8 expression enhancer
0,433  0,052  TIMP1 expression inhibitor
0,402  0,021  SRSF5 expression inhibitor
0,424  0,043  DPP4 expression enhancer
0,415  0,035  FOS expression inhibitor
0,435  0,055  WAS expression enhancer
0,458  0,078  STRBP expression inhibitor
0,467  0,088  TERT expression enhancer
0,403  0,024  UGT2B15 expression enhancer
0,459  0,081  CDKN1A expression enhancer
0,420  0,041  DNMT1 expression inhibitor
0,408  0,029  CYP19A1 expression inhibitor
0,444  0,066  CYB5R2 expression enhancer
0,436  0,060  MDK expression enhancer
0,404  0,028  CIRBP expression inhibitor
0,402  0,026  RHOC expression enhancer
0,438  0,062  KLK6 expression enhancer
0,438  0,062  PADI3 expression enhancer
0,432  0,057  ST3GAL1 expression enhancer
0,482  0,107  TMEM158 expression enhancer
0,403  0,029  RRM2B expression enhancer
0,427  0,053  PIK3R2 expression inhibitor
0,434  0,060  TFF1 expression inhibitor
0,449  0,074  SERPINE1 expression enhancer
0,417  0,043  MAFF expression enhancer
0,423  0,049  IGFBP2 expression inhibitor
0,400  0,028  PICALM expression inhibitor
0,424  0,051  IL6ST expression inhibitor
0,402  0,030  ASRGL1 expression enhancer
0,473  0,103  TP53 expression enhancer
0,445  0,075  CPE expression inhibitor
0,403  0,035  ESRRA expression enhancer
0,429  0,061  PLA2G2A expression enhancer
0,405  0,039  CALU expression inhibitor
0,452  0,087  BCL2L1 expression inhibitor
0,431  0,065  RRM2 expression inhibitor
0,419  0,054  E2F1 expression inhibitor
0,409  0,044  CLSTN1 expression inhibitor
0,431  0,067  CYP4A11 expression enhancer
0,412  0,049  IGFBP5 expression enhancer
0,406  0,046  LAMA3 expression enhancer
0,406  0,049  BID expression inhibitor
0,426  0,070  NOL5A expression inhibitor
0,414  0,059  CCNE1 expression inhibitor
0,428  0,075  TP53I3 expression enhancer
0,443  0,091  TNFSF9 expression enhancer
0,416  0,064  KLF10 expression inhibitor
0,409  0,058  ALPL expression enhancer
0,448  0,097  STAT3 expression inhibitor
0,424  0,075  ABCC6 expression inhibitor
0,411  0,062  PGM2 expression enhancer
0,402  0,054  TXNRD1 expression enhancer
0,446  0,102  TIMP1 expression enhancer
0,421  0,079  IL10 expression enhancer
0,408  0,069  KLK3 expression inhibitor
0,423  0,090  DDIT4 expression enhancer
0,414  0,085  SLC3A2 expression enhancer
0,449  0,124  FYTTD1 expression inhibitor
0,449  0,124  MST4 expression inhibitor
0,449  0,124  TRAK2 expression inhibitor
0,449  0,124  USP32 expression inhibitor
0,437  0,112  UGCG expression enhancer
0,433  0,112  PDE9A expression inhibitor
0,431  0,113  CD36 expression inhibitor
0,409  0,091  COL4A1 expression inhibitor
0,405  0,093  MYB expression inhibitor
0,409  0,102  AGPS expression inhibitor
0,407  0,109  CCND1 expression inhibitor

>  <Mechanisms>
0,925  0,004  5 Hydroxytryptamine release stimulant
0,855  0,006  Taurine dehydrogenase inhibitor
0,836  0,004  Polyamine-transporting ATPase inhibitor
0,838  0,008  Glucose oxidase inhibitor
0,830  0,004  Venombin AB inhibitor
0,863  0,046  Transferase stimulant
0,822  0,005  Omptin inhibitor
0,815  0,017  Transferase inhibitor
0,788  0,003  MAP kinase stimulant
0,811  0,034  Membrane integrity agonist
0,777  0,006  N-benzyloxycarbonylglycine hydrolase inhibitor
0,761  0,001  5 Hydroxytryptamine 7S antagonist
0,763  0,005  Aryl-acylamidase inhibitor
0,762  0,007  Limulus clotting factor C inhibitor
0,761  0,011  Exoribonuclease II inhibitor
0,752  0,005  Pin1 inhibitor
0,749  0,005  Protein-tyrosine phosphatase alpha inhibitor
0,754  0,009  Superoxide dismutase inhibitor
0,745  0,001  5 Hydroxytryptamine 7L antagonist
0,752  0,011  Complement factor D inhibitor
0,737  0,005  Endopeptidase So inhibitor
0,731  0,001  Aralkylamine dehydrogenase inhibitor
0,740  0,011  Dimethylargininase inhibitor
0,732  0,005  Fibrolase inhibitor
0,738  0,015  Arginine 2-monooxygenase inhibitor
0,725  0,004  Albendazole monooxygenase inhibitor
0,730  0,010  Macrophage colony stimulating factor agonist
0,738  0,026  Glycosylphosphatidylinositol phospholipase D inhibitor
0,716  0,008  Methylumbelliferyl-acetate deacetylase inhibitor
0,728  0,021  Nicotinic alpha2beta2 receptor antagonist
0,709  0,003  Arylsulfatase inhibitor
0,735  0,030  NACHT, LRR and PYD domains-containing protein 1 inhibitor
0,714  0,013  Arylsulfate sulfotransferase inhibitor
0,712  0,012  27-Hydroxycholesterol 7alpha-monooxygenase inhibitor
0,704  0,006  N-formylmethionyl-peptidase inhibitor
0,718  0,020  Lysase inhibitor
0,707  0,015  Lysine 2,3-aminomutase inhibitor
0,733  0,042  Mucomembranous protector
0,686  0,004  Imidazoline receptor agonist
0,685  0,004  N-Acyl-D-amino-acid deacylase inhibitor
0,681  0,004  Acetylornithine deacetylase inhibitor
0,675  0,004  Arylesterase inhibitor
0,671  0,006  Pyroglutamyl-peptidase II inhibitor
0,709  0,044  DNA ligase 1 inhibitor
0,680  0,015  IgA-specific serine endopeptidase inhibitor
0,676  0,012  Hydrogen dehydrogenase inhibitor
0,667  0,003  CYP2A6 inhibitor
0,681  0,019  Fragilysin inhibitor
0,680  0,022  Carboxypeptidase Taq inhibitor
0,660  0,002  Renilla-luciferin 2-monooxygenase inhibitor
0,687  0,030  Pro-opiomelanocortin converting enzyme inhibitor
0,663  0,008  Cathepsin T inhibitor
0,663  0,013  Pitrilysin inhibitor
0,660  0,010  Sulfite reductase inhibitor
0,657  0,010  Peptide alpha-N-acetyltransferase inhibitor
0,651  0,004  GABA C receptor agonist
0,673  0,030  Acylcarnitine hydrolase inhibitor
0,657  0,014  Glutamine-phenylpyruvate transaminase inhibitor
0,647  0,008  Sulfur reductase inhibitor
0,654  0,015  2-Hydroxymuconate-semialdehyde hydrolase inhibitor
0,650  0,013  Platelet aggregation stimulant
0,659  0,022  UDP-N-acetylglucosamine 4-epimerase inhibitor
0,642  0,009  Insulin growth factor agonist
0,642  0,009  Insulin like growth factor 1 agonist
0,641  0,011  S-alkylcysteine lyase inhibitor
0,629  0,003  Phenylalanine 4-hydroxylase inhibitor
0,641  0,017  Formaldehyde transketolase inhibitor
0,629  0,008  Glucan 1,4-alpha-maltotetraohydrolase inhibitor
0,640  0,019  Manganese peroxidase inhibitor
0,631  0,012  Aspartate-ammonia ligase inhibitor
0,624  0,007  Histamine release stimulant
0,658  0,042  Sugar-phosphatase inhibitor
0,636  0,020  Fatty-acyl-CoA synthase inhibitor
0,630  0,014  Acetylcholine neuromuscular blocking agent
0,629  0,013  X-methyl-His dipeptidase inhibitor
0,631  0,016  Oxygen scavenger
0,687  0,073  Ubiquinol-cytochrome-c reductase inhibitor
0,636  0,024  Alkane 1-monooxygenase inhibitor
0,624  0,017  Biotinidase inhibitor
0,609  0,004  2-Nitropropane dioxygenase inhibitor
0,618  0,013  Carnitinamidase inhibitor
0,625  0,022  Cytoprotectant
0,641  0,037  NADPH peroxidase inhibitor
0,614  0,013  Calmodulin antagonist
0,640  0,039  Penicillin binding protein antagonist
0,640  0,039  Penicillin-binding protein ampH inhibitor
0,607  0,014  Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase inhibitor
0,596  0,004  DNA-3-methyladenine glycosylase I inhibitor
0,600  0,012  Neurotransmitter antagonist
0,592  0,004  Phenylalanine racemase (ATP-hydrolysing) inhibitor
0,598  0,013  Collagen inhibitor
0,602  0,019  Phenol O-methyltransferase inhibitor
0,581  0,001  Tyrosine kinase stimulant
0,601  0,026  Pterin deaminase inhibitor
0,609  0,035  Dehydro-L-gulonate decarboxylase inhibitor
0,580  0,007  Glycine dehydrogenase (decarboxylating) inhibitor
0,578  0,006  Guanidinoacetase inhibitor
0,604  0,033  Glutathione thiolesterase inhibitor
0,596  0,025  Muramoyltetrapeptide carboxypeptidase inhibitor
0,591  0,020  Aspartate-phenylpyruvate transaminase inhibitor
0,576  0,008  Meprin B inhibitor
0,573  0,006  Pancreatic ribonuclease inhibitor
0,626  0,060  Polyporopepsin inhibitor
0,593  0,027  Phosphatidylserine decarboxylase inhibitor
0,576  0,011  Fructan beta-fructosidase inhibitor
0,586  0,023  Pullulanase inhibitor
0,593  0,030  Thioredoxin inhibitor
0,601  0,040  Kidney function stimulant
0,598  0,038  Methylenetetrahydrofolate reductase (NADPH) inhibitor
0,567  0,007  Gamma-D-Glutamyl-meso-diaminopimelate peptidase inhibitor
0,576  0,019  Platelet adhesion inhibitor
0,566  0,009  Gingipain K inhibitor
0,570  0,015  Thiol oxidase inhibitor
0,568  0,015  Enteropeptidase inhibitor
0,562  0,009  Yeast ribonuclease inhibitor
0,577  0,025  L-glutamate oxidase inhibitor
0,575  0,029  Peptidyl-dipeptidase Dcp inhibitor
0,564  0,020  Mitochondrial processing peptidase inhibitor
0,547  0,004  Calcium-sensing receptor agonist
0,566  0,026  Ecdysone 20-monooxygenase inhibitor
0,559  0,021  Urethanase inhibitor
0,566  0,028  Adenomatous polyposis treatment
0,565  0,028  Gluconate 5-dehydrogenase inhibitor
0,566  0,030  Peroxidase inhibitor
0,536  0,003  Tryptophan 2,3-dioxygenase inhibitor
0,552  0,022  Chenodeoxycholoyltaurine hydrolase inhibitor
0,538  0,009  Inulinase inhibitor
0,546  0,016  Psychostimulant
0,547  0,021  Mannan endo-1,4-beta-mannosidase inhibitor
0,546  0,022  Gamma-guanidinobutyraldehyde dehydrogenase inhibitor
0,569  0,047  Oxidoreductase inhibitor
0,556  0,036  Lipoprotein lipase inhibitor
0,537  0,019  Choline-phosphate cytidylyltransferase inhibitor
0,537  0,020  Threonine aldolase inhibitor
0,523  0,006  Oxidizing agent
0,529  0,013  Ethanolamine-phosphate cytidylyltransferase inhibitor
0,540  0,025  Lysostaphin inhibitor
0,519  0,003  Tryptophan 2-monooxygenase inhibitor
0,544  0,028  3-Hydroxybenzoate 6-monooxygenase inhibitor
0,520  0,004  Phenylalanine dehydrogenase inhibitor
0,543  0,028  Methylamine-glutamate N-methyltransferase inhibitor
0,536  0,022  Renal tissue kallikrein inhibitor
0,549  0,036  Protein-glutamate methylesterase inhibitor
0,520  0,008  Ferredoxin hydrogenase inhibitor
0,521  0,009  2,3,4,5-Tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase inhibitor
0,536  0,025  All-trans-retinyl-palmitate hydrolase inhibitor
0,539  0,031  Fucosterol-epoxide lyase inhibitor
0,564  0,057  Vasodilator, cerebral
0,519  0,012  Myeloblastin inhibitor
0,549  0,042  Anorexiant
0,521  0,014  Mydriatic
0,521  0,016  Cyclohexyl-isocyanide hydratase inhibitor
0,522  0,018  Isopenicillin-N epimerase inhibitor
0,527  0,023  Chitinase inhibitor
0,518  0,015  Opine dehydrogenase inhibitor
0,522  0,020  Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase inhibitor
0,506  0,003  Histamine H1 receptor agonist
0,525  0,023  Glyoxylate reductase inhibitor
0,529  0,028  Fibroblast growth factor agonist
0,568  0,068  Chlordecone reductase inhibitor
0,516  0,017  2-Haloacid dehalogenase inhibitor
0,514  0,015  Phosphatidylglycerophosphatase inhibitor
0,525  0,026  Creatininase inhibitor
0,526  0,026  Arylacetonitrilase inhibitor
0,522  0,025  Ferredoxin-NAD+ reductase inhibitor
0,522  0,025  Naphthalene 1,2-dioxygenase inhibitor
0,517  0,021  Arylmalonate decarboxylase inhibitor
0,498  0,002  Putrescine oxidase inhibitor
0,520  0,024  Cyclic AMP agonist
0,499  0,003  Adrenergic, ophthalmic
0,533  0,038  Nitrate reductase (cytochrome) inhibitor
0,501  0,008  Methane monooxygenase inhibitor
0,503  0,009  Ubiquitin thiolesterase inhibitor
0,514  0,022  Corticosteroid side-chain-isomerase inhibitor
0,535  0,043  2-Hydroxyquinoline 8-monooxygenase inhibitor
0,507  0,015  Carboxypeptidase D inhibitor
0,534  0,043  Beta-adrenergic receptor kinase inhibitor
0,534  0,043  G-protein-coupled receptor kinase inhibitor
0,504  0,015  Leucolysin inhibitor
0,497  0,008  Flavin-containing monooxygenase inhibitor
0,520  0,032  ADP-thymidine kinase inhibitor
0,500  0,013  Glucuronate isomerase inhibitor
0,500  0,013  D-xylulose reductase inhibitor
0,516  0,030  NAD(P)+-arginine ADP-ribosyltransferase inhibitor
0,491  0,008  Indoleacetaldoxime dehydratase inhibitor
0,495  0,014  Diamine N-acetyltransferase inhibitor
0,530  0,050  Phospholipid-translocating ATPase inhibitor
0,498  0,018  Hypocalcaemic
0,516  0,036  HIV rev inhibitor
0,489  0,010  Carnosine synthase inhibitor
0,504  0,026  Cyclohexanone monooxygenase inhibitor
0,486  0,010  Acidifying agent non gastric
0,502  0,028  Bisphosphoglycerate phosphatase inhibitor
0,513  0,039  Cyclic AMP antagonist
0,478  0,005  5 Hydroxytryptamine 1E antagonist
0,516  0,043  Feruloyl esterase inhibitor
0,483  0,011  Styrene-oxide isomerase inhibitor
0,474  0,003  Phenylalanine decarboxylase inhibitor
0,475  0,004  Sodium channel blocker class Ib
0,503  0,032  (S)-6-hydroxynicotine oxidase inhibitor
0,485  0,015  Tryptophanamidase inhibitor
0,513  0,043  (R)-6-hydroxynicotine oxidase inhibitor
0,520  0,050  Glucan endo-1,3-beta-D-glucosidase inhibitor
0,488  0,018  Histidinol-phosphatase inhibitor
0,475  0,006  Xaa-Pro dipeptidyl-peptidase inhibitor
0,481  0,013  Guanidinoacetate kinase inhibitor
0,488  0,020  Opheline kinase inhibitor
0,488  0,020  Taurocyamine kinase inhibitor
0,473  0,006  N-Carbamoyl-D-amino acid hydrolase inhibitor
0,482  0,016  Procollagen N-endopeptidase inhibitor
0,481  0,015  D-alanine 2-hydroxymethyltransferase inhibitor
0,487  0,022  Long-chain-aldehyde dehydrogenase inhibitor
0,497  0,032  Benzodiazepine omega receptor agonist
0,471  0,007  5 Hydroxytryptamine agonist
0,477  0,014  Taurine-2-oxoglutarate transaminase inhibitor
0,496  0,033  Thromboxane B2 antagonist
0,486  0,024  (-)-(4S)-limonene synthase inhibitor
0,484  0,023  4-Hydroxyphenylacetate 3-monooxygenase inhibitor
0,470  0,009  Glycine amidinotransferase inhibitor
0,474  0,016  Hematopoietic inhibitor
0,468  0,010  Aminoacylase inhibitor
0,488  0,030  Hydroxylamine oxidase inhibitor
0,465  0,008  Tryptophan transaminase inhibitor
0,495  0,038  Linoleate diol synthase inhibitor
0,459  0,003  Tryptophan alpha,beta-oxidase inhibitor
0,472  0,018  Glycolate dehydrogenase inhibitor
0,461  0,007  Aspartoacylase inhibitor
0,461  0,007  Nitrilase inhibitor
0,482  0,030  Leukotriene-B4 20-monooxygenase inhibitor
0,485  0,033  Insulin promoter
0,480  0,029  Sigma receptor agonist
0,464  0,014  Phenylalanine(histidine) transaminase inhibitor
0,458  0,010  5 Hydroxytryptamine 2B agonist
0,472  0,024  Nitrite reductase (NO-forming) inhibitor
0,494  0,047  Galanin receptor antagonist
0,470  0,024  Alanine-tRNA ligase inhibitor
0,483  0,038  Complement factor 1s inhibitor
0,469  0,024  Nav1.6 sodium channel blocker
0,497  0,053  Glucan endo-1,6-beta-glucosidase inhibitor
0,461  0,021  Acylaminoacyl-peptidase inhibitor
0,476  0,036  5 Hydroxytryptamine release inhibitor
0,454  0,014  Dipeptidase E inhibitor
0,477  0,037  Nucleotide metabolism regulator
0,446  0,007  Aryl hydrocarbon receptor agonist
0,487  0,048  Fibrinogen receptor antagonist
0,493  0,055  Potassium sparing diuretic
0,452  0,015  Benzaldehyde dehydrogenase (NADP+) inhibitor
0,456  0,020  Glutarate-semialdehyde dehydrogenase inhibitor
0,442  0,006  Adrenaline release stimulant
0,460  0,025  Sulfite oxidase inhibitor
0,478  0,044  Cl--transporting ATPase inhibitor
0,444  0,011  Botulin neurotoxin A light chain inhibitor
0,456  0,024  Poly(beta-D-mannuronate) lyase inhibitor
0,445  0,013  L-threonine 3-dehydrogenase inhibitor
0,442  0,010  TRPA1 agonist
0,443  0,014  Serine-pyruvate transaminase inhibitor
0,443  0,015  N-hydroxy-2-acetamidofluorene reductase inhibitor
0,463  0,035  Cytochrome P450 stimulant
0,461  0,034  tRNA-pseudouridine synthase I inhibitor
0,463  0,036  S-formylglutathione hydrolase inhibitor
0,489  0,064  Alkenylglycerophosphocholine hydrolase inhibitor
0,447  0,021  Methanol dehydrogenase inhibitor
0,450  0,025  Cyanoalanine nitrilase inhibitor
0,545  0,120  Membrane permeability inhibitor
0,427  0,004  Lysyl oxidase inhibitor
0,461  0,038  Acetylesterase inhibitor
0,431  0,009  2-Dehydropantoate aldolase inhibitor
0,471  0,049  Erythropoiesis stimulant
0,438  0,018  Horrilysin inhibitor
0,442  0,023  Gluconolactonase inhibitor
0,443  0,024  Fibroblast growth factor 1 agonist
0,433  0,015  6-Carboxyhexanoate-CoA ligase inhibitor
0,433  0,015  Biotin-CoA ligase inhibitor
0,433  0,015  Homoaconitate hydratase inhibitor
0,433  0,015  Triacetate-lactonase inhibitor
0,466  0,049  GABA C receptor rho-3 antagonist
0,422  0,005  Acetylenecarboxylate hydratase inhibitor
0,443  0,026  Chitosanase inhibitor
0,429  0,013  Cyclopentanone monooxygenase inhibitor
0,449  0,033  Phosphoinositide 5-phosphatase inhibitor
0,425  0,010  Acetylspermidine deacetylase inhibitor
0,425  0,010  Tyrosine 3 hydroxylase inhibitor
0,422  0,007  Valine decarboxylase inhibitor
0,477  0,062  Alkylacetylglycerophosphatase inhibitor
0,418  0,004  Pyridoxal kinase inhibitor
0,418  0,005  Gingipain R inhibitor
0,426  0,014  Bontoxilysin inhibitor
0,471  0,060  Insulysin inhibitor
0,425  0,014  Nardilysin inhibitor
0,427  0,016  3-Hydroxybenzoate 4-monooxygenase inhibitor
0,419  0,009  Phenylpyruvate decarboxylase inhibitor
0,424  0,014  Phosphoenolpyruvate mutase inhibitor
0,427  0,017  Polyneuridine-aldehyde esterase inhibitor
0,424  0,014  Picornain 3C inhibitor
0,451  0,043  Galanin receptor 2 antagonist
0,434  0,027  IgA-specific metalloendopeptidase inhibitor
0,433  0,026  Mannose isomerase inhibitor
0,410  0,004  Procollagen-lysine 5-dioxygenase inhibitor
0,424  0,019  Succinyl-diaminopimelate desuccinylase inhibitor
0,417  0,012  N-acetylneuraminate synthase inhibitor
0,427  0,022  Di-trans,poly-cis-decaprenylcistransferase inhibitor
0,417  0,013  Gallate decarboxylase inhibitor
0,434  0,031  NADH kinase inhibitor
0,424  0,022  Transketolase inhibitor
0,481  0,079  Gastrin inhibitor
0,431  0,029  Adenylyl-sulfate reductase inhibitor
0,429  0,028  DNA-(apurinic or apyrimidinic site) lyase inhibitor
0,437  0,036  (R)-Pantolactone dehydrogenase (flavin) inhibitor
0,424  0,024  Bothrolysin inhibitor
0,416  0,017  Aminopeptidase Y inhibitor
0,404  0,005  L-lysine 6-transaminase inhibitor
0,429  0,032  N-methylhydantoinase (ATP-hydrolysing) inhibitor
0,402  0,007  Histidinol dehydrogenase inhibitor
0,434  0,039  Prostaglandin-A1 DELTA-isomerase inhibitor
0,413  0,019  Glycerol 2-dehydrogenase (NADP+) inhibitor
0,408  0,015  Polygalacturonase inhibitor
0,411  0,018  Urease inhibitor
0,430  0,038  Caspase 8 stimulant
0,418  0,026  DELTA14-sterol reductase inhibitor
0,425  0,033  3-Phytase inhibitor
0,403  0,011  Penicillin amidase inhibitor
0,411  0,022  Catechol oxidase inhibitor
0,415  0,027  Cholestanetriol 26-monooxygenase inhibitor
0,411  0,023  Crotonoyl-[acyl-carrier-protein] hydratase inhibitor
0,418  0,030  Leukotriene-C4 synthase inhibitor
0,427  0,040  N-hydroxyarylamine O-acetyltransferase inhibitor
0,415  0,028  Prolyl aminopeptidase inhibitor
0,414  0,029  Glyoxylate oxidase inhibitor
0,422  0,037  Nucleoside oxidase (H2O2-forming) inhibitor
0,413  0,031  Nicotinate dehydrogenase inhibitor
0,407  0,028  Venom exonuclease inhibitor
0,400  0,022  Opioid kappa 3 receptor antagonist
0,419  0,041  Steroid N-acetylglucosaminyltransferase inhibitor
0,415  0,038  Malate oxidase inhibitor
0,420  0,045  Glucan 1,4-alpha-maltotriohydrolase inhibitor
0,406  0,031  4-Hydroxymandelate oxidase inhibitor
0,404  0,031  Phosphatidylinositol diacylglycerol-lyase inhibitor
0,402  0,030  Coccolysin inhibitor
0,403  0,032  Levanase inhibitor
0,403  0,032  Phosphatidylcholine-sterol O-acyltransferase inhibitor
0,405  0,035  Monodehydroascorbate reductase (NADH) inhibitor
0,403  0,033  Carbon-monoxide dehydrogenase inhibitor
0,413  0,043  GABA aminotransferase inhibitor
0,414  0,046  Peptidoglycan glycosyltransferase inhibitor
0,412  0,045  RNA-directed RNA polymerase inhibitor
0,422  0,062  Aldehyde oxidase inhibitor
0,426  0,068  Peptide agonist
0,411  0,057  Malate dehydrogenase (acceptor) inhibitor
0,407  0,053  Amine dehydrogenase inhibitor
0,408  0,054  Na+-transporting two-sector ATPase inhibitor
0,405  0,051  Plastoquinol-plastocyanin reductase inhibitor
0,403  0,056  Gonadotropin antagonist
0,402  0,057  Membrane permeability enhancer
0,442  0,098  General pump inhibitor
0,424  0,095  NACHT, LRR and PYD domains-containing protein 3 inhibitor
0,423  0,170  Phosphatase inhibitor
0,410  0,206  Nootropic

>  <Metabolism>
0,803  0,003  CYP2D16 substrate
0,811  0,034  CYP2C12 substrate
0,732  0,001  MAO B substrate
0,746  0,035  CYP2J substrate
0,679  0,002  Monoamine oxidase substrate
0,670  0,004  Flavin-containing monooxygenase substrate
0,667  0,003  CYP2A6 inhibitor
0,651  0,004  GST M substrate
0,663  0,028  GST A substrate
0,633  0,002  CYP2A5 inhibitor
0,630  0,004  Peroxidase substrate
0,618  0,004  FMO3 substrate
0,607  0,019  CYP2B6 inhibitor
0,586  0,002  MAO A substrate
0,574  0,017  CYP2F1 substrate
0,539  0,014  CYP2D2 inhibitor
0,545  0,025  CYP2D6 substrate
0,543  0,025  CYP2D substrate
0,519  0,012  CYP1A inducer
0,508  0,004  CYP2C3 substrate
0,522  0,052  CYP2C8 inhibitor
0,476  0,013  CYP2C10 substrate
0,482  0,027  FMO1 substrate
0,446  0,004  SULT1A3 substrate
0,477  0,038  CYP2A8 substrate
0,470  0,039  CYP2B5 substrate
0,449  0,021  CYP4A1 inhibitor
0,463  0,037  CYP3A3 substrate
0,437  0,023  CYP2G1 substrate
0,464  0,054  CYP2 substrate
0,418  0,016  CYP2E1 inhibitor
0,434  0,038  CYP2C18 substrate
0,430  0,041  CYP1A substrate
0,429  0,041  CYP1 substrate
0,404  0,024  UGT1A6 substrate
0,420  0,050  CYP2A4 substrate
0,401  0,040  CYP2C19 inducer
0,418  0,060  CYP2C8 substrate
0,416  0,071  CYP2A1 substrate
0,443  0,111  CYP3A2 substrate

>  <Toxicity>
0,958  0,009  Toxic, respiration
0,926  0,004  Hyperactivity
0,917  0,011  Bone marrow suppression
0,912  0,008  Euphoria
0,892  0,004  Fibrillation, atrial
0,893  0,009  Alopecia (hair loss)
0,878  0,005  Aseptic meningitis
0,872  0,004  Myocardial ischemia
0,857  0,011  Ejaculation dysfunction
0,852  0,018  Shivering
0,826  0,007  Galactorrhea
0,811  0,004  Anorgasmia
0,823  0,017  Lichenoid eruption
0,810  0,008  Hyperreflexia
0,799  0,013  Hyponatremia
0,790  0,005  Hypersexuality
0,800  0,017  Psychomotor impairment
0,787  0,012  Mania
0,787  0,016  Postural (orthostatic) hypotension
0,778  0,008  Lymphocytosis
0,768  0,012  Apnea
0,772  0,019  Nystagmus
0,767  0,014  Hyperglycemic
0,774  0,024  Dysesthesia
0,763  0,013  Urine discoloration
0,776  0,028  Pure red cell aplasia
0,763  0,018  Acidosis, metabolic
0,768  0,023  Psychosexual disorder
0,768  0,024  Cerebral hemorrhage
0,744  0,006  Parkinsonism
0,748  0,012  Depression
0,744  0,010  Cyanosis
0,754  0,022  Gait disturbance
0,734  0,005  Acneiform eruption
0,751  0,026  Reproductive dysfunction
0,760  0,036  Stroke
0,733  0,010  Fibrosis, interstitial
0,733  0,013  Withdrawal
0,730  0,010  Psychoses
0,754  0,034  Anemia, hemolytic
0,724  0,007  Anemia, sideroblastic
0,743  0,028  Toxic, vascular
0,743  0,033  Paranoia
0,728  0,018  Weight gain
0,729  0,022  Enuresis
0,697  0,005  Palpitation
0,705  0,016  Hypomagnesemia
0,702  0,016  Dependence
0,692  0,008  Yawning
0,697  0,014  Chorea
0,721  0,044  Leukocytosis
0,704  0,031  Hypoxia
0,713  0,042  Hiccups
0,679  0,016  Hematuria
0,678  0,015  Pseudoporphyria
0,672  0,009  Porphyria
0,673  0,012  Akinesia
0,707  0,047  Eye pain
0,672  0,020  Panic
0,669  0,019  Hallucinogen
0,677  0,027  Aphasia
0,674  0,025  Osteoporosis
0,667  0,022  Hyperthermic
0,674  0,030  Aggression
0,673  0,029  Delirium
0,654  0,013  ANCA-positive vasculitis
0,672  0,032  Diplopia
0,661  0,021  Ototoxicity
0,684  0,046  Renal insufficiency
0,657  0,018  Cardiogenic shock
0,649  0,013  Adrenal cortex hypoplasia
0,663  0,028  Nightmare
0,648  0,013  Visual acuity impairment
0,664  0,030  Akathisia
0,655  0,021  Respiratory impairment
0,665  0,034  Hypotonia
0,652  0,022  Hypothermic
0,664  0,038  Ulcer, esophageal
0,666  0,042  Photophobia
0,649  0,027  Splenomegaly
0,670  0,050  Ulcer, aphthous
0,657  0,038  Extrapyramidal effect
0,645  0,029  Desquamation
0,648  0,034  Dysarthria
0,620  0,013  Hypomania
0,612  0,008  Vasopressor
0,632  0,033  Bradycardic
0,625  0,027  Dystonia
0,637  0,040  Erectile dysfunction
0,614  0,017  Choreoathetosis
0,641  0,045  Tachycardiac
0,635  0,042  Hypertensive
0,614  0,022  Spasmogenic
0,623  0,032  Scleroderma
0,604  0,014  Fatty liver
0,636  0,049  Muscle rigidity
0,620  0,034  Tremor
0,632  0,047  Status epilepticus
0,587  0,004  Piloerection
0,607  0,026  Delusion
0,621  0,040  Neurotoxic
0,613  0,038  Edema
0,617  0,042  Hematemesis
0,590  0,016  Raynaud's phenomenon
0,626  0,051  Hypercholesterolemic
0,606  0,036  Paralysis
0,608  0,039  Asthma
0,586  0,019  Systemic lupus erythematosus
0,589  0,022  Dysphoria
0,604  0,041  Necrosis
0,621  0,060  Neuritis
0,602  0,043  Drug eruption
0,591  0,033  Dyspnea
0,600  0,044  Myoclonus
0,597  0,040  Bronchoconstrictor
0,588  0,032  Hyperuricemia
0,609  0,055  Myocardial infarction
0,566  0,013  Parotid gland enlargement
0,613  0,065  Migraine
0,582  0,035  Speech disturbance
0,568  0,022  Nephrotic syndrome
0,601  0,055  Gastrointestinal hemorrhage
0,584  0,038  Coma
0,593  0,049  Urinary retention
0,585  0,041  Allergic contact dermatitis
0,576  0,033  Keratitis
0,580  0,036  Allergic dermatitis
0,593  0,055  Shock
0,589  0,051  Lethargy
0,587  0,051  Acidosis
0,585  0,052  Optic neuritis
0,586  0,054  Memory impairment
0,589  0,059  Anxiety
0,576  0,050  Confusion
0,586  0,063  Sexual dysfunction
0,572  0,056  Optic neuropathy
0,569  0,054  Amnesia
0,568  0,055  Thrombophlebitis
0,552  0,040  Keratopathy
0,550  0,039  Enterocolitis
0,564  0,054  Arrhythmogenic
0,545  0,037  Endocrine disruptor
0,542  0,035  Peripheral neuropathy
0,532  0,025  Miotic
0,549  0,042  Anorexiant
0,521  0,014  Mydriatic
0,511  0,006  Carcinogenic, group 1
0,567  0,063  Consciousness alteration
0,545  0,041  Colitis
0,564  0,063  Weakness
0,563  0,064  Ectropion
0,517  0,019  Torticollis
0,582  0,083  Electrolyte imbalance
0,529  0,033  Glaucoma
0,559  0,064  Proteinuria
0,542  0,047  Hyperkinesia
0,526  0,032  Laryngospasm
0,579  0,084  Abdominal pain
0,544  0,052  Ataxia
0,559  0,069  Erythema multiforme
0,549  0,064  Hypotension
0,560  0,077  Dry eye
0,551  0,068  Urticaria
0,538  0,055  Respiratory failure
0,516  0,034  Pulmonary edema
0,534  0,053  Nephritis
0,498  0,018  Hypocalcaemic
0,538  0,058  Dyskinesia
0,507  0,029  Methemoglobinemia
0,558  0,081  Heart failure
0,560  0,084  Hot flush
0,537  0,063  Anaphylaxis
0,524  0,050  Glycosuria
0,496  0,023  Lacrimal secretion stimulant
0,536  0,067  Toxic epidermal necrolysis
0,490  0,022  Bullous pemphigoid
0,542  0,075  Purpura
0,497  0,036  Torsades de pointes
0,539  0,081  Pancreatitis
0,478  0,021  Cleft palate
0,537  0,080  Dizziness
0,531  0,074  Behavioral disturbance
0,486  0,030  Demyelination
0,545  0,091  Rhinitis
0,532  0,079  Hemolysis
0,503  0,053  Priapism
0,532  0,081  Stomatitis
0,532  0,082  Xerostomia
0,544  0,095  Chest pain
0,504  0,057  Pancytopenia
0,450  0,009  Zinc deficiency
0,505  0,064  Cataract
0,520  0,080  Syncope
0,450  0,009  Renal papillary necrosis
0,518  0,077  Jaundice
0,522  0,084  Vasculitis
0,524  0,087  Hepatitis
0,514  0,078  Hyperbilirubinemia
0,522  0,088  Emetic
0,465  0,032  Thrombocytopoiesis inhibitor
0,466  0,034  Fasciculation
0,522  0,090  Dermatitis
0,471  0,039  Acidosis, lactic
0,523  0,091  Pain
0,512  0,082  Vision disturbance
0,454  0,026  Cardiodepressant
0,518  0,090  Headache
0,469  0,042  QT interval prolongation
0,505  0,079  Inflammation
0,515  0,090  Allergic reaction
0,518  0,094  Nausea
0,475  0,053  Serum sickness
0,509  0,087  Sensory disturbance
0,494  0,072  Weight loss
0,506  0,085  Diarrhea
0,520  0,099  Vertigo
0,476  0,055  Eosinophilia
0,526  0,107  Arthralgia
0,510  0,093  Malaise
0,435  0,020  Henoch-Schonlein purpura
0,439  0,026  Pemphigus
0,484  0,072  Agitation
0,502  0,091  Excitability
0,513  0,102  Myalgia
0,491  0,082  Cardiotoxic
0,510  0,104  Dyspepsia
0,472  0,072  Hirsutism
0,425  0,028  Catatonia
0,492  0,098  Chills
0,457  0,065  Immunotoxin
0,463  0,077  Anemia
0,462  0,076  Muscle weakness
0,466  0,081  Convulsant
0,475  0,092  Ocular toxicity
0,446  0,063  Photoallergy dermatitis
0,420  0,038  Myasthenia Gravis
0,467  0,090  Hepatic necrosis
0,440  0,064  Cholestasis
0,501  0,127  Hemorrhage
0,478  0,107  Constipation
0,473  0,104  Erythema
0,417  0,050  Ulceration
0,441  0,075  Interstitial nephritis
0,471  0,107  Toxic, gastrointestinal
0,468  0,108  Insomnia
0,461  0,105  Sleep disturbance
0,462  0,107  Drowsiness
0,467  0,116  Thrombocytopenia
0,447  0,099  Injection site pain
0,431  0,102  Nephrotoxic
0,439  0,116  Pruritus
0,430  0,108  Leukopenia
0,405  0,097  Agranulocytosis
0,437  0,129  Exanthema

>  <Transporter>
0,702  0,003  Monoamine uptake inhibitor

>  <Murcko.CdId>
9412

>  <Murcko.Mol Weight>
128.1705

>  <Murcko.Formula>
C10H8

>  <Murcko.AKOS_NUMBER>
AKOS000151504

>  <Murcko.IntegerID>
9411

$$$$
